Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant

Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an e...
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Gespeichert in:

Autor*in:	Ma, Xinqian [verfasserIn] Xi, Wen [verfasserIn] Yang, Deqing [verfasserIn] Zhao, Lili [verfasserIn] Yu, Wenyi [verfasserIn] He, Yukun [verfasserIn] Ni, Wentao [verfasserIn] Gao, Zhancheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides

Übergeordnetes Werk:	Enthalten in: Drug resistance updates - Oxford : Elsevier, 1998, 68
Übergeordnetes Werk:	volume:68

DOI / URN:	10.1016/j.drup.2023.100961

Katalog-ID:	ELV009609040

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024	7		\|a 10.1016/j.drup.2023.100961 \|2 doi
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245	1	0	\|a Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
264		1	\|c 2023
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337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies.
650		4	\|a Carbapenem-resistant
650		4	\|a Collateral sensitivity
650		4	\|a Resistance evolution
650		4	\|a Tetracyclines
650		4	\|a Aminoglycosides
700	1		\|a Xi, Wen \|e verfasserin \|4 aut
700	1		\|a Yang, Deqing \|e verfasserin \|4 aut
700	1		\|a Zhao, Lili \|e verfasserin \|4 aut
700	1		\|a Yu, Wenyi \|e verfasserin \|4 aut
700	1		\|a He, Yukun \|e verfasserin \|4 aut
700	1		\|a Ni, Wentao \|e verfasserin \|4 aut
700	1		\|a Gao, Zhancheng \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Drug resistance updates \|d Oxford : Elsevier, 1998 \|g 68 \|h Online-Ressource \|w (DE-627)320421198 \|w (DE-600)2002582-8 \|w (DE-576)259271179 \|x 1532-2084 \|7 nnns
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936	b	k	\|a 44.40 \|j Pharmazie \|j Pharmazeutika \|q VZ
936	b	k	\|a 44.38 \|j Pharmakologie \|q VZ
951			\|a AR
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author_variant	x m xm w x wx d y dy l z lz w y wy y h yh w n wn z g zg
matchkey_str	article:15322084:2023----::oltrlestvtbtenerccieadmngyoiecntanrssace
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publishDate	2023
allfields	10.1016/j.drup.2023.100961 doi (DE-627)ELV009609040 (ELSEVIER)S1368-7646(23)00044-4 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.40 bkl 44.38 bkl Ma, Xinqian verfasserin aut Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies. Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides Xi, Wen verfasserin aut Yang, Deqing verfasserin aut Zhao, Lili verfasserin aut Yu, Wenyi verfasserin aut He, Yukun verfasserin aut Ni, Wentao verfasserin aut Gao, Zhancheng verfasserin aut Enthalten in Drug resistance updates Oxford : Elsevier, 1998 68 Online-Ressource (DE-627)320421198 (DE-600)2002582-8 (DE-576)259271179 1532-2084 nnns volume:68 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ 44.38 Pharmakologie VZ AR 68
spelling	10.1016/j.drup.2023.100961 doi (DE-627)ELV009609040 (ELSEVIER)S1368-7646(23)00044-4 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.40 bkl 44.38 bkl Ma, Xinqian verfasserin aut Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies. Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides Xi, Wen verfasserin aut Yang, Deqing verfasserin aut Zhao, Lili verfasserin aut Yu, Wenyi verfasserin aut He, Yukun verfasserin aut Ni, Wentao verfasserin aut Gao, Zhancheng verfasserin aut Enthalten in Drug resistance updates Oxford : Elsevier, 1998 68 Online-Ressource (DE-627)320421198 (DE-600)2002582-8 (DE-576)259271179 1532-2084 nnns volume:68 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ 44.38 Pharmakologie VZ AR 68
allfields_unstemmed	10.1016/j.drup.2023.100961 doi (DE-627)ELV009609040 (ELSEVIER)S1368-7646(23)00044-4 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.40 bkl 44.38 bkl Ma, Xinqian verfasserin aut Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies. Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides Xi, Wen verfasserin aut Yang, Deqing verfasserin aut Zhao, Lili verfasserin aut Yu, Wenyi verfasserin aut He, Yukun verfasserin aut Ni, Wentao verfasserin aut Gao, Zhancheng verfasserin aut Enthalten in Drug resistance updates Oxford : Elsevier, 1998 68 Online-Ressource (DE-627)320421198 (DE-600)2002582-8 (DE-576)259271179 1532-2084 nnns volume:68 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ 44.38 Pharmakologie VZ AR 68
allfieldsGer	10.1016/j.drup.2023.100961 doi (DE-627)ELV009609040 (ELSEVIER)S1368-7646(23)00044-4 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.40 bkl 44.38 bkl Ma, Xinqian verfasserin aut Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies. Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides Xi, Wen verfasserin aut Yang, Deqing verfasserin aut Zhao, Lili verfasserin aut Yu, Wenyi verfasserin aut He, Yukun verfasserin aut Ni, Wentao verfasserin aut Gao, Zhancheng verfasserin aut Enthalten in Drug resistance updates Oxford : Elsevier, 1998 68 Online-Ressource (DE-627)320421198 (DE-600)2002582-8 (DE-576)259271179 1532-2084 nnns volume:68 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ 44.38 Pharmakologie VZ AR 68
allfieldsSound	10.1016/j.drup.2023.100961 doi (DE-627)ELV009609040 (ELSEVIER)S1368-7646(23)00044-4 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 44.40 bkl 44.38 bkl Ma, Xinqian verfasserin aut Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies. Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides Xi, Wen verfasserin aut Yang, Deqing verfasserin aut Zhao, Lili verfasserin aut Yu, Wenyi verfasserin aut He, Yukun verfasserin aut Ni, Wentao verfasserin aut Gao, Zhancheng verfasserin aut Enthalten in Drug resistance updates Oxford : Elsevier, 1998 68 Online-Ressource (DE-627)320421198 (DE-600)2002582-8 (DE-576)259271179 1532-2084 nnns volume:68 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ 44.38 Pharmakologie VZ AR 68
language	English
source	Enthalten in Drug resistance updates 68 volume:68
sourceStr	Enthalten in Drug resistance updates 68 volume:68
format_phy_str_mv	Article
bklname	Pharmazie Pharmazeutika Pharmakologie
institution	findex.gbv.de
topic_facet	Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides
dewey-raw	610
isfreeaccess_bool	false
container_title	Drug resistance updates
authorswithroles_txt_mv	Ma, Xinqian @@aut@@ Xi, Wen @@aut@@ Yang, Deqing @@aut@@ Zhao, Lili @@aut@@ Yu, Wenyi @@aut@@ He, Yukun @@aut@@ Ni, Wentao @@aut@@ Gao, Zhancheng @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	320421198
dewey-sort	3610
id	ELV009609040
language_de	englisch
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author	Ma, Xinqian
spellingShingle	Ma, Xinqian ddc 610 fid PHARM bkl 44.40 bkl 44.38 misc Carbapenem-resistant misc Collateral sensitivity misc Resistance evolution misc Tetracyclines misc Aminoglycosides Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
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topic_title	610 VZ PHARM DE-84 fid 44.40 bkl 44.38 bkl Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Carbapenem-resistant Collateral sensitivity Resistance evolution Tetracyclines Aminoglycosides
topic	ddc 610 fid PHARM bkl 44.40 bkl 44.38 misc Carbapenem-resistant misc Collateral sensitivity misc Resistance evolution misc Tetracyclines misc Aminoglycosides
topic_unstemmed	ddc 610 fid PHARM bkl 44.40 bkl 44.38 misc Carbapenem-resistant misc Collateral sensitivity misc Resistance evolution misc Tetracyclines misc Aminoglycosides
topic_browse	ddc 610 fid PHARM bkl 44.40 bkl 44.38 misc Carbapenem-resistant misc Collateral sensitivity misc Resistance evolution misc Tetracyclines misc Aminoglycosides
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title	Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
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title_full	Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
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author_browse	Ma, Xinqian Xi, Wen Yang, Deqing Zhao, Lili Yu, Wenyi He, Yukun Ni, Wentao Gao, Zhancheng
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title_sort	collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
title_auth	Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
abstract	Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies.
abstractGer	Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies.
abstract_unstemmed	Aims: The acquisition of resistance to one antibiotic may confer an increased sensitivity to another antibiotic in bacteria, which is an evolutionary trade-off between different resistance mechanisms, defined as collateral sensitivity (CS). Exploiting the role of CS in treatment design could be an effective method to suppress or even reverse resistance evolution.Methods: Using experimental evolution, we systematically studied the CS between aminoglycosides and tetracyclines in carbapenem-resistant Klebsiella pneumoniae (CRKP) and explored the underlying mechanisms through genomic and transcriptome analyses. The application of CS-based therapies for resistance suppression, including combination therapy and alternating antibiotic therapy, was further evaluated in vitro and in vivo.Results: Reciprocal CS existed between tetracyclines and aminoglycosides in CRKP. The increased sensitivity of aminoglycoside-resistant strains to tetracyclines was associated with the alteration of bacterial membrane potential, whereas the unbalanced oxidation-reduction process of tetracycline-resistant strains may lead to an increased bacterial sensitivity to aminoglycosides. CS-based combination therapy could efficiently constrain the evolution of CRKP resistance in vitro and in vivo. In addition, alternating antibiotic therapy can re-sensitize CRKP to previously resistant drugs, thereby maintaining the trade-off.Conclusions: These results provide new insights into constraining the evolution of CRKP resistance through CS-based therapies.
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title_short	Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant
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author2	Xi, Wen Yang, Deqing Zhao, Lili Yu, Wenyi He, Yukun Ni, Wentao Gao, Zhancheng
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doi_str	10.1016/j.drup.2023.100961
up_date	2024-07-06T23:44:46.756Z
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Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant

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