Lighting up the changes of plasma membranes during apoptosis with fluorescent probes
Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morpholo...
Ausführliche Beschreibung
Autor*in: |
Niu, Jie [verfasserIn] Ma, Yanyan [verfasserIn] Yang, Yingdong [verfasserIn] Lv, Hongmin [verfasserIn] Wang, Jing [verfasserIn] Wang, Tao [verfasserIn] Liu, Fengchen [verfasserIn] Xu, Shanshan [verfasserIn] Jiang, Zike [verfasserIn] Lin, Weiying [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Coordination chemistry reviews - Amsterdam [u.a.] : Elsevier Science, 1966, 476 |
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Übergeordnetes Werk: |
volume:476 |
DOI / URN: |
10.1016/j.ccr.2022.214926 |
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Katalog-ID: |
ELV008835098 |
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520 | |a Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. | ||
650 | 4 | |a Plasma membranes | |
650 | 4 | |a Fluorescent probe | |
650 | 4 | |a Apoptosis | |
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700 | 1 | |a Ma, Yanyan |e verfasserin |4 aut | |
700 | 1 | |a Yang, Yingdong |e verfasserin |4 aut | |
700 | 1 | |a Lv, Hongmin |e verfasserin |4 aut | |
700 | 1 | |a Wang, Jing |e verfasserin |4 aut | |
700 | 1 | |a Wang, Tao |e verfasserin |4 aut | |
700 | 1 | |a Liu, Fengchen |e verfasserin |4 aut | |
700 | 1 | |a Xu, Shanshan |e verfasserin |4 aut | |
700 | 1 | |a Jiang, Zike |e verfasserin |4 aut | |
700 | 1 | |a Lin, Weiying |e verfasserin |4 aut | |
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allfields |
10.1016/j.ccr.2022.214926 doi (DE-627)ELV008835098 (ELSEVIER)S0010-8545(22)00521-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Niu, Jie verfasserin aut Lighting up the changes of plasma membranes during apoptosis with fluorescent probes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. Plasma membranes Fluorescent probe Apoptosis Bioimaging Ma, Yanyan verfasserin aut Yang, Yingdong verfasserin aut Lv, Hongmin verfasserin aut Wang, Jing verfasserin aut Wang, Tao verfasserin aut Liu, Fengchen verfasserin aut Xu, Shanshan verfasserin aut Jiang, Zike verfasserin aut Lin, Weiying verfasserin aut Enthalten in Coordination chemistry reviews Amsterdam [u.a.] : Elsevier Science, 1966 476 Online-Ressource (DE-627)306655020 (DE-600)1499984-5 (DE-576)081985002 0010-8545 nnns volume:476 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 476 |
spelling |
10.1016/j.ccr.2022.214926 doi (DE-627)ELV008835098 (ELSEVIER)S0010-8545(22)00521-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Niu, Jie verfasserin aut Lighting up the changes of plasma membranes during apoptosis with fluorescent probes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. Plasma membranes Fluorescent probe Apoptosis Bioimaging Ma, Yanyan verfasserin aut Yang, Yingdong verfasserin aut Lv, Hongmin verfasserin aut Wang, Jing verfasserin aut Wang, Tao verfasserin aut Liu, Fengchen verfasserin aut Xu, Shanshan verfasserin aut Jiang, Zike verfasserin aut Lin, Weiying verfasserin aut Enthalten in Coordination chemistry reviews Amsterdam [u.a.] : Elsevier Science, 1966 476 Online-Ressource (DE-627)306655020 (DE-600)1499984-5 (DE-576)081985002 0010-8545 nnns volume:476 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 476 |
allfields_unstemmed |
10.1016/j.ccr.2022.214926 doi (DE-627)ELV008835098 (ELSEVIER)S0010-8545(22)00521-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Niu, Jie verfasserin aut Lighting up the changes of plasma membranes during apoptosis with fluorescent probes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. Plasma membranes Fluorescent probe Apoptosis Bioimaging Ma, Yanyan verfasserin aut Yang, Yingdong verfasserin aut Lv, Hongmin verfasserin aut Wang, Jing verfasserin aut Wang, Tao verfasserin aut Liu, Fengchen verfasserin aut Xu, Shanshan verfasserin aut Jiang, Zike verfasserin aut Lin, Weiying verfasserin aut Enthalten in Coordination chemistry reviews Amsterdam [u.a.] : Elsevier Science, 1966 476 Online-Ressource (DE-627)306655020 (DE-600)1499984-5 (DE-576)081985002 0010-8545 nnns volume:476 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 476 |
allfieldsGer |
10.1016/j.ccr.2022.214926 doi (DE-627)ELV008835098 (ELSEVIER)S0010-8545(22)00521-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Niu, Jie verfasserin aut Lighting up the changes of plasma membranes during apoptosis with fluorescent probes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. Plasma membranes Fluorescent probe Apoptosis Bioimaging Ma, Yanyan verfasserin aut Yang, Yingdong verfasserin aut Lv, Hongmin verfasserin aut Wang, Jing verfasserin aut Wang, Tao verfasserin aut Liu, Fengchen verfasserin aut Xu, Shanshan verfasserin aut Jiang, Zike verfasserin aut Lin, Weiying verfasserin aut Enthalten in Coordination chemistry reviews Amsterdam [u.a.] : Elsevier Science, 1966 476 Online-Ressource (DE-627)306655020 (DE-600)1499984-5 (DE-576)081985002 0010-8545 nnns volume:476 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 476 |
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10.1016/j.ccr.2022.214926 doi (DE-627)ELV008835098 (ELSEVIER)S0010-8545(22)00521-5 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Niu, Jie verfasserin aut Lighting up the changes of plasma membranes during apoptosis with fluorescent probes 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. Plasma membranes Fluorescent probe Apoptosis Bioimaging Ma, Yanyan verfasserin aut Yang, Yingdong verfasserin aut Lv, Hongmin verfasserin aut Wang, Jing verfasserin aut Wang, Tao verfasserin aut Liu, Fengchen verfasserin aut Xu, Shanshan verfasserin aut Jiang, Zike verfasserin aut Lin, Weiying verfasserin aut Enthalten in Coordination chemistry reviews Amsterdam [u.a.] : Elsevier Science, 1966 476 Online-Ressource (DE-627)306655020 (DE-600)1499984-5 (DE-576)081985002 0010-8545 nnns volume:476 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 476 |
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title |
Lighting up the changes of plasma membranes during apoptosis with fluorescent probes |
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title_full |
Lighting up the changes of plasma membranes during apoptosis with fluorescent probes |
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Niu, Jie |
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Coordination chemistry reviews |
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Coordination chemistry reviews |
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eng |
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2022 |
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Niu, Jie Ma, Yanyan Yang, Yingdong Lv, Hongmin Wang, Jing Wang, Tao Liu, Fengchen Xu, Shanshan Jiang, Zike Lin, Weiying |
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476 |
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540 DE-600 35.00 bkl |
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Niu, Jie |
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10.1016/j.ccr.2022.214926 |
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540 |
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verfasserin |
title_sort |
lighting up the changes of plasma membranes during apoptosis with fluorescent probes |
title_auth |
Lighting up the changes of plasma membranes during apoptosis with fluorescent probes |
abstract |
Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. |
abstractGer |
Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. |
abstract_unstemmed |
Plasma membranes, as the network for transferring information and constituents between cells and their microenvironment, play important roles in physiological and pathological processes. As the first defensive barriers of cells, cell membranes take further actions through changes in shapes, morphologies or components once they sense damages from exterior poison stimulations. Thus, the changes of plasma membranes are the direct indication for apoptosis induced by drugs, and non-destructive visualization of these changes is of great significance. Various fluorescent probes for real-time and in situ monitoring these changes of plasma membranes have been explored for more than 20 years. However, a concise review on this specific and important topic is still lacking, which may hamper the development of this field. In this review, the typical fluorescent probes for visualization the changes of plasma membranes during apoptosis in the past decades have been summarized. The representative examples have been classified into five categories according to the biological changes, which included the changes of phosphatidylserine (PS), changes in membrane composition, changes in membrane permeability, changes in morphologies and lipid order in plasma membranes. The basic principle, design strategies, sensing mechanisms and the applications of these fluorescent sensors that have been achieved were discussed. The perspectives and challenges with respect to this field were also presented. We anticipated that this review can promote the development of the probes for sensing the changes of plasma membranes during apoptosis, and facilitate the studies of drug discovery and other relative biomedical fields. |
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title_short |
Lighting up the changes of plasma membranes during apoptosis with fluorescent probes |
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Ma, Yanyan Yang, Yingdong Lv, Hongmin Wang, Jing Wang, Tao Liu, Fengchen Xu, Shanshan Jiang, Zike Lin, Weiying |
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up_date |
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