HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications
Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identi...
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Gespeichert in:
| Autor*in: |
Tarantino, Paolo [verfasserIn] Niman, Samuel M. [verfasserIn] Erick, Timothy K. [verfasserIn] Priedigkeit, Nolan [verfasserIn] Harrison, Beth T. [verfasserIn] Giordano, Antonio [verfasserIn] Nakhlis, Faina [verfasserIn] Bellon, Jennifer R. [verfasserIn] Parker, Tonia [verfasserIn] Strauss, Sarah [verfasserIn] Jin, Qingchun [verfasserIn] King, Tari A. [verfasserIn] Overmoyer, Beth A. [verfasserIn] Curigliano, Giuseppe [verfasserIn] Regan, Meredith M. [verfasserIn] Tolaney, Sara M. [verfasserIn] Lynce, Filipa [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of cancer - Amsterdam [u.a.] : Elsevier, 1965, 174, Seite 277-286 |
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| Übergeordnetes Werk: |
volume:174 ; pages:277-286 |
| DOI / URN: |
10.1016/j.ejca.2022.07.001 |
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| Katalog-ID: |
ELV008462372 |
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| 024 | 7 | |a 10.1016/j.ejca.2022.07.001 |2 doi | |
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| 100 | 1 | |a Tarantino, Paolo |e verfasserin |0 (orcid)0000-0001-8686-0228 |4 aut | |
| 245 | 1 | 0 | |a HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications |
| 264 | 1 | |c 2022 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. | ||
| 650 | 4 | |a Inflammatory breast cancer (IBC) | |
| 650 | 4 | |a HER2-low | |
| 650 | 4 | |a Antibody-drug conjugates (ADCs) | |
| 700 | 1 | |a Niman, Samuel M. |e verfasserin |4 aut | |
| 700 | 1 | |a Erick, Timothy K. |e verfasserin |4 aut | |
| 700 | 1 | |a Priedigkeit, Nolan |e verfasserin |4 aut | |
| 700 | 1 | |a Harrison, Beth T. |e verfasserin |4 aut | |
| 700 | 1 | |a Giordano, Antonio |e verfasserin |0 (orcid)0000-0002-7760-9717 |4 aut | |
| 700 | 1 | |a Nakhlis, Faina |e verfasserin |4 aut | |
| 700 | 1 | |a Bellon, Jennifer R. |e verfasserin |4 aut | |
| 700 | 1 | |a Parker, Tonia |e verfasserin |4 aut | |
| 700 | 1 | |a Strauss, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Qingchun |e verfasserin |0 (orcid)0000-0001-6388-5123 |4 aut | |
| 700 | 1 | |a King, Tari A. |e verfasserin |4 aut | |
| 700 | 1 | |a Overmoyer, Beth A. |e verfasserin |0 (orcid)0000-0003-4438-7000 |4 aut | |
| 700 | 1 | |a Curigliano, Giuseppe |e verfasserin |0 (orcid)0000-0003-1781-2518 |4 aut | |
| 700 | 1 | |a Regan, Meredith M. |e verfasserin |4 aut | |
| 700 | 1 | |a Tolaney, Sara M. |e verfasserin |4 aut | |
| 700 | 1 | |a Lynce, Filipa |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cancer |d Amsterdam [u.a.] : Elsevier, 1965 |g 174, Seite 277-286 |w (DE-627)266883400 |w (DE-600)1468190-0 |w (DE-576)090954173 |x 1879-2995 |7 nnns |
| 773 | 1 | 8 | |g volume:174 |g pages:277-286 |
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2022 |
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44.81 |
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2022 |
| allfields |
10.1016/j.ejca.2022.07.001 doi (DE-627)ELV008462372 (ELSEVIER)S0959-8049(22)00405-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Tarantino, Paolo verfasserin (orcid)0000-0001-8686-0228 aut HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) Niman, Samuel M. verfasserin aut Erick, Timothy K. verfasserin aut Priedigkeit, Nolan verfasserin aut Harrison, Beth T. verfasserin aut Giordano, Antonio verfasserin (orcid)0000-0002-7760-9717 aut Nakhlis, Faina verfasserin aut Bellon, Jennifer R. verfasserin aut Parker, Tonia verfasserin aut Strauss, Sarah verfasserin aut Jin, Qingchun verfasserin (orcid)0000-0001-6388-5123 aut King, Tari A. verfasserin aut Overmoyer, Beth A. verfasserin (orcid)0000-0003-4438-7000 aut Curigliano, Giuseppe verfasserin (orcid)0000-0003-1781-2518 aut Regan, Meredith M. verfasserin aut Tolaney, Sara M. verfasserin aut Lynce, Filipa verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 174, Seite 277-286 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:174 pages:277-286 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 174 277-286 |
| spelling |
10.1016/j.ejca.2022.07.001 doi (DE-627)ELV008462372 (ELSEVIER)S0959-8049(22)00405-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Tarantino, Paolo verfasserin (orcid)0000-0001-8686-0228 aut HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) Niman, Samuel M. verfasserin aut Erick, Timothy K. verfasserin aut Priedigkeit, Nolan verfasserin aut Harrison, Beth T. verfasserin aut Giordano, Antonio verfasserin (orcid)0000-0002-7760-9717 aut Nakhlis, Faina verfasserin aut Bellon, Jennifer R. verfasserin aut Parker, Tonia verfasserin aut Strauss, Sarah verfasserin aut Jin, Qingchun verfasserin (orcid)0000-0001-6388-5123 aut King, Tari A. verfasserin aut Overmoyer, Beth A. verfasserin (orcid)0000-0003-4438-7000 aut Curigliano, Giuseppe verfasserin (orcid)0000-0003-1781-2518 aut Regan, Meredith M. verfasserin aut Tolaney, Sara M. verfasserin aut Lynce, Filipa verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 174, Seite 277-286 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:174 pages:277-286 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 174 277-286 |
| allfields_unstemmed |
10.1016/j.ejca.2022.07.001 doi (DE-627)ELV008462372 (ELSEVIER)S0959-8049(22)00405-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Tarantino, Paolo verfasserin (orcid)0000-0001-8686-0228 aut HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) Niman, Samuel M. verfasserin aut Erick, Timothy K. verfasserin aut Priedigkeit, Nolan verfasserin aut Harrison, Beth T. verfasserin aut Giordano, Antonio verfasserin (orcid)0000-0002-7760-9717 aut Nakhlis, Faina verfasserin aut Bellon, Jennifer R. verfasserin aut Parker, Tonia verfasserin aut Strauss, Sarah verfasserin aut Jin, Qingchun verfasserin (orcid)0000-0001-6388-5123 aut King, Tari A. verfasserin aut Overmoyer, Beth A. verfasserin (orcid)0000-0003-4438-7000 aut Curigliano, Giuseppe verfasserin (orcid)0000-0003-1781-2518 aut Regan, Meredith M. verfasserin aut Tolaney, Sara M. verfasserin aut Lynce, Filipa verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 174, Seite 277-286 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:174 pages:277-286 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 174 277-286 |
| allfieldsGer |
10.1016/j.ejca.2022.07.001 doi (DE-627)ELV008462372 (ELSEVIER)S0959-8049(22)00405-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Tarantino, Paolo verfasserin (orcid)0000-0001-8686-0228 aut HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) Niman, Samuel M. verfasserin aut Erick, Timothy K. verfasserin aut Priedigkeit, Nolan verfasserin aut Harrison, Beth T. verfasserin aut Giordano, Antonio verfasserin (orcid)0000-0002-7760-9717 aut Nakhlis, Faina verfasserin aut Bellon, Jennifer R. verfasserin aut Parker, Tonia verfasserin aut Strauss, Sarah verfasserin aut Jin, Qingchun verfasserin (orcid)0000-0001-6388-5123 aut King, Tari A. verfasserin aut Overmoyer, Beth A. verfasserin (orcid)0000-0003-4438-7000 aut Curigliano, Giuseppe verfasserin (orcid)0000-0003-1781-2518 aut Regan, Meredith M. verfasserin aut Tolaney, Sara M. verfasserin aut Lynce, Filipa verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 174, Seite 277-286 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:174 pages:277-286 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 174 277-286 |
| allfieldsSound |
10.1016/j.ejca.2022.07.001 doi (DE-627)ELV008462372 (ELSEVIER)S0959-8049(22)00405-1 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Tarantino, Paolo verfasserin (orcid)0000-0001-8686-0228 aut HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) Niman, Samuel M. verfasserin aut Erick, Timothy K. verfasserin aut Priedigkeit, Nolan verfasserin aut Harrison, Beth T. verfasserin aut Giordano, Antonio verfasserin (orcid)0000-0002-7760-9717 aut Nakhlis, Faina verfasserin aut Bellon, Jennifer R. verfasserin aut Parker, Tonia verfasserin aut Strauss, Sarah verfasserin aut Jin, Qingchun verfasserin (orcid)0000-0001-6388-5123 aut King, Tari A. verfasserin aut Overmoyer, Beth A. verfasserin (orcid)0000-0003-4438-7000 aut Curigliano, Giuseppe verfasserin (orcid)0000-0003-1781-2518 aut Regan, Meredith M. verfasserin aut Tolaney, Sara M. verfasserin aut Lynce, Filipa verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 174, Seite 277-286 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:174 pages:277-286 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 174 277-286 |
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Enthalten in European journal of cancer 174, Seite 277-286 volume:174 pages:277-286 |
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Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) |
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European journal of cancer |
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Tarantino, Paolo @@aut@@ Niman, Samuel M. @@aut@@ Erick, Timothy K. @@aut@@ Priedigkeit, Nolan @@aut@@ Harrison, Beth T. @@aut@@ Giordano, Antonio @@aut@@ Nakhlis, Faina @@aut@@ Bellon, Jennifer R. @@aut@@ Parker, Tonia @@aut@@ Strauss, Sarah @@aut@@ Jin, Qingchun @@aut@@ King, Tari A. @@aut@@ Overmoyer, Beth A. @@aut@@ Curigliano, Giuseppe @@aut@@ Regan, Meredith M. @@aut@@ Tolaney, Sara M. @@aut@@ Lynce, Filipa @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008462372</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524150019.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230508s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ejca.2022.07.001</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008462372</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0959-8049(22)00405-1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Tarantino, Paolo</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-8686-0228</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). 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Tarantino, Paolo |
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Tarantino, Paolo ddc 610 bkl 44.81 misc Inflammatory breast cancer (IBC) misc HER2-low misc Antibody-drug conjugates (ADCs) HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications |
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610 DE-600 44.81 bkl HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications Inflammatory breast cancer (IBC) HER2-low Antibody-drug conjugates (ADCs) |
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ddc 610 bkl 44.81 misc Inflammatory breast cancer (IBC) misc HER2-low misc Antibody-drug conjugates (ADCs) |
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ddc 610 bkl 44.81 misc Inflammatory breast cancer (IBC) misc HER2-low misc Antibody-drug conjugates (ADCs) |
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ddc 610 bkl 44.81 misc Inflammatory breast cancer (IBC) misc HER2-low misc Antibody-drug conjugates (ADCs) |
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HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications |
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HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications |
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Tarantino, Paolo |
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Tarantino, Paolo Niman, Samuel M. Erick, Timothy K. Priedigkeit, Nolan Harrison, Beth T. Giordano, Antonio Nakhlis, Faina Bellon, Jennifer R. Parker, Tonia Strauss, Sarah Jin, Qingchun King, Tari A. Overmoyer, Beth A. Curigliano, Giuseppe Regan, Meredith M. Tolaney, Sara M. Lynce, Filipa |
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10.1016/j.ejca.2022.07.001 |
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her2-low inflammatory breast cancer: clinicopathologic features and prognostic implications |
| title_auth |
HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications |
| abstract |
Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. |
| abstractGer |
Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. |
| abstract_unstemmed |
Background: HER2)-low expression is a predictive biomarker for novel anti-HER2 antibody-drug conjugates. However, little is known about its clinical significance in inflammatory breast cancer (IBC).Methods: Patients diagnosed with HER2-negative IBC between December 1999 and December 2020 were identified from the Dana-Farber Cancer Institute IBC registry. Patients were divided into HER2-low (IHC 1+ or 2+/ISH–) and HER2-zero (IHC 0), comparing clinicopathologic features and disease outcomes between the two subgroups.Results: The study included 276 patients. Among patients with stage III (n = 209) and stage IV (n = 67) IBC, 54% and 39% had HER2-low tumours, respectively. Oestrogen receptor (ER)-expressing tumours were more common in patients with HER2-low versus HER2-zero stage III IBC (65% versus 38%, p < 0.01). Among stage III patients undergoing surgery (n = 182), pathologic complete response (pCR) rates were higher for HER2-zero versus HER2-low IBC (11% versus 6%, OR: 1.8, 95%CI:0.6–5.3), but minimal differences persisted when separately analysing pCR by ER status. Similar invasive disease-free survival (iDFS) outcomes were observed among ER-positive HER2-zero versus HER2-low IBC (48-month iDFS: 63% versus 63%, HR: 1.10, 95%CI:0.57–2.13) and ER-negative HER2-zero versus HER2-low IBC (48-month iDFS: 28% versus 25%, HR: 1.19, 95%CI:0.69–2.04). Differences in overall survival (OS) were small, both among ER-positive HER2-zero versus HER2-low IBC (48-month OS: 80% versus 81%, HR: 0.82, 95%CI:0.39–1.73) and ER-negative HER2-zero versus HER2-low IBC (48-month OS: 34% versus 47%, HR: 1.34, 95%CI: 0.74–2.41).Conclusions: Marginal differences in clinicopathologic features and outcomes were observed in HER2-low versus HER2-zero IBC when controlling for ER status, not supporting the definition of HER2-low as a distinct subtype of IBC. |
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HER2-low inflammatory breast cancer: Clinicopathologic features and prognostic implications |
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Niman, Samuel M. Erick, Timothy K. Priedigkeit, Nolan Harrison, Beth T. Giordano, Antonio Nakhlis, Faina Bellon, Jennifer R. Parker, Tonia Strauss, Sarah Jin, Qingchun King, Tari A. Overmoyer, Beth A. Curigliano, Giuseppe Regan, Meredith M. Tolaney, Sara M. Lynce, Filipa |
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Niman, Samuel M. Erick, Timothy K. Priedigkeit, Nolan Harrison, Beth T. Giordano, Antonio Nakhlis, Faina Bellon, Jennifer R. Parker, Tonia Strauss, Sarah Jin, Qingchun King, Tari A. Overmoyer, Beth A. Curigliano, Giuseppe Regan, Meredith M. Tolaney, Sara M. Lynce, Filipa |
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| doi_str |
10.1016/j.ejca.2022.07.001 |
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2024-07-06T19:46:56.090Z |
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