Effects of anti-ulcer drugs on delirium in trauma patients

Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the...
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Autor*in:	Sogawa, Rintaro [verfasserIn] Matsuoka, Ayaka [verfasserIn] Murakawa-Hirachi, Toru [verfasserIn] Kikkawa, Nao [verfasserIn] Kamo, Masahiro [verfasserIn] Tobita, Shuko [verfasserIn] Shinada, Kota [verfasserIn] Mizoguchi, Yoshito [verfasserIn] Monji, Akira [verfasserIn] Sakamoto, Yuichiro [verfasserIn] Shimanoe, Chisato [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Delirium Histamine-2 receptor antagonist Proton pump inhibitor

Übergeordnetes Werk:	Enthalten in: General hospital psychiatry - Amsterdam [u.a.] : Elsevier Science, 1979, 80, Seite 43-47
Übergeordnetes Werk:	volume:80 ; pages:43-47

DOI / URN:	10.1016/j.genhosppsych.2022.12.007

Katalog-ID:	ELV009113614

Internformat


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245	1	0	\|a Effects of anti-ulcer drugs on delirium in trauma patients
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520			\|a Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection.
650		4	\|a Delirium
650		4	\|a Histamine-2 receptor antagonist
650		4	\|a Proton pump inhibitor
700	1		\|a Matsuoka, Ayaka \|e verfasserin \|4 aut
700	1		\|a Murakawa-Hirachi, Toru \|e verfasserin \|4 aut
700	1		\|a Kikkawa, Nao \|e verfasserin \|4 aut
700	1		\|a Kamo, Masahiro \|e verfasserin \|4 aut
700	1		\|a Tobita, Shuko \|e verfasserin \|4 aut
700	1		\|a Shinada, Kota \|e verfasserin \|4 aut
700	1		\|a Mizoguchi, Yoshito \|e verfasserin \|4 aut
700	1		\|a Monji, Akira \|e verfasserin \|4 aut
700	1		\|a Sakamoto, Yuichiro \|e verfasserin \|4 aut
700	1		\|a Shimanoe, Chisato \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t General hospital psychiatry \|d Amsterdam [u.a.] : Elsevier Science, 1979 \|g 80, Seite 43-47 \|h Online-Ressource \|w (DE-627)32045276X \|w (DE-600)2006259-X \|w (DE-576)259983748 \|x 1873-7714 \|7 nnns
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912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
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912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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912			\|a GBV_ILN_4393
936	b	k	\|a 44.91 \|j Psychiatrie \|j Psychopathologie
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publishDate	2022
allfields	10.1016/j.genhosppsych.2022.12.007 doi (DE-627)ELV009113614 (ELSEVIER)S0163-8343(22)00149-9 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Sogawa, Rintaro verfasserin aut Effects of anti-ulcer drugs on delirium in trauma patients 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection. Delirium Histamine-2 receptor antagonist Proton pump inhibitor Matsuoka, Ayaka verfasserin aut Murakawa-Hirachi, Toru verfasserin aut Kikkawa, Nao verfasserin aut Kamo, Masahiro verfasserin aut Tobita, Shuko verfasserin aut Shinada, Kota verfasserin aut Mizoguchi, Yoshito verfasserin aut Monji, Akira verfasserin aut Sakamoto, Yuichiro verfasserin aut Shimanoe, Chisato verfasserin aut Enthalten in General hospital psychiatry Amsterdam [u.a.] : Elsevier Science, 1979 80, Seite 43-47 Online-Ressource (DE-627)32045276X (DE-600)2006259-X (DE-576)259983748 1873-7714 nnns volume:80 pages:43-47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 80 43-47
spelling	10.1016/j.genhosppsych.2022.12.007 doi (DE-627)ELV009113614 (ELSEVIER)S0163-8343(22)00149-9 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Sogawa, Rintaro verfasserin aut Effects of anti-ulcer drugs on delirium in trauma patients 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection. Delirium Histamine-2 receptor antagonist Proton pump inhibitor Matsuoka, Ayaka verfasserin aut Murakawa-Hirachi, Toru verfasserin aut Kikkawa, Nao verfasserin aut Kamo, Masahiro verfasserin aut Tobita, Shuko verfasserin aut Shinada, Kota verfasserin aut Mizoguchi, Yoshito verfasserin aut Monji, Akira verfasserin aut Sakamoto, Yuichiro verfasserin aut Shimanoe, Chisato verfasserin aut Enthalten in General hospital psychiatry Amsterdam [u.a.] : Elsevier Science, 1979 80, Seite 43-47 Online-Ressource (DE-627)32045276X (DE-600)2006259-X (DE-576)259983748 1873-7714 nnns volume:80 pages:43-47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 80 43-47
allfields_unstemmed	10.1016/j.genhosppsych.2022.12.007 doi (DE-627)ELV009113614 (ELSEVIER)S0163-8343(22)00149-9 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Sogawa, Rintaro verfasserin aut Effects of anti-ulcer drugs on delirium in trauma patients 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection. Delirium Histamine-2 receptor antagonist Proton pump inhibitor Matsuoka, Ayaka verfasserin aut Murakawa-Hirachi, Toru verfasserin aut Kikkawa, Nao verfasserin aut Kamo, Masahiro verfasserin aut Tobita, Shuko verfasserin aut Shinada, Kota verfasserin aut Mizoguchi, Yoshito verfasserin aut Monji, Akira verfasserin aut Sakamoto, Yuichiro verfasserin aut Shimanoe, Chisato verfasserin aut Enthalten in General hospital psychiatry Amsterdam [u.a.] : Elsevier Science, 1979 80, Seite 43-47 Online-Ressource (DE-627)32045276X (DE-600)2006259-X (DE-576)259983748 1873-7714 nnns volume:80 pages:43-47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 80 43-47
allfieldsGer	10.1016/j.genhosppsych.2022.12.007 doi (DE-627)ELV009113614 (ELSEVIER)S0163-8343(22)00149-9 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Sogawa, Rintaro verfasserin aut Effects of anti-ulcer drugs on delirium in trauma patients 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection. Delirium Histamine-2 receptor antagonist Proton pump inhibitor Matsuoka, Ayaka verfasserin aut Murakawa-Hirachi, Toru verfasserin aut Kikkawa, Nao verfasserin aut Kamo, Masahiro verfasserin aut Tobita, Shuko verfasserin aut Shinada, Kota verfasserin aut Mizoguchi, Yoshito verfasserin aut Monji, Akira verfasserin aut Sakamoto, Yuichiro verfasserin aut Shimanoe, Chisato verfasserin aut Enthalten in General hospital psychiatry Amsterdam [u.a.] : Elsevier Science, 1979 80, Seite 43-47 Online-Ressource (DE-627)32045276X (DE-600)2006259-X (DE-576)259983748 1873-7714 nnns volume:80 pages:43-47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 80 43-47
allfieldsSound	10.1016/j.genhosppsych.2022.12.007 doi (DE-627)ELV009113614 (ELSEVIER)S0163-8343(22)00149-9 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Sogawa, Rintaro verfasserin aut Effects of anti-ulcer drugs on delirium in trauma patients 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection. Delirium Histamine-2 receptor antagonist Proton pump inhibitor Matsuoka, Ayaka verfasserin aut Murakawa-Hirachi, Toru verfasserin aut Kikkawa, Nao verfasserin aut Kamo, Masahiro verfasserin aut Tobita, Shuko verfasserin aut Shinada, Kota verfasserin aut Mizoguchi, Yoshito verfasserin aut Monji, Akira verfasserin aut Sakamoto, Yuichiro verfasserin aut Shimanoe, Chisato verfasserin aut Enthalten in General hospital psychiatry Amsterdam [u.a.] : Elsevier Science, 1979 80, Seite 43-47 Online-Ressource (DE-627)32045276X (DE-600)2006259-X (DE-576)259983748 1873-7714 nnns volume:80 pages:43-47 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 80 43-47
language	English
source	Enthalten in General hospital psychiatry 80, Seite 43-47 volume:80 pages:43-47
sourceStr	Enthalten in General hospital psychiatry 80, Seite 43-47 volume:80 pages:43-47
format_phy_str_mv	Article
bklname	Psychiatrie Psychopathologie
institution	findex.gbv.de
topic_facet	Delirium Histamine-2 receptor antagonist Proton pump inhibitor
dewey-raw	610
isfreeaccess_bool	false
container_title	General hospital psychiatry
authorswithroles_txt_mv	Sogawa, Rintaro @@aut@@ Matsuoka, Ayaka @@aut@@ Murakawa-Hirachi, Toru @@aut@@ Kikkawa, Nao @@aut@@ Kamo, Masahiro @@aut@@ Tobita, Shuko @@aut@@ Shinada, Kota @@aut@@ Mizoguchi, Yoshito @@aut@@ Monji, Akira @@aut@@ Sakamoto, Yuichiro @@aut@@ Shimanoe, Chisato @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	32045276X
dewey-sort	3610
id	ELV009113614
language_de	englisch
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author	Sogawa, Rintaro
spellingShingle	Sogawa, Rintaro ddc 610 bkl 44.91 misc Delirium misc Histamine-2 receptor antagonist misc Proton pump inhibitor Effects of anti-ulcer drugs on delirium in trauma patients
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topic_title	610 DE-600 44.91 bkl Effects of anti-ulcer drugs on delirium in trauma patients Delirium Histamine-2 receptor antagonist Proton pump inhibitor
topic	ddc 610 bkl 44.91 misc Delirium misc Histamine-2 receptor antagonist misc Proton pump inhibitor
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title	Effects of anti-ulcer drugs on delirium in trauma patients
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title_full	Effects of anti-ulcer drugs on delirium in trauma patients
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author_browse	Sogawa, Rintaro Matsuoka, Ayaka Murakawa-Hirachi, Toru Kikkawa, Nao Kamo, Masahiro Tobita, Shuko Shinada, Kota Mizoguchi, Yoshito Monji, Akira Sakamoto, Yuichiro Shimanoe, Chisato
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title_sort	effects of anti-ulcer drugs on delirium in trauma patients
title_auth	Effects of anti-ulcer drugs on delirium in trauma patients
abstract	Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection.
abstractGer	Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection.
abstract_unstemmed	Objective: Histamine-2 receptor antagonists (H2RAs) may induce a higher risk of developing delirium than proton pump inhibitors (PPIs), but current evidence is insufficient. Therefore, this study aimed to investigate whether anti-ulcer drugs increase delirium risk.Method: Data were obtained from the medical records of patients admitted to a hospital due to trauma. We compared the incidence of delirium in patients who received H2RAs and PPIs with that in patients who received no anti-ulcer drugs.Results: A total of 150, 158, and 238 patients received H2RAs, PPIs, and no anti-ulcer drugs, respectively. Delirium incidence was significantly higher in patients who received H2RAs (34.0%) and PPIs (44.9%) than in those who did not receive anti-ulcer drugs (22.3%). Even after adjustment for possible confounding factors, the association between H2RAs and delirium remained (adjusted OR 1.78; 95% CI 1.04–3.05), but that between PPIs and delirium was attenuated (adjusted OR 1.25; 95% CI 0.71–2.23).Conclusions: Our results show that H2RAs are associated with delirium risk. We replicated findings of a previous data-driven study. Clinicians need to consider the effect of delirium in anti-ulcer drug selection.
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title_short	Effects of anti-ulcer drugs on delirium in trauma patients
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author2	Matsuoka, Ayaka Murakawa-Hirachi, Toru Kikkawa, Nao Kamo, Masahiro Tobita, Shuko Shinada, Kota Mizoguchi, Yoshito Monji, Akira Sakamoto, Yuichiro Shimanoe, Chisato
author2Str	Matsuoka, Ayaka Murakawa-Hirachi, Toru Kikkawa, Nao Kamo, Masahiro Tobita, Shuko Shinada, Kota Mizoguchi, Yoshito Monji, Akira Sakamoto, Yuichiro Shimanoe, Chisato
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up_date	2024-07-06T22:02:29.406Z
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Effects of anti-ulcer drugs on delirium in trauma patients

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