Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile

Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between...
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Autor*in:	Tans, Lisa [verfasserIn] Al-Mamgani, Abrahim [verfasserIn] Kwa, Stefan L.S. [verfasserIn] Elbers, Jos B.W. [verfasserIn] Keskin-Cambay, Fatma [verfasserIn] Sewnaik, Aniel [verfasserIn] Dorr, Maarten [verfasserIn] Nout, Remi [verfasserIn] Heemsbergen, Wilma [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index

Übergeordnetes Werk:	Enthalten in: Oral oncology - Amsterdam [u.a.] : Elsevier Science, 1997, 127
Übergeordnetes Werk:	volume:127

DOI / URN:	10.1016/j.oraloncology.2022.105782

Katalog-ID:	ELV007645309

Internformat


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245	1	0	\|a Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile
264		1	\|c 2022
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520			\|a Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results.
650		4	\|a Laryngeal cancer
650		4	\|a Single vocal cord irradiation
650		4	\|a IMRT
650		4	\|a Toxicity
650		4	\|a Voice handicap index
700	1		\|a Al-Mamgani, Abrahim \|e verfasserin \|4 aut
700	1		\|a Kwa, Stefan L.S. \|e verfasserin \|4 aut
700	1		\|a Elbers, Jos B.W. \|e verfasserin \|4 aut
700	1		\|a Keskin-Cambay, Fatma \|e verfasserin \|4 aut
700	1		\|a Sewnaik, Aniel \|e verfasserin \|4 aut
700	1		\|a Dorr, Maarten \|e verfasserin \|0 (orcid)0000-0003-0900-3438 \|4 aut
700	1		\|a Nout, Remi \|e verfasserin \|4 aut
700	1		\|a Heemsbergen, Wilma \|e verfasserin \|0 (orcid)0000-0003-2144-0729 \|4 aut
773	0	8	\|i Enthalten in \|t Oral oncology \|d Amsterdam [u.a.] : Elsevier Science, 1997 \|g 127 \|h Online-Ressource \|w (DE-627)320498980 \|w (DE-600)2011971-9 \|w (DE-576)106869612 \|x 1879-0593 \|7 nnns
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936	b	k	\|a 44.96 \|j Zahnmedizin \|q VZ
936	b	k	\|a 44.81 \|j Onkologie \|q VZ
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Indexfelder

author_variant	l t lt a a m aam s l k sl slk j b e jb jbe f k c fkc a s as m d md r n rn w h wh
matchkey_str	article:18790593:2022----::igeoacrirdainoerytggotcacrxelnlclotoa
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publishDate	2022
allfields	10.1016/j.oraloncology.2022.105782 doi (DE-627)ELV007645309 (ELSEVIER)S1368-8375(22)00071-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 44.81 bkl Tans, Lisa verfasserin aut Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results. Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index Al-Mamgani, Abrahim verfasserin aut Kwa, Stefan L.S. verfasserin aut Elbers, Jos B.W. verfasserin aut Keskin-Cambay, Fatma verfasserin aut Sewnaik, Aniel verfasserin aut Dorr, Maarten verfasserin (orcid)0000-0003-0900-3438 aut Nout, Remi verfasserin aut Heemsbergen, Wilma verfasserin (orcid)0000-0003-2144-0729 aut Enthalten in Oral oncology Amsterdam [u.a.] : Elsevier Science, 1997 127 Online-Ressource (DE-627)320498980 (DE-600)2011971-9 (DE-576)106869612 1879-0593 nnns volume:127 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 44.81 Onkologie VZ AR 127
spelling	10.1016/j.oraloncology.2022.105782 doi (DE-627)ELV007645309 (ELSEVIER)S1368-8375(22)00071-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 44.81 bkl Tans, Lisa verfasserin aut Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results. Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index Al-Mamgani, Abrahim verfasserin aut Kwa, Stefan L.S. verfasserin aut Elbers, Jos B.W. verfasserin aut Keskin-Cambay, Fatma verfasserin aut Sewnaik, Aniel verfasserin aut Dorr, Maarten verfasserin (orcid)0000-0003-0900-3438 aut Nout, Remi verfasserin aut Heemsbergen, Wilma verfasserin (orcid)0000-0003-2144-0729 aut Enthalten in Oral oncology Amsterdam [u.a.] : Elsevier Science, 1997 127 Online-Ressource (DE-627)320498980 (DE-600)2011971-9 (DE-576)106869612 1879-0593 nnns volume:127 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 44.81 Onkologie VZ AR 127
allfields_unstemmed	10.1016/j.oraloncology.2022.105782 doi (DE-627)ELV007645309 (ELSEVIER)S1368-8375(22)00071-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 44.81 bkl Tans, Lisa verfasserin aut Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results. Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index Al-Mamgani, Abrahim verfasserin aut Kwa, Stefan L.S. verfasserin aut Elbers, Jos B.W. verfasserin aut Keskin-Cambay, Fatma verfasserin aut Sewnaik, Aniel verfasserin aut Dorr, Maarten verfasserin (orcid)0000-0003-0900-3438 aut Nout, Remi verfasserin aut Heemsbergen, Wilma verfasserin (orcid)0000-0003-2144-0729 aut Enthalten in Oral oncology Amsterdam [u.a.] : Elsevier Science, 1997 127 Online-Ressource (DE-627)320498980 (DE-600)2011971-9 (DE-576)106869612 1879-0593 nnns volume:127 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 44.81 Onkologie VZ AR 127
allfieldsGer	10.1016/j.oraloncology.2022.105782 doi (DE-627)ELV007645309 (ELSEVIER)S1368-8375(22)00071-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 44.81 bkl Tans, Lisa verfasserin aut Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results. Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index Al-Mamgani, Abrahim verfasserin aut Kwa, Stefan L.S. verfasserin aut Elbers, Jos B.W. verfasserin aut Keskin-Cambay, Fatma verfasserin aut Sewnaik, Aniel verfasserin aut Dorr, Maarten verfasserin (orcid)0000-0003-0900-3438 aut Nout, Remi verfasserin aut Heemsbergen, Wilma verfasserin (orcid)0000-0003-2144-0729 aut Enthalten in Oral oncology Amsterdam [u.a.] : Elsevier Science, 1997 127 Online-Ressource (DE-627)320498980 (DE-600)2011971-9 (DE-576)106869612 1879-0593 nnns volume:127 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 44.81 Onkologie VZ AR 127
allfieldsSound	10.1016/j.oraloncology.2022.105782 doi (DE-627)ELV007645309 (ELSEVIER)S1368-8375(22)00071-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 44.81 bkl Tans, Lisa verfasserin aut Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results. Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index Al-Mamgani, Abrahim verfasserin aut Kwa, Stefan L.S. verfasserin aut Elbers, Jos B.W. verfasserin aut Keskin-Cambay, Fatma verfasserin aut Sewnaik, Aniel verfasserin aut Dorr, Maarten verfasserin (orcid)0000-0003-0900-3438 aut Nout, Remi verfasserin aut Heemsbergen, Wilma verfasserin (orcid)0000-0003-2144-0729 aut Enthalten in Oral oncology Amsterdam [u.a.] : Elsevier Science, 1997 127 Online-Ressource (DE-627)320498980 (DE-600)2011971-9 (DE-576)106869612 1879-0593 nnns volume:127 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 44.81 Onkologie VZ AR 127
language	English
source	Enthalten in Oral oncology 127 volume:127
sourceStr	Enthalten in Oral oncology 127 volume:127
format_phy_str_mv	Article
bklname	Zahnmedizin Onkologie
institution	findex.gbv.de
topic_facet	Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index
dewey-raw	610
isfreeaccess_bool	false
container_title	Oral oncology
authorswithroles_txt_mv	Tans, Lisa @@aut@@ Al-Mamgani, Abrahim @@aut@@ Kwa, Stefan L.S. @@aut@@ Elbers, Jos B.W. @@aut@@ Keskin-Cambay, Fatma @@aut@@ Sewnaik, Aniel @@aut@@ Dorr, Maarten @@aut@@ Nout, Remi @@aut@@ Heemsbergen, Wilma @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	320498980
dewey-sort	3610
id	ELV007645309
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV007645309</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240106093028.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.oraloncology.2022.105782</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV007645309</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1368-8375(22)00071-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.96</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Tans, Lisa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. 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author	Tans, Lisa
spellingShingle	Tans, Lisa ddc 610 bkl 44.96 bkl 44.81 misc Laryngeal cancer misc Single vocal cord irradiation misc IMRT misc Toxicity misc Voice handicap index Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile
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topic_title	610 VZ 44.96 bkl 44.81 bkl Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile Laryngeal cancer Single vocal cord irradiation IMRT Toxicity Voice handicap index
topic	ddc 610 bkl 44.96 bkl 44.81 misc Laryngeal cancer misc Single vocal cord irradiation misc IMRT misc Toxicity misc Voice handicap index
topic_unstemmed	ddc 610 bkl 44.96 bkl 44.81 misc Laryngeal cancer misc Single vocal cord irradiation misc IMRT misc Toxicity misc Voice handicap index
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title	Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile
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title_full	Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile
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author_browse	Tans, Lisa Al-Mamgani, Abrahim Kwa, Stefan L.S. Elbers, Jos B.W. Keskin-Cambay, Fatma Sewnaik, Aniel Dorr, Maarten Nout, Remi Heemsbergen, Wilma
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title_sort	single vocal cord irradiation for early-stage glottic cancer: excellent local control and favorable toxicity profile
title_auth	Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile
abstract	Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results.
abstractGer	Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results.
abstract_unstemmed	Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.Materials and methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3.63 Gy). Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. These results validate our early results.
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title_short	Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile
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author2	Al-Mamgani, Abrahim Kwa, Stefan L.S. Elbers, Jos B.W. Keskin-Cambay, Fatma Sewnaik, Aniel Dorr, Maarten Nout, Remi Heemsbergen, Wilma
author2Str	Al-Mamgani, Abrahim Kwa, Stefan L.S. Elbers, Jos B.W. Keskin-Cambay, Fatma Sewnaik, Aniel Dorr, Maarten Nout, Remi Heemsbergen, Wilma
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doi_str	10.1016/j.oraloncology.2022.105782
up_date	2024-07-06T16:58:41.077Z
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Setup verification was done using cone-beam CT, prior to each fraction. The endpoints were local control (LC), overall survival (OS), grade ≥ 3 toxicity and voice quality assessment using voice-handicap index (VHI) questionnaires.Results: Median follow-up was 41 months (range; 8–84). Two patients developed in-field local failure (LF). The 3- and 5-year LC rates were 99.1% and 97.1%, respectively. As both patients with LF were successfully salvaged with total laryngectomy, the 5-year ultimate LC-rates was 99%. The 5-years OS was 80.6%. All patients finished treatment without any interruption. No patients developed acute grade ≥ 3 toxicity. Late grade 3 toxicity was reported in 7 patients (6.5%) out of 108 patients evaluable for late toxicity; 2 because of severe hoarseness and 5 because of laryngeal radionecrosis (4.5%). The 5-years laryngectomy-free survival was 98.1%. The VHI-scores improved over time, only 22% of patients had VHI > 30 at 3-years post-radiotherapy, compared to 38% at baseline.Conclusions: Local control rate and laryngectomy-free survival of SVCI are excellent with favorable toxicity profile and good VHI-score. 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Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile

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