Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes

Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing...
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Gespeichert in:

Autor*in:	Liu, Shixian [verfasserIn] Shen, Zhuping [verfasserIn] Deng, Liping [verfasserIn] Liu, Guozhen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes

Übergeordnetes Werk:	Enthalten in: Biosensors and bioelectronics - Amsterdam [u.a.] : Elsevier Science, 1989, 209
Übergeordnetes Werk:	volume:209

DOI / URN:	10.1016/j.bios.2022.114251

Katalog-ID:	ELV007870744

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024	7		\|a 10.1016/j.bios.2022.114251 \|2 doi
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520			\|a Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion.
650		4	\|a Electrochemical aptasensors
650		4	\|a Simultaneous detection
650		4	\|a Glucose and insulin
650		4	\|a Smartphone assisted portable biochip
650		4	\|a Pre/diabetes
700	1		\|a Shen, Zhuping \|e verfasserin \|4 aut
700	1		\|a Deng, Liping \|e verfasserin \|4 aut
700	1		\|a Liu, Guozhen \|e verfasserin \|0 (orcid)0000-0002-0556-6404 \|4 aut
773	0	8	\|i Enthalten in \|t Biosensors and bioelectronics \|d Amsterdam [u.a.] : Elsevier Science, 1989 \|g 209 \|h Online-Ressource \|w (DE-627)30632122X \|w (DE-600)1496379-6 \|w (DE-576)094082596 \|x 1873-4235 \|7 nnns
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912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
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936	b	k	\|a 58.30 \|j Biotechnologie
936	b	k	\|a 50.22 \|j Sensorik
936	b	k	\|a 44.09 \|j Medizintechnik
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952			\|d 209

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publishDate	2022
allfields	10.1016/j.bios.2022.114251 doi (DE-627)ELV007870744 (ELSEVIER)S0956-5663(22)00291-3 DE-627 ger DE-627 rda eng 570 610 DE-600 58.30 bkl 50.22 bkl 44.09 bkl Liu, Shixian verfasserin aut Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion. Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes Shen, Zhuping verfasserin aut Deng, Liping verfasserin aut Liu, Guozhen verfasserin (orcid)0000-0002-0556-6404 aut Enthalten in Biosensors and bioelectronics Amsterdam [u.a.] : Elsevier Science, 1989 209 Online-Ressource (DE-627)30632122X (DE-600)1496379-6 (DE-576)094082596 1873-4235 nnns volume:209 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.30 Biotechnologie 50.22 Sensorik 44.09 Medizintechnik AR 209
spelling	10.1016/j.bios.2022.114251 doi (DE-627)ELV007870744 (ELSEVIER)S0956-5663(22)00291-3 DE-627 ger DE-627 rda eng 570 610 DE-600 58.30 bkl 50.22 bkl 44.09 bkl Liu, Shixian verfasserin aut Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion. Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes Shen, Zhuping verfasserin aut Deng, Liping verfasserin aut Liu, Guozhen verfasserin (orcid)0000-0002-0556-6404 aut Enthalten in Biosensors and bioelectronics Amsterdam [u.a.] : Elsevier Science, 1989 209 Online-Ressource (DE-627)30632122X (DE-600)1496379-6 (DE-576)094082596 1873-4235 nnns volume:209 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.30 Biotechnologie 50.22 Sensorik 44.09 Medizintechnik AR 209
allfields_unstemmed	10.1016/j.bios.2022.114251 doi (DE-627)ELV007870744 (ELSEVIER)S0956-5663(22)00291-3 DE-627 ger DE-627 rda eng 570 610 DE-600 58.30 bkl 50.22 bkl 44.09 bkl Liu, Shixian verfasserin aut Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion. Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes Shen, Zhuping verfasserin aut Deng, Liping verfasserin aut Liu, Guozhen verfasserin (orcid)0000-0002-0556-6404 aut Enthalten in Biosensors and bioelectronics Amsterdam [u.a.] : Elsevier Science, 1989 209 Online-Ressource (DE-627)30632122X (DE-600)1496379-6 (DE-576)094082596 1873-4235 nnns volume:209 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.30 Biotechnologie 50.22 Sensorik 44.09 Medizintechnik AR 209
allfieldsGer	10.1016/j.bios.2022.114251 doi (DE-627)ELV007870744 (ELSEVIER)S0956-5663(22)00291-3 DE-627 ger DE-627 rda eng 570 610 DE-600 58.30 bkl 50.22 bkl 44.09 bkl Liu, Shixian verfasserin aut Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion. Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes Shen, Zhuping verfasserin aut Deng, Liping verfasserin aut Liu, Guozhen verfasserin (orcid)0000-0002-0556-6404 aut Enthalten in Biosensors and bioelectronics Amsterdam [u.a.] : Elsevier Science, 1989 209 Online-Ressource (DE-627)30632122X (DE-600)1496379-6 (DE-576)094082596 1873-4235 nnns volume:209 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.30 Biotechnologie 50.22 Sensorik 44.09 Medizintechnik AR 209
allfieldsSound	10.1016/j.bios.2022.114251 doi (DE-627)ELV007870744 (ELSEVIER)S0956-5663(22)00291-3 DE-627 ger DE-627 rda eng 570 610 DE-600 58.30 bkl 50.22 bkl 44.09 bkl Liu, Shixian verfasserin aut Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion. Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes Shen, Zhuping verfasserin aut Deng, Liping verfasserin aut Liu, Guozhen verfasserin (orcid)0000-0002-0556-6404 aut Enthalten in Biosensors and bioelectronics Amsterdam [u.a.] : Elsevier Science, 1989 209 Online-Ressource (DE-627)30632122X (DE-600)1496379-6 (DE-576)094082596 1873-4235 nnns volume:209 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.30 Biotechnologie 50.22 Sensorik 44.09 Medizintechnik AR 209
language	English
source	Enthalten in Biosensors and bioelectronics 209 volume:209
sourceStr	Enthalten in Biosensors and bioelectronics 209 volume:209
format_phy_str_mv	Article
bklname	Biotechnologie Sensorik Medizintechnik
institution	findex.gbv.de
topic_facet	Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes
dewey-raw	570
isfreeaccess_bool	false
container_title	Biosensors and bioelectronics
authorswithroles_txt_mv	Liu, Shixian @@aut@@ Shen, Zhuping @@aut@@ Deng, Liping @@aut@@ Liu, Guozhen @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	30632122X
dewey-sort	3570
id	ELV007870744
language_de	englisch
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author	Liu, Shixian
spellingShingle	Liu, Shixian ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 misc Electrochemical aptasensors misc Simultaneous detection misc Glucose and insulin misc Smartphone assisted portable biochip misc Pre/diabetes Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
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topic_title	570 610 DE-600 58.30 bkl 50.22 bkl 44.09 bkl Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes Electrochemical aptasensors Simultaneous detection Glucose and insulin Smartphone assisted portable biochip Pre/diabetes
topic	ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 misc Electrochemical aptasensors misc Simultaneous detection misc Glucose and insulin misc Smartphone assisted portable biochip misc Pre/diabetes
topic_unstemmed	ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 misc Electrochemical aptasensors misc Simultaneous detection misc Glucose and insulin misc Smartphone assisted portable biochip misc Pre/diabetes
topic_browse	ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 misc Electrochemical aptasensors misc Simultaneous detection misc Glucose and insulin misc Smartphone assisted portable biochip misc Pre/diabetes
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title	Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
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title_full	Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
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author-letter	Liu, Shixian
doi_str_mv	10.1016/j.bios.2022.114251
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title_sort	smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
title_auth	Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
abstract	Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion.
abstractGer	Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion.
abstract_unstemmed	Diabetes is a chronic disease with metabolic disorders. Prediabetes is a condition in which the blood glucose levels are not high enough to be diagnosed as diabetes, but insulin resistance and β-cell dysfunction are simultaneously present. Glucose and insulin are important biomarkers for diagnosing diabetes/prediabetes. It is critical and essential to monitor glucose and insulin levels to achieve the early and precise diagnosis, timely prevention and scientific management of diabetes/prediabetes. Here, an electrochemical aptasensor on screen-printed carbon electrode (SPCE) was developed for non-invasive simultaneous real-time detection of glucose and insulin in saliva. Two thiolated aptamers specific to glucose and insulin, respectively, were fabricated onto gold nanoparticles (AuNPs) decorated SPCE through Au–S bonds to form the sensing interface terminated with redox probes methylene blue (SPCE-AuNPs-GluApt-MB and SPCE-AuNPs-InsApt-MB). With the electrochemical signal readout on SPCE, the sensing interface responded to glucose linearly in the range of 0.1–50 mM with a detection limit of 0.08 mM, and responded linearly to insulin in the range of 0.05–15 nM with a detection limit of 0.85 nM. Integration of a SPCE based sensing interface with a portable wireless biochip, the continuous real-time detection of glucose and insulin in saliva was successfully realized with smartphone signal readout in a non-invasive way, demonstrating its potential as a non-invasive and reliable tool for precise diagnosis of diabetes/prediabetes in a point of care fashion.
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title_short	Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes
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author2	Shen, Zhuping Deng, Liping Liu, Guozhen
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doi_str	10.1016/j.bios.2022.114251
up_date	2024-07-06T17:45:10.217Z
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Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes

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