High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer
Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Buckley, Elizabeth [verfasserIn] Mullen, Mary M. [verfasserIn] Nizamuddin, Rehan A. [verfasserIn] Stein, Jonathan H. [verfasserIn] Kuroki, Lindsay M. [verfasserIn] Fuh, Katherine C. [verfasserIn] Hagemann, Andrea R. [verfasserIn] McCourt, Carolyn K. [verfasserIn] Mutch, David [verfasserIn] Khabele, Dineo [verfasserIn] Powell, Matthew A. [verfasserIn] Ippolito, Joseph E. [verfasserIn] Thaker, Premal H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Gynecologic oncology - Orlando, Fla. : Academic Press, 1972, 167 |
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| Übergeordnetes Werk: |
volume:167 |
| DOI / URN: |
10.1016/j.ygyno.2022.09.011 |
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| Katalog-ID: |
ELV008931402 |
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| 024 | 7 | |a 10.1016/j.ygyno.2022.09.011 |2 doi | |
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| 035 | |a (ELSEVIER)S0090-8258(22)01824-8 | ||
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| 100 | 1 | |a Buckley, Elizabeth |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
| 264 | 1 | |c 2022 | |
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| 520 | |a Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. | ||
| 650 | 4 | |a Endometrial cancer | |
| 650 | 4 | |a Body composition | |
| 650 | 4 | |a Computed tomography | |
| 650 | 4 | |a Visceral fat | |
| 650 | 4 | |a Subcutaneous fat | |
| 700 | 1 | |a Mullen, Mary M. |e verfasserin |4 aut | |
| 700 | 1 | |a Nizamuddin, Rehan A. |e verfasserin |4 aut | |
| 700 | 1 | |a Stein, Jonathan H. |e verfasserin |4 aut | |
| 700 | 1 | |a Kuroki, Lindsay M. |e verfasserin |4 aut | |
| 700 | 1 | |a Fuh, Katherine C. |e verfasserin |4 aut | |
| 700 | 1 | |a Hagemann, Andrea R. |e verfasserin |4 aut | |
| 700 | 1 | |a McCourt, Carolyn K. |e verfasserin |4 aut | |
| 700 | 1 | |a Mutch, David |e verfasserin |4 aut | |
| 700 | 1 | |a Khabele, Dineo |e verfasserin |4 aut | |
| 700 | 1 | |a Powell, Matthew A. |e verfasserin |4 aut | |
| 700 | 1 | |a Ippolito, Joseph E. |e verfasserin |4 aut | |
| 700 | 1 | |a Thaker, Premal H. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gynecologic oncology |d Orlando, Fla. : Academic Press, 1972 |g 167 |h Online-Ressource |w (DE-627)266881351 |w (DE-600)1467974-7 |w (DE-576)104193735 |x 1095-6859 |7 nnns |
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2022 |
| allfields |
10.1016/j.ygyno.2022.09.011 doi (DE-627)ELV008931402 (ELSEVIER)S0090-8258(22)01824-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Buckley, Elizabeth verfasserin aut High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat Mullen, Mary M. verfasserin aut Nizamuddin, Rehan A. verfasserin aut Stein, Jonathan H. verfasserin aut Kuroki, Lindsay M. verfasserin aut Fuh, Katherine C. verfasserin aut Hagemann, Andrea R. verfasserin aut McCourt, Carolyn K. verfasserin aut Mutch, David verfasserin aut Khabele, Dineo verfasserin aut Powell, Matthew A. verfasserin aut Ippolito, Joseph E. verfasserin aut Thaker, Premal H. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 167 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:167 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 167 |
| spelling |
10.1016/j.ygyno.2022.09.011 doi (DE-627)ELV008931402 (ELSEVIER)S0090-8258(22)01824-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Buckley, Elizabeth verfasserin aut High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat Mullen, Mary M. verfasserin aut Nizamuddin, Rehan A. verfasserin aut Stein, Jonathan H. verfasserin aut Kuroki, Lindsay M. verfasserin aut Fuh, Katherine C. verfasserin aut Hagemann, Andrea R. verfasserin aut McCourt, Carolyn K. verfasserin aut Mutch, David verfasserin aut Khabele, Dineo verfasserin aut Powell, Matthew A. verfasserin aut Ippolito, Joseph E. verfasserin aut Thaker, Premal H. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 167 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:167 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 167 |
| allfields_unstemmed |
10.1016/j.ygyno.2022.09.011 doi (DE-627)ELV008931402 (ELSEVIER)S0090-8258(22)01824-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Buckley, Elizabeth verfasserin aut High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat Mullen, Mary M. verfasserin aut Nizamuddin, Rehan A. verfasserin aut Stein, Jonathan H. verfasserin aut Kuroki, Lindsay M. verfasserin aut Fuh, Katherine C. verfasserin aut Hagemann, Andrea R. verfasserin aut McCourt, Carolyn K. verfasserin aut Mutch, David verfasserin aut Khabele, Dineo verfasserin aut Powell, Matthew A. verfasserin aut Ippolito, Joseph E. verfasserin aut Thaker, Premal H. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 167 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:167 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 167 |
| allfieldsGer |
10.1016/j.ygyno.2022.09.011 doi (DE-627)ELV008931402 (ELSEVIER)S0090-8258(22)01824-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Buckley, Elizabeth verfasserin aut High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat Mullen, Mary M. verfasserin aut Nizamuddin, Rehan A. verfasserin aut Stein, Jonathan H. verfasserin aut Kuroki, Lindsay M. verfasserin aut Fuh, Katherine C. verfasserin aut Hagemann, Andrea R. verfasserin aut McCourt, Carolyn K. verfasserin aut Mutch, David verfasserin aut Khabele, Dineo verfasserin aut Powell, Matthew A. verfasserin aut Ippolito, Joseph E. verfasserin aut Thaker, Premal H. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 167 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:167 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 167 |
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10.1016/j.ygyno.2022.09.011 doi (DE-627)ELV008931402 (ELSEVIER)S0090-8258(22)01824-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Buckley, Elizabeth verfasserin aut High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat Mullen, Mary M. verfasserin aut Nizamuddin, Rehan A. verfasserin aut Stein, Jonathan H. verfasserin aut Kuroki, Lindsay M. verfasserin aut Fuh, Katherine C. verfasserin aut Hagemann, Andrea R. verfasserin aut McCourt, Carolyn K. verfasserin aut Mutch, David verfasserin aut Khabele, Dineo verfasserin aut Powell, Matthew A. verfasserin aut Ippolito, Joseph E. verfasserin aut Thaker, Premal H. verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 167 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:167 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 167 |
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Enthalten in Gynecologic oncology 167 volume:167 |
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Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat |
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Buckley, Elizabeth @@aut@@ Mullen, Mary M. @@aut@@ Nizamuddin, Rehan A. @@aut@@ Stein, Jonathan H. @@aut@@ Kuroki, Lindsay M. @@aut@@ Fuh, Katherine C. @@aut@@ Hagemann, Andrea R. @@aut@@ McCourt, Carolyn K. @@aut@@ Mutch, David @@aut@@ Khabele, Dineo @@aut@@ Powell, Matthew A. @@aut@@ Ippolito, Joseph E. @@aut@@ Thaker, Premal H. @@aut@@ |
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2022-01-01T00:00:00Z |
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Buckley, Elizabeth |
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Buckley, Elizabeth ddc 610 bkl 44.81 bkl 44.92 misc Endometrial cancer misc Body composition misc Computed tomography misc Visceral fat misc Subcutaneous fat High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
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610 DE-600 44.81 bkl 44.92 bkl High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer Endometrial cancer Body composition Computed tomography Visceral fat Subcutaneous fat |
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ddc 610 bkl 44.81 bkl 44.92 misc Endometrial cancer misc Body composition misc Computed tomography misc Visceral fat misc Subcutaneous fat |
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High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
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High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
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Buckley, Elizabeth Mullen, Mary M. Nizamuddin, Rehan A. Stein, Jonathan H. Kuroki, Lindsay M. Fuh, Katherine C. Hagemann, Andrea R. McCourt, Carolyn K. Mutch, David Khabele, Dineo Powell, Matthew A. Ippolito, Joseph E. Thaker, Premal H. |
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10.1016/j.ygyno.2022.09.011 |
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high visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
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High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
| abstract |
Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. |
| abstractGer |
Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. |
| abstract_unstemmed |
Objectives: Visceral adiposity has been established as a predictor of outcomes in various cancers. We aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer.Methods: A retrospective review of patients with stage III-IV endometrial cancer who underwent surgery between 2004 and 2014 was performed. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT;VAT+SAT) were assessed on preoperative computed tomography (CT) scans. Exploratory analysis was performed to establish the optimal cut-off values for VAT, SAT, and TAT to identify patients with poor prognostic body composition. Survival rates were analyzed using Kaplan-Meier analysis, log-rank tests, and cox-regression.Results: Eighty-three patients were included. Forty-two (51%) patients had a low VAT/SAT ratio (<0.45) and 41 (49.4%) had a high VAT/SAT ratio (>0.45). There were no significant differences in demographics between the groups. The mean VAT, SAT, and TAT were 176.3 cm2, 379.3 cm2, and 555.3 cm2 respectively. Compared to patients with low VAT/SAT ratios, patients with high VAT/SAT ratios had a shorter recurrence-free survival (median 29.6 vs 32.3 months, P = 0.01) and shorter overall survival (median 56 vs 93.7 months, P = 0.03).Conclusions: Visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival. Future studies should be pursued to identify potential therapeutic targets and biological mechanisms that underlie obesity's relationship with endometrial cancer. |
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| title_short |
High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer |
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Mullen, Mary M. Nizamuddin, Rehan A. Stein, Jonathan H. Kuroki, Lindsay M. Fuh, Katherine C. Hagemann, Andrea R. McCourt, Carolyn K. Mutch, David Khabele, Dineo Powell, Matthew A. Ippolito, Joseph E. Thaker, Premal H. |
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| score |
7.4002924 |