Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis

Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum am...
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Autor*in:	Malézieux-Picard, Astrid [verfasserIn] Nascè, Alberto [verfasserIn] Azurmendi, Leire [verfasserIn] Pagano, Sabrina [verfasserIn] Vuilleumier, Nicolas [verfasserIn] Sanchez, Jean-Charles [verfasserIn] Reny, Jean-Luc [verfasserIn] Zekry, Dina [verfasserIn] Roux, Xavier [verfasserIn] Stirnemann, Jérôme [verfasserIn] Garin, Nicolas [verfasserIn] Prendki, Virginie [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality

Übergeordnetes Werk:	Enthalten in: International journal of infectious diseases - Amsterdam [u.a.] : Elsevier, 1997, 122, Seite 63-69
Übergeordnetes Werk:	volume:122 ; pages:63-69

DOI / URN:	10.1016/j.ijid.2022.05.002

Katalog-ID:	ELV008956995

Internformat


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100	1		\|a Malézieux-Picard, Astrid \|e verfasserin \|0 (orcid)0000-0001-8021-8787 \|4 aut
245	1	0	\|a Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
264		1	\|c 2022
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
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520			\|a Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality.
650		4	\|a Pneumonia
650		4	\|a Elderly
650		4	\|a Biomarkers
650		4	\|a CRP
650		4	\|a IL-8
650		4	\|a Long-term mortality
700	1		\|a Nascè, Alberto \|e verfasserin \|4 aut
700	1		\|a Azurmendi, Leire \|e verfasserin \|4 aut
700	1		\|a Pagano, Sabrina \|e verfasserin \|0 (orcid)0000-0001-7075-1182 \|4 aut
700	1		\|a Vuilleumier, Nicolas \|e verfasserin \|4 aut
700	1		\|a Sanchez, Jean-Charles \|e verfasserin \|4 aut
700	1		\|a Reny, Jean-Luc \|e verfasserin \|4 aut
700	1		\|a Zekry, Dina \|e verfasserin \|0 (orcid)0000-0002-6263-7803 \|4 aut
700	1		\|a Roux, Xavier \|e verfasserin \|0 (orcid)0000-0003-4356-1898 \|4 aut
700	1		\|a Stirnemann, Jérôme \|e verfasserin \|0 (orcid)0000-0001-9964-4452 \|4 aut
700	1		\|a Garin, Nicolas \|e verfasserin \|4 aut
700	1		\|a Prendki, Virginie \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t International journal of infectious diseases \|d Amsterdam [u.a.] : Elsevier, 1997 \|g 122, Seite 63-69 \|h Online-Ressource \|w (DE-627)341907669 \|w (DE-600)2070533-5 \|w (DE-576)271360844 \|x 1878-3511 \|7 nnns
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912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
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912			\|a GBV_ILN_2059
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912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
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912			\|a GBV_ILN_2336
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912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4012
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912			\|a GBV_ILN_4126
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951			\|a AR
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allfields	10.1016/j.ijid.2022.05.002 doi (DE-627)ELV008956995 (ELSEVIER)S1201-9712(22)00265-X DE-627 ger DE-627 rda eng 610 VZ 44.75 bkl Malézieux-Picard, Astrid verfasserin (orcid)0000-0001-8021-8787 aut Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality. Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality Nascè, Alberto verfasserin aut Azurmendi, Leire verfasserin aut Pagano, Sabrina verfasserin (orcid)0000-0001-7075-1182 aut Vuilleumier, Nicolas verfasserin aut Sanchez, Jean-Charles verfasserin aut Reny, Jean-Luc verfasserin aut Zekry, Dina verfasserin (orcid)0000-0002-6263-7803 aut Roux, Xavier verfasserin (orcid)0000-0003-4356-1898 aut Stirnemann, Jérôme verfasserin (orcid)0000-0001-9964-4452 aut Garin, Nicolas verfasserin aut Prendki, Virginie verfasserin aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 122, Seite 63-69 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:122 pages:63-69 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 122 63-69
spelling	10.1016/j.ijid.2022.05.002 doi (DE-627)ELV008956995 (ELSEVIER)S1201-9712(22)00265-X DE-627 ger DE-627 rda eng 610 VZ 44.75 bkl Malézieux-Picard, Astrid verfasserin (orcid)0000-0001-8021-8787 aut Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality. Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality Nascè, Alberto verfasserin aut Azurmendi, Leire verfasserin aut Pagano, Sabrina verfasserin (orcid)0000-0001-7075-1182 aut Vuilleumier, Nicolas verfasserin aut Sanchez, Jean-Charles verfasserin aut Reny, Jean-Luc verfasserin aut Zekry, Dina verfasserin (orcid)0000-0002-6263-7803 aut Roux, Xavier verfasserin (orcid)0000-0003-4356-1898 aut Stirnemann, Jérôme verfasserin (orcid)0000-0001-9964-4452 aut Garin, Nicolas verfasserin aut Prendki, Virginie verfasserin aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 122, Seite 63-69 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:122 pages:63-69 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 122 63-69
allfields_unstemmed	10.1016/j.ijid.2022.05.002 doi (DE-627)ELV008956995 (ELSEVIER)S1201-9712(22)00265-X DE-627 ger DE-627 rda eng 610 VZ 44.75 bkl Malézieux-Picard, Astrid verfasserin (orcid)0000-0001-8021-8787 aut Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality. Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality Nascè, Alberto verfasserin aut Azurmendi, Leire verfasserin aut Pagano, Sabrina verfasserin (orcid)0000-0001-7075-1182 aut Vuilleumier, Nicolas verfasserin aut Sanchez, Jean-Charles verfasserin aut Reny, Jean-Luc verfasserin aut Zekry, Dina verfasserin (orcid)0000-0002-6263-7803 aut Roux, Xavier verfasserin (orcid)0000-0003-4356-1898 aut Stirnemann, Jérôme verfasserin (orcid)0000-0001-9964-4452 aut Garin, Nicolas verfasserin aut Prendki, Virginie verfasserin aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 122, Seite 63-69 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:122 pages:63-69 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 122 63-69
allfieldsGer	10.1016/j.ijid.2022.05.002 doi (DE-627)ELV008956995 (ELSEVIER)S1201-9712(22)00265-X DE-627 ger DE-627 rda eng 610 VZ 44.75 bkl Malézieux-Picard, Astrid verfasserin (orcid)0000-0001-8021-8787 aut Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality. Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality Nascè, Alberto verfasserin aut Azurmendi, Leire verfasserin aut Pagano, Sabrina verfasserin (orcid)0000-0001-7075-1182 aut Vuilleumier, Nicolas verfasserin aut Sanchez, Jean-Charles verfasserin aut Reny, Jean-Luc verfasserin aut Zekry, Dina verfasserin (orcid)0000-0002-6263-7803 aut Roux, Xavier verfasserin (orcid)0000-0003-4356-1898 aut Stirnemann, Jérôme verfasserin (orcid)0000-0001-9964-4452 aut Garin, Nicolas verfasserin aut Prendki, Virginie verfasserin aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 122, Seite 63-69 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:122 pages:63-69 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 122 63-69
allfieldsSound	10.1016/j.ijid.2022.05.002 doi (DE-627)ELV008956995 (ELSEVIER)S1201-9712(22)00265-X DE-627 ger DE-627 rda eng 610 VZ 44.75 bkl Malézieux-Picard, Astrid verfasserin (orcid)0000-0001-8021-8787 aut Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality. Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality Nascè, Alberto verfasserin aut Azurmendi, Leire verfasserin aut Pagano, Sabrina verfasserin (orcid)0000-0001-7075-1182 aut Vuilleumier, Nicolas verfasserin aut Sanchez, Jean-Charles verfasserin aut Reny, Jean-Luc verfasserin aut Zekry, Dina verfasserin (orcid)0000-0002-6263-7803 aut Roux, Xavier verfasserin (orcid)0000-0003-4356-1898 aut Stirnemann, Jérôme verfasserin (orcid)0000-0001-9964-4452 aut Garin, Nicolas verfasserin aut Prendki, Virginie verfasserin aut Enthalten in International journal of infectious diseases Amsterdam [u.a.] : Elsevier, 1997 122, Seite 63-69 Online-Ressource (DE-627)341907669 (DE-600)2070533-5 (DE-576)271360844 1878-3511 nnns volume:122 pages:63-69 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin VZ AR 122 63-69
language	English
source	Enthalten in International journal of infectious diseases 122, Seite 63-69 volume:122 pages:63-69
sourceStr	Enthalten in International journal of infectious diseases 122, Seite 63-69 volume:122 pages:63-69
format_phy_str_mv	Article
bklname	Infektionskrankheiten parasitäre Krankheiten
institution	findex.gbv.de
topic_facet	Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality
dewey-raw	610
isfreeaccess_bool	false
container_title	International journal of infectious diseases
authorswithroles_txt_mv	Malézieux-Picard, Astrid @@aut@@ Nascè, Alberto @@aut@@ Azurmendi, Leire @@aut@@ Pagano, Sabrina @@aut@@ Vuilleumier, Nicolas @@aut@@ Sanchez, Jean-Charles @@aut@@ Reny, Jean-Luc @@aut@@ Zekry, Dina @@aut@@ Roux, Xavier @@aut@@ Stirnemann, Jérôme @@aut@@ Garin, Nicolas @@aut@@ Prendki, Virginie @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	341907669
dewey-sort	3610
id	ELV008956995
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008956995</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230928075044.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230509s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijid.2022.05.002</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008956995</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1201-9712(22)00265-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.75</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Malézieux-Picard, Astrid</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-8021-8787</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. 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author	Malézieux-Picard, Astrid
spellingShingle	Malézieux-Picard, Astrid ddc 610 bkl 44.75 misc Pneumonia misc Elderly misc Biomarkers misc CRP misc IL-8 misc Long-term mortality Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
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topic_title	610 VZ 44.75 bkl Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis Pneumonia Elderly Biomarkers CRP IL-8 Long-term mortality
topic	ddc 610 bkl 44.75 misc Pneumonia misc Elderly misc Biomarkers misc CRP misc IL-8 misc Long-term mortality
topic_unstemmed	ddc 610 bkl 44.75 misc Pneumonia misc Elderly misc Biomarkers misc CRP misc IL-8 misc Long-term mortality
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title	Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
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title_full	Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
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author_browse	Malézieux-Picard, Astrid Nascè, Alberto Azurmendi, Leire Pagano, Sabrina Vuilleumier, Nicolas Sanchez, Jean-Charles Reny, Jean-Luc Zekry, Dina Roux, Xavier Stirnemann, Jérôme Garin, Nicolas Prendki, Virginie
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title_sort	kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
title_auth	Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
abstract	Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality.
abstractGer	Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality.
abstract_unstemmed	Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. The relative CRP difference during hospitalization was the best individual biomarker for predicting one-year mortality.
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title_short	Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis
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author2	Nascè, Alberto Azurmendi, Leire Pagano, Sabrina Vuilleumier, Nicolas Sanchez, Jean-Charles Reny, Jean-Luc Zekry, Dina Roux, Xavier Stirnemann, Jérôme Garin, Nicolas Prendki, Virginie
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up_date	2024-07-06T21:29:20.553Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV008956995</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230928075044.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230509s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijid.2022.05.002</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV008956995</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1201-9712(22)00265-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.75</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Malézieux-Picard, Astrid</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-8021-8787</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives: Long-term mortality is increased in older patients with pneumonia. We aimed to test whether residual inflammation is predictive of one-year mortality after pneumonia.Methods: Inflammation biomarkers (C-reactive protein [CRP], interleukin [IL]-6 and IL-8, tumor necrosis factor–α, serum amyloid A, neopterin, myeloperoxidase, anti-apolipoprotein A-1, and anti-phosphorylcholine IgM) were measured at admission and discharge in older patients hospitalized for pneumonia in a prospective study. Univariate and multivariate analyses were conducted using absolute level at discharge and relative and absolute differences between admission and discharge for all biomarkers, along with usual prognostic factors.Results: In the 133 included patients (median age, 83 years [interquartile range: 78–89]), one-year mortality was 26%. In univariate analysis, the relative difference of CRP levels had the highest area under the receiver operating characteristic curve (0.70; 95% confidence interval [CI] 0.60–0.80). A decrease of CRP levels of more than 67% between admission and discharge had 68% sensitivity and 68% specificity to predict survival. In multivariate analysis, lower body mass index (hazard ratio=0.87 [CI 95% 0.79–0.96], P-value=0.01), higher IL-8 (hazard ratio=1.02 [CI 95% 1.00–1.04], P-value=0.02), and higher CRP (1.01 [95% CI 1.00–1.02], P=0.01) at discharge were independently associated with mortality.Conclusion: Higher IL-8 and CRP levels at discharge were independently associated with one-year mortality. 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Kinetics of inflammatory biomarkers to predict one-year mortality in older patients hospitalized for pneumonia: a multivariable analysis

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