Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs

Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the f...
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Gespeichert in:

Autor*in:	Ari, Betul [verfasserIn] Demirci, Sahin [verfasserIn] Ayyala, Ramesh S. [verfasserIn] Salih, Bekir [verfasserIn] Sahiner, Nurettin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release

Übergeordnetes Werk:	Enthalten in: European polymer journal - New York, NY [u.a.] : Elsevier, 1965, 176
Übergeordnetes Werk:	volume:176

DOI / URN:	10.1016/j.eurpolymj.2022.111399

Katalog-ID:	ELV008271070

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245	1	0	\|a Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
264		1	\|c 2022
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
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520			\|a Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h.
650		4	\|a Cyclodextrin
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650		4	\|a Simultaneous drug release
650		4	\|a Hydrophilic/hydrophobic drugs release
700	1		\|a Demirci, Sahin \|e verfasserin \|4 aut
700	1		\|a Ayyala, Ramesh S. \|e verfasserin \|4 aut
700	1		\|a Salih, Bekir \|e verfasserin \|4 aut
700	1		\|a Sahiner, Nurettin \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t European polymer journal \|d New York, NY [u.a.] : Elsevier, 1965 \|g 176 \|h Online-Ressource \|w (DE-627)300897375 \|w (DE-600)1483529-0 \|w (DE-576)259270830 \|7 nnns
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912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
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912			\|a GBV_ILN_73
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912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
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912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2411
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 35.80 \|j Makromolekulare Chemie \|q VZ
951			\|a AR
952			\|d 176

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publishDate	2022
allfields	10.1016/j.eurpolymj.2022.111399 doi (DE-627)ELV008271070 (ELSEVIER)S0014-3057(22)00403-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Ari, Betul verfasserin aut Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h. Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release Demirci, Sahin verfasserin aut Ayyala, Ramesh S. verfasserin aut Salih, Bekir verfasserin aut Sahiner, Nurettin verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 176 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie VZ AR 176
spelling	10.1016/j.eurpolymj.2022.111399 doi (DE-627)ELV008271070 (ELSEVIER)S0014-3057(22)00403-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Ari, Betul verfasserin aut Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h. Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release Demirci, Sahin verfasserin aut Ayyala, Ramesh S. verfasserin aut Salih, Bekir verfasserin aut Sahiner, Nurettin verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 176 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie VZ AR 176
allfields_unstemmed	10.1016/j.eurpolymj.2022.111399 doi (DE-627)ELV008271070 (ELSEVIER)S0014-3057(22)00403-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Ari, Betul verfasserin aut Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h. Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release Demirci, Sahin verfasserin aut Ayyala, Ramesh S. verfasserin aut Salih, Bekir verfasserin aut Sahiner, Nurettin verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 176 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie VZ AR 176
allfieldsGer	10.1016/j.eurpolymj.2022.111399 doi (DE-627)ELV008271070 (ELSEVIER)S0014-3057(22)00403-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Ari, Betul verfasserin aut Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h. Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release Demirci, Sahin verfasserin aut Ayyala, Ramesh S. verfasserin aut Salih, Bekir verfasserin aut Sahiner, Nurettin verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 176 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie VZ AR 176
allfieldsSound	10.1016/j.eurpolymj.2022.111399 doi (DE-627)ELV008271070 (ELSEVIER)S0014-3057(22)00403-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Ari, Betul verfasserin aut Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h. Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release Demirci, Sahin verfasserin aut Ayyala, Ramesh S. verfasserin aut Salih, Bekir verfasserin aut Sahiner, Nurettin verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 176 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:176 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie VZ AR 176
language	English
source	Enthalten in European polymer journal 176 volume:176
sourceStr	Enthalten in European polymer journal 176 volume:176
format_phy_str_mv	Article
bklname	Makromolekulare Chemie
institution	findex.gbv.de
topic_facet	Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release
dewey-raw	670
isfreeaccess_bool	false
container_title	European polymer journal
authorswithroles_txt_mv	Ari, Betul @@aut@@ Demirci, Sahin @@aut@@ Ayyala, Ramesh S. @@aut@@ Salih, Bekir @@aut@@ Sahiner, Nurettin @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	300897375
dewey-sort	3670
id	ELV008271070
language_de	englisch
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The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. 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author	Ari, Betul
spellingShingle	Ari, Betul ddc 670 bkl 35.80 misc Cyclodextrin misc β-Cyclodextrin cryogel misc Oligosaccharide cryogel misc Simultaneous drug release misc Hydrophilic/hydrophobic drugs release Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
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topic_title	670 VZ 35.80 bkl Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs Cyclodextrin β-Cyclodextrin cryogel Oligosaccharide cryogel Simultaneous drug release Hydrophilic/hydrophobic drugs release
topic	ddc 670 bkl 35.80 misc Cyclodextrin misc β-Cyclodextrin cryogel misc Oligosaccharide cryogel misc Simultaneous drug release misc Hydrophilic/hydrophobic drugs release
topic_unstemmed	ddc 670 bkl 35.80 misc Cyclodextrin misc β-Cyclodextrin cryogel misc Oligosaccharide cryogel misc Simultaneous drug release misc Hydrophilic/hydrophobic drugs release
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title	Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
ctrlnum	(DE-627)ELV008271070 (ELSEVIER)S0014-3057(22)00403-7
title_full	Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
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doi_str_mv	10.1016/j.eurpolymj.2022.111399
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title_sort	superporous poly(β-cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
title_auth	Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
abstract	Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h.
abstractGer	Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h.
abstract_unstemmed	Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(β-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 ± 2.7 mg/g (23.4 ± 1.8% of the loaded amount), and 36.3 ± 1.3 mg/g (23.6 ± 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h.
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title_short	Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
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author2	Demirci, Sahin Ayyala, Ramesh S. Salih, Bekir Sahiner, Nurettin
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doi_str	10.1016/j.eurpolymj.2022.111399
up_date	2024-07-06T19:07:42.303Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008271070</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230606134232.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230508s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.eurpolymj.2022.111399</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008271070</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0014-3057(22)00403-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">670</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.80</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ari, Betul</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(β-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(β-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(β-CD)-1 cryogel that was 100% crosslinked exhibited 14 ± 3.7%, 34 ± 4.8%, and 45 ± 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(β-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(β-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(β-CD) cryogels, in sustained release profiles with 76.7 ± 9.0 mg/g of vancomycin (89.9 ± 10.5% of the loaded amount) and 146.5 ± 19.4 mg/g tetracycline g (83.1 ± 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. 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Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs

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