A design-of-experiment approach for obtaining
Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dresler, Sławomir [verfasserIn] Ziemlewska, Aleksandra [verfasserIn] Nizioł-Łukaszewska, Zofia [verfasserIn] Zagórska-Dziok, Martyna [verfasserIn] Bujak, Tomasz [verfasserIn] Skic, Kamil [verfasserIn] Feldo, Marcin [verfasserIn] Hanaka, Agnieszka [verfasserIn] Wójciak, Magdalena [verfasserIn] Sowa, Ireneusz [verfasserIn] Strzemski, Maciej [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: Industrial crops and products - New York, NY [u.a.] : Elsevier, 1992, 199 |
|---|---|
| Übergeordnetes Werk: |
volume:199 |
| DOI / URN: |
10.1016/j.indcrop.2023.116768 |
|---|
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ELV009675337 |
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| 520 | |a Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. | ||
| 650 | 4 | |a Comfrey | |
| 650 | 4 | |a Mixture design | |
| 650 | 4 | |a Polyphenolics | |
| 650 | 4 | |a Extraction efficiency | |
| 650 | 4 | |a Allantoin | |
| 650 | 4 | |a 1,3-propanediol | |
| 700 | 1 | |a Ziemlewska, Aleksandra |e verfasserin |0 (orcid)0000-0001-8871-8911 |4 aut | |
| 700 | 1 | |a Nizioł-Łukaszewska, Zofia |e verfasserin |4 aut | |
| 700 | 1 | |a Zagórska-Dziok, Martyna |e verfasserin |4 aut | |
| 700 | 1 | |a Bujak, Tomasz |e verfasserin |4 aut | |
| 700 | 1 | |a Skic, Kamil |e verfasserin |4 aut | |
| 700 | 1 | |a Feldo, Marcin |e verfasserin |4 aut | |
| 700 | 1 | |a Hanaka, Agnieszka |e verfasserin |0 (orcid)0000-0002-0648-5681 |4 aut | |
| 700 | 1 | |a Wójciak, Magdalena |e verfasserin |0 (orcid)0000-0003-0466-1343 |4 aut | |
| 700 | 1 | |a Sowa, Ireneusz |e verfasserin |4 aut | |
| 700 | 1 | |a Strzemski, Maciej |e verfasserin |0 (orcid)0000-0002-0039-4455 |4 aut | |
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10.1016/j.indcrop.2023.116768 doi (DE-627)ELV009675337 (ELSEVIER)S0926-6690(23)00533-2 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Dresler, Sławomir verfasserin aut A design-of-experiment approach for obtaining 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol Ziemlewska, Aleksandra verfasserin (orcid)0000-0001-8871-8911 aut Nizioł-Łukaszewska, Zofia verfasserin aut Zagórska-Dziok, Martyna verfasserin aut Bujak, Tomasz verfasserin aut Skic, Kamil verfasserin aut Feldo, Marcin verfasserin aut Hanaka, Agnieszka verfasserin (orcid)0000-0002-0648-5681 aut Wójciak, Magdalena verfasserin (orcid)0000-0003-0466-1343 aut Sowa, Ireneusz verfasserin aut Strzemski, Maciej verfasserin (orcid)0000-0002-0039-4455 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 199 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:199 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 199 |
| spelling |
10.1016/j.indcrop.2023.116768 doi (DE-627)ELV009675337 (ELSEVIER)S0926-6690(23)00533-2 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Dresler, Sławomir verfasserin aut A design-of-experiment approach for obtaining 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol Ziemlewska, Aleksandra verfasserin (orcid)0000-0001-8871-8911 aut Nizioł-Łukaszewska, Zofia verfasserin aut Zagórska-Dziok, Martyna verfasserin aut Bujak, Tomasz verfasserin aut Skic, Kamil verfasserin aut Feldo, Marcin verfasserin aut Hanaka, Agnieszka verfasserin (orcid)0000-0002-0648-5681 aut Wójciak, Magdalena verfasserin (orcid)0000-0003-0466-1343 aut Sowa, Ireneusz verfasserin aut Strzemski, Maciej verfasserin (orcid)0000-0002-0039-4455 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 199 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:199 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 199 |
| allfields_unstemmed |
10.1016/j.indcrop.2023.116768 doi (DE-627)ELV009675337 (ELSEVIER)S0926-6690(23)00533-2 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Dresler, Sławomir verfasserin aut A design-of-experiment approach for obtaining 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol Ziemlewska, Aleksandra verfasserin (orcid)0000-0001-8871-8911 aut Nizioł-Łukaszewska, Zofia verfasserin aut Zagórska-Dziok, Martyna verfasserin aut Bujak, Tomasz verfasserin aut Skic, Kamil verfasserin aut Feldo, Marcin verfasserin aut Hanaka, Agnieszka verfasserin (orcid)0000-0002-0648-5681 aut Wójciak, Magdalena verfasserin (orcid)0000-0003-0466-1343 aut Sowa, Ireneusz verfasserin aut Strzemski, Maciej verfasserin (orcid)0000-0002-0039-4455 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 199 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:199 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 199 |
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10.1016/j.indcrop.2023.116768 doi (DE-627)ELV009675337 (ELSEVIER)S0926-6690(23)00533-2 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Dresler, Sławomir verfasserin aut A design-of-experiment approach for obtaining 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol Ziemlewska, Aleksandra verfasserin (orcid)0000-0001-8871-8911 aut Nizioł-Łukaszewska, Zofia verfasserin aut Zagórska-Dziok, Martyna verfasserin aut Bujak, Tomasz verfasserin aut Skic, Kamil verfasserin aut Feldo, Marcin verfasserin aut Hanaka, Agnieszka verfasserin (orcid)0000-0002-0648-5681 aut Wójciak, Magdalena verfasserin (orcid)0000-0003-0466-1343 aut Sowa, Ireneusz verfasserin aut Strzemski, Maciej verfasserin (orcid)0000-0002-0039-4455 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 199 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:199 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 199 |
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10.1016/j.indcrop.2023.116768 doi (DE-627)ELV009675337 (ELSEVIER)S0926-6690(23)00533-2 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Dresler, Sławomir verfasserin aut A design-of-experiment approach for obtaining 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol Ziemlewska, Aleksandra verfasserin (orcid)0000-0001-8871-8911 aut Nizioł-Łukaszewska, Zofia verfasserin aut Zagórska-Dziok, Martyna verfasserin aut Bujak, Tomasz verfasserin aut Skic, Kamil verfasserin aut Feldo, Marcin verfasserin aut Hanaka, Agnieszka verfasserin (orcid)0000-0002-0648-5681 aut Wójciak, Magdalena verfasserin (orcid)0000-0003-0466-1343 aut Sowa, Ireneusz verfasserin aut Strzemski, Maciej verfasserin (orcid)0000-0002-0039-4455 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 199 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:199 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 199 |
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Enthalten in Industrial crops and products 199 volume:199 |
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Enthalten in Industrial crops and products 199 volume:199 |
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Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol |
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Dresler, Sławomir @@aut@@ Ziemlewska, Aleksandra @@aut@@ Nizioł-Łukaszewska, Zofia @@aut@@ Zagórska-Dziok, Martyna @@aut@@ Bujak, Tomasz @@aut@@ Skic, Kamil @@aut@@ Feldo, Marcin @@aut@@ Hanaka, Agnieszka @@aut@@ Wójciak, Magdalena @@aut@@ Sowa, Ireneusz @@aut@@ Strzemski, Maciej @@aut@@ |
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2023-01-01T00:00:00Z |
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Dresler, Sławomir |
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630 640 DE-600 48.30 bkl A design-of-experiment approach for obtaining Comfrey Mixture design Polyphenolics Extraction efficiency Allantoin 1,3-propanediol |
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Dresler, Sławomir Ziemlewska, Aleksandra Nizioł-Łukaszewska, Zofia Zagórska-Dziok, Martyna Bujak, Tomasz Skic, Kamil Feldo, Marcin Hanaka, Agnieszka Wójciak, Magdalena Sowa, Ireneusz Strzemski, Maciej |
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A design-of-experiment approach for obtaining |
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Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. |
| abstractGer |
Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. |
| abstract_unstemmed |
Promotion of wound or bone healing and reduction of inflammation are commonly known therapeutic qualities of comfrey (Symphytum officinale). Given the presence of active constituents, including allantoin and phenolics, comfrey is widely used in cosmetic and pharmaceutical industries. The aim of this study was to optimize a three-solvent system (water, ethanol, 1,3-propanediol) to maximize the extraction efficiency of allantoin, rosmarinic acid, rabdosiin, and globoidnan A in accordance with the approach of the simplex centroid mixture design. Polynomial regression models of the mixture composition showed the impact of the extracts on cytotoxicity, metalloproteinase inhibition activity, and antioxidant properties response. Additionally, the physical properties, including surface tension and contact angle of the mixture composition, were measured. Based on the maximization of the extraction efficiency of all compounds, an optimum solvent composition was determined as 30.9% of water, 39.2% of ethanol, and 29.9% of propanediol. Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. In the near future, in vivo studies with instrumental methods should be conducted to evaluate the practical application of the extracts in the cosmetic industry. |
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Such a mixture allowed extraction of 93.6%, 96.8%, 77.0%, and 97.2% of the total amount of allantoin, rosmarinic acid, rabdosiin, and globoidnan A, respectively. The optimal mixture composition for extraction of the compounds was not correlated with inhibition of metalloproteinase activity and cell viability, while a strong positive relationship with antioxidant properties was observed. The optimized solvent composition ensured good extraction efficiency, and the extract had high antioxidant properties. 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