Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice

Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like beh...
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Autor*in:	Li, Tingting [verfasserIn] Yuan, Lin [verfasserIn] Zhao, Yijing [verfasserIn] Jiang, Zige [verfasserIn] Gai, Chengcheng [verfasserIn] Xin, Danqing [verfasserIn] Ke, Hongfei [verfasserIn] Guo, Xiaofan [verfasserIn] Chen, Wenqiang [verfasserIn] Liu, Dexiang [verfasserIn] Wang, Zhen [verfasserIn] Ho, Cyrus S.H. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Depressive Microglia Neuro-inflammation Osteopontin

Übergeordnetes Werk:	Enthalten in: Journal of affective disorders - Amsterdam [u.a.] : Elsevier Science, 1979, 330, Seite 83-93
Übergeordnetes Werk:	volume:330 ; pages:83-93

DOI / URN:	10.1016/j.jad.2023.02.105

Katalog-ID:	ELV009464441

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100	1		\|a Li, Tingting \|e verfasserin \|4 aut
245	1	0	\|a Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
264		1	\|c 2023
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337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity.
650		4	\|a Depressive
650		4	\|a Microglia
650		4	\|a Neuro-inflammation
650		4	\|a Osteopontin
700	1		\|a Yuan, Lin \|e verfasserin \|4 aut
700	1		\|a Zhao, Yijing \|e verfasserin \|4 aut
700	1		\|a Jiang, Zige \|e verfasserin \|4 aut
700	1		\|a Gai, Chengcheng \|e verfasserin \|4 aut
700	1		\|a Xin, Danqing \|e verfasserin \|4 aut
700	1		\|a Ke, Hongfei \|e verfasserin \|4 aut
700	1		\|a Guo, Xiaofan \|e verfasserin \|4 aut
700	1		\|a Chen, Wenqiang \|e verfasserin \|4 aut
700	1		\|a Liu, Dexiang \|e verfasserin \|4 aut
700	1		\|a Wang, Zhen \|e verfasserin \|4 aut
700	1		\|a Ho, Cyrus S.H. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Journal of affective disorders \|d Amsterdam [u.a.] : Elsevier Science, 1979 \|g 330, Seite 83-93 \|h Online-Ressource \|w (DE-627)306659670 \|w (DE-600)1500487-9 \|w (DE-576)081986327 \|x 1573-2517 \|7 nnns
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912			\|a GBV_ILN_4324
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912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.91 \|j Psychiatrie \|j Psychopathologie \|q VZ
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publishDate	2023
allfields	10.1016/j.jad.2023.02.105 doi (DE-627)ELV009464441 (ELSEVIER)S0165-0327(23)00273-2 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Li, Tingting verfasserin aut Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity. Depressive Microglia Neuro-inflammation Osteopontin Yuan, Lin verfasserin aut Zhao, Yijing verfasserin aut Jiang, Zige verfasserin aut Gai, Chengcheng verfasserin aut Xin, Danqing verfasserin aut Ke, Hongfei verfasserin aut Guo, Xiaofan verfasserin aut Chen, Wenqiang verfasserin aut Liu, Dexiang verfasserin aut Wang, Zhen verfasserin aut Ho, Cyrus S.H. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 330, Seite 83-93 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:330 pages:83-93 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 330 83-93
spelling	10.1016/j.jad.2023.02.105 doi (DE-627)ELV009464441 (ELSEVIER)S0165-0327(23)00273-2 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Li, Tingting verfasserin aut Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity. Depressive Microglia Neuro-inflammation Osteopontin Yuan, Lin verfasserin aut Zhao, Yijing verfasserin aut Jiang, Zige verfasserin aut Gai, Chengcheng verfasserin aut Xin, Danqing verfasserin aut Ke, Hongfei verfasserin aut Guo, Xiaofan verfasserin aut Chen, Wenqiang verfasserin aut Liu, Dexiang verfasserin aut Wang, Zhen verfasserin aut Ho, Cyrus S.H. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 330, Seite 83-93 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:330 pages:83-93 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 330 83-93
allfields_unstemmed	10.1016/j.jad.2023.02.105 doi (DE-627)ELV009464441 (ELSEVIER)S0165-0327(23)00273-2 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Li, Tingting verfasserin aut Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity. Depressive Microglia Neuro-inflammation Osteopontin Yuan, Lin verfasserin aut Zhao, Yijing verfasserin aut Jiang, Zige verfasserin aut Gai, Chengcheng verfasserin aut Xin, Danqing verfasserin aut Ke, Hongfei verfasserin aut Guo, Xiaofan verfasserin aut Chen, Wenqiang verfasserin aut Liu, Dexiang verfasserin aut Wang, Zhen verfasserin aut Ho, Cyrus S.H. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 330, Seite 83-93 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:330 pages:83-93 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 330 83-93
allfieldsGer	10.1016/j.jad.2023.02.105 doi (DE-627)ELV009464441 (ELSEVIER)S0165-0327(23)00273-2 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Li, Tingting verfasserin aut Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity. Depressive Microglia Neuro-inflammation Osteopontin Yuan, Lin verfasserin aut Zhao, Yijing verfasserin aut Jiang, Zige verfasserin aut Gai, Chengcheng verfasserin aut Xin, Danqing verfasserin aut Ke, Hongfei verfasserin aut Guo, Xiaofan verfasserin aut Chen, Wenqiang verfasserin aut Liu, Dexiang verfasserin aut Wang, Zhen verfasserin aut Ho, Cyrus S.H. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 330, Seite 83-93 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:330 pages:83-93 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 330 83-93
allfieldsSound	10.1016/j.jad.2023.02.105 doi (DE-627)ELV009464441 (ELSEVIER)S0165-0327(23)00273-2 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Li, Tingting verfasserin aut Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity. Depressive Microglia Neuro-inflammation Osteopontin Yuan, Lin verfasserin aut Zhao, Yijing verfasserin aut Jiang, Zige verfasserin aut Gai, Chengcheng verfasserin aut Xin, Danqing verfasserin aut Ke, Hongfei verfasserin aut Guo, Xiaofan verfasserin aut Chen, Wenqiang verfasserin aut Liu, Dexiang verfasserin aut Wang, Zhen verfasserin aut Ho, Cyrus S.H. verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 330, Seite 83-93 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:330 pages:83-93 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 330 83-93
language	English
source	Enthalten in Journal of affective disorders 330, Seite 83-93 volume:330 pages:83-93
sourceStr	Enthalten in Journal of affective disorders 330, Seite 83-93 volume:330 pages:83-93
format_phy_str_mv	Article
bklname	Psychiatrie Psychopathologie
institution	findex.gbv.de
topic_facet	Depressive Microglia Neuro-inflammation Osteopontin
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of affective disorders
authorswithroles_txt_mv	Li, Tingting @@aut@@ Yuan, Lin @@aut@@ Zhao, Yijing @@aut@@ Jiang, Zige @@aut@@ Gai, Chengcheng @@aut@@ Xin, Danqing @@aut@@ Ke, Hongfei @@aut@@ Guo, Xiaofan @@aut@@ Chen, Wenqiang @@aut@@ Liu, Dexiang @@aut@@ Wang, Zhen @@aut@@ Ho, Cyrus S.H. @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306659670
dewey-sort	3610
id	ELV009464441
language_de	englisch
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author	Li, Tingting
spellingShingle	Li, Tingting ddc 610 bkl 44.91 misc Depressive misc Microglia misc Neuro-inflammation misc Osteopontin Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
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topic_title	610 VZ 44.91 bkl Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice Depressive Microglia Neuro-inflammation Osteopontin
topic	ddc 610 bkl 44.91 misc Depressive misc Microglia misc Neuro-inflammation misc Osteopontin
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title	Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
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title_full	Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
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author_browse	Li, Tingting Yuan, Lin Zhao, Yijing Jiang, Zige Gai, Chengcheng Xin, Danqing Ke, Hongfei Guo, Xiaofan Chen, Wenqiang Liu, Dexiang Wang, Zhen Ho, Cyrus S.H.
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title_sort	blocking osteopontin expression attenuates neuroinflammation and mitigates lps-induced depressive-like behavior in mice
title_auth	Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
abstract	Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity.
abstractGer	Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity.
abstract_unstemmed	Introduction: Neuroinflammation plays an important role in the development of major depressive disorder (MDD). Osteopontin (OPN) is one of the key molecules involved in neuroinflammation. We demonstrate here for the first time a key role of OPN in lipopolysaccharide (LPS)-induced depressive-like behavioral syndrome.Methods: Systemic administration of LPS (5 mg/kg) mimics distinct depressive-like behavior, which could significantly upregulate OPN expression in microglia/macrophage in the hippocampus. The neurobehavioral assessments, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescent staining, flow cytometry cell staining and Golgi staining were performed.Results: Similar to fluoxetine treatment (the positive control), OPN knockdown with shRNA lentivirus markedly reversed LPS-induced depressive-like behavior. Moreover, knockdown of OPN suppressed LPS-induced proinflammatory cytokine expression, microglial activation, dendritic spines loss, as well as unregulated PSD-95 and BDNF in the hippocampus.Conclusion: We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity.
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title_short	Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
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author2	Yuan, Lin Zhao, Yijing Jiang, Zige Gai, Chengcheng Xin, Danqing Ke, Hongfei Guo, Xiaofan Chen, Wenqiang Liu, Dexiang Wang, Zhen Ho, Cyrus S.H.
author2Str	Yuan, Lin Zhao, Yijing Jiang, Zige Gai, Chengcheng Xin, Danqing Ke, Hongfei Guo, Xiaofan Chen, Wenqiang Liu, Dexiang Wang, Zhen Ho, Cyrus S.H.
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doi_str	10.1016/j.jad.2023.02.105
up_date	2024-07-06T23:15:06.810Z
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Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice

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