Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives
Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yu, Jiaheng [verfasserIn] Yin, Yuqi [verfasserIn] Leng, Yubing [verfasserIn] Zhang, Jingcheng [verfasserIn] Wang, Chunyan [verfasserIn] Chen, Yanyun [verfasserIn] Li, Xiaorui [verfasserIn] Wang, Xudong [verfasserIn] Liu, Hui [verfasserIn] Liao, Yulong [verfasserIn] Jin, Yishan [verfasserIn] Zhang, Yihan [verfasserIn] Lu, Keyu [verfasserIn] Wang, Kehao [verfasserIn] Wang, Xiaofei [verfasserIn] Wang, Lizhen [verfasserIn] Zheng, Fuyin [verfasserIn] Gu, Zhongze [verfasserIn] Li, Yinghui [verfasserIn] Fan, Yubo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Advanced drug delivery reviews - Amsterdam [u.a.] : Elsevier Science, 1987, 197 |
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| Übergeordnetes Werk: |
volume:197 |
| DOI / URN: |
10.1016/j.addr.2023.114842 |
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| Katalog-ID: |
ELV009924272 |
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| 245 | 1 | 0 | |a Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives |
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| 520 | |a Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. | ||
| 650 | 4 | |a Retinal organoids | |
| 650 | 4 | |a Organoid-on-a-chip | |
| 650 | 4 | |a Vascularization | |
| 650 | 4 | |a Biosensor | |
| 650 | 4 | |a Intraocular drug delivery | |
| 700 | 1 | |a Yin, Yuqi |e verfasserin |4 aut | |
| 700 | 1 | |a Leng, Yubing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jingcheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chunyan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yanyun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaorui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xudong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Yulong |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Yishan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yihan |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Keyu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Kehao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaofei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Lizhen |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Fuyin |e verfasserin |0 (orcid)0000-0003-2113-8810 |4 aut | |
| 700 | 1 | |a Gu, Zhongze |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yinghui |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Yubo |e verfasserin |4 aut | |
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10.1016/j.addr.2023.114842 doi (DE-627)ELV009924272 (ELSEVIER)S0169-409X(23)00157-6 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Yu, Jiaheng verfasserin aut Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. Retinal organoids Organoid-on-a-chip Vascularization Biosensor Intraocular drug delivery Yin, Yuqi verfasserin aut Leng, Yubing verfasserin aut Zhang, Jingcheng verfasserin aut Wang, Chunyan verfasserin aut Chen, Yanyun verfasserin aut Li, Xiaorui verfasserin aut Wang, Xudong verfasserin aut Liu, Hui verfasserin aut Liao, Yulong verfasserin aut Jin, Yishan verfasserin aut Zhang, Yihan verfasserin aut Lu, Keyu verfasserin aut Wang, Kehao verfasserin aut Wang, Xiaofei verfasserin aut Wang, Lizhen verfasserin aut Zheng, Fuyin verfasserin (orcid)0000-0003-2113-8810 aut Gu, Zhongze verfasserin aut Li, Yinghui verfasserin aut Fan, Yubo verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 197 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:197 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.28 Pharmazeutische Technologie VZ 44.40 Pharmazie Pharmazeutika VZ AR 197 |
| spelling |
10.1016/j.addr.2023.114842 doi (DE-627)ELV009924272 (ELSEVIER)S0169-409X(23)00157-6 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Yu, Jiaheng verfasserin aut Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. Retinal organoids Organoid-on-a-chip Vascularization Biosensor Intraocular drug delivery Yin, Yuqi verfasserin aut Leng, Yubing verfasserin aut Zhang, Jingcheng verfasserin aut Wang, Chunyan verfasserin aut Chen, Yanyun verfasserin aut Li, Xiaorui verfasserin aut Wang, Xudong verfasserin aut Liu, Hui verfasserin aut Liao, Yulong verfasserin aut Jin, Yishan verfasserin aut Zhang, Yihan verfasserin aut Lu, Keyu verfasserin aut Wang, Kehao verfasserin aut Wang, Xiaofei verfasserin aut Wang, Lizhen verfasserin aut Zheng, Fuyin verfasserin (orcid)0000-0003-2113-8810 aut Gu, Zhongze verfasserin aut Li, Yinghui verfasserin aut Fan, Yubo verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 197 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:197 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.28 Pharmazeutische Technologie VZ 44.40 Pharmazie Pharmazeutika VZ AR 197 |
| allfields_unstemmed |
10.1016/j.addr.2023.114842 doi (DE-627)ELV009924272 (ELSEVIER)S0169-409X(23)00157-6 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Yu, Jiaheng verfasserin aut Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. Retinal organoids Organoid-on-a-chip Vascularization Biosensor Intraocular drug delivery Yin, Yuqi verfasserin aut Leng, Yubing verfasserin aut Zhang, Jingcheng verfasserin aut Wang, Chunyan verfasserin aut Chen, Yanyun verfasserin aut Li, Xiaorui verfasserin aut Wang, Xudong verfasserin aut Liu, Hui verfasserin aut Liao, Yulong verfasserin aut Jin, Yishan verfasserin aut Zhang, Yihan verfasserin aut Lu, Keyu verfasserin aut Wang, Kehao verfasserin aut Wang, Xiaofei verfasserin aut Wang, Lizhen verfasserin aut Zheng, Fuyin verfasserin (orcid)0000-0003-2113-8810 aut Gu, Zhongze verfasserin aut Li, Yinghui verfasserin aut Fan, Yubo verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 197 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:197 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.28 Pharmazeutische Technologie VZ 44.40 Pharmazie Pharmazeutika VZ AR 197 |
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10.1016/j.addr.2023.114842 doi (DE-627)ELV009924272 (ELSEVIER)S0169-409X(23)00157-6 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Yu, Jiaheng verfasserin aut Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. Retinal organoids Organoid-on-a-chip Vascularization Biosensor Intraocular drug delivery Yin, Yuqi verfasserin aut Leng, Yubing verfasserin aut Zhang, Jingcheng verfasserin aut Wang, Chunyan verfasserin aut Chen, Yanyun verfasserin aut Li, Xiaorui verfasserin aut Wang, Xudong verfasserin aut Liu, Hui verfasserin aut Liao, Yulong verfasserin aut Jin, Yishan verfasserin aut Zhang, Yihan verfasserin aut Lu, Keyu verfasserin aut Wang, Kehao verfasserin aut Wang, Xiaofei verfasserin aut Wang, Lizhen verfasserin aut Zheng, Fuyin verfasserin (orcid)0000-0003-2113-8810 aut Gu, Zhongze verfasserin aut Li, Yinghui verfasserin aut Fan, Yubo verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 197 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:197 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.28 Pharmazeutische Technologie VZ 44.40 Pharmazie Pharmazeutika VZ AR 197 |
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10.1016/j.addr.2023.114842 doi (DE-627)ELV009924272 (ELSEVIER)S0169-409X(23)00157-6 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 58.28 bkl 44.40 bkl Yu, Jiaheng verfasserin aut Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. Retinal organoids Organoid-on-a-chip Vascularization Biosensor Intraocular drug delivery Yin, Yuqi verfasserin aut Leng, Yubing verfasserin aut Zhang, Jingcheng verfasserin aut Wang, Chunyan verfasserin aut Chen, Yanyun verfasserin aut Li, Xiaorui verfasserin aut Wang, Xudong verfasserin aut Liu, Hui verfasserin aut Liao, Yulong verfasserin aut Jin, Yishan verfasserin aut Zhang, Yihan verfasserin aut Lu, Keyu verfasserin aut Wang, Kehao verfasserin aut Wang, Xiaofei verfasserin aut Wang, Lizhen verfasserin aut Zheng, Fuyin verfasserin (orcid)0000-0003-2113-8810 aut Gu, Zhongze verfasserin aut Li, Yinghui verfasserin aut Fan, Yubo verfasserin aut Enthalten in Advanced drug delivery reviews Amsterdam [u.a.] : Elsevier Science, 1987 197 Online-Ressource (DE-627)320602346 (DE-600)2020327-5 (DE-576)255622589 1872-8294 nnns volume:197 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.28 Pharmazeutische Technologie VZ 44.40 Pharmazie Pharmazeutika VZ AR 197 |
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Yu, Jiaheng @@aut@@ Yin, Yuqi @@aut@@ Leng, Yubing @@aut@@ Zhang, Jingcheng @@aut@@ Wang, Chunyan @@aut@@ Chen, Yanyun @@aut@@ Li, Xiaorui @@aut@@ Wang, Xudong @@aut@@ Liu, Hui @@aut@@ Liao, Yulong @@aut@@ Jin, Yishan @@aut@@ Zhang, Yihan @@aut@@ Lu, Keyu @@aut@@ Wang, Kehao @@aut@@ Wang, Xiaofei @@aut@@ Wang, Lizhen @@aut@@ Zheng, Fuyin @@aut@@ Gu, Zhongze @@aut@@ Li, Yinghui @@aut@@ Fan, Yubo @@aut@@ |
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Yu, Jiaheng Yin, Yuqi Leng, Yubing Zhang, Jingcheng Wang, Chunyan Chen, Yanyun Li, Xiaorui Wang, Xudong Liu, Hui Liao, Yulong Jin, Yishan Zhang, Yihan Lu, Keyu Wang, Kehao Wang, Xiaofei Wang, Lizhen Zheng, Fuyin Gu, Zhongze Li, Yinghui Fan, Yubo |
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emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: current progress and future perspectives |
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Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: Current progress and future perspectives |
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Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. |
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Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. |
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Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells. In this study, we review the generation and application of ROs resembling the human retina in cell subtypes and laminated structures and introduce the emerging engineered ROoC as a technological opportunity to address critical issues. On-chip vascularization, perfusion, and close inter-tissue interactions recreate physiological environments in vitro, whilst integrating with biosensors facilitates real-time analysis and monitoring during organogenesis of the retina representing engineering efforts in ROoC models. We also emphasize that ROs and ROoCs hold the potential for applications in modeling intraocular drug delivery in vitro and developing next-generation retinal drug delivery strategies. |
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