Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014
Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Severi, Ettore [verfasserIn] Georgalis, Leonidas [verfasserIn] Pijnacker, Roan [verfasserIn] Veneti, Lamprini [verfasserIn] Turiac, Iulia Adelina [verfasserIn] Chiesa, Flaminia [verfasserIn] Rizzo, Caterina [verfasserIn] Martinelli, Domenico [verfasserIn] Vold, Line [verfasserIn] Herrador, Bernardo Guzman [verfasserIn] Martinez, Carmen Varela [verfasserIn] Sanchez, Elena Vanessa Martinez [verfasserIn] Semenza, Jan C. [verfasserIn] Lopalco, Pierluigi [verfasserIn] Dahlström, Lisen Arnheim [verfasserIn] Giesecke, Johan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of infectious diseases - Amsterdam [u.a.] : Elsevier, 1997, 118, Seite 34-43 |
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| Übergeordnetes Werk: |
volume:118 ; pages:34-43 |
| DOI / URN: |
10.1016/j.ijid.2022.01.053 |
|---|
| Katalog-ID: |
ELV007781954 |
|---|
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| 024 | 7 | |a 10.1016/j.ijid.2022.01.053 |2 doi | |
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| 100 | 1 | |a Severi, Ettore |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 |
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| 520 | |a Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. | ||
| 650 | 4 | |a Viral hepatitis | |
| 650 | 4 | |a Hepatitis A virus | |
| 650 | 4 | |a Hepatitis A infection | |
| 650 | 4 | |a severity | |
| 650 | 4 | |a Hospitalisation | |
| 650 | 4 | |a Surveillance | |
| 650 | 4 | |a Europe | |
| 700 | 1 | |a Georgalis, Leonidas |e verfasserin |4 aut | |
| 700 | 1 | |a Pijnacker, Roan |e verfasserin |4 aut | |
| 700 | 1 | |a Veneti, Lamprini |e verfasserin |0 (orcid)0000-0002-9117-5310 |4 aut | |
| 700 | 1 | |a Turiac, Iulia Adelina |e verfasserin |4 aut | |
| 700 | 1 | |a Chiesa, Flaminia |e verfasserin |4 aut | |
| 700 | 1 | |a Rizzo, Caterina |e verfasserin |4 aut | |
| 700 | 1 | |a Martinelli, Domenico |e verfasserin |0 (orcid)0000-0001-8028-3167 |4 aut | |
| 700 | 1 | |a Vold, Line |e verfasserin |4 aut | |
| 700 | 1 | |a Herrador, Bernardo Guzman |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez, Carmen Varela |e verfasserin |0 (orcid)0000-0001-7754-4020 |4 aut | |
| 700 | 1 | |a Sanchez, Elena Vanessa Martinez |e verfasserin |0 (orcid)0000-0003-1620-7113 |4 aut | |
| 700 | 1 | |a Semenza, Jan C. |e verfasserin |4 aut | |
| 700 | 1 | |a Lopalco, Pierluigi |e verfasserin |4 aut | |
| 700 | 1 | |a Dahlström, Lisen Arnheim |e verfasserin |4 aut | |
| 700 | 1 | |a Giesecke, Johan |e verfasserin |0 (orcid)0000-0001-6107-4204 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of infectious diseases |d Amsterdam [u.a.] : Elsevier, 1997 |g 118, Seite 34-43 |h Online-Ressource |w (DE-627)341907669 |w (DE-600)2070533-5 |w (DE-576)271360844 |x 1878-3511 |7 nnns |
| 773 | 1 | 8 | |g volume:118 |g pages:34-43 |
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10.1016/j.ijid.2022.01.053 doi (DE-627)ELV007781954 (ELSEVIER)S1201-9712(22)00058-3 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Severi, Ettore verfasserin aut Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. Viral hepatitis Hepatitis A virus Hepatitis A infection severity Hospitalisation Surveillance Europe Georgalis, Leonidas verfasserin aut Pijnacker, Roan verfasserin aut Veneti, Lamprini verfasserin (orcid)0000-0002-9117-5310 aut Turiac, Iulia Adelina verfasserin aut Chiesa, Flaminia verfasserin aut Rizzo, Caterina verfasserin aut Martinelli, Domenico verfasserin (orcid)0000-0001-8028-3167 aut Vold, Line verfasserin aut Herrador, Bernardo Guzman verfasserin aut Martinez, Carmen Varela verfasserin (orcid)0000-0001-7754-4020 aut Sanchez, Elena Vanessa Martinez verfasserin (orcid)0000-0003-1620-7113 aut Semenza, Jan C. verfasserin aut Lopalco, Pierluigi verfasserin aut Dahlström, Lisen Arnheim verfasserin aut Giesecke, Johan verfasserin (orcid)0000-0001-6107-4204 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 34-43 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:34-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 34-43 |
| spelling |
10.1016/j.ijid.2022.01.053 doi (DE-627)ELV007781954 (ELSEVIER)S1201-9712(22)00058-3 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Severi, Ettore verfasserin aut Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. Viral hepatitis Hepatitis A virus Hepatitis A infection severity Hospitalisation Surveillance Europe Georgalis, Leonidas verfasserin aut Pijnacker, Roan verfasserin aut Veneti, Lamprini verfasserin (orcid)0000-0002-9117-5310 aut Turiac, Iulia Adelina verfasserin aut Chiesa, Flaminia verfasserin aut Rizzo, Caterina verfasserin aut Martinelli, Domenico verfasserin (orcid)0000-0001-8028-3167 aut Vold, Line verfasserin aut Herrador, Bernardo Guzman verfasserin aut Martinez, Carmen Varela verfasserin (orcid)0000-0001-7754-4020 aut Sanchez, Elena Vanessa Martinez verfasserin (orcid)0000-0003-1620-7113 aut Semenza, Jan C. verfasserin aut Lopalco, Pierluigi verfasserin aut Dahlström, Lisen Arnheim verfasserin aut Giesecke, Johan verfasserin (orcid)0000-0001-6107-4204 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 34-43 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:34-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 34-43 |
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10.1016/j.ijid.2022.01.053 doi (DE-627)ELV007781954 (ELSEVIER)S1201-9712(22)00058-3 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Severi, Ettore verfasserin aut Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. Viral hepatitis Hepatitis A virus Hepatitis A infection severity Hospitalisation Surveillance Europe Georgalis, Leonidas verfasserin aut Pijnacker, Roan verfasserin aut Veneti, Lamprini verfasserin (orcid)0000-0002-9117-5310 aut Turiac, Iulia Adelina verfasserin aut Chiesa, Flaminia verfasserin aut Rizzo, Caterina verfasserin aut Martinelli, Domenico verfasserin (orcid)0000-0001-8028-3167 aut Vold, Line verfasserin aut Herrador, Bernardo Guzman verfasserin aut Martinez, Carmen Varela verfasserin (orcid)0000-0001-7754-4020 aut Sanchez, Elena Vanessa Martinez verfasserin (orcid)0000-0003-1620-7113 aut Semenza, Jan C. verfasserin aut Lopalco, Pierluigi verfasserin aut Dahlström, Lisen Arnheim verfasserin aut Giesecke, Johan verfasserin (orcid)0000-0001-6107-4204 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 34-43 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:34-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 34-43 |
| allfieldsGer |
10.1016/j.ijid.2022.01.053 doi (DE-627)ELV007781954 (ELSEVIER)S1201-9712(22)00058-3 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Severi, Ettore verfasserin aut Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. Viral hepatitis Hepatitis A virus Hepatitis A infection severity Hospitalisation Surveillance Europe Georgalis, Leonidas verfasserin aut Pijnacker, Roan verfasserin aut Veneti, Lamprini verfasserin (orcid)0000-0002-9117-5310 aut Turiac, Iulia Adelina verfasserin aut Chiesa, Flaminia verfasserin aut Rizzo, Caterina verfasserin aut Martinelli, Domenico verfasserin (orcid)0000-0001-8028-3167 aut Vold, Line verfasserin aut Herrador, Bernardo Guzman verfasserin aut Martinez, Carmen Varela verfasserin (orcid)0000-0001-7754-4020 aut Sanchez, Elena Vanessa Martinez verfasserin (orcid)0000-0003-1620-7113 aut Semenza, Jan C. verfasserin aut Lopalco, Pierluigi verfasserin aut Dahlström, Lisen Arnheim verfasserin aut Giesecke, Johan verfasserin (orcid)0000-0001-6107-4204 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 34-43 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:34-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 34-43 |
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10.1016/j.ijid.2022.01.053 doi (DE-627)ELV007781954 (ELSEVIER)S1201-9712(22)00058-3 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Severi, Ettore verfasserin aut Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. Viral hepatitis Hepatitis A virus Hepatitis A infection severity Hospitalisation Surveillance Europe Georgalis, Leonidas verfasserin aut Pijnacker, Roan verfasserin aut Veneti, Lamprini verfasserin (orcid)0000-0002-9117-5310 aut Turiac, Iulia Adelina verfasserin aut Chiesa, Flaminia verfasserin aut Rizzo, Caterina verfasserin aut Martinelli, Domenico verfasserin (orcid)0000-0001-8028-3167 aut Vold, Line verfasserin aut Herrador, Bernardo Guzman verfasserin aut Martinez, Carmen Varela verfasserin (orcid)0000-0001-7754-4020 aut Sanchez, Elena Vanessa Martinez verfasserin (orcid)0000-0003-1620-7113 aut Semenza, Jan C. verfasserin aut Lopalco, Pierluigi verfasserin aut Dahlström, Lisen Arnheim verfasserin aut Giesecke, Johan verfasserin (orcid)0000-0001-6107-4204 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 34-43 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:34-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 34-43 |
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Severi, Ettore @@aut@@ Georgalis, Leonidas @@aut@@ Pijnacker, Roan @@aut@@ Veneti, Lamprini @@aut@@ Turiac, Iulia Adelina @@aut@@ Chiesa, Flaminia @@aut@@ Rizzo, Caterina @@aut@@ Martinelli, Domenico @@aut@@ Vold, Line @@aut@@ Herrador, Bernardo Guzman @@aut@@ Martinez, Carmen Varela @@aut@@ Sanchez, Elena Vanessa Martinez @@aut@@ Semenza, Jan C. @@aut@@ Lopalco, Pierluigi @@aut@@ Dahlström, Lisen Arnheim @@aut@@ Giesecke, Johan @@aut@@ |
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Severi, Ettore |
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Severi, Ettore ddc 610 bkl 44.75 misc Viral hepatitis misc Hepatitis A virus misc Hepatitis A infection misc severity misc Hospitalisation misc Surveillance misc Europe Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 |
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610 DE-600 44.75 bkl Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 Viral hepatitis Hepatitis A virus Hepatitis A infection severity Hospitalisation Surveillance Europe |
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ddc 610 bkl 44.75 misc Viral hepatitis misc Hepatitis A virus misc Hepatitis A infection misc severity misc Hospitalisation misc Surveillance misc Europe |
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ddc 610 bkl 44.75 misc Viral hepatitis misc Hepatitis A virus misc Hepatitis A infection misc severity misc Hospitalisation misc Surveillance misc Europe |
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Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 |
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Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 |
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Severi, Ettore Georgalis, Leonidas Pijnacker, Roan Veneti, Lamprini Turiac, Iulia Adelina Chiesa, Flaminia Rizzo, Caterina Martinelli, Domenico Vold, Line Herrador, Bernardo Guzman Martinez, Carmen Varela Sanchez, Elena Vanessa Martinez Semenza, Jan C. Lopalco, Pierluigi Dahlström, Lisen Arnheim Giesecke, Johan |
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10.1016/j.ijid.2022.01.053 |
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severity of the clinical presentation of hepatitis a in five european countries from 1995 to 2014 |
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Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 |
| abstract |
Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. |
| abstractGer |
Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. |
| abstract_unstemmed |
Objectives: We analysed hepatitis A (HepA) notifications and hospitalisations in Italy, the Netherlands, Norway, Spain, and Sweden for available periods between 1995 and 2014. We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. Older patients and patients with comorbidities, particularly liver diseases, were more likely to experience severe disease.Conclusions: We used digitalised health information to confirm decreasing trends in HepA hospitalisations and notifications, and the increasing age of patients with HepA in Europe. We did not identify an increase in the severity of the clinical presentation of patients with HepA. Older patients with liver diseases are at increased risk of severe disease and should be prioritised for vaccination. |
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Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014 |
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Georgalis, Leonidas Pijnacker, Roan Veneti, Lamprini Turiac, Iulia Adelina Chiesa, Flaminia Rizzo, Caterina Martinelli, Domenico Vold, Line Herrador, Bernardo Guzman Martinez, Carmen Varela Sanchez, Elena Vanessa Martinez Semenza, Jan C. Lopalco, Pierluigi Dahlström, Lisen Arnheim Giesecke, Johan |
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Georgalis, Leonidas Pijnacker, Roan Veneti, Lamprini Turiac, Iulia Adelina Chiesa, Flaminia Rizzo, Caterina Martinelli, Domenico Vold, Line Herrador, Bernardo Guzman Martinez, Carmen Varela Sanchez, Elena Vanessa Martinez Semenza, Jan C. Lopalco, Pierluigi Dahlström, Lisen Arnheim Giesecke, Johan |
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10.1016/j.ijid.2022.01.053 |
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2024-07-06T17:26:40.536Z |
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We aimed to investigate whether decreasing HepA incidence is associated with increasing age at infection and worsening HepA presentation and to identify groups at risk of severe disease.Methods: We performed a retrospective cohort study including 36 734 notified and 36 849 hospitalised patients. We used negative binomial regressions to identify over time: i) trends in hospitalisation and notification rates; ii) proportion of hospitalised and notified patients aged ≥40 years; iii) proportion of “severe hospitalisations”; and iv) risk factors for severe hospitalisation.Results: During the study period both HepA notifications and hospitalisations decreased, with notification rates decreasing faster, patients aged ≥40 years increased, however, the proportion of severe HepA hospitalisations remained stable. 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