Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade

The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tight...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Xiang, Yukai [verfasserIn] Dai, Shengjie [verfasserIn] Li, Ding [verfasserIn] Zhu, Xiandong [verfasserIn] Su, Jiadong [verfasserIn] Chen, Bicheng [verfasserIn] Wu, Minmin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 92
Übergeordnetes Werk:	volume:92

DOI / URN:	10.1016/j.jff.2022.105024

Katalog-ID:	ELV007761627

Internformat


LEADER	01000caa a22002652 4500
001	ELV007761627
003	DE-627
005	20230524122554.0
007	cr uuu---uuuuu
008	230507s2022 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1016/j.jff.2022.105024 \|2 doi
035			\|a (DE-627)ELV007761627
035			\|a (ELSEVIER)S1756-4646(22)00094-9
040			\|a DE-627 \|b ger \|c DE-627 \|e rda
041			\|a eng
082	0	4	\|a 630 \|a 640 \|a 610 \|q DE-600
100	1		\|a Xiang, Yukai \|e verfasserin \|4 aut
245	1	0	\|a Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade
264		1	\|c 2022
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade.
650		4	\|a Pancreatic cancer
650		4	\|a Cancer invasion and migration
650		4	\|a NRF2/NF-κB/STAT3 pathway
650		4	\|a Chemotherapeutic resistance
700	1		\|a Dai, Shengjie \|e verfasserin \|4 aut
700	1		\|a Li, Ding \|e verfasserin \|4 aut
700	1		\|a Zhu, Xiandong \|e verfasserin \|4 aut
700	1		\|a Su, Jiadong \|e verfasserin \|4 aut
700	1		\|a Chen, Bicheng \|e verfasserin \|4 aut
700	1		\|a Wu, Minmin \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Journal of functional foods \|d Amsterdam [u.a.] : Elsevier, 2009 \|g 92 \|h Online-Ressource \|w (DE-627)587138432 \|w (DE-600)2467241-5 \|w (DE-576)302178430 \|x 1756-4646 \|7 nnns
773	1	8	\|g volume:92
912			\|a GBV_USEFLAG_U
912			\|a SYSFLAG_U
912			\|a GBV_ELV
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_165
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 92

Indexfelder

author_variant	y x yx s d sd d l dl x z xz j s js b c bc m w mw
matchkey_str	article:17564646:2022----::rstlniishivsoadirtoopnraicneclsyupesn
hierarchy_sort_str	2022
publishDate	2022
allfields	10.1016/j.jff.2022.105024 doi (DE-627)ELV007761627 (ELSEVIER)S1756-4646(22)00094-9 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Xiang, Yukai verfasserin aut Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade. Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance Dai, Shengjie verfasserin aut Li, Ding verfasserin aut Zhu, Xiandong verfasserin aut Su, Jiadong verfasserin aut Chen, Bicheng verfasserin aut Wu, Minmin verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 92 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:92 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 92
spelling	10.1016/j.jff.2022.105024 doi (DE-627)ELV007761627 (ELSEVIER)S1756-4646(22)00094-9 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Xiang, Yukai verfasserin aut Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade. Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance Dai, Shengjie verfasserin aut Li, Ding verfasserin aut Zhu, Xiandong verfasserin aut Su, Jiadong verfasserin aut Chen, Bicheng verfasserin aut Wu, Minmin verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 92 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:92 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 92
allfields_unstemmed	10.1016/j.jff.2022.105024 doi (DE-627)ELV007761627 (ELSEVIER)S1756-4646(22)00094-9 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Xiang, Yukai verfasserin aut Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade. Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance Dai, Shengjie verfasserin aut Li, Ding verfasserin aut Zhu, Xiandong verfasserin aut Su, Jiadong verfasserin aut Chen, Bicheng verfasserin aut Wu, Minmin verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 92 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:92 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 92
allfieldsGer	10.1016/j.jff.2022.105024 doi (DE-627)ELV007761627 (ELSEVIER)S1756-4646(22)00094-9 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Xiang, Yukai verfasserin aut Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade. Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance Dai, Shengjie verfasserin aut Li, Ding verfasserin aut Zhu, Xiandong verfasserin aut Su, Jiadong verfasserin aut Chen, Bicheng verfasserin aut Wu, Minmin verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 92 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:92 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 92
allfieldsSound	10.1016/j.jff.2022.105024 doi (DE-627)ELV007761627 (ELSEVIER)S1756-4646(22)00094-9 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Xiang, Yukai verfasserin aut Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade. Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance Dai, Shengjie verfasserin aut Li, Ding verfasserin aut Zhu, Xiandong verfasserin aut Su, Jiadong verfasserin aut Chen, Bicheng verfasserin aut Wu, Minmin verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 92 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:92 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 92
language	English
source	Enthalten in Journal of functional foods 92 volume:92
sourceStr	Enthalten in Journal of functional foods 92 volume:92
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance
dewey-raw	630
isfreeaccess_bool	false
container_title	Journal of functional foods
authorswithroles_txt_mv	Xiang, Yukai @@aut@@ Dai, Shengjie @@aut@@ Li, Ding @@aut@@ Zhu, Xiandong @@aut@@ Su, Jiadong @@aut@@ Chen, Bicheng @@aut@@ Wu, Minmin @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	587138432
dewey-sort	3630
id	ELV007761627
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV007761627</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524122554.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jff.2022.105024</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV007761627</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1756-4646(22)00094-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Xiang, Yukai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pancreatic cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer invasion and migration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NRF2/NF-κB/STAT3 pathway</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemotherapeutic resistance</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dai, Shengjie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Ding</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhu, Xiandong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Su, Jiadong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Bicheng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Minmin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of functional foods</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 2009</subfield><subfield code="g">92</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)587138432</subfield><subfield code="w">(DE-600)2467241-5</subfield><subfield code="w">(DE-576)302178430</subfield><subfield code="x">1756-4646</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:92</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_165</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">92</subfield></datafield></record></collection>
author	Xiang, Yukai
spellingShingle	Xiang, Yukai ddc 630 misc Pancreatic cancer misc Cancer invasion and migration misc NRF2/NF-κB/STAT3 pathway misc Chemotherapeutic resistance Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade
authorStr	Xiang, Yukai
ppnlink_with_tag_str_mv	@@773@@(DE-627)587138432
format	electronic Article
dewey-ones	630 - Agriculture & related technologies 640 - Home & family management 610 - Medicine & health
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut
collection	elsevier
remote_str	true
illustrated	Not Illustrated
issn	1756-4646
topic_title	630 640 610 DE-600 Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade Pancreatic cancer Cancer invasion and migration NRF2/NF-κB/STAT3 pathway Chemotherapeutic resistance
topic	ddc 630 misc Pancreatic cancer misc Cancer invasion and migration misc NRF2/NF-κB/STAT3 pathway misc Chemotherapeutic resistance
topic_unstemmed	ddc 630 misc Pancreatic cancer misc Cancer invasion and migration misc NRF2/NF-κB/STAT3 pathway misc Chemotherapeutic resistance
topic_browse	ddc 630 misc Pancreatic cancer misc Cancer invasion and migration misc NRF2/NF-κB/STAT3 pathway misc Chemotherapeutic resistance
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Journal of functional foods
hierarchy_parent_id	587138432
dewey-tens	630 - Agriculture 640 - Home & family management 610 - Medicine & health
hierarchy_top_title	Journal of functional foods
isfreeaccess_txt	false
familylinks_str_mv	(DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430
title	Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade
ctrlnum	(DE-627)ELV007761627 (ELSEVIER)S1756-4646(22)00094-9
title_full	Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade
author_sort	Xiang, Yukai
journal	Journal of functional foods
journalStr	Journal of functional foods
lang_code	eng
isOA_bool	false
dewey-hundreds	600 - Technology
recordtype	marc
publishDateSort	2022
contenttype_str_mv	zzz
author_browse	Xiang, Yukai Dai, Shengjie Li, Ding Zhu, Xiandong Su, Jiadong Chen, Bicheng Wu, Minmin
container_volume	92
class	630 640 610 DE-600
format_se	Elektronische Aufsätze
author-letter	Xiang, Yukai
doi_str_mv	10.1016/j.jff.2022.105024
dewey-full	630 640 610
author2-role	verfasserin
title_sort	brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the nrf2/nf-κb/stat3 signal cascade
title_auth	Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade
abstract	The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade.
abstractGer	The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade.
abstract_unstemmed	The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade.
collection_details	GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade
remote_bool	true
author2	Dai, Shengjie Li, Ding Zhu, Xiandong Su, Jiadong Chen, Bicheng Wu, Minmin
author2Str	Dai, Shengjie Li, Ding Zhu, Xiandong Su, Jiadong Chen, Bicheng Wu, Minmin
ppnlink	587138432
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1016/j.jff.2022.105024
up_date	2024-07-06T17:22:20.019Z
_version_	1803851178988011520
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV007761627</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524122554.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jff.2022.105024</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV007761627</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1756-4646(22)00094-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Xiang, Yukai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment analysis has also revealed that the JAK-STAT pathway could be suppressed by brusatol and is significantly enriched for phenotypes associated with high expression of the NRF2 gene. Therefore, we speculated and confirmed that brusatol can inhibit cell invasion and migration via the NRF2 pathway. Additionally, low NRF2 gene expression results in a function similar to that of brusatol as well as decreased expression of NF-κB and p-STAT3. Furthermore, brusatol reversed gemcitabine-induced overexpression of NF-κB and p-STAT3. Together, our results suggest that brusatol can inhibit the invasion and migration of pancreatic cancer cells through NRF2/NF-κB/STAT3 signaling cascade.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pancreatic cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer invasion and migration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NRF2/NF-κB/STAT3 pathway</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemotherapeutic resistance</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dai, Shengjie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Ding</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhu, Xiandong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Su, Jiadong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Bicheng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Minmin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of functional foods</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 2009</subfield><subfield code="g">92</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)587138432</subfield><subfield code="w">(DE-600)2467241-5</subfield><subfield code="w">(DE-576)302178430</subfield><subfield code="x">1756-4646</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:92</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_165</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">92</subfield></datafield></record></collection>
score	7.4010277

Nicht das Richtige dabei?

Schreiben Sie uns!

Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?