Bacterial co-infection at hospital admission in patients with COVID-19

Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >4...
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Autor*in:	Moreno-García, Estela [verfasserIn] Puerta-Alcalde, Pedro [verfasserIn] Letona, Laura [verfasserIn] Meira, Fernanda [verfasserIn] Dueñas, Gerard [verfasserIn] Chumbita, Mariana [verfasserIn] Garcia-Pouton, Nicole [verfasserIn] Monzó, Patricia [verfasserIn] Lopera, Carlos [verfasserIn] Serra, Laia [verfasserIn] Cardozo, Celia [verfasserIn] Hernandez-Meneses, Marta [verfasserIn] Rico, Verónica [verfasserIn] Bodro, Marta [verfasserIn] Morata, Laura [verfasserIn] Fernandez-Pittol, Mariana [verfasserIn] Grafia, Ignacio [verfasserIn] Castro, Pedro [verfasserIn] Mensa, Josep [verfasserIn] Martínez, José Antonio [verfasserIn] Sanjuan, Gemma [verfasserIn] Marcos, Mª Angeles [verfasserIn] Soriano, Alex [verfasserIn] Garcia-Vidal, Carolina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2

Übergeordnetes Werk:	Enthalten in: International journal of infectious diseases - Amsterdam [u.a.] : Elsevier, 1997, 118, Seite 197-202
Übergeordnetes Werk:	volume:118 ; pages:197-202

DOI / URN:	10.1016/j.ijid.2022.03.003

Katalog-ID:	ELV00778208X

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245	1	0	\|a Bacterial co-infection at hospital admission in patients with COVID-19
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336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.
650		4	\|a COVID-19
650		4	\|a bacterial infection
650		4	\|a co-infection
650		4	\|a antibiotics
650		4	\|a SARS-CoV-2
700	1		\|a Puerta-Alcalde, Pedro \|e verfasserin \|0 (orcid)0000-0003-2490-0217 \|4 aut
700	1		\|a Letona, Laura \|e verfasserin \|4 aut
700	1		\|a Meira, Fernanda \|e verfasserin \|0 (orcid)0000-0002-5096-4823 \|4 aut
700	1		\|a Dueñas, Gerard \|e verfasserin \|4 aut
700	1		\|a Chumbita, Mariana \|e verfasserin \|4 aut
700	1		\|a Garcia-Pouton, Nicole \|e verfasserin \|4 aut
700	1		\|a Monzó, Patricia \|e verfasserin \|4 aut
700	1		\|a Lopera, Carlos \|e verfasserin \|4 aut
700	1		\|a Serra, Laia \|e verfasserin \|4 aut
700	1		\|a Cardozo, Celia \|e verfasserin \|4 aut
700	1		\|a Hernandez-Meneses, Marta \|e verfasserin \|4 aut
700	1		\|a Rico, Verónica \|e verfasserin \|4 aut
700	1		\|a Bodro, Marta \|e verfasserin \|4 aut
700	1		\|a Morata, Laura \|e verfasserin \|4 aut
700	1		\|a Fernandez-Pittol, Mariana \|e verfasserin \|4 aut
700	1		\|a Grafia, Ignacio \|e verfasserin \|4 aut
700	1		\|a Castro, Pedro \|e verfasserin \|0 (orcid)0000-0002-6118-8970 \|4 aut
700	1		\|a Mensa, Josep \|e verfasserin \|4 aut
700	1		\|a Martínez, José Antonio \|e verfasserin \|4 aut
700	1		\|a Sanjuan, Gemma \|e verfasserin \|4 aut
700	1		\|a Marcos, Mª Angeles \|e verfasserin \|4 aut
700	1		\|a Soriano, Alex \|e verfasserin \|0 (orcid)0000-0002-9374-0811 \|4 aut
700	1		\|a Garcia-Vidal, Carolina \|e verfasserin \|0 (orcid)0000-0002-8915-0683 \|4 aut
773	0	8	\|i Enthalten in \|t International journal of infectious diseases \|d Amsterdam [u.a.] : Elsevier, 1997 \|g 118, Seite 197-202 \|h Online-Ressource \|w (DE-627)341907669 \|w (DE-600)2070533-5 \|w (DE-576)271360844 \|x 1878-3511 \|7 nnns
773	1	8	\|g volume:118 \|g pages:197-202
912			\|a GBV_USEFLAG_U
912			\|a SYSFLAG_U
912			\|a GBV_ELV
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.75 \|j Infektionskrankheiten \|j parasitäre Krankheiten \|x Medizin
951			\|a AR
952			\|d 118 \|h 197-202

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author_variant	e m g emg p p a ppa l l ll f m fm g d gd m c mc n g p ngp p m pm c l cl l s ls c c cc m h m mhm v r vr m b mb l m lm m f p mfp i g ig p c pc j m jm j a m ja jam g s gs m a m ma mam a s as c g v cgv
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hierarchy_sort_str	2022
bklnumber	44.75
publishDate	2022
allfields	10.1016/j.ijid.2022.03.003 doi (DE-627)ELV00778208X (ELSEVIER)S1201-9712(22)00143-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Moreno-García, Estela verfasserin aut Bacterial co-infection at hospital admission in patients with COVID-19 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%. COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2 Puerta-Alcalde, Pedro verfasserin (orcid)0000-0003-2490-0217 aut Letona, Laura verfasserin aut Meira, Fernanda verfasserin (orcid)0000-0002-5096-4823 aut Dueñas, Gerard verfasserin aut Chumbita, Mariana verfasserin aut Garcia-Pouton, Nicole verfasserin aut Monzó, Patricia verfasserin aut Lopera, Carlos verfasserin aut Serra, Laia verfasserin aut Cardozo, Celia verfasserin aut Hernandez-Meneses, Marta verfasserin aut Rico, Verónica verfasserin aut Bodro, Marta verfasserin aut Morata, Laura verfasserin aut Fernandez-Pittol, Mariana verfasserin aut Grafia, Ignacio verfasserin aut Castro, Pedro verfasserin (orcid)0000-0002-6118-8970 aut Mensa, Josep verfasserin aut Martínez, José Antonio verfasserin aut Sanjuan, Gemma verfasserin aut Marcos, Mª Angeles verfasserin aut Soriano, Alex verfasserin (orcid)0000-0002-9374-0811 aut Garcia-Vidal, Carolina verfasserin (orcid)0000-0002-8915-0683 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 197-202 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:197-202 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 197-202
spelling	10.1016/j.ijid.2022.03.003 doi (DE-627)ELV00778208X (ELSEVIER)S1201-9712(22)00143-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Moreno-García, Estela verfasserin aut Bacterial co-infection at hospital admission in patients with COVID-19 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%. COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2 Puerta-Alcalde, Pedro verfasserin (orcid)0000-0003-2490-0217 aut Letona, Laura verfasserin aut Meira, Fernanda verfasserin (orcid)0000-0002-5096-4823 aut Dueñas, Gerard verfasserin aut Chumbita, Mariana verfasserin aut Garcia-Pouton, Nicole verfasserin aut Monzó, Patricia verfasserin aut Lopera, Carlos verfasserin aut Serra, Laia verfasserin aut Cardozo, Celia verfasserin aut Hernandez-Meneses, Marta verfasserin aut Rico, Verónica verfasserin aut Bodro, Marta verfasserin aut Morata, Laura verfasserin aut Fernandez-Pittol, Mariana verfasserin aut Grafia, Ignacio verfasserin aut Castro, Pedro verfasserin (orcid)0000-0002-6118-8970 aut Mensa, Josep verfasserin aut Martínez, José Antonio verfasserin aut Sanjuan, Gemma verfasserin aut Marcos, Mª Angeles verfasserin aut Soriano, Alex verfasserin (orcid)0000-0002-9374-0811 aut Garcia-Vidal, Carolina verfasserin (orcid)0000-0002-8915-0683 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 197-202 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:197-202 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 197-202
allfields_unstemmed	10.1016/j.ijid.2022.03.003 doi (DE-627)ELV00778208X (ELSEVIER)S1201-9712(22)00143-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Moreno-García, Estela verfasserin aut Bacterial co-infection at hospital admission in patients with COVID-19 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%. COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2 Puerta-Alcalde, Pedro verfasserin (orcid)0000-0003-2490-0217 aut Letona, Laura verfasserin aut Meira, Fernanda verfasserin (orcid)0000-0002-5096-4823 aut Dueñas, Gerard verfasserin aut Chumbita, Mariana verfasserin aut Garcia-Pouton, Nicole verfasserin aut Monzó, Patricia verfasserin aut Lopera, Carlos verfasserin aut Serra, Laia verfasserin aut Cardozo, Celia verfasserin aut Hernandez-Meneses, Marta verfasserin aut Rico, Verónica verfasserin aut Bodro, Marta verfasserin aut Morata, Laura verfasserin aut Fernandez-Pittol, Mariana verfasserin aut Grafia, Ignacio verfasserin aut Castro, Pedro verfasserin (orcid)0000-0002-6118-8970 aut Mensa, Josep verfasserin aut Martínez, José Antonio verfasserin aut Sanjuan, Gemma verfasserin aut Marcos, Mª Angeles verfasserin aut Soriano, Alex verfasserin (orcid)0000-0002-9374-0811 aut Garcia-Vidal, Carolina verfasserin (orcid)0000-0002-8915-0683 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 197-202 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:197-202 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 197-202
allfieldsGer	10.1016/j.ijid.2022.03.003 doi (DE-627)ELV00778208X (ELSEVIER)S1201-9712(22)00143-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Moreno-García, Estela verfasserin aut Bacterial co-infection at hospital admission in patients with COVID-19 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%. COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2 Puerta-Alcalde, Pedro verfasserin (orcid)0000-0003-2490-0217 aut Letona, Laura verfasserin aut Meira, Fernanda verfasserin (orcid)0000-0002-5096-4823 aut Dueñas, Gerard verfasserin aut Chumbita, Mariana verfasserin aut Garcia-Pouton, Nicole verfasserin aut Monzó, Patricia verfasserin aut Lopera, Carlos verfasserin aut Serra, Laia verfasserin aut Cardozo, Celia verfasserin aut Hernandez-Meneses, Marta verfasserin aut Rico, Verónica verfasserin aut Bodro, Marta verfasserin aut Morata, Laura verfasserin aut Fernandez-Pittol, Mariana verfasserin aut Grafia, Ignacio verfasserin aut Castro, Pedro verfasserin (orcid)0000-0002-6118-8970 aut Mensa, Josep verfasserin aut Martínez, José Antonio verfasserin aut Sanjuan, Gemma verfasserin aut Marcos, Mª Angeles verfasserin aut Soriano, Alex verfasserin (orcid)0000-0002-9374-0811 aut Garcia-Vidal, Carolina verfasserin (orcid)0000-0002-8915-0683 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 197-202 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:197-202 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 197-202
allfieldsSound	10.1016/j.ijid.2022.03.003 doi (DE-627)ELV00778208X (ELSEVIER)S1201-9712(22)00143-6 DE-627 ger DE-627 rda eng 610 DE-600 44.75 bkl Moreno-García, Estela verfasserin aut Bacterial co-infection at hospital admission in patients with COVID-19 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%. COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2 Puerta-Alcalde, Pedro verfasserin (orcid)0000-0003-2490-0217 aut Letona, Laura verfasserin aut Meira, Fernanda verfasserin (orcid)0000-0002-5096-4823 aut Dueñas, Gerard verfasserin aut Chumbita, Mariana verfasserin aut Garcia-Pouton, Nicole verfasserin aut Monzó, Patricia verfasserin aut Lopera, Carlos verfasserin aut Serra, Laia verfasserin aut Cardozo, Celia verfasserin aut Hernandez-Meneses, Marta verfasserin aut Rico, Verónica verfasserin aut Bodro, Marta verfasserin aut Morata, Laura verfasserin aut Fernandez-Pittol, Mariana verfasserin aut Grafia, Ignacio verfasserin aut Castro, Pedro verfasserin (orcid)0000-0002-6118-8970 aut Mensa, Josep verfasserin aut Martínez, José Antonio verfasserin aut Sanjuan, Gemma verfasserin aut Marcos, Mª Angeles verfasserin aut Soriano, Alex verfasserin (orcid)0000-0002-9374-0811 aut Garcia-Vidal, Carolina verfasserin (orcid)0000-0002-8915-0683 aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 118, Seite 197-202 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:118 pages:197-202 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 118 197-202
language	English
source	Enthalten in International journal of infectious diseases 118, Seite 197-202 volume:118 pages:197-202
sourceStr	Enthalten in International journal of infectious diseases 118, Seite 197-202 volume:118 pages:197-202
format_phy_str_mv	Article
bklname	Infektionskrankheiten parasitäre Krankheiten
institution	findex.gbv.de
topic_facet	COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2
dewey-raw	610
isfreeaccess_bool	false
container_title	International journal of infectious diseases
authorswithroles_txt_mv	Moreno-García, Estela @@aut@@ Puerta-Alcalde, Pedro @@aut@@ Letona, Laura @@aut@@ Meira, Fernanda @@aut@@ Dueñas, Gerard @@aut@@ Chumbita, Mariana @@aut@@ Garcia-Pouton, Nicole @@aut@@ Monzó, Patricia @@aut@@ Lopera, Carlos @@aut@@ Serra, Laia @@aut@@ Cardozo, Celia @@aut@@ Hernandez-Meneses, Marta @@aut@@ Rico, Verónica @@aut@@ Bodro, Marta @@aut@@ Morata, Laura @@aut@@ Fernandez-Pittol, Mariana @@aut@@ Grafia, Ignacio @@aut@@ Castro, Pedro @@aut@@ Mensa, Josep @@aut@@ Martínez, José Antonio @@aut@@ Sanjuan, Gemma @@aut@@ Marcos, Mª Angeles @@aut@@ Soriano, Alex @@aut@@ Garcia-Vidal, Carolina @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	341907669
dewey-sort	3610
id	ELV00778208X
language_de	englisch
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All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. 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author	Moreno-García, Estela
spellingShingle	Moreno-García, Estela ddc 610 bkl 44.75 misc COVID-19 misc bacterial infection misc co-infection misc antibiotics misc SARS-CoV-2 Bacterial co-infection at hospital admission in patients with COVID-19
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topic_title	610 DE-600 44.75 bkl Bacterial co-infection at hospital admission in patients with COVID-19 COVID-19 bacterial infection co-infection antibiotics SARS-CoV-2
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title	Bacterial co-infection at hospital admission in patients with COVID-19
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title_full	Bacterial co-infection at hospital admission in patients with COVID-19
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author_browse	Moreno-García, Estela Puerta-Alcalde, Pedro Letona, Laura Meira, Fernanda Dueñas, Gerard Chumbita, Mariana Garcia-Pouton, Nicole Monzó, Patricia Lopera, Carlos Serra, Laia Cardozo, Celia Hernandez-Meneses, Marta Rico, Verónica Bodro, Marta Morata, Laura Fernandez-Pittol, Mariana Grafia, Ignacio Castro, Pedro Mensa, Josep Martínez, José Antonio Sanjuan, Gemma Marcos, Mª Angeles Soriano, Alex Garcia-Vidal, Carolina
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title_sort	bacterial co-infection at hospital admission in patients with covid-19
title_auth	Bacterial co-infection at hospital admission in patients with COVID-19
abstract	Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.
abstractGer	Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.
abstract_unstemmed	Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.
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title_short	Bacterial co-infection at hospital admission in patients with COVID-19
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author2	Puerta-Alcalde, Pedro Letona, Laura Meira, Fernanda Dueñas, Gerard Chumbita, Mariana Garcia-Pouton, Nicole Monzó, Patricia Lopera, Carlos Serra, Laia Cardozo, Celia Hernandez-Meneses, Marta Rico, Verónica Bodro, Marta Morata, Laura Fernandez-Pittol, Mariana Grafia, Ignacio Castro, Pedro Mensa, Josep Martínez, José Antonio Sanjuan, Gemma Marcos, Mª Angeles Soriano, Alex Garcia-Vidal, Carolina
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up_date	2024-07-06T17:26:42.626Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV00778208X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524145814.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijid.2022.03.003</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV00778208X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1201-9712(22)00143-6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.75</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Moreno-García, Estela</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Bacterial co-infection at hospital admission in patients with COVID-19</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19.Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020–February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included.Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57–3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69–4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11–2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19.Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. 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Bacterial co-infection at hospital admission in patients with COVID-19

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