Antifungal activity of miltefosine against both azole-susceptible and -resistant
Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Haghani, Iman [verfasserIn] Yahyazadeh, Zahra [verfasserIn] Hedayati, Mohammad Taghi [verfasserIn] Shokohi, Tahereh [verfasserIn] Badali, Hamid [verfasserIn] Khojasteh, Shaghayegh [verfasserIn] Akhtari, Javad [verfasserIn] Javidnia, Javad [verfasserIn] Moazeni, Maryam [verfasserIn] Al-Harrasi, Ahmed [verfasserIn] Aghili, Seyed Reza [verfasserIn] Kermani, Firoozeh [verfasserIn] Hajheydari, Zohreh [verfasserIn] Al Hatmi, Abdullah M.S. [verfasserIn] Abastabar, Mahdi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of antimicrobial agents - Amsterdam [u.a.] : Elsevier Science, 1991, 61 |
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| Übergeordnetes Werk: |
volume:61 |
| DOI / URN: |
10.1016/j.ijantimicag.2023.106715 |
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| Katalog-ID: |
ELV009408835 |
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| 245 | 1 | 0 | |a Antifungal activity of miltefosine against both azole-susceptible and -resistant |
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| 520 | |a Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. | ||
| 650 | 4 | |a Miltefosine | |
| 650 | 4 | |a Azole-susceptible | |
| 650 | 4 | |a Azole-resistant | |
| 700 | 1 | |a Yahyazadeh, Zahra |e verfasserin |4 aut | |
| 700 | 1 | |a Hedayati, Mohammad Taghi |e verfasserin |4 aut | |
| 700 | 1 | |a Shokohi, Tahereh |e verfasserin |0 (orcid)0000-0003-3094-8436 |4 aut | |
| 700 | 1 | |a Badali, Hamid |e verfasserin |4 aut | |
| 700 | 1 | |a Khojasteh, Shaghayegh |e verfasserin |0 (orcid)0000-0003-1151-9265 |4 aut | |
| 700 | 1 | |a Akhtari, Javad |e verfasserin |0 (orcid)0000-0001-9040-0267 |4 aut | |
| 700 | 1 | |a Javidnia, Javad |e verfasserin |0 (orcid)0000-0001-9336-2518 |4 aut | |
| 700 | 1 | |a Moazeni, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Harrasi, Ahmed |e verfasserin |4 aut | |
| 700 | 1 | |a Aghili, Seyed Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Kermani, Firoozeh |e verfasserin |4 aut | |
| 700 | 1 | |a Hajheydari, Zohreh |e verfasserin |4 aut | |
| 700 | 1 | |a Al Hatmi, Abdullah M.S. |e verfasserin |4 aut | |
| 700 | 1 | |a Abastabar, Mahdi |e verfasserin |0 (orcid)0000-0002-0016-2849 |4 aut | |
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| 912 | |a GBV_ILN_40 | ||
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| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_65 | ||
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| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
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| 912 | |a GBV_ILN_100 | ||
| 912 | |a GBV_ILN_101 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_187 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_224 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2056 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
| 912 | |a GBV_ILN_4700 | ||
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10.1016/j.ijantimicag.2023.106715 doi (DE-627)ELV009408835 (ELSEVIER)S0924-8579(23)00007-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.38 bkl Haghani, Iman verfasserin (orcid)0000-0001-9723-7618 aut Antifungal activity of miltefosine against both azole-susceptible and -resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. Miltefosine Azole-susceptible Azole-resistant Yahyazadeh, Zahra verfasserin aut Hedayati, Mohammad Taghi verfasserin aut Shokohi, Tahereh verfasserin (orcid)0000-0003-3094-8436 aut Badali, Hamid verfasserin aut Khojasteh, Shaghayegh verfasserin (orcid)0000-0003-1151-9265 aut Akhtari, Javad verfasserin (orcid)0000-0001-9040-0267 aut Javidnia, Javad verfasserin (orcid)0000-0001-9336-2518 aut Moazeni, Maryam verfasserin aut Al-Harrasi, Ahmed verfasserin aut Aghili, Seyed Reza verfasserin aut Kermani, Firoozeh verfasserin aut Hajheydari, Zohreh verfasserin aut Al Hatmi, Abdullah M.S. verfasserin aut Abastabar, Mahdi verfasserin (orcid)0000-0002-0016-2849 aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 61 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:61 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie AR 61 |
| spelling |
10.1016/j.ijantimicag.2023.106715 doi (DE-627)ELV009408835 (ELSEVIER)S0924-8579(23)00007-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.38 bkl Haghani, Iman verfasserin (orcid)0000-0001-9723-7618 aut Antifungal activity of miltefosine against both azole-susceptible and -resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. Miltefosine Azole-susceptible Azole-resistant Yahyazadeh, Zahra verfasserin aut Hedayati, Mohammad Taghi verfasserin aut Shokohi, Tahereh verfasserin (orcid)0000-0003-3094-8436 aut Badali, Hamid verfasserin aut Khojasteh, Shaghayegh verfasserin (orcid)0000-0003-1151-9265 aut Akhtari, Javad verfasserin (orcid)0000-0001-9040-0267 aut Javidnia, Javad verfasserin (orcid)0000-0001-9336-2518 aut Moazeni, Maryam verfasserin aut Al-Harrasi, Ahmed verfasserin aut Aghili, Seyed Reza verfasserin aut Kermani, Firoozeh verfasserin aut Hajheydari, Zohreh verfasserin aut Al Hatmi, Abdullah M.S. verfasserin aut Abastabar, Mahdi verfasserin (orcid)0000-0002-0016-2849 aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 61 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:61 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie AR 61 |
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10.1016/j.ijantimicag.2023.106715 doi (DE-627)ELV009408835 (ELSEVIER)S0924-8579(23)00007-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.38 bkl Haghani, Iman verfasserin (orcid)0000-0001-9723-7618 aut Antifungal activity of miltefosine against both azole-susceptible and -resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. Miltefosine Azole-susceptible Azole-resistant Yahyazadeh, Zahra verfasserin aut Hedayati, Mohammad Taghi verfasserin aut Shokohi, Tahereh verfasserin (orcid)0000-0003-3094-8436 aut Badali, Hamid verfasserin aut Khojasteh, Shaghayegh verfasserin (orcid)0000-0003-1151-9265 aut Akhtari, Javad verfasserin (orcid)0000-0001-9040-0267 aut Javidnia, Javad verfasserin (orcid)0000-0001-9336-2518 aut Moazeni, Maryam verfasserin aut Al-Harrasi, Ahmed verfasserin aut Aghili, Seyed Reza verfasserin aut Kermani, Firoozeh verfasserin aut Hajheydari, Zohreh verfasserin aut Al Hatmi, Abdullah M.S. verfasserin aut Abastabar, Mahdi verfasserin (orcid)0000-0002-0016-2849 aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 61 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:61 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie AR 61 |
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10.1016/j.ijantimicag.2023.106715 doi (DE-627)ELV009408835 (ELSEVIER)S0924-8579(23)00007-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.38 bkl Haghani, Iman verfasserin (orcid)0000-0001-9723-7618 aut Antifungal activity of miltefosine against both azole-susceptible and -resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. Miltefosine Azole-susceptible Azole-resistant Yahyazadeh, Zahra verfasserin aut Hedayati, Mohammad Taghi verfasserin aut Shokohi, Tahereh verfasserin (orcid)0000-0003-3094-8436 aut Badali, Hamid verfasserin aut Khojasteh, Shaghayegh verfasserin (orcid)0000-0003-1151-9265 aut Akhtari, Javad verfasserin (orcid)0000-0001-9040-0267 aut Javidnia, Javad verfasserin (orcid)0000-0001-9336-2518 aut Moazeni, Maryam verfasserin aut Al-Harrasi, Ahmed verfasserin aut Aghili, Seyed Reza verfasserin aut Kermani, Firoozeh verfasserin aut Hajheydari, Zohreh verfasserin aut Al Hatmi, Abdullah M.S. verfasserin aut Abastabar, Mahdi verfasserin (orcid)0000-0002-0016-2849 aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 61 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:61 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie AR 61 |
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10.1016/j.ijantimicag.2023.106715 doi (DE-627)ELV009408835 (ELSEVIER)S0924-8579(23)00007-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.38 bkl Haghani, Iman verfasserin (orcid)0000-0001-9723-7618 aut Antifungal activity of miltefosine against both azole-susceptible and -resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. Miltefosine Azole-susceptible Azole-resistant Yahyazadeh, Zahra verfasserin aut Hedayati, Mohammad Taghi verfasserin aut Shokohi, Tahereh verfasserin (orcid)0000-0003-3094-8436 aut Badali, Hamid verfasserin aut Khojasteh, Shaghayegh verfasserin (orcid)0000-0003-1151-9265 aut Akhtari, Javad verfasserin (orcid)0000-0001-9040-0267 aut Javidnia, Javad verfasserin (orcid)0000-0001-9336-2518 aut Moazeni, Maryam verfasserin aut Al-Harrasi, Ahmed verfasserin aut Aghili, Seyed Reza verfasserin aut Kermani, Firoozeh verfasserin aut Hajheydari, Zohreh verfasserin aut Al Hatmi, Abdullah M.S. verfasserin aut Abastabar, Mahdi verfasserin (orcid)0000-0002-0016-2849 aut Enthalten in International journal of antimicrobial agents Amsterdam [u.a.] : Elsevier Science, 1991 61 Online-Ressource (DE-627)32049781X (DE-600)2011829-6 (DE-576)264627466 1872-7913 nnns volume:61 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.38 Pharmakologie AR 61 |
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Enthalten in International journal of antimicrobial agents 61 volume:61 |
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Enthalten in International journal of antimicrobial agents 61 volume:61 |
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Miltefosine Azole-susceptible Azole-resistant |
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International journal of antimicrobial agents |
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Haghani, Iman @@aut@@ Yahyazadeh, Zahra @@aut@@ Hedayati, Mohammad Taghi @@aut@@ Shokohi, Tahereh @@aut@@ Badali, Hamid @@aut@@ Khojasteh, Shaghayegh @@aut@@ Akhtari, Javad @@aut@@ Javidnia, Javad @@aut@@ Moazeni, Maryam @@aut@@ Al-Harrasi, Ahmed @@aut@@ Aghili, Seyed Reza @@aut@@ Kermani, Firoozeh @@aut@@ Hajheydari, Zohreh @@aut@@ Al Hatmi, Abdullah M.S. @@aut@@ Abastabar, Mahdi @@aut@@ |
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2023-01-01T00:00:00Z |
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Haghani, Iman |
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Haghani, Iman ddc 610 ssgn 15,3 fid PHARM bkl 44.38 misc Miltefosine misc Azole-susceptible misc Azole-resistant Antifungal activity of miltefosine against both azole-susceptible and -resistant |
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610 DE-600 15,3 ssgn PHARM DE-84 fid 44.38 bkl Antifungal activity of miltefosine against both azole-susceptible and -resistant Miltefosine Azole-susceptible Azole-resistant |
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ddc 610 ssgn 15,3 fid PHARM bkl 44.38 misc Miltefosine misc Azole-susceptible misc Azole-resistant |
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Antifungal activity of miltefosine against both azole-susceptible and -resistant |
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Antifungal activity of miltefosine against both azole-susceptible and -resistant |
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Haghani, Iman |
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International journal of antimicrobial agents |
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Haghani, Iman Yahyazadeh, Zahra Hedayati, Mohammad Taghi Shokohi, Tahereh Badali, Hamid Khojasteh, Shaghayegh Akhtari, Javad Javidnia, Javad Moazeni, Maryam Al-Harrasi, Ahmed Aghili, Seyed Reza Kermani, Firoozeh Hajheydari, Zohreh Al Hatmi, Abdullah M.S. Abastabar, Mahdi |
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10.1016/j.ijantimicag.2023.106715 |
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antifungal activity of miltefosine against both azole-susceptible and -resistant |
| title_auth |
Antifungal activity of miltefosine against both azole-susceptible and -resistant |
| abstract |
Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. |
| abstractGer |
Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. |
| abstract_unstemmed |
Miltefosine, an alkylphosphocholine, has been approved recently for the treatment of visceral leishmaniasis. Miltefosine has shown promise as a treatment for paracoccidioidomycosis, and has mixed activity against other fungi and yeast. There are limited data on the in-vitro activity of miltefosine against azole-resistant and -susceptible Aspergillus spp. As such, the aim of this study was to determine the in-vitro activity of miltefosine against Aspergillus strains. Miltefosine was tested against 108 azole-susceptible and -resistant Aspergillus strains isolated from Iran and other countries using the broth microdilution method. Miltefosine was found to be effective against azole-resistant Aspergillus isolates, with minimum inhibitory concentrations (MICs) ranging from 1.562 to 6.25 µg/mL. MIC50 and MIC90 were 1.562 and 3.125 µg/mL, respectively. Miltefosine had a higher geometric mean MIC (2.459 µg/mL) for wild-type Aspergillus isolates than itraconazole (0.220 µg/mL) and voriconazole (0.298 µg/mL). No significant difference was found between miltefosine MICs for azole-resistant Aspergillus isolates and azole-susceptible Aspergillus isolates (P>0.05). Miltefosine appears to have good in-vitro activity against azole-resistant Aspergillus strains, according to these findings. Furthermore, the findings suggest that miltefosine could be used to treat infections caused by azole-resistant Aspergillus spp. |
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Antifungal activity of miltefosine against both azole-susceptible and -resistant |
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Yahyazadeh, Zahra Hedayati, Mohammad Taghi Shokohi, Tahereh Badali, Hamid Khojasteh, Shaghayegh Akhtari, Javad Javidnia, Javad Moazeni, Maryam Al-Harrasi, Ahmed Aghili, Seyed Reza Kermani, Firoozeh Hajheydari, Zohreh Al Hatmi, Abdullah M.S. Abastabar, Mahdi |
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Yahyazadeh, Zahra Hedayati, Mohammad Taghi Shokohi, Tahereh Badali, Hamid Khojasteh, Shaghayegh Akhtari, Javad Javidnia, Javad Moazeni, Maryam Al-Harrasi, Ahmed Aghili, Seyed Reza Kermani, Firoozeh Hajheydari, Zohreh Al Hatmi, Abdullah M.S. Abastabar, Mahdi |
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