Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus
Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixe...
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| Autor*in: |
Zhang, Xiu-Ping [verfasserIn] Li, Bozhao [verfasserIn] Lu, Zefang [verfasserIn] Hu, Ming-Gen [verfasserIn] Zhao, Guo-Dong [verfasserIn] Xu, Shuai [verfasserIn] Wu, Zhouliang [verfasserIn] Chu, Tianjiao [verfasserIn] Qi, Feilong [verfasserIn] Wu, Suying [verfasserIn] Nie, Guangjun [verfasserIn] Li, Suping [verfasserIn] Liu, Rong [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
Hepatocellular carcinoma (HCC) |
|---|
| Übergeordnetes Werk: |
Enthalten in: Nano today - Amsterdam [u.a.] : Elsevier, 2006, 49 |
|---|---|
| Übergeordnetes Werk: |
volume:49 |
| DOI / URN: |
10.1016/j.nantod.2023.101787 |
|---|
| Katalog-ID: |
ELV009517960 |
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| 520 | |a Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. | ||
| 650 | 4 | |a Hepatocellular carcinoma (HCC) | |
| 650 | 4 | |a Portal vein tumor thrombus (PVTT) | |
| 650 | 4 | |a Nanocarriers | |
| 650 | 4 | |a Anticoagulant therapy | |
| 650 | 4 | |a Chemotherapy | |
| 700 | 1 | |a Li, Bozhao |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Zefang |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Ming-Gen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Guo-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Zhouliang |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Tianjiao |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Feilong |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Suying |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Guangjun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Suping |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Rong |e verfasserin |4 aut | |
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10.1016/j.nantod.2023.101787 doi (DE-627)ELV009517960 (ELSEVIER)S1748-0132(23)00036-1 DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Zhang, Xiu-Ping verfasserin aut Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy Li, Bozhao verfasserin aut Lu, Zefang verfasserin aut Hu, Ming-Gen verfasserin aut Zhao, Guo-Dong verfasserin aut Xu, Shuai verfasserin aut Wu, Zhouliang verfasserin aut Chu, Tianjiao verfasserin aut Qi, Feilong verfasserin aut Wu, Suying verfasserin aut Nie, Guangjun verfasserin aut Li, Suping verfasserin aut Liu, Rong verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 49 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:49 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 49 |
| spelling |
10.1016/j.nantod.2023.101787 doi (DE-627)ELV009517960 (ELSEVIER)S1748-0132(23)00036-1 DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Zhang, Xiu-Ping verfasserin aut Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy Li, Bozhao verfasserin aut Lu, Zefang verfasserin aut Hu, Ming-Gen verfasserin aut Zhao, Guo-Dong verfasserin aut Xu, Shuai verfasserin aut Wu, Zhouliang verfasserin aut Chu, Tianjiao verfasserin aut Qi, Feilong verfasserin aut Wu, Suying verfasserin aut Nie, Guangjun verfasserin aut Li, Suping verfasserin aut Liu, Rong verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 49 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:49 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 49 |
| allfields_unstemmed |
10.1016/j.nantod.2023.101787 doi (DE-627)ELV009517960 (ELSEVIER)S1748-0132(23)00036-1 DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Zhang, Xiu-Ping verfasserin aut Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy Li, Bozhao verfasserin aut Lu, Zefang verfasserin aut Hu, Ming-Gen verfasserin aut Zhao, Guo-Dong verfasserin aut Xu, Shuai verfasserin aut Wu, Zhouliang verfasserin aut Chu, Tianjiao verfasserin aut Qi, Feilong verfasserin aut Wu, Suying verfasserin aut Nie, Guangjun verfasserin aut Li, Suping verfasserin aut Liu, Rong verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 49 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:49 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 49 |
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10.1016/j.nantod.2023.101787 doi (DE-627)ELV009517960 (ELSEVIER)S1748-0132(23)00036-1 DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Zhang, Xiu-Ping verfasserin aut Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy Li, Bozhao verfasserin aut Lu, Zefang verfasserin aut Hu, Ming-Gen verfasserin aut Zhao, Guo-Dong verfasserin aut Xu, Shuai verfasserin aut Wu, Zhouliang verfasserin aut Chu, Tianjiao verfasserin aut Qi, Feilong verfasserin aut Wu, Suying verfasserin aut Nie, Guangjun verfasserin aut Li, Suping verfasserin aut Liu, Rong verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 49 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:49 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 49 |
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10.1016/j.nantod.2023.101787 doi (DE-627)ELV009517960 (ELSEVIER)S1748-0132(23)00036-1 DE-627 ger DE-627 rda eng 540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Zhang, Xiu-Ping verfasserin aut Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy Li, Bozhao verfasserin aut Lu, Zefang verfasserin aut Hu, Ming-Gen verfasserin aut Zhao, Guo-Dong verfasserin aut Xu, Shuai verfasserin aut Wu, Zhouliang verfasserin aut Chu, Tianjiao verfasserin aut Qi, Feilong verfasserin aut Wu, Suying verfasserin aut Nie, Guangjun verfasserin aut Li, Suping verfasserin aut Liu, Rong verfasserin aut Enthalten in Nano today Amsterdam [u.a.] : Elsevier, 2006 49 Online-Ressource (DE-627)508725259 (DE-600)2224882-1 (DE-576)258762047 1878-044X nnns volume:49 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ 50.94 Mikrosystemtechnik Nanotechnologie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ AR 49 |
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Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy |
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Zhang, Xiu-Ping @@aut@@ Li, Bozhao @@aut@@ Lu, Zefang @@aut@@ Hu, Ming-Gen @@aut@@ Zhao, Guo-Dong @@aut@@ Xu, Shuai @@aut@@ Wu, Zhouliang @@aut@@ Chu, Tianjiao @@aut@@ Qi, Feilong @@aut@@ Wu, Suying @@aut@@ Nie, Guangjun @@aut@@ Li, Suping @@aut@@ Liu, Rong @@aut@@ |
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540 660 VZ 35.18 bkl 51.45 bkl 50.94 bkl 33.68 bkl Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus Hepatocellular carcinoma (HCC) Portal vein tumor thrombus (PVTT) Nanocarriers Anticoagulant therapy Chemotherapy |
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ddc 540 bkl 35.18 bkl 51.45 bkl 50.94 bkl 33.68 misc Hepatocellular carcinoma (HCC) misc Portal vein tumor thrombus (PVTT) misc Nanocarriers misc Anticoagulant therapy misc Chemotherapy |
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nanoparticle-based combination of lmwh and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus |
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Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus |
| abstract |
Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. |
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Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. |
| abstract_unstemmed |
Portal vein tumor thrombus (PVTT) is an important indicator of advanced hepatocellular carcinoma (HCC) with poor prognosis; however, there currently is no effective treatment paradigm for PVTT to improve the therapeutic efficacy of advanced HCC. Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. This work uncovers the central need for PVTT modulation in advanced HCC treatment and represents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion. |
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Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus |
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Here we demonstrate that PVTT largely comprises a mixed composition of thrombosis and tumor cells, and in this case develop an acid-responsive polymeric nanocarrier that codelivered anticoagulant and chemotherapeutic drug into PVTT to achieve effective inhibition of HCC tumors. The anticoagulant, low molecular weight heparin (LMWH), was loaded to degrade thrombus layer to expose tumor cells of HCC tissues to chemotherapeutic doxorubicin (Dox). The killing effect of tumor cells by Dox was expected to decrease fibronectin deposition leading to PVTT degradation, and thus relieving portal hypertension. This PVTT-targeted nanocarrier enabled a PVTT-localized, continuous accumulation of the two drugs at a constant ratio. In both subcutaneous and orthotopic mouse models of PVTT, the nanoparticle-based strategy achieved potent anti-tumor efficacy without harsh side effects. 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