Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and

Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE)...
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Gespeichert in:

Autor*in:	Purohit, Buddhadev [verfasserIn] Kumar, Ashutosh [verfasserIn] Mahato, Kuldeep [verfasserIn] Srivastava, Ananya [verfasserIn] Chandra, Pranjal [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis

Übergeordnetes Werk:	Enthalten in: Microchemical journal - Orlando, Fla. : Academic Press, 1957, 176
Übergeordnetes Werk:	volume:176

DOI / URN:	10.1016/j.microc.2022.107239

Katalog-ID:	ELV007426321

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520			\|a Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals.
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700	1		\|a Srivastava, Ananya \|e verfasserin \|4 aut
700	1		\|a Chandra, Pranjal \|e verfasserin \|4 aut
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publishDate	2022
allfields	10.1016/j.microc.2022.107239 doi (DE-627)ELV007426321 (ELSEVIER)S0026-265X(22)00067-4 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Purohit, Buddhadev verfasserin aut Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals. Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis Kumar, Ashutosh verfasserin aut Mahato, Kuldeep verfasserin aut Srivastava, Ananya verfasserin aut Chandra, Pranjal verfasserin aut Enthalten in Microchemical journal Orlando, Fla. : Academic Press, 1957 176 Online-Ressource (DE-627)267840217 (DE-600)1471165-5 (DE-576)259483729 1095-9149 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 176
spelling	10.1016/j.microc.2022.107239 doi (DE-627)ELV007426321 (ELSEVIER)S0026-265X(22)00067-4 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Purohit, Buddhadev verfasserin aut Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals. Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis Kumar, Ashutosh verfasserin aut Mahato, Kuldeep verfasserin aut Srivastava, Ananya verfasserin aut Chandra, Pranjal verfasserin aut Enthalten in Microchemical journal Orlando, Fla. : Academic Press, 1957 176 Online-Ressource (DE-627)267840217 (DE-600)1471165-5 (DE-576)259483729 1095-9149 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 176
allfields_unstemmed	10.1016/j.microc.2022.107239 doi (DE-627)ELV007426321 (ELSEVIER)S0026-265X(22)00067-4 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Purohit, Buddhadev verfasserin aut Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals. Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis Kumar, Ashutosh verfasserin aut Mahato, Kuldeep verfasserin aut Srivastava, Ananya verfasserin aut Chandra, Pranjal verfasserin aut Enthalten in Microchemical journal Orlando, Fla. : Academic Press, 1957 176 Online-Ressource (DE-627)267840217 (DE-600)1471165-5 (DE-576)259483729 1095-9149 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 176
allfieldsGer	10.1016/j.microc.2022.107239 doi (DE-627)ELV007426321 (ELSEVIER)S0026-265X(22)00067-4 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Purohit, Buddhadev verfasserin aut Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals. Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis Kumar, Ashutosh verfasserin aut Mahato, Kuldeep verfasserin aut Srivastava, Ananya verfasserin aut Chandra, Pranjal verfasserin aut Enthalten in Microchemical journal Orlando, Fla. : Academic Press, 1957 176 Online-Ressource (DE-627)267840217 (DE-600)1471165-5 (DE-576)259483729 1095-9149 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 176
allfieldsSound	10.1016/j.microc.2022.107239 doi (DE-627)ELV007426321 (ELSEVIER)S0026-265X(22)00067-4 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Purohit, Buddhadev verfasserin aut Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals. Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis Kumar, Ashutosh verfasserin aut Mahato, Kuldeep verfasserin aut Srivastava, Ananya verfasserin aut Chandra, Pranjal verfasserin aut Enthalten in Microchemical journal Orlando, Fla. : Academic Press, 1957 176 Online-Ressource (DE-627)267840217 (DE-600)1471165-5 (DE-576)259483729 1095-9149 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 176
language	English
source	Enthalten in Microchemical journal 176 volume:176
sourceStr	Enthalten in Microchemical journal 176 volume:176
format_phy_str_mv	Article
bklname	Chemie: Allgemeines
institution	findex.gbv.de
topic_facet	Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis
dewey-raw	540
isfreeaccess_bool	false
container_title	Microchemical journal
authorswithroles_txt_mv	Purohit, Buddhadev @@aut@@ Kumar, Ashutosh @@aut@@ Mahato, Kuldeep @@aut@@ Srivastava, Ananya @@aut@@ Chandra, Pranjal @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	267840217
dewey-sort	3540
id	ELV007426321
language_de	englisch
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author	Purohit, Buddhadev
spellingShingle	Purohit, Buddhadev ddc 540 bkl 35.00 misc Bimetallic dendrites misc Nanoengineering misc Electrochemical sensor misc Urine analysis Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and
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topic_title	540 DE-600 35.00 bkl Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and Bimetallic dendrites Nanoengineering Electrochemical sensor Urine analysis
topic	ddc 540 bkl 35.00 misc Bimetallic dendrites misc Nanoengineering misc Electrochemical sensor misc Urine analysis
topic_unstemmed	ddc 540 bkl 35.00 misc Bimetallic dendrites misc Nanoengineering misc Electrochemical sensor misc Urine analysis
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title	Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and
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title_full	Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and
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author_browse	Purohit, Buddhadev Kumar, Ashutosh Mahato, Kuldeep Srivastava, Ananya Chandra, Pranjal
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title_sort	engineered three-dimensional au-cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and
title_auth	Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and
abstract	Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals.
abstractGer	Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals.
abstract_unstemmed	Bimetallic dendrites are hierarchical, self-assembled, and multi-branched nanostructures with unique and enhanced properties than their monometallic counterparts. In this direction, a novel gold copper (AuCu) bimetallic dendritic nanostructure has been engineered on the glassy carbon electrode (GCE) by tuning the electrodeposition parameters with enhanced electrocatalytic activity. GCE/AuCuND sensor probe was systematically characterized by various physical and analytical techniques to study its physical and electrochemical properties. Acetaminophen (AP), an important clinical drug which is routinely used to treat pain and fever was tested as a model compound to evaluate the analytical performance of the fabricated sensor. The final sensor probe achieved a low limit of detection of 7.5 (±0.03) nM with a linear dynamic range of 100–1000 nM. The selectivity of the sensor probe was tested towards AP in presence of various co-existing molecules in body fluids, and negligible signals were observed towards such molecules. Human urine samples and in vitro human embryonic kidney cells were used to evaluate the sensor performance, where 89.5 to 96.4% of AP was recovered without any interference, indicating the sensors applicability in clinical settings. The sensor was found to be stable for 12 weeks, and the variation in current responses of probe to probe was found to be negligible. The fabrication and testing of AP using the sensor takes merely 12 min, hence extremely powerful in point-of-care testing in hospitals.
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title_short	Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and
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author2	Kumar, Ashutosh Mahato, Kuldeep Srivastava, Ananya Chandra, Pranjal
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up_date	2024-07-07T00:42:30.559Z
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Engineered three-dimensional Au-Cu bimetallic dendritic nanosensor for ultrasensitive drug detection in urine samples and

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