Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate

Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, an...
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Autor*in:	Song, Bo [verfasserIn] Qiu, Zhendong [verfasserIn] Li, Mingxue [verfasserIn] Luo, Tingting [verfasserIn] Wu, Qi [verfasserIn] Krishnan, Hari B. [verfasserIn] Wu, Junjiang [verfasserIn] Xu, Pengfei [verfasserIn] Zhang, Shuzhen [verfasserIn] Liu, Shanshan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 90
Übergeordnetes Werk:	volume:90

DOI / URN:	10.1016/j.jff.2022.104979

Katalog-ID:	ELV007507380

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allfields	10.1016/j.jff.2022.104979 doi (DE-627)ELV007507380 (ELSEVIER)S1756-4646(22)00049-4 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Song, Bo verfasserin aut Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF. Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate Qiu, Zhendong verfasserin aut Li, Mingxue verfasserin aut Luo, Tingting verfasserin aut Wu, Qi verfasserin aut Krishnan, Hari B. verfasserin aut Wu, Junjiang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Liu, Shanshan verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 90 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:90 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 90
spelling	10.1016/j.jff.2022.104979 doi (DE-627)ELV007507380 (ELSEVIER)S1756-4646(22)00049-4 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Song, Bo verfasserin aut Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF. Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate Qiu, Zhendong verfasserin aut Li, Mingxue verfasserin aut Luo, Tingting verfasserin aut Wu, Qi verfasserin aut Krishnan, Hari B. verfasserin aut Wu, Junjiang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Liu, Shanshan verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 90 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:90 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 90
allfields_unstemmed	10.1016/j.jff.2022.104979 doi (DE-627)ELV007507380 (ELSEVIER)S1756-4646(22)00049-4 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Song, Bo verfasserin aut Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF. Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate Qiu, Zhendong verfasserin aut Li, Mingxue verfasserin aut Luo, Tingting verfasserin aut Wu, Qi verfasserin aut Krishnan, Hari B. verfasserin aut Wu, Junjiang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Liu, Shanshan verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 90 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:90 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 90
allfieldsGer	10.1016/j.jff.2022.104979 doi (DE-627)ELV007507380 (ELSEVIER)S1756-4646(22)00049-4 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Song, Bo verfasserin aut Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF. Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate Qiu, Zhendong verfasserin aut Li, Mingxue verfasserin aut Luo, Tingting verfasserin aut Wu, Qi verfasserin aut Krishnan, Hari B. verfasserin aut Wu, Junjiang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Liu, Shanshan verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 90 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:90 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 90
allfieldsSound	10.1016/j.jff.2022.104979 doi (DE-627)ELV007507380 (ELSEVIER)S1756-4646(22)00049-4 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Song, Bo verfasserin aut Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF. Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate Qiu, Zhendong verfasserin aut Li, Mingxue verfasserin aut Luo, Tingting verfasserin aut Wu, Qi verfasserin aut Krishnan, Hari B. verfasserin aut Wu, Junjiang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Liu, Shanshan verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 90 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:90 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 90
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authorswithroles_txt_mv	Song, Bo @@aut@@ Qiu, Zhendong @@aut@@ Li, Mingxue @@aut@@ Luo, Tingting @@aut@@ Wu, Qi @@aut@@ Krishnan, Hari B. @@aut@@ Wu, Junjiang @@aut@@ Xu, Pengfei @@aut@@ Zhang, Shuzhen @@aut@@ Liu, Shanshan @@aut@@
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author	Song, Bo
spellingShingle	Song, Bo ddc 630 misc Soybean cultivar ‘DND358’ misc Soy protein isolate beverage powder misc Hypocholesterolemic effect misc Fenofibrate Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
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topic_title	630 640 610 DE-600 Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate Soybean cultivar ‘DND358’ Soy protein isolate beverage powder Hypocholesterolemic effect Fenofibrate
topic	ddc 630 misc Soybean cultivar ‘DND358’ misc Soy protein isolate beverage powder misc Hypocholesterolemic effect misc Fenofibrate
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title	Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
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title_full	Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
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author_browse	Song, Bo Qiu, Zhendong Li, Mingxue Luo, Tingting Wu, Qi Krishnan, Hari B. Wu, Junjiang Xu, Pengfei Zhang, Shuzhen Liu, Shanshan
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title_sort	breeding of ‘dnd358’: a new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
title_auth	Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
abstract	Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF.
abstractGer	Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF.
abstract_unstemmed	Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar ‘DND358’, which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). ‘DND358’ carries four recessive null alleles for the α subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the α′ subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from ‘DND358’ significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF.
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title_short	Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate
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author2	Qiu, Zhendong Li, Mingxue Luo, Tingting Wu, Qi Krishnan, Hari B. Wu, Junjiang Xu, Pengfei Zhang, Shuzhen Liu, Shanshan
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doi_str	10.1016/j.jff.2022.104979
up_date	2024-07-07T00:58:40.961Z
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Breeding of ‘DND358’: A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate

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