Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery

Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospec...
Ausführliche Beschreibung

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Autor*in:	Smith, Drew H. [verfasserIn] Falco, Jeffrey J. [verfasserIn] Devarakonda, Aditya K. [verfasserIn] Holmes, Thomas W. [verfasserIn] Shirley, Brian [verfasserIn] Prosser, John Drew [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory

Übergeordnetes Werk:	Enthalten in: International journal of pediatric otorhinolaryngology - Amsterdam [u.a.] : Elsevier Science, 1979, 161
Übergeordnetes Werk:	volume:161

DOI / URN:	10.1016/j.ijporl.2022.111249

Katalog-ID:	ELV008427119

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024	7		\|a 10.1016/j.ijporl.2022.111249 \|2 doi
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100	1		\|a Smith, Drew H. \|e verfasserin \|0 (orcid)0000-0001-9671-542X \|4 aut
245	1	0	\|a Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
264		1	\|c 2022
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337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval.
650		4	\|a Cystic fibrosis
650		4	\|a CF
650		4	\|a Outcomes
650		4	\|a PFTs
650		4	\|a FEV1
650		4	\|a Sinus surgery
650		4	\|a FESS
650		4	\|a Unified airway theory
700	1		\|a Falco, Jeffrey J. \|e verfasserin \|4 aut
700	1		\|a Devarakonda, Aditya K. \|e verfasserin \|4 aut
700	1		\|a Holmes, Thomas W. \|e verfasserin \|4 aut
700	1		\|a Shirley, Brian \|e verfasserin \|4 aut
700	1		\|a Prosser, John Drew \|e verfasserin \|4 aut
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publishDate	2022
allfields	10.1016/j.ijporl.2022.111249 doi (DE-627)ELV008427119 (ELSEVIER)S0165-5876(22)00210-5 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Smith, Drew H. verfasserin (orcid)0000-0001-9671-542X aut Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval. Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory Falco, Jeffrey J. verfasserin aut Devarakonda, Aditya K. verfasserin aut Holmes, Thomas W. verfasserin aut Shirley, Brian verfasserin aut Prosser, John Drew verfasserin aut Enthalten in International journal of pediatric otorhinolaryngology Amsterdam [u.a.] : Elsevier Science, 1979 161 Online-Ressource (DE-627)320479927 (DE-600)2009657-4 (DE-576)106846094 1872-8464 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 161
spelling	10.1016/j.ijporl.2022.111249 doi (DE-627)ELV008427119 (ELSEVIER)S0165-5876(22)00210-5 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Smith, Drew H. verfasserin (orcid)0000-0001-9671-542X aut Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval. Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory Falco, Jeffrey J. verfasserin aut Devarakonda, Aditya K. verfasserin aut Holmes, Thomas W. verfasserin aut Shirley, Brian verfasserin aut Prosser, John Drew verfasserin aut Enthalten in International journal of pediatric otorhinolaryngology Amsterdam [u.a.] : Elsevier Science, 1979 161 Online-Ressource (DE-627)320479927 (DE-600)2009657-4 (DE-576)106846094 1872-8464 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 161
allfields_unstemmed	10.1016/j.ijporl.2022.111249 doi (DE-627)ELV008427119 (ELSEVIER)S0165-5876(22)00210-5 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Smith, Drew H. verfasserin (orcid)0000-0001-9671-542X aut Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval. Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory Falco, Jeffrey J. verfasserin aut Devarakonda, Aditya K. verfasserin aut Holmes, Thomas W. verfasserin aut Shirley, Brian verfasserin aut Prosser, John Drew verfasserin aut Enthalten in International journal of pediatric otorhinolaryngology Amsterdam [u.a.] : Elsevier Science, 1979 161 Online-Ressource (DE-627)320479927 (DE-600)2009657-4 (DE-576)106846094 1872-8464 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 161
allfieldsGer	10.1016/j.ijporl.2022.111249 doi (DE-627)ELV008427119 (ELSEVIER)S0165-5876(22)00210-5 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Smith, Drew H. verfasserin (orcid)0000-0001-9671-542X aut Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval. Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory Falco, Jeffrey J. verfasserin aut Devarakonda, Aditya K. verfasserin aut Holmes, Thomas W. verfasserin aut Shirley, Brian verfasserin aut Prosser, John Drew verfasserin aut Enthalten in International journal of pediatric otorhinolaryngology Amsterdam [u.a.] : Elsevier Science, 1979 161 Online-Ressource (DE-627)320479927 (DE-600)2009657-4 (DE-576)106846094 1872-8464 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 161
allfieldsSound	10.1016/j.ijporl.2022.111249 doi (DE-627)ELV008427119 (ELSEVIER)S0165-5876(22)00210-5 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Smith, Drew H. verfasserin (orcid)0000-0001-9671-542X aut Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval. Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory Falco, Jeffrey J. verfasserin aut Devarakonda, Aditya K. verfasserin aut Holmes, Thomas W. verfasserin aut Shirley, Brian verfasserin aut Prosser, John Drew verfasserin aut Enthalten in International journal of pediatric otorhinolaryngology Amsterdam [u.a.] : Elsevier Science, 1979 161 Online-Ressource (DE-627)320479927 (DE-600)2009657-4 (DE-576)106846094 1872-8464 nnns volume:161 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 161
language	English
source	Enthalten in International journal of pediatric otorhinolaryngology 161 volume:161
sourceStr	Enthalten in International journal of pediatric otorhinolaryngology 161 volume:161
format_phy_str_mv	Article
bklname	Hals-Nasen-Ohrenheilkunde
institution	findex.gbv.de
topic_facet	Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory
dewey-raw	610
isfreeaccess_bool	false
container_title	International journal of pediatric otorhinolaryngology
authorswithroles_txt_mv	Smith, Drew H. @@aut@@ Falco, Jeffrey J. @@aut@@ Devarakonda, Aditya K. @@aut@@ Holmes, Thomas W. @@aut@@ Shirley, Brian @@aut@@ Prosser, John Drew @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	320479927
dewey-sort	3610
id	ELV008427119
language_de	englisch
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Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. 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author	Smith, Drew H.
spellingShingle	Smith, Drew H. ddc 610 bkl 44.94 misc Cystic fibrosis misc CF misc Outcomes misc PFTs misc FEV1 misc Sinus surgery misc FESS misc Unified airway theory Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
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topic_title	610 DE-600 44.94 bkl Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery Cystic fibrosis CF Outcomes PFTs FEV1 Sinus surgery FESS Unified airway theory
topic	ddc 610 bkl 44.94 misc Cystic fibrosis misc CF misc Outcomes misc PFTs misc FEV1 misc Sinus surgery misc FESS misc Unified airway theory
topic_unstemmed	ddc 610 bkl 44.94 misc Cystic fibrosis misc CF misc Outcomes misc PFTs misc FEV1 misc Sinus surgery misc FESS misc Unified airway theory
topic_browse	ddc 610 bkl 44.94 misc Cystic fibrosis misc CF misc Outcomes misc PFTs misc FEV1 misc Sinus surgery misc FESS misc Unified airway theory
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title	Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
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title_full	Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
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author_browse	Smith, Drew H. Falco, Jeffrey J. Devarakonda, Aditya K. Holmes, Thomas W. Shirley, Brian Prosser, John Drew
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author2-role	verfasserin
title_sort	cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
title_auth	Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
abstract	Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval.
abstractGer	Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval.
abstract_unstemmed	Objective: This analysis investigates any potential differences in pulmonary function test (PFT) outcomes among pediatric patients with cystic fibrosis (CF) receiving both medical management (MM) and functional endoscopic sinus surgery (FESS) versus MM alone for CF exacerbation.Study design: Prospective cohort.Setting: Pediatric tertiary care facility.Methods: The data was prospectively collected from July 2011 to March 2020. Diagnosis of CF and age ≤ to 18 were required. All patients were hospitalized and treated for CF exacerbations with both FESS with MM and MM alone at variable time intervals, although the order of initial treatment received differed. Two-way ANOVA with repeated measures were used to determine the effect of receiving FESS with MM versus MM alone on PFT outcomes over time (during admission, at discharge, at 3 months, at 6 months, and at 12 months).Results: 13 pediatric patients, 7 of which had FESS with MM initially and 6 who had MM alone initially, and 20 events of both FESS and MM were included for analysis. For PFT outcomes, there was no statistically significant two-way interaction between treatment type and time following treatment, p = 0.492. The main effect of treatment did not show a statistically significant difference in FEV1 between treatment types, p = 0.737. There was no statistically significant association between treatment type and time between hospital readmission in months, p = 0.111.Conclusion: There was no significant difference between PFT outcomes in pediatric patients hospitalized for CF exacerbation treated with MM with or without FESS at any time interval.
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title_short	Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery
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author2	Falco, Jeffrey J. Devarakonda, Aditya K. Holmes, Thomas W. Shirley, Brian Prosser, John Drew
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up_date	2024-07-06T19:40:01.136Z
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Cystic fibrosis exacerbations treated with medical therapy with and without concurrent sinus surgery

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