Glomerular Hematuria and the Utility of Urine Microscopy: A Review
Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Saha, Manish K. [verfasserIn] Massicotte-Azarniouch, David [verfasserIn] Reynolds, Monica L. [verfasserIn] Mottl, Amy K. [verfasserIn] Falk, Ronald J. [verfasserIn] Jennette, J. Charles [verfasserIn] Derebail, Vimal K. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
ANCA-associated vasculitis (AAV) |
|---|
| Übergeordnetes Werk: |
Enthalten in: American journal of kidney diseases - Philadelphia, Pa. : Elsevier Saunders, 1981, 80, Seite 383-392 |
|---|---|
| Übergeordnetes Werk: |
volume:80 ; pages:383-392 |
| DOI / URN: |
10.1053/j.ajkd.2022.02.022 |
|---|
| Katalog-ID: |
ELV008337462 |
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| 520 | |a Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. | ||
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| 650 | 4 | |a ANCA-associated vasculitis (AAV) | |
| 650 | 4 | |a anti-neutrophil cytoplasmic antibody (ANCA) | |
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| 650 | 4 | |a glomerular disease | |
| 650 | 4 | |a hematuria | |
| 650 | 4 | |a IgA nephropathy (IgAN) | |
| 650 | 4 | |a liquid biopsy | |
| 650 | 4 | |a lupus nephritis (LN) | |
| 650 | 4 | |a nephritic syndrome | |
| 650 | 4 | |a RBC casts | |
| 650 | 4 | |a red blood cell (RBC) | |
| 650 | 4 | |a review | |
| 650 | 4 | |a sensitivity and specificity | |
| 650 | 4 | |a urine microscopy | |
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| 700 | 1 | |a Falk, Ronald J. |e verfasserin |4 aut | |
| 700 | 1 | |a Jennette, J. Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Derebail, Vimal K. |e verfasserin |4 aut | |
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10.1053/j.ajkd.2022.02.022 doi (DE-627)ELV008337462 (ELSEVIER)S0272-6386(22)00584-4 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Saha, Manish K. verfasserin aut Glomerular Hematuria and the Utility of Urine Microscopy: A Review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. Acanthocytes ANCA-associated vasculitis (AAV) anti-neutrophil cytoplasmic antibody (ANCA) dysmorphic RBC glomerular disease hematuria IgA nephropathy (IgAN) liquid biopsy lupus nephritis (LN) nephritic syndrome RBC casts red blood cell (RBC) review sensitivity and specificity urine microscopy Massicotte-Azarniouch, David verfasserin aut Reynolds, Monica L. verfasserin aut Mottl, Amy K. verfasserin aut Falk, Ronald J. verfasserin aut Jennette, J. Charles verfasserin aut Derebail, Vimal K. verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 383-392 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:383-392 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 383-392 |
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10.1053/j.ajkd.2022.02.022 doi (DE-627)ELV008337462 (ELSEVIER)S0272-6386(22)00584-4 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Saha, Manish K. verfasserin aut Glomerular Hematuria and the Utility of Urine Microscopy: A Review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. Acanthocytes ANCA-associated vasculitis (AAV) anti-neutrophil cytoplasmic antibody (ANCA) dysmorphic RBC glomerular disease hematuria IgA nephropathy (IgAN) liquid biopsy lupus nephritis (LN) nephritic syndrome RBC casts red blood cell (RBC) review sensitivity and specificity urine microscopy Massicotte-Azarniouch, David verfasserin aut Reynolds, Monica L. verfasserin aut Mottl, Amy K. verfasserin aut Falk, Ronald J. verfasserin aut Jennette, J. Charles verfasserin aut Derebail, Vimal K. verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 383-392 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:383-392 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 383-392 |
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10.1053/j.ajkd.2022.02.022 doi (DE-627)ELV008337462 (ELSEVIER)S0272-6386(22)00584-4 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Saha, Manish K. verfasserin aut Glomerular Hematuria and the Utility of Urine Microscopy: A Review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. Acanthocytes ANCA-associated vasculitis (AAV) anti-neutrophil cytoplasmic antibody (ANCA) dysmorphic RBC glomerular disease hematuria IgA nephropathy (IgAN) liquid biopsy lupus nephritis (LN) nephritic syndrome RBC casts red blood cell (RBC) review sensitivity and specificity urine microscopy Massicotte-Azarniouch, David verfasserin aut Reynolds, Monica L. verfasserin aut Mottl, Amy K. verfasserin aut Falk, Ronald J. verfasserin aut Jennette, J. Charles verfasserin aut Derebail, Vimal K. verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 383-392 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:383-392 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 383-392 |
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10.1053/j.ajkd.2022.02.022 doi (DE-627)ELV008337462 (ELSEVIER)S0272-6386(22)00584-4 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Saha, Manish K. verfasserin aut Glomerular Hematuria and the Utility of Urine Microscopy: A Review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. Acanthocytes ANCA-associated vasculitis (AAV) anti-neutrophil cytoplasmic antibody (ANCA) dysmorphic RBC glomerular disease hematuria IgA nephropathy (IgAN) liquid biopsy lupus nephritis (LN) nephritic syndrome RBC casts red blood cell (RBC) review sensitivity and specificity urine microscopy Massicotte-Azarniouch, David verfasserin aut Reynolds, Monica L. verfasserin aut Mottl, Amy K. verfasserin aut Falk, Ronald J. verfasserin aut Jennette, J. Charles verfasserin aut Derebail, Vimal K. verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 383-392 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:383-392 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 383-392 |
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10.1053/j.ajkd.2022.02.022 doi (DE-627)ELV008337462 (ELSEVIER)S0272-6386(22)00584-4 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Saha, Manish K. verfasserin aut Glomerular Hematuria and the Utility of Urine Microscopy: A Review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. Acanthocytes ANCA-associated vasculitis (AAV) anti-neutrophil cytoplasmic antibody (ANCA) dysmorphic RBC glomerular disease hematuria IgA nephropathy (IgAN) liquid biopsy lupus nephritis (LN) nephritic syndrome RBC casts red blood cell (RBC) review sensitivity and specificity urine microscopy Massicotte-Azarniouch, David verfasserin aut Reynolds, Monica L. verfasserin aut Mottl, Amy K. verfasserin aut Falk, Ronald J. verfasserin aut Jennette, J. Charles verfasserin aut Derebail, Vimal K. verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 383-392 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:383-392 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 383-392 |
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610 DE-600 44.88 bkl Glomerular Hematuria and the Utility of Urine Microscopy: A Review Acanthocytes ANCA-associated vasculitis (AAV) anti-neutrophil cytoplasmic antibody (ANCA) dysmorphic RBC glomerular disease hematuria IgA nephropathy (IgAN) liquid biopsy lupus nephritis (LN) nephritic syndrome RBC casts red blood cell (RBC) review sensitivity and specificity urine microscopy |
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glomerular hematuria and the utility of urine microscopy: a review |
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Glomerular Hematuria and the Utility of Urine Microscopy: A Review |
| abstract |
Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. |
| abstractGer |
Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. |
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Evaluation of hematuria and microscopic examination of urine sediment are commonly used tools by nephrologists in their assessment of glomerular diseases. Certain morphological aspects of urine red blood cells (RBCs) seen by microscopy may help in identifying the source of hematuria as glomerular or not. Recognized signs of glomerular injury are RBC casts or dysmorphic RBCs, in particular acanthocytes (ring-shaped RBCs with protruding blebs). Despite being a highly operator-dependent test, urine sediment examination revealing these signs of glomerular hematuria has demonstrated specificities and positive predictive values ranging between 90%-100% for diagnosing glomerular disease, although sensitivity can be quite variable. Hematuria is a commonly used tool for diagnosing patients with proliferative glomerulonephritis such as IgA nephropathy, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and lupus nephritis, sometimes even as a surrogate for kidney involvement. Studies examining the role for hematuria in monitoring and predicting adverse outcomes in these diseases have shown inconsistent results, possibly due to inconsistent definitions that often fail to consider specific markers of glomerular hematuria such as dysmorphic RBCs, acanthocytes, or RBC casts. A consensus definition of what constitutes glomerular hematuria would help standardize use in future studies and likely improve the diagnostic and prognostic value of hematuria as a marker of glomerulonephritis. |
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