DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler

In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the cent...
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Gespeichert in:

Autor*in:	Alfano, Francesca Orsola [verfasserIn] Sommerfeld, Martin [verfasserIn] Di Maio, Francesco Paolo [verfasserIn] Di Renzo, Alberto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler

Übergeordnetes Werk:	Enthalten in: Advanced powder technology - Amsterdam [u.a.] : Elsevier, 1990, 33
Übergeordnetes Werk:	volume:33

DOI / URN:	10.1016/j.apt.2022.103853

Katalog-ID:	ELV008956200

Internformat


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520			\|a In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls.
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publishDate	2022
allfields	10.1016/j.apt.2022.103853 doi (DE-627)ELV008956200 (ELSEVIER)S0921-8831(22)00432-0 DE-627 ger DE-627 rda eng 670 DE-600 52.77 bkl Alfano, Francesca Orsola verfasserin aut DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls. Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler Sommerfeld, Martin verfasserin aut Di Maio, Francesco Paolo verfasserin aut Di Renzo, Alberto verfasserin aut Enthalten in Advanced powder technology Amsterdam [u.a.] : Elsevier, 1990 33 Online-Ressource (DE-627)324914989 (DE-600)2032425-X (DE-576)252680197 1568-5527 nnns volume:33 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 52.77 Urformen AR 33
spelling	10.1016/j.apt.2022.103853 doi (DE-627)ELV008956200 (ELSEVIER)S0921-8831(22)00432-0 DE-627 ger DE-627 rda eng 670 DE-600 52.77 bkl Alfano, Francesca Orsola verfasserin aut DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls. Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler Sommerfeld, Martin verfasserin aut Di Maio, Francesco Paolo verfasserin aut Di Renzo, Alberto verfasserin aut Enthalten in Advanced powder technology Amsterdam [u.a.] : Elsevier, 1990 33 Online-Ressource (DE-627)324914989 (DE-600)2032425-X (DE-576)252680197 1568-5527 nnns volume:33 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 52.77 Urformen AR 33
allfields_unstemmed	10.1016/j.apt.2022.103853 doi (DE-627)ELV008956200 (ELSEVIER)S0921-8831(22)00432-0 DE-627 ger DE-627 rda eng 670 DE-600 52.77 bkl Alfano, Francesca Orsola verfasserin aut DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls. Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler Sommerfeld, Martin verfasserin aut Di Maio, Francesco Paolo verfasserin aut Di Renzo, Alberto verfasserin aut Enthalten in Advanced powder technology Amsterdam [u.a.] : Elsevier, 1990 33 Online-Ressource (DE-627)324914989 (DE-600)2032425-X (DE-576)252680197 1568-5527 nnns volume:33 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 52.77 Urformen AR 33
allfieldsGer	10.1016/j.apt.2022.103853 doi (DE-627)ELV008956200 (ELSEVIER)S0921-8831(22)00432-0 DE-627 ger DE-627 rda eng 670 DE-600 52.77 bkl Alfano, Francesca Orsola verfasserin aut DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls. Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler Sommerfeld, Martin verfasserin aut Di Maio, Francesco Paolo verfasserin aut Di Renzo, Alberto verfasserin aut Enthalten in Advanced powder technology Amsterdam [u.a.] : Elsevier, 1990 33 Online-Ressource (DE-627)324914989 (DE-600)2032425-X (DE-576)252680197 1568-5527 nnns volume:33 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 52.77 Urformen AR 33
allfieldsSound	10.1016/j.apt.2022.103853 doi (DE-627)ELV008956200 (ELSEVIER)S0921-8831(22)00432-0 DE-627 ger DE-627 rda eng 670 DE-600 52.77 bkl Alfano, Francesca Orsola verfasserin aut DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls. Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler Sommerfeld, Martin verfasserin aut Di Maio, Francesco Paolo verfasserin aut Di Renzo, Alberto verfasserin aut Enthalten in Advanced powder technology Amsterdam [u.a.] : Elsevier, 1990 33 Online-Ressource (DE-627)324914989 (DE-600)2032425-X (DE-576)252680197 1568-5527 nnns volume:33 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 52.77 Urformen AR 33
language	English
source	Enthalten in Advanced powder technology 33 volume:33
sourceStr	Enthalten in Advanced powder technology 33 volume:33
format_phy_str_mv	Article
bklname	Urformen
institution	findex.gbv.de
topic_facet	Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler
dewey-raw	670
isfreeaccess_bool	false
container_title	Advanced powder technology
authorswithroles_txt_mv	Alfano, Francesca Orsola @@aut@@ Sommerfeld, Martin @@aut@@ Di Maio, Francesco Paolo @@aut@@ Di Renzo, Alberto @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	324914989
dewey-sort	3670
id	ELV008956200
language_de	englisch
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author	Alfano, Francesca Orsola
spellingShingle	Alfano, Francesca Orsola ddc 670 bkl 52.77 misc Simulation misc DEM misc Pharmaceutical powders misc Dry coating misc Dry Powder Inhaler DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler
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topic_title	670 DE-600 52.77 bkl DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler Simulation DEM Pharmaceutical powders Dry coating Dry Powder Inhaler
topic	ddc 670 bkl 52.77 misc Simulation misc DEM misc Pharmaceutical powders misc Dry coating misc Dry Powder Inhaler
topic_unstemmed	ddc 670 bkl 52.77 misc Simulation misc DEM misc Pharmaceutical powders misc Dry coating misc Dry Powder Inhaler
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title	DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler
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title_full	DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler
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title_sort	dem analysis of powder deaggregation and discharge from the capsule of a carrier-based dry powder inhaler
title_auth	DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler
abstract	In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls.
abstractGer	In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls.
abstract_unstemmed	In carrier-based Dry Powder Inhalers (DPI), fine API powder covers the surface of bigger carrier particles giving rise to dry coated particles, such that their flow properties are improved. In the hard-shell capsule of Cyclohaler DPI, powder deaggregation and discharge occurs as a result of the centrifugal motion and the subsequent aerodispersion to the mouthpiece induced by the patient’s inhalation. In this work, the crucial initial transient of this dispersion process was analysed through DEM (Discrete Element Method) simulations, by considering the solid phase only. The accelerated rotational motion of the capsule was simulated in the frame of reference of an observer rotating with the capsule, appropriately considering fictitious forces. The effect of the vibrations due to collisions between the capsule and the inhaler on powder discharge was evaluated as well for carrier particle systems. The results provide a punctual mapping of the particle-wall collisions within the capsule, allowing the path of the solids to be tracked until discharge. Simulations were carried out on drug-carrier blends with extreme size difference, considering adhesive interactions, elucidating the early-stage dynamics of the detachment process that occurs inside the capsule due to the interactions between particles and between particles and walls.
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title_short	DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler
remote_bool	true
author2	Sommerfeld, Martin Di Maio, Francesco Paolo Di Renzo, Alberto
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doi_str	10.1016/j.apt.2022.103853
up_date	2024-07-06T21:29:10.437Z
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DEM analysis of powder deaggregation and discharge from the capsule of a carrier-based Dry Powder Inhaler

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