Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota

Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yu, Ruyang [verfasserIn] Gu, Yinping [verfasserIn] Zheng, Lanyan [verfasserIn] Liu, Zhongjie [verfasserIn] Bian, Yifei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	NAFLD Naringenin HFD Gut barrier Intestinal microbiota

Übergeordnetes Werk:	Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 105
Übergeordnetes Werk:	volume:105

DOI / URN:	10.1016/j.jff.2023.105578

Katalog-ID:	ELV009958746

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245	1	0	\|a Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota
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520			\|a Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD.
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700	1		\|a Bian, Yifei \|e verfasserin \|0 (orcid)0000-0001-8923-3748 \|4 aut
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matchkey_str	article:17564646:2023----::aignnrvnsaliteitnuec7ljbstmdlyeuaighitsi
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allfields	10.1016/j.jff.2023.105578 doi (DE-627)ELV009958746 (ELSEVIER)S1756-4646(23)00178-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Yu, Ruyang verfasserin aut Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD. NAFLD Naringenin HFD Gut barrier Intestinal microbiota Gu, Yinping verfasserin aut Zheng, Lanyan verfasserin aut Liu, Zhongjie verfasserin (orcid)0000-0003-0790-3635 aut Bian, Yifei verfasserin (orcid)0000-0001-8923-3748 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 105 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:105 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 105
spelling	10.1016/j.jff.2023.105578 doi (DE-627)ELV009958746 (ELSEVIER)S1756-4646(23)00178-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Yu, Ruyang verfasserin aut Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD. NAFLD Naringenin HFD Gut barrier Intestinal microbiota Gu, Yinping verfasserin aut Zheng, Lanyan verfasserin aut Liu, Zhongjie verfasserin (orcid)0000-0003-0790-3635 aut Bian, Yifei verfasserin (orcid)0000-0001-8923-3748 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 105 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:105 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 105
allfields_unstemmed	10.1016/j.jff.2023.105578 doi (DE-627)ELV009958746 (ELSEVIER)S1756-4646(23)00178-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Yu, Ruyang verfasserin aut Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD. NAFLD Naringenin HFD Gut barrier Intestinal microbiota Gu, Yinping verfasserin aut Zheng, Lanyan verfasserin aut Liu, Zhongjie verfasserin (orcid)0000-0003-0790-3635 aut Bian, Yifei verfasserin (orcid)0000-0001-8923-3748 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 105 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:105 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 105
allfieldsGer	10.1016/j.jff.2023.105578 doi (DE-627)ELV009958746 (ELSEVIER)S1756-4646(23)00178-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Yu, Ruyang verfasserin aut Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD. NAFLD Naringenin HFD Gut barrier Intestinal microbiota Gu, Yinping verfasserin aut Zheng, Lanyan verfasserin aut Liu, Zhongjie verfasserin (orcid)0000-0003-0790-3635 aut Bian, Yifei verfasserin (orcid)0000-0001-8923-3748 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 105 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:105 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 105
allfieldsSound	10.1016/j.jff.2023.105578 doi (DE-627)ELV009958746 (ELSEVIER)S1756-4646(23)00178-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Yu, Ruyang verfasserin aut Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD. NAFLD Naringenin HFD Gut barrier Intestinal microbiota Gu, Yinping verfasserin aut Zheng, Lanyan verfasserin aut Liu, Zhongjie verfasserin (orcid)0000-0003-0790-3635 aut Bian, Yifei verfasserin (orcid)0000-0001-8923-3748 aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 105 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:105 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 105
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However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. 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author	Yu, Ruyang
spellingShingle	Yu, Ruyang ddc 630 misc NAFLD misc Naringenin misc HFD misc Gut barrier misc Intestinal microbiota Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota
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topic_title	630 640 610 VZ Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota NAFLD Naringenin HFD Gut barrier Intestinal microbiota
topic	ddc 630 misc NAFLD misc Naringenin misc HFD misc Gut barrier misc Intestinal microbiota
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title	Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota
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title_full	Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota
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title_sort	naringenin prevents nafld in the diet-induced c57bl/6j obesity model by regulating the intestinal barrier function and microbiota
title_auth	Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota
abstract	Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD.
abstractGer	Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD.
abstract_unstemmed	Objectives: The intestinal immunity and the microbiota play an essential role in metabolic syndrome associated with obesity, for instance, non-alcoholic fatty liver disease (NAFLD). However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD.
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title_short	Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota
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author2	Gu, Yinping Zheng, Lanyan Liu, Zhongjie Bian, Yifei
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doi_str	10.1016/j.jff.2023.105578
up_date	2024-07-07T00:56:09.503Z
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However, the effects of naringenin on diet-induced NAFLD and intestinal functions have not been reported.Methods: The effects of naringenin on NAFLD were assessed in C57BL/6J administrated with a high-fat diet (HFD) and high-fat diet with 0.1% naringenin (HFN). The ELISA, histopathology, and flow cytometry were conducted to assess the effects of naringenin on the liver and intestinal inflammation. The FITC-dextran, western blot, and real-time quantitative PCR were used to evaluate the effects of naringenin on intestinal permeability. The regulatory effects of naringenin on intestinal microbiota in NAFLD mice were detected by 16S rRNA sequencing.Results: Naringenin could curb weight gain in obese mice, reduce the content of triglyceride (TG) and total cholesterol (TC) in blood and liver, and even improve the steatosis of liver cells. Naringenin alleviated the rate of infiltration in dendritic cells and macrophages in colon tissues and inhibited inflammatory factors in the intestinal and liver tissues. Naringenin reduced the gut barrier permeability caused by HFD and increased the expression of tight junction proteins (TJs). Furthermore, naringenin significantly improved the cecal microbiota disorder by enhancing the growth of salutary symbiotic bacteria and restraining the colonization of pathogenic bacteria.Conclusion: Naringenin could relieve metabolic disorders caused by HFD and improve gut barrier functions, thereby inhibiting the migration of intestinal microorganisms and products via the gut-liver axis, thus preventing NAFLD.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NAFLD</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Naringenin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HFD</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gut barrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intestinal microbiota</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gu, Yinping</subfield><subfield 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Naringenin prevents NAFLD in the diet-induced C57BL/6J obesity model by regulating the intestinal barrier function and microbiota

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