Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams
Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion B...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Baack, Leon [verfasserIn] Schuy, Christoph [verfasserIn] Brons, Stephan [verfasserIn] Horst, Felix [verfasserIn] Voss, Bernd [verfasserIn] Zink, Klemens [verfasserIn] Haberer, Thomas [verfasserIn] Durante, Marco [verfasserIn] Weber, Uli [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Physica medica - Amsterdam : Elsevier, 1996, 104, Seite 136-144 |
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| Übergeordnetes Werk: |
volume:104 ; pages:136-144 |
| DOI / URN: |
10.1016/j.ejmp.2022.10.029 |
|---|
| Katalog-ID: |
ELV008918511 |
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| 245 | 1 | 0 | |a Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams |
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| 520 | |a Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. | ||
| 650 | 4 | |a FLASH | |
| 650 | 4 | |a Ultra High Dose Rate (UHDR) | |
| 650 | 4 | |a Ionisation chamber | |
| 650 | 4 | |a Beam monitor | |
| 650 | 4 | |a Recombination | |
| 650 | 4 | |a Space charge effect | |
| 700 | 1 | |a Schuy, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Brons, Stephan |e verfasserin |0 (orcid)0000-0002-4695-0816 |4 aut | |
| 700 | 1 | |a Horst, Felix |e verfasserin |0 (orcid)0000-0003-0707-0856 |4 aut | |
| 700 | 1 | |a Voss, Bernd |e verfasserin |4 aut | |
| 700 | 1 | |a Zink, Klemens |e verfasserin |0 (orcid)0000-0001-5785-4101 |4 aut | |
| 700 | 1 | |a Haberer, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Durante, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Weber, Uli |e verfasserin |0 (orcid)0000-0002-8147-0084 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Physica medica |d Amsterdam : Elsevier, 1996 |g 104, Seite 136-144 |h Online-Ressource |w (DE-627)364471417 |w (DE-600)2110535-2 |w (DE-576)272350176 |x 1724-191X |7 nnns |
| 773 | 1 | 8 | |g volume:104 |g pages:136-144 |
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10.1016/j.ejmp.2022.10.029 doi (DE-627)ELV008918511 (ELSEVIER)S1120-1797(22)02090-7 DE-627 ger DE-627 rda eng 530 610 DE-600 44.31 bkl Baack, Leon verfasserin (orcid)0000-0001-6982-6298 aut Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. FLASH Ultra High Dose Rate (UHDR) Ionisation chamber Beam monitor Recombination Space charge effect Schuy, Christoph verfasserin aut Brons, Stephan verfasserin (orcid)0000-0002-4695-0816 aut Horst, Felix verfasserin (orcid)0000-0003-0707-0856 aut Voss, Bernd verfasserin aut Zink, Klemens verfasserin (orcid)0000-0001-5785-4101 aut Haberer, Thomas verfasserin aut Durante, Marco verfasserin aut Weber, Uli verfasserin (orcid)0000-0002-8147-0084 aut Enthalten in Physica medica Amsterdam : Elsevier, 1996 104, Seite 136-144 Online-Ressource (DE-627)364471417 (DE-600)2110535-2 (DE-576)272350176 1724-191X nnns volume:104 pages:136-144 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.31 Medizinische Physik AR 104 136-144 |
| spelling |
10.1016/j.ejmp.2022.10.029 doi (DE-627)ELV008918511 (ELSEVIER)S1120-1797(22)02090-7 DE-627 ger DE-627 rda eng 530 610 DE-600 44.31 bkl Baack, Leon verfasserin (orcid)0000-0001-6982-6298 aut Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. FLASH Ultra High Dose Rate (UHDR) Ionisation chamber Beam monitor Recombination Space charge effect Schuy, Christoph verfasserin aut Brons, Stephan verfasserin (orcid)0000-0002-4695-0816 aut Horst, Felix verfasserin (orcid)0000-0003-0707-0856 aut Voss, Bernd verfasserin aut Zink, Klemens verfasserin (orcid)0000-0001-5785-4101 aut Haberer, Thomas verfasserin aut Durante, Marco verfasserin aut Weber, Uli verfasserin (orcid)0000-0002-8147-0084 aut Enthalten in Physica medica Amsterdam : Elsevier, 1996 104, Seite 136-144 Online-Ressource (DE-627)364471417 (DE-600)2110535-2 (DE-576)272350176 1724-191X nnns volume:104 pages:136-144 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.31 Medizinische Physik AR 104 136-144 |
| allfields_unstemmed |
10.1016/j.ejmp.2022.10.029 doi (DE-627)ELV008918511 (ELSEVIER)S1120-1797(22)02090-7 DE-627 ger DE-627 rda eng 530 610 DE-600 44.31 bkl Baack, Leon verfasserin (orcid)0000-0001-6982-6298 aut Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. FLASH Ultra High Dose Rate (UHDR) Ionisation chamber Beam monitor Recombination Space charge effect Schuy, Christoph verfasserin aut Brons, Stephan verfasserin (orcid)0000-0002-4695-0816 aut Horst, Felix verfasserin (orcid)0000-0003-0707-0856 aut Voss, Bernd verfasserin aut Zink, Klemens verfasserin (orcid)0000-0001-5785-4101 aut Haberer, Thomas verfasserin aut Durante, Marco verfasserin aut Weber, Uli verfasserin (orcid)0000-0002-8147-0084 aut Enthalten in Physica medica Amsterdam : Elsevier, 1996 104, Seite 136-144 Online-Ressource (DE-627)364471417 (DE-600)2110535-2 (DE-576)272350176 1724-191X nnns volume:104 pages:136-144 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.31 Medizinische Physik AR 104 136-144 |
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10.1016/j.ejmp.2022.10.029 doi (DE-627)ELV008918511 (ELSEVIER)S1120-1797(22)02090-7 DE-627 ger DE-627 rda eng 530 610 DE-600 44.31 bkl Baack, Leon verfasserin (orcid)0000-0001-6982-6298 aut Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. FLASH Ultra High Dose Rate (UHDR) Ionisation chamber Beam monitor Recombination Space charge effect Schuy, Christoph verfasserin aut Brons, Stephan verfasserin (orcid)0000-0002-4695-0816 aut Horst, Felix verfasserin (orcid)0000-0003-0707-0856 aut Voss, Bernd verfasserin aut Zink, Klemens verfasserin (orcid)0000-0001-5785-4101 aut Haberer, Thomas verfasserin aut Durante, Marco verfasserin aut Weber, Uli verfasserin (orcid)0000-0002-8147-0084 aut Enthalten in Physica medica Amsterdam : Elsevier, 1996 104, Seite 136-144 Online-Ressource (DE-627)364471417 (DE-600)2110535-2 (DE-576)272350176 1724-191X nnns volume:104 pages:136-144 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.31 Medizinische Physik AR 104 136-144 |
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10.1016/j.ejmp.2022.10.029 doi (DE-627)ELV008918511 (ELSEVIER)S1120-1797(22)02090-7 DE-627 ger DE-627 rda eng 530 610 DE-600 44.31 bkl Baack, Leon verfasserin (orcid)0000-0001-6982-6298 aut Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. FLASH Ultra High Dose Rate (UHDR) Ionisation chamber Beam monitor Recombination Space charge effect Schuy, Christoph verfasserin aut Brons, Stephan verfasserin (orcid)0000-0002-4695-0816 aut Horst, Felix verfasserin (orcid)0000-0003-0707-0856 aut Voss, Bernd verfasserin aut Zink, Klemens verfasserin (orcid)0000-0001-5785-4101 aut Haberer, Thomas verfasserin aut Durante, Marco verfasserin aut Weber, Uli verfasserin (orcid)0000-0002-8147-0084 aut Enthalten in Physica medica Amsterdam : Elsevier, 1996 104, Seite 136-144 Online-Ressource (DE-627)364471417 (DE-600)2110535-2 (DE-576)272350176 1724-191X nnns volume:104 pages:136-144 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.31 Medizinische Physik AR 104 136-144 |
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Baack, Leon @@aut@@ Schuy, Christoph @@aut@@ Brons, Stephan @@aut@@ Horst, Felix @@aut@@ Voss, Bernd @@aut@@ Zink, Klemens @@aut@@ Haberer, Thomas @@aut@@ Durante, Marco @@aut@@ Weber, Uli @@aut@@ |
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Baack, Leon ddc 530 bkl 44.31 misc FLASH misc Ultra High Dose Rate (UHDR) misc Ionisation chamber misc Beam monitor misc Recombination misc Space charge effect Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams |
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530 610 DE-600 44.31 bkl Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams FLASH Ultra High Dose Rate (UHDR) Ionisation chamber Beam monitor Recombination Space charge effect |
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Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams |
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Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams |
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Baack, Leon Schuy, Christoph Brons, Stephan Horst, Felix Voss, Bernd Zink, Klemens Haberer, Thomas Durante, Marco Weber, Uli |
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reduction of recombination effects in large plane parallel beam monitors for flash radiotherapy with scanned ion beams |
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Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams |
| abstract |
Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. |
| abstractGer |
Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. |
| abstract_unstemmed |
Purpose:: Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs).Methods:: Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO 2 (80/20) and pure He and also for He/CO 2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO 2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams.Results:: Even at high intensities the He/CO 2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 1010 12 C-ions per second. Our measurements show that added fractions of CO 2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He. |
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Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams |
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Schuy, Christoph Brons, Stephan Horst, Felix Voss, Bernd Zink, Klemens Haberer, Thomas Durante, Marco Weber, Uli |
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