Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Mutation research - Amsterdam [u.a.] : Elsevier Science, 2011, 789 |
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| Übergeordnetes Werk: |
volume:789 |
| DOI / URN: |
10.1016/j.mrrev.2022.108415 |
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| Katalog-ID: |
ELV008019282 |
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| 024 | 7 | |a 10.1016/j.mrrev.2022.108415 |2 doi | |
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| 100 | 1 | |a Solomon, Olivia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation |
| 264 | 1 | |c 2022 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. | ||
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a Sex | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Cord blood | |
| 650 | 4 | |a EWAS | |
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| 700 | 1 | |a Yousefi, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Küpers, Leanne K. |e verfasserin |4 aut | |
| 700 | 1 | |a González, Juan R. |e verfasserin |4 aut | |
| 700 | 1 | |a Suderman, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Reese, Sarah E. |e verfasserin |4 aut | |
| 700 | 1 | |a Page, Christian M. |e verfasserin |4 aut | |
| 700 | 1 | |a Gruzieva, Olena |e verfasserin |4 aut | |
| 700 | 1 | |a Rzehak, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Bakulski, Kelly M. |e verfasserin |4 aut | |
| 700 | 1 | |a Novoloaca, Alexei |e verfasserin |4 aut | |
| 700 | 1 | |a Allard, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Pappa, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Llambrich, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Vives, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Jima, Dereje D. |e verfasserin |4 aut | |
| 700 | 1 | |a Kvist, Tuomas |e verfasserin |4 aut | |
| 700 | 1 | |a Baccarelli, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a White, Cory |e verfasserin |4 aut | |
| 700 | 1 | |a Rezwan, Faisal I. |e verfasserin |4 aut | |
| 700 | 1 | |a Sharp, Gemma C. |e verfasserin |4 aut | |
| 700 | 1 | |a Tindula, Gwen |e verfasserin |4 aut | |
| 700 | 1 | |a Bergström, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Grote, Veit |e verfasserin |4 aut | |
| 700 | 1 | |a Dou, John F. |e verfasserin |4 aut | |
| 700 | 1 | |a Isaevska, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Magnus, Maria C. |e verfasserin |4 aut | |
| 700 | 1 | |a Corpeleijn, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Perron, Patrice |e verfasserin |4 aut | |
| 700 | 1 | |a Jaddoe, Vincent W.V. |e verfasserin |4 aut | |
| 700 | 1 | |a Nohr, Ellen A. |e verfasserin |4 aut | |
| 700 | 1 | |a Maitre, Lea |e verfasserin |4 aut | |
| 700 | 1 | |a Foraster, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Hoyo, Cathrine |e verfasserin |4 aut | |
| 700 | 1 | |a Håberg, Siri E. |e verfasserin |4 aut | |
| 700 | 1 | |a Lahti, Jari |e verfasserin |4 aut | |
| 700 | 1 | |a DeMeo, Dawn L. |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hongmei |e verfasserin |4 aut | |
| 700 | 1 | |a Karmaus, Wilfried |e verfasserin |4 aut | |
| 700 | 1 | |a Kull, Inger |e verfasserin |4 aut | |
| 700 | 1 | |a Koletzko, Berthold |e verfasserin |4 aut | |
| 700 | 1 | |a Feinberg, Jason I. |e verfasserin |4 aut | |
| 700 | 1 | |a Gagliardi, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Bouchard, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Ramlau-Hansen, Cecilia Høst |e verfasserin |4 aut | |
| 700 | 1 | |a Tiemeier, Henning |e verfasserin |4 aut | |
| 700 | 1 | |a Santorelli, Gillian |e verfasserin |4 aut | |
| 700 | 1 | |a Maguire, Rachel L. |e verfasserin |4 aut | |
| 700 | 1 | |a Czamara, Darina |e verfasserin |4 aut | |
| 700 | 1 | |a Litonjua, Augusto A. |e verfasserin |4 aut | |
| 700 | 1 | |a Langhendries, Jean-Paul |e verfasserin |4 aut | |
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| 700 | 1 | |a Binder, Elisabeth B. |e verfasserin |4 aut | |
| 700 | 1 | |a Verduci, Elvira |e verfasserin |4 aut | |
| 700 | 1 | |a Dwyer, Terence |e verfasserin |4 aut | |
| 700 | 1 | |a Carracedo, Ángel |e verfasserin |4 aut | |
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| 700 | 1 | |a Sørensen, Thorkild I.A. |e verfasserin |4 aut | |
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10.1016/j.mrrev.2022.108415 doi (DE-627)ELV008019282 (ELSEVIER)S1383-5742(22)00005-9 DE-627 ger DE-627 rda eng 570 VZ Solomon, Olivia verfasserin aut Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. DNA methylation Sex Children Cord blood EWAS Huen, Karen verfasserin aut Yousefi, Paul verfasserin aut Küpers, Leanne K. verfasserin aut González, Juan R. verfasserin aut Suderman, Matthew verfasserin aut Reese, Sarah E. verfasserin aut Page, Christian M. verfasserin aut Gruzieva, Olena verfasserin aut Rzehak, Peter verfasserin aut Gao, Lu verfasserin aut Bakulski, Kelly M. verfasserin aut Novoloaca, Alexei verfasserin aut Allard, Catherine verfasserin aut Pappa, Irene verfasserin aut Llambrich, Maria verfasserin aut Vives, Marta verfasserin aut Jima, Dereje D. verfasserin aut Kvist, Tuomas verfasserin aut Baccarelli, Andrea verfasserin aut White, Cory verfasserin aut Rezwan, Faisal I. verfasserin aut Sharp, Gemma C. verfasserin aut Tindula, Gwen verfasserin aut Bergström, Anna verfasserin aut Grote, Veit verfasserin aut Dou, John F. verfasserin aut Isaevska, Elena verfasserin aut Magnus, Maria C. verfasserin aut Corpeleijn, Eva verfasserin aut Perron, Patrice verfasserin aut Jaddoe, Vincent W.V. verfasserin aut Nohr, Ellen A. verfasserin aut Maitre, Lea verfasserin aut Foraster, Maria verfasserin aut Hoyo, Cathrine verfasserin aut Håberg, Siri E. verfasserin aut Lahti, Jari verfasserin aut DeMeo, Dawn L. verfasserin aut Zhang, Hongmei verfasserin aut Karmaus, Wilfried verfasserin aut Kull, Inger verfasserin aut Koletzko, Berthold verfasserin aut Feinberg, Jason I. verfasserin aut Gagliardi, Luigi verfasserin aut Bouchard, Luigi verfasserin aut Ramlau-Hansen, Cecilia Høst verfasserin aut Tiemeier, Henning verfasserin aut Santorelli, Gillian verfasserin aut Maguire, Rachel L. verfasserin aut Czamara, Darina verfasserin aut Litonjua, Augusto A. verfasserin aut Langhendries, Jean-Paul verfasserin aut Plusquin, Michelle verfasserin aut Lepeule, Johanna verfasserin aut Binder, Elisabeth B. verfasserin aut Verduci, Elvira verfasserin aut Dwyer, Terence verfasserin aut Carracedo, Ángel verfasserin aut Ferre, Natalia verfasserin aut Eskenazi, Brenda verfasserin aut Kogevinas, Manolis verfasserin aut Nawrot, Tim S. verfasserin aut Munthe-Kaas, Monica C. verfasserin aut Herceg, Zdenko verfasserin aut Relton, Caroline verfasserin aut Melén, Erik verfasserin aut Gruszfeld, Dariusz verfasserin aut Breton, Carrie verfasserin aut Fallin, M.D. verfasserin aut Ghantous, Akram verfasserin aut Nystad, Wenche verfasserin aut Heude, Barbara verfasserin aut Snieder, Harold verfasserin aut Hivert, Marie-France verfasserin aut Felix, Janine F. verfasserin aut Sørensen, Thorkild I.A. verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Raikkönen, Katri verfasserin aut Oken, Emily verfasserin aut Holloway, John W. verfasserin aut Arshad, Syed Hasan verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Enthalten in Mutation research Amsterdam [u.a.] : Elsevier Science, 2011 789 (DE-627)503327301 (DE-600)2210266-8 138-82139 nnns volume:789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 789 |
| spelling |
10.1016/j.mrrev.2022.108415 doi (DE-627)ELV008019282 (ELSEVIER)S1383-5742(22)00005-9 DE-627 ger DE-627 rda eng 570 VZ Solomon, Olivia verfasserin aut Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. DNA methylation Sex Children Cord blood EWAS Huen, Karen verfasserin aut Yousefi, Paul verfasserin aut Küpers, Leanne K. verfasserin aut González, Juan R. verfasserin aut Suderman, Matthew verfasserin aut Reese, Sarah E. verfasserin aut Page, Christian M. verfasserin aut Gruzieva, Olena verfasserin aut Rzehak, Peter verfasserin aut Gao, Lu verfasserin aut Bakulski, Kelly M. verfasserin aut Novoloaca, Alexei verfasserin aut Allard, Catherine verfasserin aut Pappa, Irene verfasserin aut Llambrich, Maria verfasserin aut Vives, Marta verfasserin aut Jima, Dereje D. verfasserin aut Kvist, Tuomas verfasserin aut Baccarelli, Andrea verfasserin aut White, Cory verfasserin aut Rezwan, Faisal I. verfasserin aut Sharp, Gemma C. verfasserin aut Tindula, Gwen verfasserin aut Bergström, Anna verfasserin aut Grote, Veit verfasserin aut Dou, John F. verfasserin aut Isaevska, Elena verfasserin aut Magnus, Maria C. verfasserin aut Corpeleijn, Eva verfasserin aut Perron, Patrice verfasserin aut Jaddoe, Vincent W.V. verfasserin aut Nohr, Ellen A. verfasserin aut Maitre, Lea verfasserin aut Foraster, Maria verfasserin aut Hoyo, Cathrine verfasserin aut Håberg, Siri E. verfasserin aut Lahti, Jari verfasserin aut DeMeo, Dawn L. verfasserin aut Zhang, Hongmei verfasserin aut Karmaus, Wilfried verfasserin aut Kull, Inger verfasserin aut Koletzko, Berthold verfasserin aut Feinberg, Jason I. verfasserin aut Gagliardi, Luigi verfasserin aut Bouchard, Luigi verfasserin aut Ramlau-Hansen, Cecilia Høst verfasserin aut Tiemeier, Henning verfasserin aut Santorelli, Gillian verfasserin aut Maguire, Rachel L. verfasserin aut Czamara, Darina verfasserin aut Litonjua, Augusto A. verfasserin aut Langhendries, Jean-Paul verfasserin aut Plusquin, Michelle verfasserin aut Lepeule, Johanna verfasserin aut Binder, Elisabeth B. verfasserin aut Verduci, Elvira verfasserin aut Dwyer, Terence verfasserin aut Carracedo, Ángel verfasserin aut Ferre, Natalia verfasserin aut Eskenazi, Brenda verfasserin aut Kogevinas, Manolis verfasserin aut Nawrot, Tim S. verfasserin aut Munthe-Kaas, Monica C. verfasserin aut Herceg, Zdenko verfasserin aut Relton, Caroline verfasserin aut Melén, Erik verfasserin aut Gruszfeld, Dariusz verfasserin aut Breton, Carrie verfasserin aut Fallin, M.D. verfasserin aut Ghantous, Akram verfasserin aut Nystad, Wenche verfasserin aut Heude, Barbara verfasserin aut Snieder, Harold verfasserin aut Hivert, Marie-France verfasserin aut Felix, Janine F. verfasserin aut Sørensen, Thorkild I.A. verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Raikkönen, Katri verfasserin aut Oken, Emily verfasserin aut Holloway, John W. verfasserin aut Arshad, Syed Hasan verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Enthalten in Mutation research Amsterdam [u.a.] : Elsevier Science, 2011 789 (DE-627)503327301 (DE-600)2210266-8 138-82139 nnns volume:789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 789 |
| allfields_unstemmed |
10.1016/j.mrrev.2022.108415 doi (DE-627)ELV008019282 (ELSEVIER)S1383-5742(22)00005-9 DE-627 ger DE-627 rda eng 570 VZ Solomon, Olivia verfasserin aut Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. DNA methylation Sex Children Cord blood EWAS Huen, Karen verfasserin aut Yousefi, Paul verfasserin aut Küpers, Leanne K. verfasserin aut González, Juan R. verfasserin aut Suderman, Matthew verfasserin aut Reese, Sarah E. verfasserin aut Page, Christian M. verfasserin aut Gruzieva, Olena verfasserin aut Rzehak, Peter verfasserin aut Gao, Lu verfasserin aut Bakulski, Kelly M. verfasserin aut Novoloaca, Alexei verfasserin aut Allard, Catherine verfasserin aut Pappa, Irene verfasserin aut Llambrich, Maria verfasserin aut Vives, Marta verfasserin aut Jima, Dereje D. verfasserin aut Kvist, Tuomas verfasserin aut Baccarelli, Andrea verfasserin aut White, Cory verfasserin aut Rezwan, Faisal I. verfasserin aut Sharp, Gemma C. verfasserin aut Tindula, Gwen verfasserin aut Bergström, Anna verfasserin aut Grote, Veit verfasserin aut Dou, John F. verfasserin aut Isaevska, Elena verfasserin aut Magnus, Maria C. verfasserin aut Corpeleijn, Eva verfasserin aut Perron, Patrice verfasserin aut Jaddoe, Vincent W.V. verfasserin aut Nohr, Ellen A. verfasserin aut Maitre, Lea verfasserin aut Foraster, Maria verfasserin aut Hoyo, Cathrine verfasserin aut Håberg, Siri E. verfasserin aut Lahti, Jari verfasserin aut DeMeo, Dawn L. verfasserin aut Zhang, Hongmei verfasserin aut Karmaus, Wilfried verfasserin aut Kull, Inger verfasserin aut Koletzko, Berthold verfasserin aut Feinberg, Jason I. verfasserin aut Gagliardi, Luigi verfasserin aut Bouchard, Luigi verfasserin aut Ramlau-Hansen, Cecilia Høst verfasserin aut Tiemeier, Henning verfasserin aut Santorelli, Gillian verfasserin aut Maguire, Rachel L. verfasserin aut Czamara, Darina verfasserin aut Litonjua, Augusto A. verfasserin aut Langhendries, Jean-Paul verfasserin aut Plusquin, Michelle verfasserin aut Lepeule, Johanna verfasserin aut Binder, Elisabeth B. verfasserin aut Verduci, Elvira verfasserin aut Dwyer, Terence verfasserin aut Carracedo, Ángel verfasserin aut Ferre, Natalia verfasserin aut Eskenazi, Brenda verfasserin aut Kogevinas, Manolis verfasserin aut Nawrot, Tim S. verfasserin aut Munthe-Kaas, Monica C. verfasserin aut Herceg, Zdenko verfasserin aut Relton, Caroline verfasserin aut Melén, Erik verfasserin aut Gruszfeld, Dariusz verfasserin aut Breton, Carrie verfasserin aut Fallin, M.D. verfasserin aut Ghantous, Akram verfasserin aut Nystad, Wenche verfasserin aut Heude, Barbara verfasserin aut Snieder, Harold verfasserin aut Hivert, Marie-France verfasserin aut Felix, Janine F. verfasserin aut Sørensen, Thorkild I.A. verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Raikkönen, Katri verfasserin aut Oken, Emily verfasserin aut Holloway, John W. verfasserin aut Arshad, Syed Hasan verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Enthalten in Mutation research Amsterdam [u.a.] : Elsevier Science, 2011 789 (DE-627)503327301 (DE-600)2210266-8 138-82139 nnns volume:789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 789 |
| allfieldsGer |
10.1016/j.mrrev.2022.108415 doi (DE-627)ELV008019282 (ELSEVIER)S1383-5742(22)00005-9 DE-627 ger DE-627 rda eng 570 VZ Solomon, Olivia verfasserin aut Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. DNA methylation Sex Children Cord blood EWAS Huen, Karen verfasserin aut Yousefi, Paul verfasserin aut Küpers, Leanne K. verfasserin aut González, Juan R. verfasserin aut Suderman, Matthew verfasserin aut Reese, Sarah E. verfasserin aut Page, Christian M. verfasserin aut Gruzieva, Olena verfasserin aut Rzehak, Peter verfasserin aut Gao, Lu verfasserin aut Bakulski, Kelly M. verfasserin aut Novoloaca, Alexei verfasserin aut Allard, Catherine verfasserin aut Pappa, Irene verfasserin aut Llambrich, Maria verfasserin aut Vives, Marta verfasserin aut Jima, Dereje D. verfasserin aut Kvist, Tuomas verfasserin aut Baccarelli, Andrea verfasserin aut White, Cory verfasserin aut Rezwan, Faisal I. verfasserin aut Sharp, Gemma C. verfasserin aut Tindula, Gwen verfasserin aut Bergström, Anna verfasserin aut Grote, Veit verfasserin aut Dou, John F. verfasserin aut Isaevska, Elena verfasserin aut Magnus, Maria C. verfasserin aut Corpeleijn, Eva verfasserin aut Perron, Patrice verfasserin aut Jaddoe, Vincent W.V. verfasserin aut Nohr, Ellen A. verfasserin aut Maitre, Lea verfasserin aut Foraster, Maria verfasserin aut Hoyo, Cathrine verfasserin aut Håberg, Siri E. verfasserin aut Lahti, Jari verfasserin aut DeMeo, Dawn L. verfasserin aut Zhang, Hongmei verfasserin aut Karmaus, Wilfried verfasserin aut Kull, Inger verfasserin aut Koletzko, Berthold verfasserin aut Feinberg, Jason I. verfasserin aut Gagliardi, Luigi verfasserin aut Bouchard, Luigi verfasserin aut Ramlau-Hansen, Cecilia Høst verfasserin aut Tiemeier, Henning verfasserin aut Santorelli, Gillian verfasserin aut Maguire, Rachel L. verfasserin aut Czamara, Darina verfasserin aut Litonjua, Augusto A. verfasserin aut Langhendries, Jean-Paul verfasserin aut Plusquin, Michelle verfasserin aut Lepeule, Johanna verfasserin aut Binder, Elisabeth B. verfasserin aut Verduci, Elvira verfasserin aut Dwyer, Terence verfasserin aut Carracedo, Ángel verfasserin aut Ferre, Natalia verfasserin aut Eskenazi, Brenda verfasserin aut Kogevinas, Manolis verfasserin aut Nawrot, Tim S. verfasserin aut Munthe-Kaas, Monica C. verfasserin aut Herceg, Zdenko verfasserin aut Relton, Caroline verfasserin aut Melén, Erik verfasserin aut Gruszfeld, Dariusz verfasserin aut Breton, Carrie verfasserin aut Fallin, M.D. verfasserin aut Ghantous, Akram verfasserin aut Nystad, Wenche verfasserin aut Heude, Barbara verfasserin aut Snieder, Harold verfasserin aut Hivert, Marie-France verfasserin aut Felix, Janine F. verfasserin aut Sørensen, Thorkild I.A. verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Raikkönen, Katri verfasserin aut Oken, Emily verfasserin aut Holloway, John W. verfasserin aut Arshad, Syed Hasan verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Enthalten in Mutation research Amsterdam [u.a.] : Elsevier Science, 2011 789 (DE-627)503327301 (DE-600)2210266-8 138-82139 nnns volume:789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 789 |
| allfieldsSound |
10.1016/j.mrrev.2022.108415 doi (DE-627)ELV008019282 (ELSEVIER)S1383-5742(22)00005-9 DE-627 ger DE-627 rda eng 570 VZ Solomon, Olivia verfasserin aut Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. DNA methylation Sex Children Cord blood EWAS Huen, Karen verfasserin aut Yousefi, Paul verfasserin aut Küpers, Leanne K. verfasserin aut González, Juan R. verfasserin aut Suderman, Matthew verfasserin aut Reese, Sarah E. verfasserin aut Page, Christian M. verfasserin aut Gruzieva, Olena verfasserin aut Rzehak, Peter verfasserin aut Gao, Lu verfasserin aut Bakulski, Kelly M. verfasserin aut Novoloaca, Alexei verfasserin aut Allard, Catherine verfasserin aut Pappa, Irene verfasserin aut Llambrich, Maria verfasserin aut Vives, Marta verfasserin aut Jima, Dereje D. verfasserin aut Kvist, Tuomas verfasserin aut Baccarelli, Andrea verfasserin aut White, Cory verfasserin aut Rezwan, Faisal I. verfasserin aut Sharp, Gemma C. verfasserin aut Tindula, Gwen verfasserin aut Bergström, Anna verfasserin aut Grote, Veit verfasserin aut Dou, John F. verfasserin aut Isaevska, Elena verfasserin aut Magnus, Maria C. verfasserin aut Corpeleijn, Eva verfasserin aut Perron, Patrice verfasserin aut Jaddoe, Vincent W.V. verfasserin aut Nohr, Ellen A. verfasserin aut Maitre, Lea verfasserin aut Foraster, Maria verfasserin aut Hoyo, Cathrine verfasserin aut Håberg, Siri E. verfasserin aut Lahti, Jari verfasserin aut DeMeo, Dawn L. verfasserin aut Zhang, Hongmei verfasserin aut Karmaus, Wilfried verfasserin aut Kull, Inger verfasserin aut Koletzko, Berthold verfasserin aut Feinberg, Jason I. verfasserin aut Gagliardi, Luigi verfasserin aut Bouchard, Luigi verfasserin aut Ramlau-Hansen, Cecilia Høst verfasserin aut Tiemeier, Henning verfasserin aut Santorelli, Gillian verfasserin aut Maguire, Rachel L. verfasserin aut Czamara, Darina verfasserin aut Litonjua, Augusto A. verfasserin aut Langhendries, Jean-Paul verfasserin aut Plusquin, Michelle verfasserin aut Lepeule, Johanna verfasserin aut Binder, Elisabeth B. verfasserin aut Verduci, Elvira verfasserin aut Dwyer, Terence verfasserin aut Carracedo, Ángel verfasserin aut Ferre, Natalia verfasserin aut Eskenazi, Brenda verfasserin aut Kogevinas, Manolis verfasserin aut Nawrot, Tim S. verfasserin aut Munthe-Kaas, Monica C. verfasserin aut Herceg, Zdenko verfasserin aut Relton, Caroline verfasserin aut Melén, Erik verfasserin aut Gruszfeld, Dariusz verfasserin aut Breton, Carrie verfasserin aut Fallin, M.D. verfasserin aut Ghantous, Akram verfasserin aut Nystad, Wenche verfasserin aut Heude, Barbara verfasserin aut Snieder, Harold verfasserin aut Hivert, Marie-France verfasserin aut Felix, Janine F. verfasserin aut Sørensen, Thorkild I.A. verfasserin aut Bustamante, Mariona verfasserin aut Murphy, Susan K. verfasserin aut Raikkönen, Katri verfasserin aut Oken, Emily verfasserin aut Holloway, John W. verfasserin aut Arshad, Syed Hasan verfasserin aut London, Stephanie J. verfasserin aut Holland, Nina verfasserin aut Enthalten in Mutation research Amsterdam [u.a.] : Elsevier Science, 2011 789 (DE-627)503327301 (DE-600)2210266-8 138-82139 nnns volume:789 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 789 |
| language |
English |
| source |
Enthalten in Mutation research 789 volume:789 |
| sourceStr |
Enthalten in Mutation research 789 volume:789 |
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Article |
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findex.gbv.de |
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DNA methylation Sex Children Cord blood EWAS |
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Mutation research |
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Solomon, Olivia @@aut@@ Huen, Karen @@aut@@ Yousefi, Paul @@aut@@ Küpers, Leanne K. @@aut@@ González, Juan R. @@aut@@ Suderman, Matthew @@aut@@ Reese, Sarah E. @@aut@@ Page, Christian M. @@aut@@ Gruzieva, Olena @@aut@@ Rzehak, Peter @@aut@@ Gao, Lu @@aut@@ Bakulski, Kelly M. @@aut@@ Novoloaca, Alexei @@aut@@ Allard, Catherine @@aut@@ Pappa, Irene @@aut@@ Llambrich, Maria @@aut@@ Vives, Marta @@aut@@ Jima, Dereje D. @@aut@@ Kvist, Tuomas @@aut@@ Baccarelli, Andrea @@aut@@ White, Cory @@aut@@ Rezwan, Faisal I. @@aut@@ Sharp, Gemma C. @@aut@@ Tindula, Gwen @@aut@@ Bergström, Anna @@aut@@ Grote, Veit @@aut@@ Dou, John F. @@aut@@ Isaevska, Elena @@aut@@ Magnus, Maria C. @@aut@@ Corpeleijn, Eva @@aut@@ Perron, Patrice @@aut@@ Jaddoe, Vincent W.V. @@aut@@ Nohr, Ellen A. @@aut@@ Maitre, Lea @@aut@@ Foraster, Maria @@aut@@ Hoyo, Cathrine @@aut@@ Håberg, Siri E. @@aut@@ Lahti, Jari @@aut@@ DeMeo, Dawn L. @@aut@@ Zhang, Hongmei @@aut@@ Karmaus, Wilfried @@aut@@ Kull, Inger @@aut@@ Koletzko, Berthold @@aut@@ Feinberg, Jason I. @@aut@@ Gagliardi, Luigi @@aut@@ Bouchard, Luigi @@aut@@ Ramlau-Hansen, Cecilia Høst @@aut@@ Tiemeier, Henning @@aut@@ Santorelli, Gillian @@aut@@ Maguire, Rachel L. @@aut@@ Czamara, Darina @@aut@@ Litonjua, Augusto A. @@aut@@ Langhendries, Jean-Paul @@aut@@ Plusquin, Michelle @@aut@@ Lepeule, Johanna @@aut@@ Binder, Elisabeth B. @@aut@@ Verduci, Elvira @@aut@@ Dwyer, Terence @@aut@@ Carracedo, Ángel @@aut@@ Ferre, Natalia @@aut@@ Eskenazi, Brenda @@aut@@ Kogevinas, Manolis @@aut@@ Nawrot, Tim S. @@aut@@ Munthe-Kaas, Monica C. @@aut@@ Herceg, Zdenko @@aut@@ Relton, Caroline @@aut@@ Melén, Erik @@aut@@ Gruszfeld, Dariusz @@aut@@ Breton, Carrie @@aut@@ Fallin, M.D. @@aut@@ Ghantous, Akram @@aut@@ Nystad, Wenche @@aut@@ Heude, Barbara @@aut@@ Snieder, Harold @@aut@@ Hivert, Marie-France @@aut@@ Felix, Janine F. @@aut@@ Sørensen, Thorkild I.A. @@aut@@ Bustamante, Mariona @@aut@@ Murphy, Susan K. @@aut@@ Raikkönen, Katri @@aut@@ Oken, Emily @@aut@@ Holloway, John W. @@aut@@ Arshad, Syed Hasan @@aut@@ London, Stephanie J. @@aut@@ Holland, Nina @@aut@@ |
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2022-01-01T00:00:00Z |
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3570 |
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ELV008019282 |
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englisch |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008019282</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240103093321.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.mrrev.2022.108415</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008019282</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1383-5742(22)00005-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Solomon, Olivia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. 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570 VZ Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation DNA methylation Sex Children Cord blood EWAS |
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Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation |
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Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation |
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Solomon, Olivia Huen, Karen Yousefi, Paul Küpers, Leanne K. González, Juan R. Suderman, Matthew Reese, Sarah E. Page, Christian M. Gruzieva, Olena Rzehak, Peter Gao, Lu Bakulski, Kelly M. Novoloaca, Alexei Allard, Catherine Pappa, Irene Llambrich, Maria Vives, Marta Jima, Dereje D. Kvist, Tuomas Baccarelli, Andrea White, Cory Rezwan, Faisal I. Sharp, Gemma C. Tindula, Gwen Bergström, Anna Grote, Veit Dou, John F. Isaevska, Elena Magnus, Maria C. Corpeleijn, Eva Perron, Patrice Jaddoe, Vincent W.V. Nohr, Ellen A. Maitre, Lea Foraster, Maria Hoyo, Cathrine Håberg, Siri E. Lahti, Jari DeMeo, Dawn L. Zhang, Hongmei Karmaus, Wilfried Kull, Inger Koletzko, Berthold Feinberg, Jason I. Gagliardi, Luigi Bouchard, Luigi Ramlau-Hansen, Cecilia Høst Tiemeier, Henning Santorelli, Gillian Maguire, Rachel L. Czamara, Darina Litonjua, Augusto A. Langhendries, Jean-Paul Plusquin, Michelle Lepeule, Johanna Binder, Elisabeth B. Verduci, Elvira Dwyer, Terence Carracedo, Ángel Ferre, Natalia Eskenazi, Brenda Kogevinas, Manolis Nawrot, Tim S. Munthe-Kaas, Monica C. Herceg, Zdenko Relton, Caroline Melén, Erik Gruszfeld, Dariusz Breton, Carrie Fallin, M.D. Ghantous, Akram Nystad, Wenche Heude, Barbara Snieder, Harold Hivert, Marie-France Felix, Janine F. Sørensen, Thorkild I.A. Bustamante, Mariona Murphy, Susan K. Raikkönen, Katri Oken, Emily Holloway, John W. Arshad, Syed Hasan London, Stephanie J. Holland, Nina |
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meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood dna methylation |
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Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation |
| abstract |
Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. |
| abstractGer |
Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. |
| abstract_unstemmed |
Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes. |
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Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation |
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Huen, Karen Yousefi, Paul Küpers, Leanne K. González, Juan R. Suderman, Matthew Reese, Sarah E. Page, Christian M. Gruzieva, Olena Rzehak, Peter Gao, Lu Bakulski, Kelly M. Novoloaca, Alexei Allard, Catherine Pappa, Irene Llambrich, Maria Vives, Marta Jima, Dereje D. Kvist, Tuomas Baccarelli, Andrea White, Cory Rezwan, Faisal I. Sharp, Gemma C. Tindula, Gwen Bergström, Anna Grote, Veit Dou, John F. Isaevska, Elena Magnus, Maria C. Corpeleijn, Eva Perron, Patrice Jaddoe, Vincent W.V. Nohr, Ellen A. Maitre, Lea Foraster, Maria Hoyo, Cathrine Håberg, Siri E. Lahti, Jari DeMeo, Dawn L. Zhang, Hongmei Karmaus, Wilfried Kull, Inger Koletzko, Berthold Feinberg, Jason I. Gagliardi, Luigi Bouchard, Luigi Ramlau-Hansen, Cecilia Høst Tiemeier, Henning Santorelli, Gillian Maguire, Rachel L. Czamara, Darina Litonjua, Augusto A. Langhendries, Jean-Paul Plusquin, Michelle Lepeule, Johanna Binder, Elisabeth B. Verduci, Elvira Dwyer, Terence Carracedo, Ángel Ferre, Natalia Eskenazi, Brenda Kogevinas, Manolis Nawrot, Tim S. Munthe-Kaas, Monica C. Herceg, Zdenko Relton, Caroline Melén, Erik Gruszfeld, Dariusz Breton, Carrie Fallin, M.D. Ghantous, Akram Nystad, Wenche Heude, Barbara Snieder, Harold Hivert, Marie-France Felix, Janine F. Sørensen, Thorkild I.A. Bustamante, Mariona Murphy, Susan K. Raikkönen, Katri Oken, Emily Holloway, John W. Arshad, Syed Hasan London, Stephanie J. Holland, Nina |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008019282</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240103093321.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230507s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.mrrev.2022.108415</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008019282</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1383-5742(22)00005-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Solomon, Olivia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268).Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction.Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. 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|
| score |
7.399205 |