A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging
Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pratt, Ronald G. [verfasserIn] Lee, Greg [verfasserIn] McAllister, Aaron S. [verfasserIn] Smith, Daniel R. [verfasserIn] Myer, Gregory D. [verfasserIn] Ireland, Christopher M. [verfasserIn] Loew, Wolfgang M. [verfasserIn] Lanier, Matt [verfasserIn] Wang, Hui [verfasserIn] Diekfuss, Jed A. [verfasserIn] Yuan, Weihong [verfasserIn] Dumoulin, Charles L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuroscience methods - Amsterdam [u.a.] : Elsevier Science, 1979, 382 |
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| Übergeordnetes Werk: |
volume:382 |
| DOI / URN: |
10.1016/j.jneumeth.2022.109728 |
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ELV008691126 |
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| 245 | 1 | 0 | |a A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging |
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| 520 | |a Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). | ||
| 650 | 4 | |a Brain slosh | |
| 650 | 4 | |a Tissue shear | |
| 650 | 4 | |a Tissue strain | |
| 650 | 4 | |a Mild traumatic brain injury | |
| 700 | 1 | |a Lee, Greg |e verfasserin |4 aut | |
| 700 | 1 | |a McAllister, Aaron S. |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Daniel R. |e verfasserin |4 aut | |
| 700 | 1 | |a Myer, Gregory D. |e verfasserin |4 aut | |
| 700 | 1 | |a Ireland, Christopher M. |e verfasserin |4 aut | |
| 700 | 1 | |a Loew, Wolfgang M. |e verfasserin |4 aut | |
| 700 | 1 | |a Lanier, Matt |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Diekfuss, Jed A. |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Weihong |e verfasserin |4 aut | |
| 700 | 1 | |a Dumoulin, Charles L. |e verfasserin |4 aut | |
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10.1016/j.jneumeth.2022.109728 doi (DE-627)ELV008691126 (ELSEVIER)S0165-0270(22)00254-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Pratt, Ronald G. verfasserin aut A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). Brain slosh Tissue shear Tissue strain Mild traumatic brain injury Lee, Greg verfasserin aut McAllister, Aaron S. verfasserin aut Smith, Daniel R. verfasserin aut Myer, Gregory D. verfasserin aut Ireland, Christopher M. verfasserin aut Loew, Wolfgang M. verfasserin aut Lanier, Matt verfasserin aut Wang, Hui verfasserin aut Diekfuss, Jed A. verfasserin aut Yuan, Weihong verfasserin aut Dumoulin, Charles L. verfasserin aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 382 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:382 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 382 |
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10.1016/j.jneumeth.2022.109728 doi (DE-627)ELV008691126 (ELSEVIER)S0165-0270(22)00254-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Pratt, Ronald G. verfasserin aut A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). Brain slosh Tissue shear Tissue strain Mild traumatic brain injury Lee, Greg verfasserin aut McAllister, Aaron S. verfasserin aut Smith, Daniel R. verfasserin aut Myer, Gregory D. verfasserin aut Ireland, Christopher M. verfasserin aut Loew, Wolfgang M. verfasserin aut Lanier, Matt verfasserin aut Wang, Hui verfasserin aut Diekfuss, Jed A. verfasserin aut Yuan, Weihong verfasserin aut Dumoulin, Charles L. verfasserin aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 382 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:382 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 382 |
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10.1016/j.jneumeth.2022.109728 doi (DE-627)ELV008691126 (ELSEVIER)S0165-0270(22)00254-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Pratt, Ronald G. verfasserin aut A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). Brain slosh Tissue shear Tissue strain Mild traumatic brain injury Lee, Greg verfasserin aut McAllister, Aaron S. verfasserin aut Smith, Daniel R. verfasserin aut Myer, Gregory D. verfasserin aut Ireland, Christopher M. verfasserin aut Loew, Wolfgang M. verfasserin aut Lanier, Matt verfasserin aut Wang, Hui verfasserin aut Diekfuss, Jed A. verfasserin aut Yuan, Weihong verfasserin aut Dumoulin, Charles L. verfasserin aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 382 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:382 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 382 |
| allfieldsGer |
10.1016/j.jneumeth.2022.109728 doi (DE-627)ELV008691126 (ELSEVIER)S0165-0270(22)00254-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Pratt, Ronald G. verfasserin aut A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). Brain slosh Tissue shear Tissue strain Mild traumatic brain injury Lee, Greg verfasserin aut McAllister, Aaron S. verfasserin aut Smith, Daniel R. verfasserin aut Myer, Gregory D. verfasserin aut Ireland, Christopher M. verfasserin aut Loew, Wolfgang M. verfasserin aut Lanier, Matt verfasserin aut Wang, Hui verfasserin aut Diekfuss, Jed A. verfasserin aut Yuan, Weihong verfasserin aut Dumoulin, Charles L. verfasserin aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 382 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:382 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 382 |
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10.1016/j.jneumeth.2022.109728 doi (DE-627)ELV008691126 (ELSEVIER)S0165-0270(22)00254-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Pratt, Ronald G. verfasserin aut A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). Brain slosh Tissue shear Tissue strain Mild traumatic brain injury Lee, Greg verfasserin aut McAllister, Aaron S. verfasserin aut Smith, Daniel R. verfasserin aut Myer, Gregory D. verfasserin aut Ireland, Christopher M. verfasserin aut Loew, Wolfgang M. verfasserin aut Lanier, Matt verfasserin aut Wang, Hui verfasserin aut Diekfuss, Jed A. verfasserin aut Yuan, Weihong verfasserin aut Dumoulin, Charles L. verfasserin aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 382 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:382 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 382 |
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a weighted head accelerator mechanism (wham) for visualizing brain rheology using magnetic resonance imaging |
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A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging |
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Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). |
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Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). |
| abstract_unstemmed |
Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. Consequently, this approach might find utility in evaluating strategies to protect the brain from mild traumatic brain injury (mTBI). |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008691126</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524153919.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230509s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jneumeth.2022.109728</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008691126</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0165-0270(22)00254-0</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Pratt, Ronald G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">A Weighted Head Accelerator Mechanism (WHAM) for visualizing brain rheology using magnetic resonance imaging</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: A device for moving the head during MR imaging, called a Weighted Head Accelerator Mechanism (WHAM), rotates the head of a supine subject within programmable rotation limits and acceleration profiles. The WHAM can be used with custom MRI sequences to visualize the deformation and recoil of in vivo brain parenchyma with high temporal resolution, allowing element-wise calculation of strain and shear forces in the brain. Unlike previous devices, the WHAM can be configured to provide a wide range of motion and acceleration profiles.New method: The WHAM was calibrated using a high-speed camera on a laboratory bench and in 1.5 Tesla and 3.0 Tesla MRI scanners using gel phantoms and human subjects. The MR imaging studies employed a spatial spin-saturation tagging sub-sequence, followed by serial image acquisition. In these studies, 256 images were acquired with a temporal resolution of 2.56 ms. Deformation of the brain was quantified by following the spatial tags in the images.Results: MR imaging showed that the WHAM drove quantifiable brain motions using g forces less than those typically observed in day-to-day activities, with peak accelerations of ∼250 rad/sec2.Comparison with existing methods: The peak pre-contact accelerations and velocities achieved by the WHAM device in this study are both higher than devices used in previous studies, while also allowing for modification of these factors.Conclusions: MR imaging performed with the WHAM provides a direct method to visualize and quantify “brain slosh” in response to rotational acceleration. 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