A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples

Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biol...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fan, Yufan [verfasserIn] Wang, Fangyuan [verfasserIn] Hou, Fanbin [verfasserIn] Wei, Lai [verfasserIn] Zhu, Guanghao [verfasserIn] Zhao, Dongfang [verfasserIn] Hu, Qing [verfasserIn] Lei, Tao [verfasserIn] Yang, Ling [verfasserIn] Wang, Ping [verfasserIn] Ge, Guangbo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Human serum albumin Near-infrared probe High-throughput detection Confocal imaging

Übergeordnetes Werk:	Enthalten in: Chinese chemical letters - Amsterdam : Elsevier, 1990, 34
Übergeordnetes Werk:	volume:34

DOI / URN:	10.1016/j.cclet.2022.05.071

Katalog-ID:	ELV009264566

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245	1	0	\|a A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
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520			\|a Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes.
650		4	\|a Human serum albumin
650		4	\|a Near-infrared probe
650		4	\|a High-throughput detection
650		4	\|a Confocal imaging
700	1		\|a Wang, Fangyuan \|e verfasserin \|4 aut
700	1		\|a Hou, Fanbin \|e verfasserin \|4 aut
700	1		\|a Wei, Lai \|e verfasserin \|4 aut
700	1		\|a Zhu, Guanghao \|e verfasserin \|0 (orcid)0000-0001-9815-1939 \|4 aut
700	1		\|a Zhao, Dongfang \|e verfasserin \|4 aut
700	1		\|a Hu, Qing \|e verfasserin \|4 aut
700	1		\|a Lei, Tao \|e verfasserin \|4 aut
700	1		\|a Yang, Ling \|e verfasserin \|4 aut
700	1		\|a Wang, Ping \|e verfasserin \|4 aut
700	1		\|a Ge, Guangbo \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Chinese chemical letters \|d Amsterdam : Elsevier, 1990 \|g 34 \|h Online-Ressource \|w (DE-627)358144019 \|w (DE-600)2096242-3 \|w (DE-576)267762151 \|x 1878-5964 \|7 nnns
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912			\|a GBV_ILN_2048
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912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
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912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
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912			\|a GBV_ILN_2068
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912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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allfields	10.1016/j.cclet.2022.05.071 doi (DE-627)ELV009264566 (ELSEVIER)S1001-8417(22)00534-4 DE-627 ger DE-627 rda eng 540 DE-600 6,25 ssgn ASIEN DE-1a fid 35.00 bkl 35.04 bkl Fan, Yufan verfasserin aut A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes. Human serum albumin Near-infrared probe High-throughput detection Confocal imaging Wang, Fangyuan verfasserin aut Hou, Fanbin verfasserin aut Wei, Lai verfasserin aut Zhu, Guanghao verfasserin (orcid)0000-0001-9815-1939 aut Zhao, Dongfang verfasserin aut Hu, Qing verfasserin aut Lei, Tao verfasserin aut Yang, Ling verfasserin aut Wang, Ping verfasserin aut Ge, Guangbo verfasserin aut Enthalten in Chinese chemical letters Amsterdam : Elsevier, 1990 34 Online-Ressource (DE-627)358144019 (DE-600)2096242-3 (DE-576)267762151 1878-5964 nnns volume:34 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-ASIEN GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines 35.04 Ausbildung Beruf Organisationen Chemie AR 34
spelling	10.1016/j.cclet.2022.05.071 doi (DE-627)ELV009264566 (ELSEVIER)S1001-8417(22)00534-4 DE-627 ger DE-627 rda eng 540 DE-600 6,25 ssgn ASIEN DE-1a fid 35.00 bkl 35.04 bkl Fan, Yufan verfasserin aut A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes. Human serum albumin Near-infrared probe High-throughput detection Confocal imaging Wang, Fangyuan verfasserin aut Hou, Fanbin verfasserin aut Wei, Lai verfasserin aut Zhu, Guanghao verfasserin (orcid)0000-0001-9815-1939 aut Zhao, Dongfang verfasserin aut Hu, Qing verfasserin aut Lei, Tao verfasserin aut Yang, Ling verfasserin aut Wang, Ping verfasserin aut Ge, Guangbo verfasserin aut Enthalten in Chinese chemical letters Amsterdam : Elsevier, 1990 34 Online-Ressource (DE-627)358144019 (DE-600)2096242-3 (DE-576)267762151 1878-5964 nnns volume:34 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-ASIEN GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines 35.04 Ausbildung Beruf Organisationen Chemie AR 34
allfields_unstemmed	10.1016/j.cclet.2022.05.071 doi (DE-627)ELV009264566 (ELSEVIER)S1001-8417(22)00534-4 DE-627 ger DE-627 rda eng 540 DE-600 6,25 ssgn ASIEN DE-1a fid 35.00 bkl 35.04 bkl Fan, Yufan verfasserin aut A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes. Human serum albumin Near-infrared probe High-throughput detection Confocal imaging Wang, Fangyuan verfasserin aut Hou, Fanbin verfasserin aut Wei, Lai verfasserin aut Zhu, Guanghao verfasserin (orcid)0000-0001-9815-1939 aut Zhao, Dongfang verfasserin aut Hu, Qing verfasserin aut Lei, Tao verfasserin aut Yang, Ling verfasserin aut Wang, Ping verfasserin aut Ge, Guangbo verfasserin aut Enthalten in Chinese chemical letters Amsterdam : Elsevier, 1990 34 Online-Ressource (DE-627)358144019 (DE-600)2096242-3 (DE-576)267762151 1878-5964 nnns volume:34 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-ASIEN GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines 35.04 Ausbildung Beruf Organisationen Chemie AR 34
allfieldsGer	10.1016/j.cclet.2022.05.071 doi (DE-627)ELV009264566 (ELSEVIER)S1001-8417(22)00534-4 DE-627 ger DE-627 rda eng 540 DE-600 6,25 ssgn ASIEN DE-1a fid 35.00 bkl 35.04 bkl Fan, Yufan verfasserin aut A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes. Human serum albumin Near-infrared probe High-throughput detection Confocal imaging Wang, Fangyuan verfasserin aut Hou, Fanbin verfasserin aut Wei, Lai verfasserin aut Zhu, Guanghao verfasserin (orcid)0000-0001-9815-1939 aut Zhao, Dongfang verfasserin aut Hu, Qing verfasserin aut Lei, Tao verfasserin aut Yang, Ling verfasserin aut Wang, Ping verfasserin aut Ge, Guangbo verfasserin aut Enthalten in Chinese chemical letters Amsterdam : Elsevier, 1990 34 Online-Ressource (DE-627)358144019 (DE-600)2096242-3 (DE-576)267762151 1878-5964 nnns volume:34 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-ASIEN GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines 35.04 Ausbildung Beruf Organisationen Chemie AR 34
allfieldsSound	10.1016/j.cclet.2022.05.071 doi (DE-627)ELV009264566 (ELSEVIER)S1001-8417(22)00534-4 DE-627 ger DE-627 rda eng 540 DE-600 6,25 ssgn ASIEN DE-1a fid 35.00 bkl 35.04 bkl Fan, Yufan verfasserin aut A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes. Human serum albumin Near-infrared probe High-throughput detection Confocal imaging Wang, Fangyuan verfasserin aut Hou, Fanbin verfasserin aut Wei, Lai verfasserin aut Zhu, Guanghao verfasserin (orcid)0000-0001-9815-1939 aut Zhao, Dongfang verfasserin aut Hu, Qing verfasserin aut Lei, Tao verfasserin aut Yang, Ling verfasserin aut Wang, Ping verfasserin aut Ge, Guangbo verfasserin aut Enthalten in Chinese chemical letters Amsterdam : Elsevier, 1990 34 Online-Ressource (DE-627)358144019 (DE-600)2096242-3 (DE-576)267762151 1878-5964 nnns volume:34 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-ASIEN GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines 35.04 Ausbildung Beruf Organisationen Chemie AR 34
language	English
source	Enthalten in Chinese chemical letters 34 volume:34
sourceStr	Enthalten in Chinese chemical letters 34 volume:34
format_phy_str_mv	Article
bklname	Chemie: Allgemeines Ausbildung Beruf Organisationen
institution	findex.gbv.de
topic_facet	Human serum albumin Near-infrared probe High-throughput detection Confocal imaging
dewey-raw	540
isfreeaccess_bool	false
container_title	Chinese chemical letters
authorswithroles_txt_mv	Fan, Yufan @@aut@@ Wang, Fangyuan @@aut@@ Hou, Fanbin @@aut@@ Wei, Lai @@aut@@ Zhu, Guanghao @@aut@@ Zhao, Dongfang @@aut@@ Hu, Qing @@aut@@ Lei, Tao @@aut@@ Yang, Ling @@aut@@ Wang, Ping @@aut@@ Ge, Guangbo @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	358144019
dewey-sort	3540
id	ELV009264566
language_de	englisch
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author	Fan, Yufan
spellingShingle	Fan, Yufan ddc 540 ssgn 6,25 fid ASIEN bkl 35.00 bkl 35.04 misc Human serum albumin misc Near-infrared probe misc High-throughput detection misc Confocal imaging A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
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topic_title	540 DE-600 6,25 ssgn ASIEN DE-1a fid 35.00 bkl 35.04 bkl A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples Human serum albumin Near-infrared probe High-throughput detection Confocal imaging
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title	A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
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title_full	A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
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author_browse	Fan, Yufan Wang, Fangyuan Hou, Fanbin Wei, Lai Zhu, Guanghao Zhao, Dongfang Hu, Qing Lei, Tao Yang, Ling Wang, Ping Ge, Guangbo
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title_sort	a novel tict-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
title_auth	A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
abstract	Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes.
abstractGer	Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes.
abstract_unstemmed	Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes.
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title_short	A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples
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author2	Wang, Fangyuan Hou, Fanbin Wei, Lai Zhu, Guanghao Zhao, Dongfang Hu, Qing Lei, Tao Yang, Ling Wang, Ping Ge, Guangbo
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doi_str	10.1016/j.cclet.2022.05.071
up_date	2024-07-06T22:34:08.628Z
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Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. 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A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples

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