Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Muiru, Anthony N. [verfasserIn] Yang, Jingrong [verfasserIn] Derebail, Vimal K. [verfasserIn] Liu, Kathleen D. [verfasserIn] Feldman, Harold I. [verfasserIn] Srivastava, Anand [verfasserIn] Bhat, Zeenat [verfasserIn] Saraf, Santosh L. [verfasserIn] Chen, Teresa K. [verfasserIn] He, Jiang [verfasserIn] Estrella, Michelle M. [verfasserIn] Go, Alan S. [verfasserIn] Hsu, Chi-yuan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: American journal of kidney diseases - Philadelphia, Pa. : Elsevier Saunders, 1981, 80, Seite 610-618.e1 |
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| Übergeordnetes Werk: |
volume:80 ; pages:610-618.e1 |
| DOI / URN: |
10.1053/j.ajkd.2022.02.021 |
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| Katalog-ID: |
ELV008633495 |
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| 245 | 1 | 0 | |a Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study |
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| 520 | |a Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. | ||
| 650 | 4 | |a Acute kidney injury (AKI) | |
| 650 | 4 | |a Black race | |
| 650 | 4 | |a chronic kidney disease (CKD) | |
| 650 | 4 | |a clinical risk factors | |
| 650 | 4 | |a CRIC | |
| 650 | 4 | |a health care inequity | |
| 650 | 4 | |a hospitalization | |
| 650 | 4 | |a racial disparities | |
| 650 | 4 | |a serum creatinine (Scr) | |
| 650 | 4 | |a White race | |
| 700 | 1 | |a Yang, Jingrong |e verfasserin |4 aut | |
| 700 | 1 | |a Derebail, Vimal K. |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Kathleen D. |e verfasserin |4 aut | |
| 700 | 1 | |a Feldman, Harold I. |e verfasserin |4 aut | |
| 700 | 1 | |a Srivastava, Anand |e verfasserin |4 aut | |
| 700 | 1 | |a Bhat, Zeenat |e verfasserin |4 aut | |
| 700 | 1 | |a Saraf, Santosh L. |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Teresa K. |e verfasserin |4 aut | |
| 700 | 1 | |a He, Jiang |e verfasserin |4 aut | |
| 700 | 1 | |a Estrella, Michelle M. |e verfasserin |4 aut | |
| 700 | 1 | |a Go, Alan S. |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Chi-yuan |e verfasserin |4 aut | |
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10.1053/j.ajkd.2022.02.021 doi (DE-627)ELV008633495 (ELSEVIER)S0272-6386(22)00583-2 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Muiru, Anthony N. verfasserin aut Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. Acute kidney injury (AKI) Black race chronic kidney disease (CKD) clinical risk factors CRIC health care inequity hospitalization racial disparities serum creatinine (Scr) White race Yang, Jingrong verfasserin aut Derebail, Vimal K. verfasserin aut Liu, Kathleen D. verfasserin aut Feldman, Harold I. verfasserin aut Srivastava, Anand verfasserin aut Bhat, Zeenat verfasserin aut Saraf, Santosh L. verfasserin aut Chen, Teresa K. verfasserin aut He, Jiang verfasserin aut Estrella, Michelle M. verfasserin aut Go, Alan S. verfasserin aut Hsu, Chi-yuan verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 610-618.e1 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:610-618.e1 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 610-618.e1 |
| spelling |
10.1053/j.ajkd.2022.02.021 doi (DE-627)ELV008633495 (ELSEVIER)S0272-6386(22)00583-2 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Muiru, Anthony N. verfasserin aut Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. Acute kidney injury (AKI) Black race chronic kidney disease (CKD) clinical risk factors CRIC health care inequity hospitalization racial disparities serum creatinine (Scr) White race Yang, Jingrong verfasserin aut Derebail, Vimal K. verfasserin aut Liu, Kathleen D. verfasserin aut Feldman, Harold I. verfasserin aut Srivastava, Anand verfasserin aut Bhat, Zeenat verfasserin aut Saraf, Santosh L. verfasserin aut Chen, Teresa K. verfasserin aut He, Jiang verfasserin aut Estrella, Michelle M. verfasserin aut Go, Alan S. verfasserin aut Hsu, Chi-yuan verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 610-618.e1 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:610-618.e1 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 610-618.e1 |
| allfields_unstemmed |
10.1053/j.ajkd.2022.02.021 doi (DE-627)ELV008633495 (ELSEVIER)S0272-6386(22)00583-2 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Muiru, Anthony N. verfasserin aut Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. Acute kidney injury (AKI) Black race chronic kidney disease (CKD) clinical risk factors CRIC health care inequity hospitalization racial disparities serum creatinine (Scr) White race Yang, Jingrong verfasserin aut Derebail, Vimal K. verfasserin aut Liu, Kathleen D. verfasserin aut Feldman, Harold I. verfasserin aut Srivastava, Anand verfasserin aut Bhat, Zeenat verfasserin aut Saraf, Santosh L. verfasserin aut Chen, Teresa K. verfasserin aut He, Jiang verfasserin aut Estrella, Michelle M. verfasserin aut Go, Alan S. verfasserin aut Hsu, Chi-yuan verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 610-618.e1 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:610-618.e1 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 610-618.e1 |
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10.1053/j.ajkd.2022.02.021 doi (DE-627)ELV008633495 (ELSEVIER)S0272-6386(22)00583-2 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Muiru, Anthony N. verfasserin aut Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. Acute kidney injury (AKI) Black race chronic kidney disease (CKD) clinical risk factors CRIC health care inequity hospitalization racial disparities serum creatinine (Scr) White race Yang, Jingrong verfasserin aut Derebail, Vimal K. verfasserin aut Liu, Kathleen D. verfasserin aut Feldman, Harold I. verfasserin aut Srivastava, Anand verfasserin aut Bhat, Zeenat verfasserin aut Saraf, Santosh L. verfasserin aut Chen, Teresa K. verfasserin aut He, Jiang verfasserin aut Estrella, Michelle M. verfasserin aut Go, Alan S. verfasserin aut Hsu, Chi-yuan verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 610-618.e1 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:610-618.e1 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 610-618.e1 |
| allfieldsSound |
10.1053/j.ajkd.2022.02.021 doi (DE-627)ELV008633495 (ELSEVIER)S0272-6386(22)00583-2 DE-627 ger DE-627 rda eng 610 DE-600 44.88 bkl Muiru, Anthony N. verfasserin aut Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. Acute kidney injury (AKI) Black race chronic kidney disease (CKD) clinical risk factors CRIC health care inequity hospitalization racial disparities serum creatinine (Scr) White race Yang, Jingrong verfasserin aut Derebail, Vimal K. verfasserin aut Liu, Kathleen D. verfasserin aut Feldman, Harold I. verfasserin aut Srivastava, Anand verfasserin aut Bhat, Zeenat verfasserin aut Saraf, Santosh L. verfasserin aut Chen, Teresa K. verfasserin aut He, Jiang verfasserin aut Estrella, Michelle M. verfasserin aut Go, Alan S. verfasserin aut Hsu, Chi-yuan verfasserin aut Enthalten in American journal of kidney diseases Philadelphia, Pa. : Elsevier Saunders, 1981 80, Seite 610-618.e1 Online-Ressource (DE-627)320593169 (DE-600)2019205-8 (DE-576)091138760 1523-6838 nnns volume:80 pages:610-618.e1 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_31 GBV_ILN_2011 44.88 Urologie Nephrologie AR 80 610-618.e1 |
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Muiru, Anthony N. @@aut@@ Yang, Jingrong @@aut@@ Derebail, Vimal K. @@aut@@ Liu, Kathleen D. @@aut@@ Feldman, Harold I. @@aut@@ Srivastava, Anand @@aut@@ Bhat, Zeenat @@aut@@ Saraf, Santosh L. @@aut@@ Chen, Teresa K. @@aut@@ He, Jiang @@aut@@ Estrella, Michelle M. @@aut@@ Go, Alan S. @@aut@@ Hsu, Chi-yuan @@aut@@ |
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We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). 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Muiru, Anthony N. |
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610 DE-600 44.88 bkl Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Acute kidney injury (AKI) Black race chronic kidney disease (CKD) clinical risk factors CRIC health care inequity hospitalization racial disparities serum creatinine (Scr) White race |
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ddc 610 bkl 44.88 misc Acute kidney injury (AKI) misc Black race misc chronic kidney disease (CKD) misc clinical risk factors misc CRIC misc health care inequity misc hospitalization misc racial disparities misc serum creatinine (Scr) misc White race |
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Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study |
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Muiru, Anthony N. Yang, Jingrong Derebail, Vimal K. Liu, Kathleen D. Feldman, Harold I. Srivastava, Anand Bhat, Zeenat Saraf, Santosh L. Chen, Teresa K. He, Jiang Estrella, Michelle M. Go, Alan S. Hsu, Chi-yuan |
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black and white adults with ckd hospitalized with acute kidney injury: findings from the chronic renal insufficiency cohort (cric) study |
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Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study |
| abstract |
Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. |
| abstractGer |
Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. |
| abstract_unstemmed |
Rationale & Objective: Few studies have investigated racial disparities in acute kidney injury (AKI), in contrast to the extensive literature on racial differences in the risk of kidney failure. We sought to study potential differences in risk in the setting of chronic kidney disease (CKD).Study Design: Prospective cohort study.Setting & Participants: We studied 2,720 self-identified Black or White participants with CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study from July 1, 2013, to December 31, 2017.Exposure: Self-reported race (Black vs White).Outcome: Hospitalized AKI (≥50% increase from nadir to peak serum creatinine).Analytical Approach: Cox regression models adjusting for demographics (age and sex), prehospitalization clinical risk factors (diabetes, blood pressure, cardiovascular disease, estimated glomerular filtration rate, proteinuria, receipt of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers), and socioeconomic status (insurance status and education level). In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors. |
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Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study |
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Yang, Jingrong Derebail, Vimal K. Liu, Kathleen D. Feldman, Harold I. Srivastava, Anand Bhat, Zeenat Saraf, Santosh L. Chen, Teresa K. He, Jiang Estrella, Michelle M. Go, Alan S. Hsu, Chi-yuan |
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In a subset of participants with genotype data, we adjusted for apolipoprotein L1 gene (APOL1) high-risk status and sickle cell trait.Results: Black participants (n = 1,266) were younger but had a higher burden of prehospitalization clinical risk factors. The incidence rate of first AKI hospitalization among Black participants was 6.3 (95% CI, 5.5-7.2) per 100 person-years versus 5.3 (95% CI, 4.6-6.1) per 100 person-years among White participants. In an unadjusted Cox regression model, Black participants were at a modestly increased risk of incident AKI (HR, 1.22 [95% CI, 1.01-1.48]) compared with White participants. However, this risk was attenuated and no longer significant after adjusting for prehospitalization clinical risk factors (adjusted HR, 1.02 [95% CI, 0.83-1.25]). There were only 11 AKI hospitalizations among individuals with high-risk APOL1 risk status and 14 AKI hospitalizations among individuals with sickle cell trait.Limitations: Participants were limited to research volunteers and potentially not fully representative of all CKD patients.Conclusions: In this multicenter prospective cohort of CKD patients, racial disparities in AKI incidence were modest and were explained by differences in prehospitalization clinical risk factors.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Acute kidney injury (AKI)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Black race</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">chronic kidney disease (CKD)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">clinical risk factors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield 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code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Feldman, Harold I.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Srivastava, Anand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bhat, Zeenat</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Saraf, Santosh L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Teresa K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">He, Jiang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Estrella, Michelle M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Go, Alan S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hsu, Chi-yuan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">American journal of kidney diseases</subfield><subfield code="d">Philadelphia, Pa. : Elsevier Saunders, 1981</subfield><subfield code="g">80, Seite 610-618.e1</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)320593169</subfield><subfield code="w">(DE-600)2019205-8</subfield><subfield code="w">(DE-576)091138760</subfield><subfield code="x">1523-6838</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:80</subfield><subfield code="g">pages:610-618.e1</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.88</subfield><subfield code="j">Urologie</subfield><subfield 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