Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy
Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvan...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Carlo, Maria I. [verfasserIn] Attalla, Kyrollis [verfasserIn] Mazaheri, Yousef [verfasserIn] Gupta, Sounak [verfasserIn] Yildirim, Onur [verfasserIn] Murray, Samuel J. [verfasserIn] Coskey, Devyn T. [verfasserIn] Kotecha, Ritesh [verfasserIn] Lee, Chung-Han [verfasserIn] Feldman, Darren R. [verfasserIn] Russo, Paul [verfasserIn] Patil, Sujata [verfasserIn] Motzer, Robert J. [verfasserIn] Coleman, Jonathan A. [verfasserIn] Durack, Jeremy C. [verfasserIn] Chen, Ying-Bei [verfasserIn] Akin, Oguz [verfasserIn] Ari Hakimi, A. [verfasserIn] Voss, Martin H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European urology - Amsterdam [u.a.] : Elsevier Science, 1976, 81 |
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| Übergeordnetes Werk: |
volume:81 |
| DOI / URN: |
10.1016/j.eururo.2022.01.043 |
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| Katalog-ID: |
ELV007960158 |
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| 024 | 7 | |a 10.1016/j.eururo.2022.01.043 |2 doi | |
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| 100 | 1 | |a Carlo, Maria I. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy |
| 264 | 1 | |c 2022 | |
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| 520 | |a Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. | ||
| 650 | 4 | |a Immune checkpoint inhibitors | |
| 650 | 4 | |a Immunotherapy | |
| 650 | 4 | |a Neoadjuvant | |
| 650 | 4 | |a Nephrectomy | |
| 650 | 4 | |a Renal cell carcinoma | |
| 700 | 1 | |a Attalla, Kyrollis |e verfasserin |4 aut | |
| 700 | 1 | |a Mazaheri, Yousef |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Sounak |e verfasserin |4 aut | |
| 700 | 1 | |a Yildirim, Onur |e verfasserin |4 aut | |
| 700 | 1 | |a Murray, Samuel J. |e verfasserin |4 aut | |
| 700 | 1 | |a Coskey, Devyn T. |e verfasserin |4 aut | |
| 700 | 1 | |a Kotecha, Ritesh |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Chung-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Feldman, Darren R. |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Patil, Sujata |e verfasserin |4 aut | |
| 700 | 1 | |a Motzer, Robert J. |e verfasserin |4 aut | |
| 700 | 1 | |a Coleman, Jonathan A. |e verfasserin |4 aut | |
| 700 | 1 | |a Durack, Jeremy C. |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ying-Bei |e verfasserin |4 aut | |
| 700 | 1 | |a Akin, Oguz |e verfasserin |4 aut | |
| 700 | 1 | |a Ari Hakimi, A. |e verfasserin |4 aut | |
| 700 | 1 | |a Voss, Martin H. |e verfasserin |4 aut | |
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| 936 | b | k | |a 44.88 |j Urologie |j Nephrologie |
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2022 |
| allfields |
10.1016/j.eururo.2022.01.043 doi (DE-627)ELV007960158 (ELSEVIER)S0302-2838(22)00086-0 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Carlo, Maria I. verfasserin aut Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma Attalla, Kyrollis verfasserin aut Mazaheri, Yousef verfasserin aut Gupta, Sounak verfasserin aut Yildirim, Onur verfasserin aut Murray, Samuel J. verfasserin aut Coskey, Devyn T. verfasserin aut Kotecha, Ritesh verfasserin aut Lee, Chung-Han verfasserin aut Feldman, Darren R. verfasserin aut Russo, Paul verfasserin aut Patil, Sujata verfasserin aut Motzer, Robert J. verfasserin aut Coleman, Jonathan A. verfasserin aut Durack, Jeremy C. verfasserin aut Chen, Ying-Bei verfasserin aut Akin, Oguz verfasserin aut Ari Hakimi, A. verfasserin aut Voss, Martin H. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 81 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie AR 81 |
| spelling |
10.1016/j.eururo.2022.01.043 doi (DE-627)ELV007960158 (ELSEVIER)S0302-2838(22)00086-0 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Carlo, Maria I. verfasserin aut Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma Attalla, Kyrollis verfasserin aut Mazaheri, Yousef verfasserin aut Gupta, Sounak verfasserin aut Yildirim, Onur verfasserin aut Murray, Samuel J. verfasserin aut Coskey, Devyn T. verfasserin aut Kotecha, Ritesh verfasserin aut Lee, Chung-Han verfasserin aut Feldman, Darren R. verfasserin aut Russo, Paul verfasserin aut Patil, Sujata verfasserin aut Motzer, Robert J. verfasserin aut Coleman, Jonathan A. verfasserin aut Durack, Jeremy C. verfasserin aut Chen, Ying-Bei verfasserin aut Akin, Oguz verfasserin aut Ari Hakimi, A. verfasserin aut Voss, Martin H. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 81 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie AR 81 |
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10.1016/j.eururo.2022.01.043 doi (DE-627)ELV007960158 (ELSEVIER)S0302-2838(22)00086-0 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Carlo, Maria I. verfasserin aut Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma Attalla, Kyrollis verfasserin aut Mazaheri, Yousef verfasserin aut Gupta, Sounak verfasserin aut Yildirim, Onur verfasserin aut Murray, Samuel J. verfasserin aut Coskey, Devyn T. verfasserin aut Kotecha, Ritesh verfasserin aut Lee, Chung-Han verfasserin aut Feldman, Darren R. verfasserin aut Russo, Paul verfasserin aut Patil, Sujata verfasserin aut Motzer, Robert J. verfasserin aut Coleman, Jonathan A. verfasserin aut Durack, Jeremy C. verfasserin aut Chen, Ying-Bei verfasserin aut Akin, Oguz verfasserin aut Ari Hakimi, A. verfasserin aut Voss, Martin H. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 81 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie AR 81 |
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10.1016/j.eururo.2022.01.043 doi (DE-627)ELV007960158 (ELSEVIER)S0302-2838(22)00086-0 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Carlo, Maria I. verfasserin aut Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma Attalla, Kyrollis verfasserin aut Mazaheri, Yousef verfasserin aut Gupta, Sounak verfasserin aut Yildirim, Onur verfasserin aut Murray, Samuel J. verfasserin aut Coskey, Devyn T. verfasserin aut Kotecha, Ritesh verfasserin aut Lee, Chung-Han verfasserin aut Feldman, Darren R. verfasserin aut Russo, Paul verfasserin aut Patil, Sujata verfasserin aut Motzer, Robert J. verfasserin aut Coleman, Jonathan A. verfasserin aut Durack, Jeremy C. verfasserin aut Chen, Ying-Bei verfasserin aut Akin, Oguz verfasserin aut Ari Hakimi, A. verfasserin aut Voss, Martin H. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 81 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie AR 81 |
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10.1016/j.eururo.2022.01.043 doi (DE-627)ELV007960158 (ELSEVIER)S0302-2838(22)00086-0 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Carlo, Maria I. verfasserin aut Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma Attalla, Kyrollis verfasserin aut Mazaheri, Yousef verfasserin aut Gupta, Sounak verfasserin aut Yildirim, Onur verfasserin aut Murray, Samuel J. verfasserin aut Coskey, Devyn T. verfasserin aut Kotecha, Ritesh verfasserin aut Lee, Chung-Han verfasserin aut Feldman, Darren R. verfasserin aut Russo, Paul verfasserin aut Patil, Sujata verfasserin aut Motzer, Robert J. verfasserin aut Coleman, Jonathan A. verfasserin aut Durack, Jeremy C. verfasserin aut Chen, Ying-Bei verfasserin aut Akin, Oguz verfasserin aut Ari Hakimi, A. verfasserin aut Voss, Martin H. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 81 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie AR 81 |
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Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma |
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Carlo, Maria I. @@aut@@ Attalla, Kyrollis @@aut@@ Mazaheri, Yousef @@aut@@ Gupta, Sounak @@aut@@ Yildirim, Onur @@aut@@ Murray, Samuel J. @@aut@@ Coskey, Devyn T. @@aut@@ Kotecha, Ritesh @@aut@@ Lee, Chung-Han @@aut@@ Feldman, Darren R. @@aut@@ Russo, Paul @@aut@@ Patil, Sujata @@aut@@ Motzer, Robert J. @@aut@@ Coleman, Jonathan A. @@aut@@ Durack, Jeremy C. @@aut@@ Chen, Ying-Bei @@aut@@ Akin, Oguz @@aut@@ Ari Hakimi, A. @@aut@@ Voss, Martin H. @@aut@@ |
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2022-01-01T00:00:00Z |
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| author |
Carlo, Maria I. |
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Carlo, Maria I. ddc 610 bkl 44.88 misc Immune checkpoint inhibitors misc Immunotherapy misc Neoadjuvant misc Nephrectomy misc Renal cell carcinoma Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy |
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610 DE-600 44.88 bkl Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy Immune checkpoint inhibitors Immunotherapy Neoadjuvant Nephrectomy Renal cell carcinoma |
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ddc 610 bkl 44.88 misc Immune checkpoint inhibitors misc Immunotherapy misc Neoadjuvant misc Nephrectomy misc Renal cell carcinoma |
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ddc 610 bkl 44.88 misc Immune checkpoint inhibitors misc Immunotherapy misc Neoadjuvant misc Nephrectomy misc Renal cell carcinoma |
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ddc 610 bkl 44.88 misc Immune checkpoint inhibitors misc Immunotherapy misc Neoadjuvant misc Nephrectomy misc Renal cell carcinoma |
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Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy |
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(DE-627)ELV007960158 (ELSEVIER)S0302-2838(22)00086-0 |
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Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy |
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Carlo, Maria I. |
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European urology |
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Carlo, Maria I. Attalla, Kyrollis Mazaheri, Yousef Gupta, Sounak Yildirim, Onur Murray, Samuel J. Coskey, Devyn T. Kotecha, Ritesh Lee, Chung-Han Feldman, Darren R. Russo, Paul Patil, Sujata Motzer, Robert J. Coleman, Jonathan A. Durack, Jeremy C. Chen, Ying-Bei Akin, Oguz Ari Hakimi, A. Voss, Martin H. |
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Carlo, Maria I. |
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10.1016/j.eururo.2022.01.043 |
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phase ii study of neoadjuvant nivolumab in patients with locally advanced clear cell renal cell carcinoma undergoing nephrectomy |
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Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy |
| abstract |
Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. |
| abstractGer |
Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. |
| abstract_unstemmed |
Immune checkpoint inhibitor therapy improves survival in patients with metastatic renal cell carcinoma (RCC) but has not been studied well preoperatively in patients with localized disease undergoing nephrectomy. We conducted a single-center study to evaluate the safety and feasibility of neoadjuvant nivolumab in patients undergoing nephrectomy for localized RCC. Eligible patients had a >20% risk of recurrence, as estimated by a preoperative nomogram. Patients received nivolumab every 2 wk for four treatments prior to surgery. The primary endpoints were feasibility, defined as completing at least three treatments without significant surgical delay, and safety, defined as the rate of surgical complications. Treatment effects were assessed by radiomics and immunohistochemistry. A total of 18 patients (11 men; median age 60 yr) with clear cell RCC were enrolled. All received at least one dose of nivolumab and proceeded to nephrectomy without delay; 16/18 patients completed all four doses. Two patients discontinued nivolumab for immune-related adverse events, and four had surgical complications as per the Clavien-Dindo classification. Integrated pathology plus radiomic analysis demonstrated an association between post-treatment immune infiltration and low entropy apparent diffusion coefficient on magnetic resonance imaging. Nivolumab prior to nephrectomy was safe and feasible, without significant surgical delays and with an expected rate of immune-related adverse events.Patient summary: We evaluated the outcomes for patients with localized kidney cancer who received immunotherapy prior to surgery to remove their kidney tumor. In a small group of patients who had cancer confined to the kidney, this approach appeared safe and feasible. |
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| title_short |
Phase II Study of Neoadjuvant Nivolumab in Patients with Locally Advanced Clear Cell Renal Cell Carcinoma Undergoing Nephrectomy |
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Attalla, Kyrollis Mazaheri, Yousef Gupta, Sounak Yildirim, Onur Murray, Samuel J. Coskey, Devyn T. Kotecha, Ritesh Lee, Chung-Han Feldman, Darren R. Russo, Paul Patil, Sujata Motzer, Robert J. Coleman, Jonathan A. Durack, Jeremy C. Chen, Ying-Bei Akin, Oguz Ari Hakimi, A. Voss, Martin H. |
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Attalla, Kyrollis Mazaheri, Yousef Gupta, Sounak Yildirim, Onur Murray, Samuel J. Coskey, Devyn T. Kotecha, Ritesh Lee, Chung-Han Feldman, Darren R. Russo, Paul Patil, Sujata Motzer, Robert J. Coleman, Jonathan A. Durack, Jeremy C. Chen, Ying-Bei Akin, Oguz Ari Hakimi, A. Voss, Martin H. |
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10.1016/j.eururo.2022.01.043 |
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2024-07-06T18:03:48.723Z |
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