Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection
The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene qu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pijeira, Martha Sahylí Ortega [verfasserIn] de Menezes, Alan Silva [verfasserIn] Fechine, Pierre Basílio Almeida [verfasserIn] Shah, Syed Qaiser [verfasserIn] Ilem-Ozdemir, Derya [verfasserIn] López, Elvis O. [verfasserIn] Maricato, Juliana Terzi [verfasserIn] Rosa, Daniela Santoro [verfasserIn] Ricci-Junior, Eduardo [verfasserIn] Junior, Severino Alves [verfasserIn] Alencar, Luciana Magalhães Rebelo [verfasserIn] Santos-Oliveira, Ralph [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of pharmaceutics and biopharmaceutics - New York, NY [u.a.] : Elsevier, 1997, 180, Seite 91-100 |
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| Übergeordnetes Werk: |
volume:180 ; pages:91-100 |
| DOI / URN: |
10.1016/j.ejpb.2022.09.019 |
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| Katalog-ID: |
ELV008739064 |
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| 245 | 1 | 0 | |a Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection |
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| 520 | |a The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. | ||
| 650 | 4 | |a Drug delivery | |
| 650 | 4 | |a Graphene quantum dots | |
| 650 | 4 | |a Folic acid | |
| 650 | 4 | |a GQD-FA | |
| 650 | 4 | |a Zika virus infection | |
| 650 | 4 | |a Radium-223 | |
| 650 | 4 | |a Targeted alpha therapy | |
| 650 | 4 | |a Biomedical device | |
| 650 | 4 | |a Smart material | |
| 650 | 4 | |a Nanoparticle | |
| 700 | 1 | |a de Menezes, Alan Silva |e verfasserin |4 aut | |
| 700 | 1 | |a Fechine, Pierre Basílio Almeida |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Syed Qaiser |e verfasserin |4 aut | |
| 700 | 1 | |a Ilem-Ozdemir, Derya |e verfasserin |4 aut | |
| 700 | 1 | |a López, Elvis O. |e verfasserin |4 aut | |
| 700 | 1 | |a Maricato, Juliana Terzi |e verfasserin |4 aut | |
| 700 | 1 | |a Rosa, Daniela Santoro |e verfasserin |4 aut | |
| 700 | 1 | |a Ricci-Junior, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Junior, Severino Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Alencar, Luciana Magalhães Rebelo |e verfasserin |4 aut | |
| 700 | 1 | |a Santos-Oliveira, Ralph |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:180 |g pages:91-100 |
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10.1016/j.ejpb.2022.09.019 doi (DE-627)ELV008739064 (ELSEVIER)S0939-6411(22)00214-4 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.40 bkl Pijeira, Martha Sahylí Ortega verfasserin aut Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. Drug delivery Graphene quantum dots Folic acid GQD-FA Zika virus infection Radium-223 Targeted alpha therapy Biomedical device Smart material Nanoparticle de Menezes, Alan Silva verfasserin aut Fechine, Pierre Basílio Almeida verfasserin aut Shah, Syed Qaiser verfasserin aut Ilem-Ozdemir, Derya verfasserin aut López, Elvis O. verfasserin aut Maricato, Juliana Terzi verfasserin aut Rosa, Daniela Santoro verfasserin aut Ricci-Junior, Eduardo verfasserin aut Junior, Severino Alves verfasserin aut Alencar, Luciana Magalhães Rebelo verfasserin aut Santos-Oliveira, Ralph verfasserin aut Enthalten in European journal of pharmaceutics and biopharmaceutics New York, NY [u.a.] : Elsevier, 1997 180, Seite 91-100 Online-Ressource (DE-627)300897324 (DE-600)1483524-1 (DE-576)259270822 1873-3441 nnns volume:180 pages:91-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.40 Pharmazie Pharmazeutika AR 180 91-100 |
| spelling |
10.1016/j.ejpb.2022.09.019 doi (DE-627)ELV008739064 (ELSEVIER)S0939-6411(22)00214-4 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.40 bkl Pijeira, Martha Sahylí Ortega verfasserin aut Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. Drug delivery Graphene quantum dots Folic acid GQD-FA Zika virus infection Radium-223 Targeted alpha therapy Biomedical device Smart material Nanoparticle de Menezes, Alan Silva verfasserin aut Fechine, Pierre Basílio Almeida verfasserin aut Shah, Syed Qaiser verfasserin aut Ilem-Ozdemir, Derya verfasserin aut López, Elvis O. verfasserin aut Maricato, Juliana Terzi verfasserin aut Rosa, Daniela Santoro verfasserin aut Ricci-Junior, Eduardo verfasserin aut Junior, Severino Alves verfasserin aut Alencar, Luciana Magalhães Rebelo verfasserin aut Santos-Oliveira, Ralph verfasserin aut Enthalten in European journal of pharmaceutics and biopharmaceutics New York, NY [u.a.] : Elsevier, 1997 180, Seite 91-100 Online-Ressource (DE-627)300897324 (DE-600)1483524-1 (DE-576)259270822 1873-3441 nnns volume:180 pages:91-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.40 Pharmazie Pharmazeutika AR 180 91-100 |
| allfields_unstemmed |
10.1016/j.ejpb.2022.09.019 doi (DE-627)ELV008739064 (ELSEVIER)S0939-6411(22)00214-4 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.40 bkl Pijeira, Martha Sahylí Ortega verfasserin aut Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. Drug delivery Graphene quantum dots Folic acid GQD-FA Zika virus infection Radium-223 Targeted alpha therapy Biomedical device Smart material Nanoparticle de Menezes, Alan Silva verfasserin aut Fechine, Pierre Basílio Almeida verfasserin aut Shah, Syed Qaiser verfasserin aut Ilem-Ozdemir, Derya verfasserin aut López, Elvis O. verfasserin aut Maricato, Juliana Terzi verfasserin aut Rosa, Daniela Santoro verfasserin aut Ricci-Junior, Eduardo verfasserin aut Junior, Severino Alves verfasserin aut Alencar, Luciana Magalhães Rebelo verfasserin aut Santos-Oliveira, Ralph verfasserin aut Enthalten in European journal of pharmaceutics and biopharmaceutics New York, NY [u.a.] : Elsevier, 1997 180, Seite 91-100 Online-Ressource (DE-627)300897324 (DE-600)1483524-1 (DE-576)259270822 1873-3441 nnns volume:180 pages:91-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.40 Pharmazie Pharmazeutika AR 180 91-100 |
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10.1016/j.ejpb.2022.09.019 doi (DE-627)ELV008739064 (ELSEVIER)S0939-6411(22)00214-4 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.40 bkl Pijeira, Martha Sahylí Ortega verfasserin aut Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. Drug delivery Graphene quantum dots Folic acid GQD-FA Zika virus infection Radium-223 Targeted alpha therapy Biomedical device Smart material Nanoparticle de Menezes, Alan Silva verfasserin aut Fechine, Pierre Basílio Almeida verfasserin aut Shah, Syed Qaiser verfasserin aut Ilem-Ozdemir, Derya verfasserin aut López, Elvis O. verfasserin aut Maricato, Juliana Terzi verfasserin aut Rosa, Daniela Santoro verfasserin aut Ricci-Junior, Eduardo verfasserin aut Junior, Severino Alves verfasserin aut Alencar, Luciana Magalhães Rebelo verfasserin aut Santos-Oliveira, Ralph verfasserin aut Enthalten in European journal of pharmaceutics and biopharmaceutics New York, NY [u.a.] : Elsevier, 1997 180, Seite 91-100 Online-Ressource (DE-627)300897324 (DE-600)1483524-1 (DE-576)259270822 1873-3441 nnns volume:180 pages:91-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.40 Pharmazie Pharmazeutika AR 180 91-100 |
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10.1016/j.ejpb.2022.09.019 doi (DE-627)ELV008739064 (ELSEVIER)S0939-6411(22)00214-4 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.40 bkl Pijeira, Martha Sahylí Ortega verfasserin aut Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. Drug delivery Graphene quantum dots Folic acid GQD-FA Zika virus infection Radium-223 Targeted alpha therapy Biomedical device Smart material Nanoparticle de Menezes, Alan Silva verfasserin aut Fechine, Pierre Basílio Almeida verfasserin aut Shah, Syed Qaiser verfasserin aut Ilem-Ozdemir, Derya verfasserin aut López, Elvis O. verfasserin aut Maricato, Juliana Terzi verfasserin aut Rosa, Daniela Santoro verfasserin aut Ricci-Junior, Eduardo verfasserin aut Junior, Severino Alves verfasserin aut Alencar, Luciana Magalhães Rebelo verfasserin aut Santos-Oliveira, Ralph verfasserin aut Enthalten in European journal of pharmaceutics and biopharmaceutics New York, NY [u.a.] : Elsevier, 1997 180, Seite 91-100 Online-Ressource (DE-627)300897324 (DE-600)1483524-1 (DE-576)259270822 1873-3441 nnns volume:180 pages:91-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.40 Pharmazie Pharmazeutika AR 180 91-100 |
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Enthalten in European journal of pharmaceutics and biopharmaceutics 180, Seite 91-100 volume:180 pages:91-100 |
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Pijeira, Martha Sahylí Ortega @@aut@@ de Menezes, Alan Silva @@aut@@ Fechine, Pierre Basílio Almeida @@aut@@ Shah, Syed Qaiser @@aut@@ Ilem-Ozdemir, Derya @@aut@@ López, Elvis O. @@aut@@ Maricato, Juliana Terzi @@aut@@ Rosa, Daniela Santoro @@aut@@ Ricci-Junior, Eduardo @@aut@@ Junior, Severino Alves @@aut@@ Alencar, Luciana Magalhães Rebelo @@aut@@ Santos-Oliveira, Ralph @@aut@@ |
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Pijeira, Martha Sahylí Ortega |
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610 DE-600 15,3 ssgn PHARM DE-84 fid 44.40 bkl Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection Drug delivery Graphene quantum dots Folic acid GQD-FA Zika virus infection Radium-223 Targeted alpha therapy Biomedical device Smart material Nanoparticle |
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ddc 610 ssgn 15,3 fid PHARM bkl 44.40 misc Drug delivery misc Graphene quantum dots misc Folic acid misc GQD-FA misc Zika virus infection misc Radium-223 misc Targeted alpha therapy misc Biomedical device misc Smart material misc Nanoparticle |
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Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection |
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Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection |
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Pijeira, Martha Sahylí Ortega |
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Pijeira, Martha Sahylí Ortega de Menezes, Alan Silva Fechine, Pierre Basílio Almeida Shah, Syed Qaiser Ilem-Ozdemir, Derya López, Elvis O. Maricato, Juliana Terzi Rosa, Daniela Santoro Ricci-Junior, Eduardo Junior, Severino Alves Alencar, Luciana Magalhães Rebelo Santos-Oliveira, Ralph |
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folic acid-functionalized graphene quantum dots: synthesis, characterization, radiolabeling with radium-223 and antiviral effect against zika virus infection |
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Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection |
| abstract |
The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. |
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The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. |
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The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn’t improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223RaGQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. |
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Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection |
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de Menezes, Alan Silva Fechine, Pierre Basílio Almeida Shah, Syed Qaiser Ilem-Ozdemir, Derya López, Elvis O. Maricato, Juliana Terzi Rosa, Daniela Santoro Ricci-Junior, Eduardo Junior, Severino Alves Alencar, Luciana Magalhães Rebelo Santos-Oliveira, Ralph |
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