Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms

Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	De Vos, Shana [verfasserIn] Demeyere, Kristel [verfasserIn] De Cock, Hilde [verfasserIn] Devriendt, Nausikaa [verfasserIn] Schwarzkopf, Ilona [verfasserIn] Fortrie, Ruth [verfasserIn] Roggeman, Tom [verfasserIn] Meyer, Evelyne [verfasserIn] De Spiegelaere, Ward [verfasserIn] de Rooster, Hilde [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase

Übergeordnetes Werk:	Enthalten in: Research in veterinary science - Amsterdam [u.a.] : Elsevier, 1960, 151, Seite 90-95
Übergeordnetes Werk:	volume:151 ; pages:90-95

DOI / URN:	10.1016/j.rvsc.2022.05.008

Katalog-ID:	ELV008412073

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245	1	0	\|a Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
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520			\|a Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy.
650		4	\|a Comparative oncology
650		4	\|a Oncological marker
650		4	\|a Mastocytosis
650		4	\|a Canine mast cell tumor
650		4	\|a Serum tryptase
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700	1		\|a De Cock, Hilde \|e verfasserin \|4 aut
700	1		\|a Devriendt, Nausikaa \|e verfasserin \|4 aut
700	1		\|a Schwarzkopf, Ilona \|e verfasserin \|4 aut
700	1		\|a Fortrie, Ruth \|e verfasserin \|4 aut
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700	1		\|a Meyer, Evelyne \|e verfasserin \|4 aut
700	1		\|a De Spiegelaere, Ward \|e verfasserin \|4 aut
700	1		\|a de Rooster, Hilde \|e verfasserin \|4 aut
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publishDate	2022
allfields	10.1016/j.rvsc.2022.05.008 doi (DE-627)ELV008412073 (ELSEVIER)S0034-5288(22)00166-7 DE-627 ger DE-627 rda eng 630 DE-600 22 ssgn De Vos, Shana verfasserin aut Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy. Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase Demeyere, Kristel verfasserin aut De Cock, Hilde verfasserin aut Devriendt, Nausikaa verfasserin aut Schwarzkopf, Ilona verfasserin aut Fortrie, Ruth verfasserin aut Roggeman, Tom verfasserin aut Meyer, Evelyne verfasserin aut De Spiegelaere, Ward verfasserin aut de Rooster, Hilde verfasserin aut Enthalten in Research in veterinary science Amsterdam [u.a.] : Elsevier, 1960 151, Seite 90-95 Online-Ressource (DE-627)320420795 (DE-600)2002535-X (DE-576)120883538 1532-2661 nnns volume:151 pages:90-95 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 151 90-95
spelling	10.1016/j.rvsc.2022.05.008 doi (DE-627)ELV008412073 (ELSEVIER)S0034-5288(22)00166-7 DE-627 ger DE-627 rda eng 630 DE-600 22 ssgn De Vos, Shana verfasserin aut Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy. Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase Demeyere, Kristel verfasserin aut De Cock, Hilde verfasserin aut Devriendt, Nausikaa verfasserin aut Schwarzkopf, Ilona verfasserin aut Fortrie, Ruth verfasserin aut Roggeman, Tom verfasserin aut Meyer, Evelyne verfasserin aut De Spiegelaere, Ward verfasserin aut de Rooster, Hilde verfasserin aut Enthalten in Research in veterinary science Amsterdam [u.a.] : Elsevier, 1960 151, Seite 90-95 Online-Ressource (DE-627)320420795 (DE-600)2002535-X (DE-576)120883538 1532-2661 nnns volume:151 pages:90-95 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 151 90-95
allfields_unstemmed	10.1016/j.rvsc.2022.05.008 doi (DE-627)ELV008412073 (ELSEVIER)S0034-5288(22)00166-7 DE-627 ger DE-627 rda eng 630 DE-600 22 ssgn De Vos, Shana verfasserin aut Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy. Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase Demeyere, Kristel verfasserin aut De Cock, Hilde verfasserin aut Devriendt, Nausikaa verfasserin aut Schwarzkopf, Ilona verfasserin aut Fortrie, Ruth verfasserin aut Roggeman, Tom verfasserin aut Meyer, Evelyne verfasserin aut De Spiegelaere, Ward verfasserin aut de Rooster, Hilde verfasserin aut Enthalten in Research in veterinary science Amsterdam [u.a.] : Elsevier, 1960 151, Seite 90-95 Online-Ressource (DE-627)320420795 (DE-600)2002535-X (DE-576)120883538 1532-2661 nnns volume:151 pages:90-95 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 151 90-95
allfieldsGer	10.1016/j.rvsc.2022.05.008 doi (DE-627)ELV008412073 (ELSEVIER)S0034-5288(22)00166-7 DE-627 ger DE-627 rda eng 630 DE-600 22 ssgn De Vos, Shana verfasserin aut Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy. Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase Demeyere, Kristel verfasserin aut De Cock, Hilde verfasserin aut Devriendt, Nausikaa verfasserin aut Schwarzkopf, Ilona verfasserin aut Fortrie, Ruth verfasserin aut Roggeman, Tom verfasserin aut Meyer, Evelyne verfasserin aut De Spiegelaere, Ward verfasserin aut de Rooster, Hilde verfasserin aut Enthalten in Research in veterinary science Amsterdam [u.a.] : Elsevier, 1960 151, Seite 90-95 Online-Ressource (DE-627)320420795 (DE-600)2002535-X (DE-576)120883538 1532-2661 nnns volume:151 pages:90-95 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 151 90-95
allfieldsSound	10.1016/j.rvsc.2022.05.008 doi (DE-627)ELV008412073 (ELSEVIER)S0034-5288(22)00166-7 DE-627 ger DE-627 rda eng 630 DE-600 22 ssgn De Vos, Shana verfasserin aut Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy. Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase Demeyere, Kristel verfasserin aut De Cock, Hilde verfasserin aut Devriendt, Nausikaa verfasserin aut Schwarzkopf, Ilona verfasserin aut Fortrie, Ruth verfasserin aut Roggeman, Tom verfasserin aut Meyer, Evelyne verfasserin aut De Spiegelaere, Ward verfasserin aut de Rooster, Hilde verfasserin aut Enthalten in Research in veterinary science Amsterdam [u.a.] : Elsevier, 1960 151, Seite 90-95 Online-Ressource (DE-627)320420795 (DE-600)2002535-X (DE-576)120883538 1532-2661 nnns volume:151 pages:90-95 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 151 90-95
language	English
source	Enthalten in Research in veterinary science 151, Seite 90-95 volume:151 pages:90-95
sourceStr	Enthalten in Research in veterinary science 151, Seite 90-95 volume:151 pages:90-95
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase
dewey-raw	630
isfreeaccess_bool	false
container_title	Research in veterinary science
authorswithroles_txt_mv	De Vos, Shana @@aut@@ Demeyere, Kristel @@aut@@ De Cock, Hilde @@aut@@ Devriendt, Nausikaa @@aut@@ Schwarzkopf, Ilona @@aut@@ Fortrie, Ruth @@aut@@ Roggeman, Tom @@aut@@ Meyer, Evelyne @@aut@@ De Spiegelaere, Ward @@aut@@ de Rooster, Hilde @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	320420795
dewey-sort	3630
id	ELV008412073
language_de	englisch
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author	De Vos, Shana
spellingShingle	De Vos, Shana ddc 630 ssgn 22 misc Comparative oncology misc Oncological marker misc Mastocytosis misc Canine mast cell tumor misc Serum tryptase Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
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topic_title	630 DE-600 22 ssgn Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms Comparative oncology Oncological marker Mastocytosis Canine mast cell tumor Serum tryptase
topic	ddc 630 ssgn 22 misc Comparative oncology misc Oncological marker misc Mastocytosis misc Canine mast cell tumor misc Serum tryptase
topic_unstemmed	ddc 630 ssgn 22 misc Comparative oncology misc Oncological marker misc Mastocytosis misc Canine mast cell tumor misc Serum tryptase
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title	Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
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title_full	Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
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author_browse	De Vos, Shana Demeyere, Kristel De Cock, Hilde Devriendt, Nausikaa Schwarzkopf, Ilona Fortrie, Ruth Roggeman, Tom Meyer, Evelyne De Spiegelaere, Ward de Rooster, Hilde
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title_sort	comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
title_auth	Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
abstract	Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy.
abstractGer	Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy.
abstract_unstemmed	Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion. Surprisingly, serum tryptase levels were not yet investigated in dogs with MCTs. Therefore, the aim of this study was to investigate whether serum tryptase levels in dogs with cutaneous MCTs were elevated compared to those of a non-MCT control group. As a secondary aim, it was investigated whether surgical manipulation caused an increase in serum tryptase in canine MCT patients. A total of 48 serum samples were collected from dogs with different grades of cutaneous MCTs (n = 24) and non-MCT controls (n = 24). In dogs with cutaneous MCTs, blood was collected prior to and within 1 h after surgery. Serum tryptase levels were measured using a commercially available canine-specific ELISA kit. No significant difference in serum tryptase levels was found between cutaneous MCT patients and non-MCT controls, nor in these levels before versus after surgery. Our findings in canine cutaneous MCTs are in accordance with human cutaneous mastocytosis, where serum tryptase levels tend to remain within the normal range. However, despite various similarities between aggressive mast cell tumors in dogs and humans, serum tryptase cannot be considered a diagnostic biomarker in dogs with cutaneous MCTs as part of a comparative oncologic strategy.
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title_short	Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms
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author2	Demeyere, Kristel De Cock, Hilde Devriendt, Nausikaa Schwarzkopf, Ilona Fortrie, Ruth Roggeman, Tom Meyer, Evelyne De Spiegelaere, Ward de Rooster, Hilde
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up_date	2024-07-06T19:36:46.763Z
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Comparison of serum tryptase as a diagnostic oncological marker in canine versus human mast cell neoplasms

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