Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus

Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to...
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Autor*in:	Zhao, Ling [verfasserIn] Mühleisen, Thomas W. [verfasserIn] Pelzer, Dominique I. [verfasserIn] Burger, Bettina [verfasserIn] Beins, Eva C. [verfasserIn] Forstner, Andreas J. [verfasserIn] Herms, Stefan [verfasserIn] Hoffmann, Per [verfasserIn] Amunts, Katrin [verfasserIn] Palomero-Gallagher, Nicola [verfasserIn] Cichon, Sven [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic

Übergeordnetes Werk:	Enthalten in: NeuroImage - Orlando, Fla. : Academic Press, 1992, 273
Übergeordnetes Werk:	volume:273

DOI / URN:	10.1016/j.neuroimage.2023.120095

Katalog-ID:	ELV009835784

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520			\|a Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors.
650		4	\|a Rna expression
650		4	\|a Receptor density
650		4	\|a Human hippocampus
650		4	\|a Genomic
650		4	\|a Transcriptomic
650		4	\|a Receptomic
700	1		\|a Mühleisen, Thomas W. \|e verfasserin \|0 (orcid)0000-0002-6057-5952 \|4 aut
700	1		\|a Pelzer, Dominique I. \|e verfasserin \|0 (orcid)0000-0003-3360-5754 \|4 aut
700	1		\|a Burger, Bettina \|e verfasserin \|0 (orcid)0000-0002-7686-0176 \|4 aut
700	1		\|a Beins, Eva C. \|e verfasserin \|0 (orcid)0000-0002-7779-0210 \|4 aut
700	1		\|a Forstner, Andreas J. \|e verfasserin \|4 aut
700	1		\|a Herms, Stefan \|e verfasserin \|4 aut
700	1		\|a Hoffmann, Per \|e verfasserin \|0 (orcid)0000-0002-6573-983X \|4 aut
700	1		\|a Amunts, Katrin \|e verfasserin \|0 (orcid)0000-0001-5828-0867 \|4 aut
700	1		\|a Palomero-Gallagher, Nicola \|e verfasserin \|0 (orcid)0000-0003-4463-8578 \|4 aut
700	1		\|a Cichon, Sven \|e verfasserin \|4 aut
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Indexfelder

author_variant	l z lz t w m tw twm d i p di dip b b bb e c b ec ecb a j f aj ajf s h sh p h ph k a ka n p g npg s c sc
matchkey_str	article:10959572:2023----::eainhpbtenertasitreetresteadxrsineesfhicrep
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bklnumber	44.64 44.90
publishDate	2023
allfields	10.1016/j.neuroimage.2023.120095 doi (DE-627)ELV009835784 (ELSEVIER)S1053-8119(23)00241-0 DE-627 ger DE-627 rda eng 610 VZ LING DE-30 fid 44.64 bkl 44.90 bkl Zhao, Ling verfasserin (orcid)0000-0003-0902-1425 aut Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors. Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic Mühleisen, Thomas W. verfasserin (orcid)0000-0002-6057-5952 aut Pelzer, Dominique I. verfasserin (orcid)0000-0003-3360-5754 aut Burger, Bettina verfasserin (orcid)0000-0002-7686-0176 aut Beins, Eva C. verfasserin (orcid)0000-0002-7779-0210 aut Forstner, Andreas J. verfasserin aut Herms, Stefan verfasserin aut Hoffmann, Per verfasserin (orcid)0000-0002-6573-983X aut Amunts, Katrin verfasserin (orcid)0000-0001-5828-0867 aut Palomero-Gallagher, Nicola verfasserin (orcid)0000-0003-4463-8578 aut Cichon, Sven verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 273 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.64 Radiologie VZ 44.90 Neurologie VZ AR 273
spelling	10.1016/j.neuroimage.2023.120095 doi (DE-627)ELV009835784 (ELSEVIER)S1053-8119(23)00241-0 DE-627 ger DE-627 rda eng 610 VZ LING DE-30 fid 44.64 bkl 44.90 bkl Zhao, Ling verfasserin (orcid)0000-0003-0902-1425 aut Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors. Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic Mühleisen, Thomas W. verfasserin (orcid)0000-0002-6057-5952 aut Pelzer, Dominique I. verfasserin (orcid)0000-0003-3360-5754 aut Burger, Bettina verfasserin (orcid)0000-0002-7686-0176 aut Beins, Eva C. verfasserin (orcid)0000-0002-7779-0210 aut Forstner, Andreas J. verfasserin aut Herms, Stefan verfasserin aut Hoffmann, Per verfasserin (orcid)0000-0002-6573-983X aut Amunts, Katrin verfasserin (orcid)0000-0001-5828-0867 aut Palomero-Gallagher, Nicola verfasserin (orcid)0000-0003-4463-8578 aut Cichon, Sven verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 273 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.64 Radiologie VZ 44.90 Neurologie VZ AR 273
allfields_unstemmed	10.1016/j.neuroimage.2023.120095 doi (DE-627)ELV009835784 (ELSEVIER)S1053-8119(23)00241-0 DE-627 ger DE-627 rda eng 610 VZ LING DE-30 fid 44.64 bkl 44.90 bkl Zhao, Ling verfasserin (orcid)0000-0003-0902-1425 aut Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors. Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic Mühleisen, Thomas W. verfasserin (orcid)0000-0002-6057-5952 aut Pelzer, Dominique I. verfasserin (orcid)0000-0003-3360-5754 aut Burger, Bettina verfasserin (orcid)0000-0002-7686-0176 aut Beins, Eva C. verfasserin (orcid)0000-0002-7779-0210 aut Forstner, Andreas J. verfasserin aut Herms, Stefan verfasserin aut Hoffmann, Per verfasserin (orcid)0000-0002-6573-983X aut Amunts, Katrin verfasserin (orcid)0000-0001-5828-0867 aut Palomero-Gallagher, Nicola verfasserin (orcid)0000-0003-4463-8578 aut Cichon, Sven verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 273 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.64 Radiologie VZ 44.90 Neurologie VZ AR 273
allfieldsGer	10.1016/j.neuroimage.2023.120095 doi (DE-627)ELV009835784 (ELSEVIER)S1053-8119(23)00241-0 DE-627 ger DE-627 rda eng 610 VZ LING DE-30 fid 44.64 bkl 44.90 bkl Zhao, Ling verfasserin (orcid)0000-0003-0902-1425 aut Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors. Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic Mühleisen, Thomas W. verfasserin (orcid)0000-0002-6057-5952 aut Pelzer, Dominique I. verfasserin (orcid)0000-0003-3360-5754 aut Burger, Bettina verfasserin (orcid)0000-0002-7686-0176 aut Beins, Eva C. verfasserin (orcid)0000-0002-7779-0210 aut Forstner, Andreas J. verfasserin aut Herms, Stefan verfasserin aut Hoffmann, Per verfasserin (orcid)0000-0002-6573-983X aut Amunts, Katrin verfasserin (orcid)0000-0001-5828-0867 aut Palomero-Gallagher, Nicola verfasserin (orcid)0000-0003-4463-8578 aut Cichon, Sven verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 273 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.64 Radiologie VZ 44.90 Neurologie VZ AR 273
allfieldsSound	10.1016/j.neuroimage.2023.120095 doi (DE-627)ELV009835784 (ELSEVIER)S1053-8119(23)00241-0 DE-627 ger DE-627 rda eng 610 VZ LING DE-30 fid 44.64 bkl 44.90 bkl Zhao, Ling verfasserin (orcid)0000-0003-0902-1425 aut Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors. Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic Mühleisen, Thomas W. verfasserin (orcid)0000-0002-6057-5952 aut Pelzer, Dominique I. verfasserin (orcid)0000-0003-3360-5754 aut Burger, Bettina verfasserin (orcid)0000-0002-7686-0176 aut Beins, Eva C. verfasserin (orcid)0000-0002-7779-0210 aut Forstner, Andreas J. verfasserin aut Herms, Stefan verfasserin aut Hoffmann, Per verfasserin (orcid)0000-0002-6573-983X aut Amunts, Katrin verfasserin (orcid)0000-0001-5828-0867 aut Palomero-Gallagher, Nicola verfasserin (orcid)0000-0003-4463-8578 aut Cichon, Sven verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 273 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:273 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.64 Radiologie VZ 44.90 Neurologie VZ AR 273
language	English
source	Enthalten in NeuroImage 273 volume:273
sourceStr	Enthalten in NeuroImage 273 volume:273
format_phy_str_mv	Article
bklname	Radiologie Neurologie
institution	findex.gbv.de
topic_facet	Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic
dewey-raw	610
isfreeaccess_bool	false
container_title	NeuroImage
authorswithroles_txt_mv	Zhao, Ling @@aut@@ Mühleisen, Thomas W. @@aut@@ Pelzer, Dominique I. @@aut@@ Burger, Bettina @@aut@@ Beins, Eva C. @@aut@@ Forstner, Andreas J. @@aut@@ Herms, Stefan @@aut@@ Hoffmann, Per @@aut@@ Amunts, Katrin @@aut@@ Palomero-Gallagher, Nicola @@aut@@ Cichon, Sven @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	268125503
dewey-sort	3610
id	ELV009835784
language_de	englisch
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author	Zhao, Ling
spellingShingle	Zhao, Ling ddc 610 fid LING bkl 44.64 bkl 44.90 misc Rna expression misc Receptor density misc Human hippocampus misc Genomic misc Transcriptomic misc Receptomic Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
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topic_title	610 VZ LING DE-30 fid 44.64 bkl 44.90 bkl Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus Rna expression Receptor density Human hippocampus Genomic Transcriptomic Receptomic
topic	ddc 610 fid LING bkl 44.64 bkl 44.90 misc Rna expression misc Receptor density misc Human hippocampus misc Genomic misc Transcriptomic misc Receptomic
topic_unstemmed	ddc 610 fid LING bkl 44.64 bkl 44.90 misc Rna expression misc Receptor density misc Human hippocampus misc Genomic misc Transcriptomic misc Receptomic
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title	Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
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title_full	Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
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author_browse	Zhao, Ling Mühleisen, Thomas W. Pelzer, Dominique I. Burger, Bettina Beins, Eva C. Forstner, Andreas J. Herms, Stefan Hoffmann, Per Amunts, Katrin Palomero-Gallagher, Nicola Cichon, Sven
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title_sort	relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
title_auth	Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
abstract	Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors.
abstractGer	Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors.
abstract_unstemmed	Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their “RNA fingerprints”, which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors.
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title_short	Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus
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author2	Mühleisen, Thomas W. Pelzer, Dominique I. Burger, Bettina Beins, Eva C. Forstner, Andreas J. Herms, Stefan Hoffmann, Per Amunts, Katrin Palomero-Gallagher, Nicola Cichon, Sven
author2Str	Mühleisen, Thomas W. Pelzer, Dominique I. Burger, Bettina Beins, Eva C. Forstner, Andreas J. Herms, Stefan Hoffmann, Per Amunts, Katrin Palomero-Gallagher, Nicola Cichon, Sven
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up_date	2024-07-07T00:31:05.283Z
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Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus

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