Abbreviated or Standard Antiplatelet Therapy in HBR Patients
Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Landi, Antonio [verfasserIn] Heg, Dik [verfasserIn] Frigoli, Enrico [verfasserIn] Vranckx, Pascal [verfasserIn] Windecker, Stephan [verfasserIn] Siegrist, Patrick [verfasserIn] Cayla, Guillaume [verfasserIn] Włodarczak, Adrian [verfasserIn] Cook, Stephane [verfasserIn] Gómez-Blázquez, Iván [verfasserIn] Feld, Yair [verfasserIn] Seung-Jung, Park [verfasserIn] Mates, Martin [verfasserIn] Lotan, Chaim [verfasserIn] Gunasekaran, Sengottuvelu [verfasserIn] Nanasato, Mamoru [verfasserIn] Das, Rajiv [verfasserIn] Kelbæk, Henning [verfasserIn] Teiger, Emmanuel [verfasserIn] Escaned, Javier [verfasserIn] Ishibashi, Yuki [verfasserIn] Montalescot, Gilles [verfasserIn] Matsuo, Hitoshi [verfasserIn] Debeljacki, Dragan [verfasserIn] Smits, Pieter C. [verfasserIn] Valgimigli, Marco [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: JACC Cardiovascular interventions - American College of Cardiology ; ID: gnd/1017722-X, New York, NY : Elsevier, 2008, 16 |
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| Übergeordnetes Werk: |
volume:16 |
| DOI / URN: |
10.1016/j.jcin.2023.01.366 |
|---|
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| 245 | 1 | 0 | |a Abbreviated or Standard Antiplatelet Therapy in HBR Patients |
| 264 | 1 | |c 2023 | |
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| 520 | |a Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) | ||
| 650 | 4 | |a antiplatelet therapy | |
| 650 | 4 | |a dual antiplatelet therapy | |
| 650 | 4 | |a high bleeding risk | |
| 650 | 4 | |a percutaneous coronary intervention | |
| 700 | 1 | |a Heg, Dik |e verfasserin |4 aut | |
| 700 | 1 | |a Frigoli, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Vranckx, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Windecker, Stephan |e verfasserin |4 aut | |
| 700 | 1 | |a Siegrist, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Cayla, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Włodarczak, Adrian |e verfasserin |4 aut | |
| 700 | 1 | |a Cook, Stephane |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Blázquez, Iván |e verfasserin |4 aut | |
| 700 | 1 | |a Feld, Yair |e verfasserin |0 (orcid)0000-0001-5098-4181 |4 aut | |
| 700 | 1 | |a Seung-Jung, Park |e verfasserin |4 aut | |
| 700 | 1 | |a Mates, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Lotan, Chaim |e verfasserin |4 aut | |
| 700 | 1 | |a Gunasekaran, Sengottuvelu |e verfasserin |0 (orcid)0000-0001-5339-6449 |4 aut | |
| 700 | 1 | |a Nanasato, Mamoru |e verfasserin |4 aut | |
| 700 | 1 | |a Das, Rajiv |e verfasserin |4 aut | |
| 700 | 1 | |a Kelbæk, Henning |e verfasserin |4 aut | |
| 700 | 1 | |a Teiger, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Escaned, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Ishibashi, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Montalescot, Gilles |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuo, Hitoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Debeljacki, Dragan |e verfasserin |4 aut | |
| 700 | 1 | |a Smits, Pieter C. |e verfasserin |0 (orcid)0000-0002-9164-720X |4 aut | |
| 700 | 1 | |a Valgimigli, Marco |e verfasserin |4 aut | |
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10.1016/j.jcin.2023.01.366 doi (DE-627)ELV00952780X (ELSEVIER)S1936-8798(23)00415-6 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Landi, Antonio verfasserin aut Abbreviated or Standard Antiplatelet Therapy in HBR Patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) antiplatelet therapy dual antiplatelet therapy high bleeding risk percutaneous coronary intervention Heg, Dik verfasserin aut Frigoli, Enrico verfasserin aut Vranckx, Pascal verfasserin aut Windecker, Stephan verfasserin aut Siegrist, Patrick verfasserin aut Cayla, Guillaume verfasserin aut Włodarczak, Adrian verfasserin aut Cook, Stephane verfasserin aut Gómez-Blázquez, Iván verfasserin aut Feld, Yair verfasserin (orcid)0000-0001-5098-4181 aut Seung-Jung, Park verfasserin aut Mates, Martin verfasserin aut Lotan, Chaim verfasserin aut Gunasekaran, Sengottuvelu verfasserin (orcid)0000-0001-5339-6449 aut Nanasato, Mamoru verfasserin aut Das, Rajiv verfasserin aut Kelbæk, Henning verfasserin aut Teiger, Emmanuel verfasserin aut Escaned, Javier verfasserin aut Ishibashi, Yuki verfasserin aut Montalescot, Gilles verfasserin aut Matsuo, Hitoshi verfasserin aut Debeljacki, Dragan verfasserin aut Smits, Pieter C. verfasserin (orcid)0000-0002-9164-720X aut Valgimigli, Marco verfasserin aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular interventions New York, NY : Elsevier, 2008 16 Online-Ressource (DE-627)578539160 (DE-600)2452163-2 (DE-576)294403027 1876-7605 nnns volume:16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 16 |
| spelling |
10.1016/j.jcin.2023.01.366 doi (DE-627)ELV00952780X (ELSEVIER)S1936-8798(23)00415-6 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Landi, Antonio verfasserin aut Abbreviated or Standard Antiplatelet Therapy in HBR Patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) antiplatelet therapy dual antiplatelet therapy high bleeding risk percutaneous coronary intervention Heg, Dik verfasserin aut Frigoli, Enrico verfasserin aut Vranckx, Pascal verfasserin aut Windecker, Stephan verfasserin aut Siegrist, Patrick verfasserin aut Cayla, Guillaume verfasserin aut Włodarczak, Adrian verfasserin aut Cook, Stephane verfasserin aut Gómez-Blázquez, Iván verfasserin aut Feld, Yair verfasserin (orcid)0000-0001-5098-4181 aut Seung-Jung, Park verfasserin aut Mates, Martin verfasserin aut Lotan, Chaim verfasserin aut Gunasekaran, Sengottuvelu verfasserin (orcid)0000-0001-5339-6449 aut Nanasato, Mamoru verfasserin aut Das, Rajiv verfasserin aut Kelbæk, Henning verfasserin aut Teiger, Emmanuel verfasserin aut Escaned, Javier verfasserin aut Ishibashi, Yuki verfasserin aut Montalescot, Gilles verfasserin aut Matsuo, Hitoshi verfasserin aut Debeljacki, Dragan verfasserin aut Smits, Pieter C. verfasserin (orcid)0000-0002-9164-720X aut Valgimigli, Marco verfasserin aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular interventions New York, NY : Elsevier, 2008 16 Online-Ressource (DE-627)578539160 (DE-600)2452163-2 (DE-576)294403027 1876-7605 nnns volume:16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 16 |
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10.1016/j.jcin.2023.01.366 doi (DE-627)ELV00952780X (ELSEVIER)S1936-8798(23)00415-6 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Landi, Antonio verfasserin aut Abbreviated or Standard Antiplatelet Therapy in HBR Patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) antiplatelet therapy dual antiplatelet therapy high bleeding risk percutaneous coronary intervention Heg, Dik verfasserin aut Frigoli, Enrico verfasserin aut Vranckx, Pascal verfasserin aut Windecker, Stephan verfasserin aut Siegrist, Patrick verfasserin aut Cayla, Guillaume verfasserin aut Włodarczak, Adrian verfasserin aut Cook, Stephane verfasserin aut Gómez-Blázquez, Iván verfasserin aut Feld, Yair verfasserin (orcid)0000-0001-5098-4181 aut Seung-Jung, Park verfasserin aut Mates, Martin verfasserin aut Lotan, Chaim verfasserin aut Gunasekaran, Sengottuvelu verfasserin (orcid)0000-0001-5339-6449 aut Nanasato, Mamoru verfasserin aut Das, Rajiv verfasserin aut Kelbæk, Henning verfasserin aut Teiger, Emmanuel verfasserin aut Escaned, Javier verfasserin aut Ishibashi, Yuki verfasserin aut Montalescot, Gilles verfasserin aut Matsuo, Hitoshi verfasserin aut Debeljacki, Dragan verfasserin aut Smits, Pieter C. verfasserin (orcid)0000-0002-9164-720X aut Valgimigli, Marco verfasserin aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular interventions New York, NY : Elsevier, 2008 16 Online-Ressource (DE-627)578539160 (DE-600)2452163-2 (DE-576)294403027 1876-7605 nnns volume:16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 16 |
| allfieldsGer |
10.1016/j.jcin.2023.01.366 doi (DE-627)ELV00952780X (ELSEVIER)S1936-8798(23)00415-6 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Landi, Antonio verfasserin aut Abbreviated or Standard Antiplatelet Therapy in HBR Patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) antiplatelet therapy dual antiplatelet therapy high bleeding risk percutaneous coronary intervention Heg, Dik verfasserin aut Frigoli, Enrico verfasserin aut Vranckx, Pascal verfasserin aut Windecker, Stephan verfasserin aut Siegrist, Patrick verfasserin aut Cayla, Guillaume verfasserin aut Włodarczak, Adrian verfasserin aut Cook, Stephane verfasserin aut Gómez-Blázquez, Iván verfasserin aut Feld, Yair verfasserin (orcid)0000-0001-5098-4181 aut Seung-Jung, Park verfasserin aut Mates, Martin verfasserin aut Lotan, Chaim verfasserin aut Gunasekaran, Sengottuvelu verfasserin (orcid)0000-0001-5339-6449 aut Nanasato, Mamoru verfasserin aut Das, Rajiv verfasserin aut Kelbæk, Henning verfasserin aut Teiger, Emmanuel verfasserin aut Escaned, Javier verfasserin aut Ishibashi, Yuki verfasserin aut Montalescot, Gilles verfasserin aut Matsuo, Hitoshi verfasserin aut Debeljacki, Dragan verfasserin aut Smits, Pieter C. verfasserin (orcid)0000-0002-9164-720X aut Valgimigli, Marco verfasserin aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular interventions New York, NY : Elsevier, 2008 16 Online-Ressource (DE-627)578539160 (DE-600)2452163-2 (DE-576)294403027 1876-7605 nnns volume:16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 16 |
| allfieldsSound |
10.1016/j.jcin.2023.01.366 doi (DE-627)ELV00952780X (ELSEVIER)S1936-8798(23)00415-6 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Landi, Antonio verfasserin aut Abbreviated or Standard Antiplatelet Therapy in HBR Patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) antiplatelet therapy dual antiplatelet therapy high bleeding risk percutaneous coronary intervention Heg, Dik verfasserin aut Frigoli, Enrico verfasserin aut Vranckx, Pascal verfasserin aut Windecker, Stephan verfasserin aut Siegrist, Patrick verfasserin aut Cayla, Guillaume verfasserin aut Włodarczak, Adrian verfasserin aut Cook, Stephane verfasserin aut Gómez-Blázquez, Iván verfasserin aut Feld, Yair verfasserin (orcid)0000-0001-5098-4181 aut Seung-Jung, Park verfasserin aut Mates, Martin verfasserin aut Lotan, Chaim verfasserin aut Gunasekaran, Sengottuvelu verfasserin (orcid)0000-0001-5339-6449 aut Nanasato, Mamoru verfasserin aut Das, Rajiv verfasserin aut Kelbæk, Henning verfasserin aut Teiger, Emmanuel verfasserin aut Escaned, Javier verfasserin aut Ishibashi, Yuki verfasserin aut Montalescot, Gilles verfasserin aut Matsuo, Hitoshi verfasserin aut Debeljacki, Dragan verfasserin aut Smits, Pieter C. verfasserin (orcid)0000-0002-9164-720X aut Valgimigli, Marco verfasserin aut Enthalten in American College of Cardiology ; ID: gnd/1017722-X JACC Cardiovascular interventions New York, NY : Elsevier, 2008 16 Online-Ressource (DE-627)578539160 (DE-600)2452163-2 (DE-576)294403027 1876-7605 nnns volume:16 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 16 |
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Enthalten in JACC Cardiovascular interventions 16 volume:16 |
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antiplatelet therapy dual antiplatelet therapy high bleeding risk percutaneous coronary intervention |
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Landi, Antonio @@aut@@ Heg, Dik @@aut@@ Frigoli, Enrico @@aut@@ Vranckx, Pascal @@aut@@ Windecker, Stephan @@aut@@ Siegrist, Patrick @@aut@@ Cayla, Guillaume @@aut@@ Włodarczak, Adrian @@aut@@ Cook, Stephane @@aut@@ Gómez-Blázquez, Iván @@aut@@ Feld, Yair @@aut@@ Seung-Jung, Park @@aut@@ Mates, Martin @@aut@@ Lotan, Chaim @@aut@@ Gunasekaran, Sengottuvelu @@aut@@ Nanasato, Mamoru @@aut@@ Das, Rajiv @@aut@@ Kelbæk, Henning @@aut@@ Teiger, Emmanuel @@aut@@ Escaned, Javier @@aut@@ Ishibashi, Yuki @@aut@@ Montalescot, Gilles @@aut@@ Matsuo, Hitoshi @@aut@@ Debeljacki, Dragan @@aut@@ Smits, Pieter C. @@aut@@ Valgimigli, Marco @@aut@@ |
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2023-01-01T00:00:00Z |
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Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. 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Landi, Antonio Heg, Dik Frigoli, Enrico Vranckx, Pascal Windecker, Stephan Siegrist, Patrick Cayla, Guillaume Włodarczak, Adrian Cook, Stephane Gómez-Blázquez, Iván Feld, Yair Seung-Jung, Park Mates, Martin Lotan, Chaim Gunasekaran, Sengottuvelu Nanasato, Mamoru Das, Rajiv Kelbæk, Henning Teiger, Emmanuel Escaned, Javier Ishibashi, Yuki Montalescot, Gilles Matsuo, Hitoshi Debeljacki, Dragan Smits, Pieter C. Valgimigli, Marco |
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abbreviated or standard antiplatelet therapy in hbr patients |
| title_auth |
Abbreviated or Standard Antiplatelet Therapy in HBR Patients |
| abstract |
Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) |
| abstractGer |
Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) |
| abstract_unstemmed |
Background: Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown.Objectives: The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial.Methods: The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding.Results: At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI.Conclusions: At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) |
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| title_short |
Abbreviated or Standard Antiplatelet Therapy in HBR Patients |
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Heg, Dik Frigoli, Enrico Vranckx, Pascal Windecker, Stephan Siegrist, Patrick Cayla, Guillaume Włodarczak, Adrian Cook, Stephane Gómez-Blázquez, Iván Feld, Yair Seung-Jung, Park Mates, Martin Lotan, Chaim Gunasekaran, Sengottuvelu Nanasato, Mamoru Das, Rajiv Kelbæk, Henning Teiger, Emmanuel Escaned, Javier Ishibashi, Yuki Montalescot, Gilles Matsuo, Hitoshi Debeljacki, Dragan Smits, Pieter C. Valgimigli, Marco |
| author2Str |
Heg, Dik Frigoli, Enrico Vranckx, Pascal Windecker, Stephan Siegrist, Patrick Cayla, Guillaume Włodarczak, Adrian Cook, Stephane Gómez-Blázquez, Iván Feld, Yair Seung-Jung, Park Mates, Martin Lotan, Chaim Gunasekaran, Sengottuvelu Nanasato, Mamoru Das, Rajiv Kelbæk, Henning Teiger, Emmanuel Escaned, Javier Ishibashi, Yuki Montalescot, Gilles Matsuo, Hitoshi Debeljacki, Dragan Smits, Pieter C. Valgimigli, Marco |
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| doi_str |
10.1016/j.jcin.2023.01.366 |
| up_date |
2024-07-06T23:28:13.801Z |
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|
| score |
7.400321 |