Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply

Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provinci...
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Autor*in:	Delaney, Sarah R. [verfasserIn] Konforte, Danijela [verfasserIn] Stefan, Cristiana [verfasserIn] Palaty, Jan [verfasserIn] Sun, Difei [verfasserIn] McDonald, Karen [verfasserIn] Thompson, Hayley [verfasserIn] Werb, Dan [verfasserIn] Beriault, Daniel R. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS

Übergeordnetes Werk:	Enthalten in: Clinical biochemistry - Amsterdam [u.a.] : Elsevier Science, 1967, 111, Seite 11-16
Übergeordnetes Werk:	volume:111 ; pages:11-16

DOI / URN:	10.1016/j.clinbiochem.2022.11.003

Katalog-ID:	ELV009018344

Internformat


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100	1		\|a Delaney, Sarah R. \|e verfasserin \|4 aut
245	1	0	\|a Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply
264		1	\|c 2022
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520			\|a Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care.
650		4	\|a Clinical toxicology
650		4	\|a Unregulated drugs
650		4	\|a Urine drug testing
650		4	\|a GC–MS
650		4	\|a LC-HRMS
700	1		\|a Konforte, Danijela \|e verfasserin \|4 aut
700	1		\|a Stefan, Cristiana \|e verfasserin \|4 aut
700	1		\|a Palaty, Jan \|e verfasserin \|4 aut
700	1		\|a Sun, Difei \|e verfasserin \|4 aut
700	1		\|a McDonald, Karen \|e verfasserin \|4 aut
700	1		\|a Thompson, Hayley \|e verfasserin \|4 aut
700	1		\|a Werb, Dan \|e verfasserin \|4 aut
700	1		\|a Beriault, Daniel R. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Clinical biochemistry \|d Amsterdam [u.a.] : Elsevier Science, 1967 \|g 111, Seite 11-16 \|h Online-Ressource \|w (DE-627)306354764 \|w (DE-600)1496880-0 \|w (DE-576)094107882 \|x 1873-2933 \|7 nnns
773	1	8	\|g volume:111 \|g pages:11-16
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912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
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936	b	k	\|a 35.70 \|j Biochemie: Allgemeines
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952			\|d 111 \|h 11-16

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publishDate	2022
allfields	10.1016/j.clinbiochem.2022.11.003 doi (DE-627)ELV009018344 (ELSEVIER)S0009-9120(22)00240-5 DE-627 ger DE-627 rda eng 540 DE-600 35.70 bkl Delaney, Sarah R. verfasserin aut Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care. Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS Konforte, Danijela verfasserin aut Stefan, Cristiana verfasserin aut Palaty, Jan verfasserin aut Sun, Difei verfasserin aut McDonald, Karen verfasserin aut Thompson, Hayley verfasserin aut Werb, Dan verfasserin aut Beriault, Daniel R. verfasserin aut Enthalten in Clinical biochemistry Amsterdam [u.a.] : Elsevier Science, 1967 111, Seite 11-16 Online-Ressource (DE-627)306354764 (DE-600)1496880-0 (DE-576)094107882 1873-2933 nnns volume:111 pages:11-16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines AR 111 11-16
spelling	10.1016/j.clinbiochem.2022.11.003 doi (DE-627)ELV009018344 (ELSEVIER)S0009-9120(22)00240-5 DE-627 ger DE-627 rda eng 540 DE-600 35.70 bkl Delaney, Sarah R. verfasserin aut Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care. Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS Konforte, Danijela verfasserin aut Stefan, Cristiana verfasserin aut Palaty, Jan verfasserin aut Sun, Difei verfasserin aut McDonald, Karen verfasserin aut Thompson, Hayley verfasserin aut Werb, Dan verfasserin aut Beriault, Daniel R. verfasserin aut Enthalten in Clinical biochemistry Amsterdam [u.a.] : Elsevier Science, 1967 111, Seite 11-16 Online-Ressource (DE-627)306354764 (DE-600)1496880-0 (DE-576)094107882 1873-2933 nnns volume:111 pages:11-16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines AR 111 11-16
allfields_unstemmed	10.1016/j.clinbiochem.2022.11.003 doi (DE-627)ELV009018344 (ELSEVIER)S0009-9120(22)00240-5 DE-627 ger DE-627 rda eng 540 DE-600 35.70 bkl Delaney, Sarah R. verfasserin aut Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care. Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS Konforte, Danijela verfasserin aut Stefan, Cristiana verfasserin aut Palaty, Jan verfasserin aut Sun, Difei verfasserin aut McDonald, Karen verfasserin aut Thompson, Hayley verfasserin aut Werb, Dan verfasserin aut Beriault, Daniel R. verfasserin aut Enthalten in Clinical biochemistry Amsterdam [u.a.] : Elsevier Science, 1967 111, Seite 11-16 Online-Ressource (DE-627)306354764 (DE-600)1496880-0 (DE-576)094107882 1873-2933 nnns volume:111 pages:11-16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines AR 111 11-16
allfieldsGer	10.1016/j.clinbiochem.2022.11.003 doi (DE-627)ELV009018344 (ELSEVIER)S0009-9120(22)00240-5 DE-627 ger DE-627 rda eng 540 DE-600 35.70 bkl Delaney, Sarah R. verfasserin aut Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care. Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS Konforte, Danijela verfasserin aut Stefan, Cristiana verfasserin aut Palaty, Jan verfasserin aut Sun, Difei verfasserin aut McDonald, Karen verfasserin aut Thompson, Hayley verfasserin aut Werb, Dan verfasserin aut Beriault, Daniel R. verfasserin aut Enthalten in Clinical biochemistry Amsterdam [u.a.] : Elsevier Science, 1967 111, Seite 11-16 Online-Ressource (DE-627)306354764 (DE-600)1496880-0 (DE-576)094107882 1873-2933 nnns volume:111 pages:11-16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines AR 111 11-16
allfieldsSound	10.1016/j.clinbiochem.2022.11.003 doi (DE-627)ELV009018344 (ELSEVIER)S0009-9120(22)00240-5 DE-627 ger DE-627 rda eng 540 DE-600 35.70 bkl Delaney, Sarah R. verfasserin aut Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care. Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS Konforte, Danijela verfasserin aut Stefan, Cristiana verfasserin aut Palaty, Jan verfasserin aut Sun, Difei verfasserin aut McDonald, Karen verfasserin aut Thompson, Hayley verfasserin aut Werb, Dan verfasserin aut Beriault, Daniel R. verfasserin aut Enthalten in Clinical biochemistry Amsterdam [u.a.] : Elsevier Science, 1967 111, Seite 11-16 Online-Ressource (DE-627)306354764 (DE-600)1496880-0 (DE-576)094107882 1873-2933 nnns volume:111 pages:11-16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines AR 111 11-16
language	English
source	Enthalten in Clinical biochemistry 111, Seite 11-16 volume:111 pages:11-16
sourceStr	Enthalten in Clinical biochemistry 111, Seite 11-16 volume:111 pages:11-16
format_phy_str_mv	Article
bklname	Biochemie: Allgemeines
institution	findex.gbv.de
topic_facet	Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS
dewey-raw	540
isfreeaccess_bool	false
container_title	Clinical biochemistry
authorswithroles_txt_mv	Delaney, Sarah R. @@aut@@ Konforte, Danijela @@aut@@ Stefan, Cristiana @@aut@@ Palaty, Jan @@aut@@ Sun, Difei @@aut@@ McDonald, Karen @@aut@@ Thompson, Hayley @@aut@@ Werb, Dan @@aut@@ Beriault, Daniel R. @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	306354764
dewey-sort	3540
id	ELV009018344
language_de	englisch
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author	Delaney, Sarah R.
spellingShingle	Delaney, Sarah R. ddc 540 bkl 35.70 misc Clinical toxicology misc Unregulated drugs misc Urine drug testing misc GC–MS misc LC-HRMS Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply
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topic_title	540 DE-600 35.70 bkl Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply Clinical toxicology Unregulated drugs Urine drug testing GC–MS LC-HRMS
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title	Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply
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title_full	Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply
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author_browse	Delaney, Sarah R. Konforte, Danijela Stefan, Cristiana Palaty, Jan Sun, Difei McDonald, Karen Thompson, Hayley Werb, Dan Beriault, Daniel R.
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title_sort	drug checking services as a surveillance tool for clinical laboratories: examining trends in the unregulated fentanyl supply
title_auth	Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply
abstract	Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care.
abstractGer	Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care.
abstract_unstemmed	Objectives: Timely assessment and understanding of drug trends is essential for clinical laboratories to effectively respond to the overdose epidemic. In this proof-of-concept study, we sought to determine whether information obtained through Toronto’s Drug Checking Services (DCS) and cross-provincial urine drug testing (UDT) data can be used as a surveillance tool for clinical laboratories and discuss the value of collaboration between the clinical laboratory, clinicians, and community partners to optimize patient care.Design & Methods: Mass spectrometry-based UDT data from LifeLabs Ontario (n = 127,529) and British Columbia (n = 14,848), and drug checking data from Toronto DCS (n = 3,308 drugs or used paraphernalia) was collected between August 2020 and October 2021. Fentanyl co-positivity with toxic adulterants such as benzodiazepine-related drugs and fentanyl analogues were examined.Results: The percent co-positivity of fentanyl with etizolam, flualprazolam, flubromazolam, carfentanil, and acetylfentanyl in both Ontario UDT and DCS drugs/used paraphernalia showed similar trends. Regional differences in co-positivity with etizolam and fentanyl analogues were noted between Ontario and British Columbia UDT with patterns consistent over the entire 15-month collection period.Conclusions: Clinical laboratories should connect with their local DCS, if available, to understand and monitor unregulated drug trends. These data can be used as an important tool to help clinical laboratories tailor their UDT menus and thereby provide a community-focused service to improve patient care.
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title_short	Drug checking services as a surveillance tool for clinical laboratories: Examining trends in the unregulated fentanyl supply
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author2	Konforte, Danijela Stefan, Cristiana Palaty, Jan Sun, Difei McDonald, Karen Thompson, Hayley Werb, Dan Beriault, Daniel R.
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up_date	2024-07-06T21:42:16.326Z
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