Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis
Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search throug...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Facciorusso, Antonio [verfasserIn] Paolillo, Rosa [verfasserIn] Tartaglia, Nicola [verfasserIn] Ramai, Daryl [verfasserIn] Mohan, Babu P. [verfasserIn] Cotsoglou, Christian [verfasserIn] Chandan, Saurabh [verfasserIn] Ambrosi, Antonio [verfasserIn] Bargellini, Irene [verfasserIn] Renzulli, Matteo [verfasserIn] Sacco, Rodolfo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Digestive and liver disease - [S.l.] : Saunders, 2000, 54, Seite 316-323 |
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| Übergeordnetes Werk: |
volume:54 ; pages:316-323 |
| DOI / URN: |
10.1016/j.dld.2021.06.003 |
|---|
| Katalog-ID: |
ELV007489978 |
|---|
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| 100 | 1 | |a Facciorusso, Antonio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis |
| 264 | 1 | |c 2021 | |
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| 520 | |a Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. | ||
| 650 | 4 | |a TARE | |
| 650 | 4 | |a HCC | |
| 650 | 4 | |a Loco-regional treatment | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a Cancer | |
| 700 | 1 | |a Paolillo, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Tartaglia, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Ramai, Daryl |e verfasserin |4 aut | |
| 700 | 1 | |a Mohan, Babu P. |e verfasserin |4 aut | |
| 700 | 1 | |a Cotsoglou, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Chandan, Saurabh |e verfasserin |4 aut | |
| 700 | 1 | |a Ambrosi, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Bargellini, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Renzulli, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Sacco, Rodolfo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Digestive and liver disease |d [S.l.] : Saunders, 2000 |g 54, Seite 316-323 |h Online-Ressource |w (DE-627)336455283 |w (DE-600)2061359-3 |w (DE-576)267762070 |x 1878-3562 |7 nnns |
| 773 | 1 | 8 | |g volume:54 |g pages:316-323 |
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10.1016/j.dld.2021.06.003 doi (DE-627)ELV007489978 (ELSEVIER)S1590-8658(21)00318-2 DE-627 ger DE-627 rda eng 610 DE-600 44.87 bkl Facciorusso, Antonio verfasserin aut Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. TARE HCC Loco-regional treatment Survival Cancer Paolillo, Rosa verfasserin aut Tartaglia, Nicola verfasserin aut Ramai, Daryl verfasserin aut Mohan, Babu P. verfasserin aut Cotsoglou, Christian verfasserin aut Chandan, Saurabh verfasserin aut Ambrosi, Antonio verfasserin aut Bargellini, Irene verfasserin aut Renzulli, Matteo verfasserin aut Sacco, Rodolfo verfasserin aut Enthalten in Digestive and liver disease [S.l.] : Saunders, 2000 54, Seite 316-323 Online-Ressource (DE-627)336455283 (DE-600)2061359-3 (DE-576)267762070 1878-3562 nnns volume:54 pages:316-323 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.87 Gastroenterologie AR 54 316-323 |
| spelling |
10.1016/j.dld.2021.06.003 doi (DE-627)ELV007489978 (ELSEVIER)S1590-8658(21)00318-2 DE-627 ger DE-627 rda eng 610 DE-600 44.87 bkl Facciorusso, Antonio verfasserin aut Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. TARE HCC Loco-regional treatment Survival Cancer Paolillo, Rosa verfasserin aut Tartaglia, Nicola verfasserin aut Ramai, Daryl verfasserin aut Mohan, Babu P. verfasserin aut Cotsoglou, Christian verfasserin aut Chandan, Saurabh verfasserin aut Ambrosi, Antonio verfasserin aut Bargellini, Irene verfasserin aut Renzulli, Matteo verfasserin aut Sacco, Rodolfo verfasserin aut Enthalten in Digestive and liver disease [S.l.] : Saunders, 2000 54, Seite 316-323 Online-Ressource (DE-627)336455283 (DE-600)2061359-3 (DE-576)267762070 1878-3562 nnns volume:54 pages:316-323 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.87 Gastroenterologie AR 54 316-323 |
| allfields_unstemmed |
10.1016/j.dld.2021.06.003 doi (DE-627)ELV007489978 (ELSEVIER)S1590-8658(21)00318-2 DE-627 ger DE-627 rda eng 610 DE-600 44.87 bkl Facciorusso, Antonio verfasserin aut Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. TARE HCC Loco-regional treatment Survival Cancer Paolillo, Rosa verfasserin aut Tartaglia, Nicola verfasserin aut Ramai, Daryl verfasserin aut Mohan, Babu P. verfasserin aut Cotsoglou, Christian verfasserin aut Chandan, Saurabh verfasserin aut Ambrosi, Antonio verfasserin aut Bargellini, Irene verfasserin aut Renzulli, Matteo verfasserin aut Sacco, Rodolfo verfasserin aut Enthalten in Digestive and liver disease [S.l.] : Saunders, 2000 54, Seite 316-323 Online-Ressource (DE-627)336455283 (DE-600)2061359-3 (DE-576)267762070 1878-3562 nnns volume:54 pages:316-323 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.87 Gastroenterologie AR 54 316-323 |
| allfieldsGer |
10.1016/j.dld.2021.06.003 doi (DE-627)ELV007489978 (ELSEVIER)S1590-8658(21)00318-2 DE-627 ger DE-627 rda eng 610 DE-600 44.87 bkl Facciorusso, Antonio verfasserin aut Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. TARE HCC Loco-regional treatment Survival Cancer Paolillo, Rosa verfasserin aut Tartaglia, Nicola verfasserin aut Ramai, Daryl verfasserin aut Mohan, Babu P. verfasserin aut Cotsoglou, Christian verfasserin aut Chandan, Saurabh verfasserin aut Ambrosi, Antonio verfasserin aut Bargellini, Irene verfasserin aut Renzulli, Matteo verfasserin aut Sacco, Rodolfo verfasserin aut Enthalten in Digestive and liver disease [S.l.] : Saunders, 2000 54, Seite 316-323 Online-Ressource (DE-627)336455283 (DE-600)2061359-3 (DE-576)267762070 1878-3562 nnns volume:54 pages:316-323 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.87 Gastroenterologie AR 54 316-323 |
| allfieldsSound |
10.1016/j.dld.2021.06.003 doi (DE-627)ELV007489978 (ELSEVIER)S1590-8658(21)00318-2 DE-627 ger DE-627 rda eng 610 DE-600 44.87 bkl Facciorusso, Antonio verfasserin aut Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. TARE HCC Loco-regional treatment Survival Cancer Paolillo, Rosa verfasserin aut Tartaglia, Nicola verfasserin aut Ramai, Daryl verfasserin aut Mohan, Babu P. verfasserin aut Cotsoglou, Christian verfasserin aut Chandan, Saurabh verfasserin aut Ambrosi, Antonio verfasserin aut Bargellini, Irene verfasserin aut Renzulli, Matteo verfasserin aut Sacco, Rodolfo verfasserin aut Enthalten in Digestive and liver disease [S.l.] : Saunders, 2000 54, Seite 316-323 Online-Ressource (DE-627)336455283 (DE-600)2061359-3 (DE-576)267762070 1878-3562 nnns volume:54 pages:316-323 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.87 Gastroenterologie AR 54 316-323 |
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Enthalten in Digestive and liver disease 54, Seite 316-323 volume:54 pages:316-323 |
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Facciorusso, Antonio @@aut@@ Paolillo, Rosa @@aut@@ Tartaglia, Nicola @@aut@@ Ramai, Daryl @@aut@@ Mohan, Babu P. @@aut@@ Cotsoglou, Christian @@aut@@ Chandan, Saurabh @@aut@@ Ambrosi, Antonio @@aut@@ Bargellini, Irene @@aut@@ Renzulli, Matteo @@aut@@ Sacco, Rodolfo @@aut@@ |
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2021-01-01T00:00:00Z |
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Facciorusso, Antonio |
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Facciorusso, Antonio ddc 610 bkl 44.87 misc TARE misc HCC misc Loco-regional treatment misc Survival misc Cancer Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis |
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610 DE-600 44.87 bkl Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis TARE HCC Loco-regional treatment Survival Cancer |
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Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis |
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Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis |
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Facciorusso, Antonio Paolillo, Rosa Tartaglia, Nicola Ramai, Daryl Mohan, Babu P. Cotsoglou, Christian Chandan, Saurabh Ambrosi, Antonio Bargellini, Irene Renzulli, Matteo Sacco, Rodolfo |
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efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: a meta-analysis |
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Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis |
| abstract |
Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. |
| abstractGer |
Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. |
| abstract_unstemmed |
Background: Adjuvant sorafenib may further enhance the efficacy of transarterial radioembolization for the treatment of hepatocellular carcinoma.Aims: To evaluate the efficacy and safety of radioembolization plus sorafenib in hepatocellular carcinoma patients.Methods: With a literature search through October 2020, we identified 9 studies (632 patients). Primary outcome was overall survival. Results were expressed as pooled median, odds ratio, or hazard ratio and 95% confidence intervals.Results: Pooled overall survival after radioembolization plus sorafenib was 10.79 months (95% confidence interval 9.19–12.39) and it was longer in Barcelona Clinic Liver Cancer (BCLC) B (14.47 months, 9.07–19.86) as compared to BCLC C patients (10.22 months, 7.53–12.9). No difference between combined therapy versus radioembolization alone was observed in terms of overall survival (hazard ratio 1.07, 0.89–1.30). Pooled median progression-free survival was 6.32 months (5.68–6.98), with 1-year progression-free survival pooled rate of 38.5% (12.7%-44.2%). No difference in progression-free survival (hazard ratio 0.94, 0.79–1.12) between the two treatments was observed. Pooled rate of severe adverse events was 48.9% (26.7%-71.2%), again with no difference between the two treatment regimens (odds ratio 1.52, 0.15–15.02).Conclusions: The association of sorafenib does not seem to prolong survival nor delay disease progression in patients treated with radioembolization. |
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Efficacy of combined transarterial radioembolization and sorafenib in the treatment of hepatocarcinoma: A meta-analysis |
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7.4000244 |