A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size
Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This...
Ausführliche Beschreibung
Autor*in: |
Varmazyari, V. [verfasserIn] Ghafoorifard, H. [verfasserIn] Habibiyan, H. [verfasserIn] Ebrahimi, M. [verfasserIn] Ghafouri-Fard, S. [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
Enthalten in: Journal of molecular liquids - New York, NY [u.a.] : Elsevier, 1983, 349 |
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Übergeordnetes Werk: |
volume:349 |
DOI / URN: |
10.1016/j.molliq.2021.118192 |
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Katalog-ID: |
ELV007372094 |
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245 | 1 | 0 | |a A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
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520 | |a Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. | ||
650 | 4 | |a Microfluidics | |
650 | 4 | |a Cell separation | |
650 | 4 | |a Circulating Tumor Cell | |
650 | 4 | |a Deterministic lateral displacement | |
650 | 4 | |a Dielectrophoresis | |
700 | 1 | |a Ghafoorifard, H. |e verfasserin |4 aut | |
700 | 1 | |a Habibiyan, H. |e verfasserin |4 aut | |
700 | 1 | |a Ebrahimi, M. |e verfasserin |4 aut | |
700 | 1 | |a Ghafouri-Fard, S. |e verfasserin |4 aut | |
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10.1016/j.molliq.2021.118192 doi (DE-627)ELV007372094 (ELSEVIER)S0167-7322(21)02917-2 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Varmazyari, V. verfasserin aut A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. Microfluidics Cell separation Circulating Tumor Cell Deterministic lateral displacement Dielectrophoresis Ghafoorifard, H. verfasserin aut Habibiyan, H. verfasserin aut Ebrahimi, M. verfasserin aut Ghafouri-Fard, S. verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 349 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:349 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 349 |
spelling |
10.1016/j.molliq.2021.118192 doi (DE-627)ELV007372094 (ELSEVIER)S0167-7322(21)02917-2 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Varmazyari, V. verfasserin aut A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. Microfluidics Cell separation Circulating Tumor Cell Deterministic lateral displacement Dielectrophoresis Ghafoorifard, H. verfasserin aut Habibiyan, H. verfasserin aut Ebrahimi, M. verfasserin aut Ghafouri-Fard, S. verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 349 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:349 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 349 |
allfields_unstemmed |
10.1016/j.molliq.2021.118192 doi (DE-627)ELV007372094 (ELSEVIER)S0167-7322(21)02917-2 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Varmazyari, V. verfasserin aut A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. Microfluidics Cell separation Circulating Tumor Cell Deterministic lateral displacement Dielectrophoresis Ghafoorifard, H. verfasserin aut Habibiyan, H. verfasserin aut Ebrahimi, M. verfasserin aut Ghafouri-Fard, S. verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 349 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:349 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 349 |
allfieldsGer |
10.1016/j.molliq.2021.118192 doi (DE-627)ELV007372094 (ELSEVIER)S0167-7322(21)02917-2 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Varmazyari, V. verfasserin aut A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. Microfluidics Cell separation Circulating Tumor Cell Deterministic lateral displacement Dielectrophoresis Ghafoorifard, H. verfasserin aut Habibiyan, H. verfasserin aut Ebrahimi, M. verfasserin aut Ghafouri-Fard, S. verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 349 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:349 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 349 |
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10.1016/j.molliq.2021.118192 doi (DE-627)ELV007372094 (ELSEVIER)S0167-7322(21)02917-2 DE-627 ger DE-627 rda eng 540 DE-600 35.21 bkl Varmazyari, V. verfasserin aut A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. Microfluidics Cell separation Circulating Tumor Cell Deterministic lateral displacement Dielectrophoresis Ghafoorifard, H. verfasserin aut Habibiyan, H. verfasserin aut Ebrahimi, M. verfasserin aut Ghafouri-Fard, S. verfasserin aut Enthalten in Journal of molecular liquids New York, NY [u.a.] : Elsevier, 1983 349 Online-Ressource (DE-627)302469664 (DE-600)1491496-7 (DE-576)259483915 1873-3166 nnns volume:349 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2807 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.21 Lösungen Flüssigkeiten Physikalische Chemie AR 349 |
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Varmazyari, V. ddc 540 bkl 35.21 misc Microfluidics misc Cell separation misc Circulating Tumor Cell misc Deterministic lateral displacement misc Dielectrophoresis A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
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540 DE-600 35.21 bkl A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size Microfluidics Cell separation Circulating Tumor Cell Deterministic lateral displacement Dielectrophoresis |
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ddc 540 bkl 35.21 misc Microfluidics misc Cell separation misc Circulating Tumor Cell misc Deterministic lateral displacement misc Dielectrophoresis |
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ddc 540 bkl 35.21 misc Microfluidics misc Cell separation misc Circulating Tumor Cell misc Deterministic lateral displacement misc Dielectrophoresis |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
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A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
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Varmazyari, V. |
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Journal of molecular liquids |
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Varmazyari, V. Ghafoorifard, H. Habibiyan, H. Ebrahimi, M. Ghafouri-Fard, S. |
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Varmazyari, V. |
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10.1016/j.molliq.2021.118192 |
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540 |
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verfasserin |
title_sort |
a microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
title_auth |
A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
abstract |
Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. |
abstractGer |
Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. |
abstract_unstemmed |
Due to the heterogeneity in the size of circulating tumor cells (CTCs), label-free, high-throughput, and efficient separation of CTCs for post-processing analysis is challenging. Recent advances in hybrid microfluidics have demonstrated enormous potential for the separation of complex samples. This paper presents a hybrid microfluidic platform for label-free cell separation that utilizes a cascade deterministic lateral displacement (DLD) array in conjunction with a traveling wave dielectrophoresis (twDEP) system. CTC clusters and red blood cells are separated from the blood sample in the cascade DLD unit. Other white blood cells (WBCs) and CTCs are classified according to their diameters, ranging from 10 to 15 µm, 15 to 20 µm, and 20 to 25 µm. Each category is connected via an outlet to a twDEP unit to separate CTCs from WBCs (even the same size cells). Our proposed structure outperforms conventional designs. Among them are the uniform pressure distribution at the DLD unit's outlets and the cell viability in the twDEP unit. The effect of flow rate and Reynolds number on the separation dynamics of a cascade DLD unit is investigated in this study, as is surveyed the effect of flow rate and variation in the applied voltage to the array of electrodes on the recovery rate of the twDEP units. According to numerical simulations, a recovery rate of nearly 93% for MDA-MB-231 cells spiked into the blood sample is achievable, which is a high recovery rate for systems that can separate cells of the same and different sizes. |
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title_short |
A microfluidic device for label-free separation sensitivity enhancement of circulating tumor cells of various and similar size |
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Ghafoorifard, H. Habibiyan, H. Ebrahimi, M. Ghafouri-Fard, S. |
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