Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet
The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day),...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liu, Shanshan [verfasserIn] Luo, Tingting [verfasserIn] Song, Yanru [verfasserIn] Ren, Hongbo [verfasserIn] Qiu, Zhendong [verfasserIn] Ma, Chongxuan [verfasserIn] Tian, Yusu [verfasserIn] Wu, Qi [verfasserIn] Wang, Fu [verfasserIn] Krishnan, Hari B. [verfasserIn] Yu, Wenhua [verfasserIn] Yang, Jiliang [verfasserIn] Xu, Pengfei [verfasserIn] Zhang, Shuzhen [verfasserIn] Song, Bo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 99 |
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| Übergeordnetes Werk: |
volume:99 |
| DOI / URN: |
10.1016/j.jff.2022.105347 |
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| Katalog-ID: |
ELV009959173 |
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| 245 | 1 | 0 | |a Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet |
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| 520 | |a The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. | ||
| 650 | 4 | |a Soybean genotypes | |
| 650 | 4 | |a Hypercholesterolemia | |
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| 650 | 4 | |a Hypocholesterolemic effect | |
| 650 | 4 | |a Fenofibrate | |
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| 700 | 1 | |a Qiu, Zhendong |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Chongxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Yusu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Krishnan, Hari B. |e verfasserin |4 aut | |
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| 700 | 1 | |a Song, Bo |e verfasserin |4 aut | |
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10.1016/j.jff.2022.105347 doi (DE-627)ELV009959173 (ELSEVIER)S1756-4646(22)00417-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Liu, Shanshan verfasserin aut Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. Soybean genotypes Hypercholesterolemia Rat Hypocholesterolemic effect Fenofibrate Luo, Tingting verfasserin aut Song, Yanru verfasserin aut Ren, Hongbo verfasserin aut Qiu, Zhendong verfasserin aut Ma, Chongxuan verfasserin aut Tian, Yusu verfasserin aut Wu, Qi verfasserin aut Wang, Fu verfasserin aut Krishnan, Hari B. verfasserin aut Yu, Wenhua verfasserin aut Yang, Jiliang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Song, Bo verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 99 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 99 |
| spelling |
10.1016/j.jff.2022.105347 doi (DE-627)ELV009959173 (ELSEVIER)S1756-4646(22)00417-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Liu, Shanshan verfasserin aut Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. Soybean genotypes Hypercholesterolemia Rat Hypocholesterolemic effect Fenofibrate Luo, Tingting verfasserin aut Song, Yanru verfasserin aut Ren, Hongbo verfasserin aut Qiu, Zhendong verfasserin aut Ma, Chongxuan verfasserin aut Tian, Yusu verfasserin aut Wu, Qi verfasserin aut Wang, Fu verfasserin aut Krishnan, Hari B. verfasserin aut Yu, Wenhua verfasserin aut Yang, Jiliang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Song, Bo verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 99 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 99 |
| allfields_unstemmed |
10.1016/j.jff.2022.105347 doi (DE-627)ELV009959173 (ELSEVIER)S1756-4646(22)00417-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Liu, Shanshan verfasserin aut Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. Soybean genotypes Hypercholesterolemia Rat Hypocholesterolemic effect Fenofibrate Luo, Tingting verfasserin aut Song, Yanru verfasserin aut Ren, Hongbo verfasserin aut Qiu, Zhendong verfasserin aut Ma, Chongxuan verfasserin aut Tian, Yusu verfasserin aut Wu, Qi verfasserin aut Wang, Fu verfasserin aut Krishnan, Hari B. verfasserin aut Yu, Wenhua verfasserin aut Yang, Jiliang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Song, Bo verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 99 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 99 |
| allfieldsGer |
10.1016/j.jff.2022.105347 doi (DE-627)ELV009959173 (ELSEVIER)S1756-4646(22)00417-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Liu, Shanshan verfasserin aut Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. Soybean genotypes Hypercholesterolemia Rat Hypocholesterolemic effect Fenofibrate Luo, Tingting verfasserin aut Song, Yanru verfasserin aut Ren, Hongbo verfasserin aut Qiu, Zhendong verfasserin aut Ma, Chongxuan verfasserin aut Tian, Yusu verfasserin aut Wu, Qi verfasserin aut Wang, Fu verfasserin aut Krishnan, Hari B. verfasserin aut Yu, Wenhua verfasserin aut Yang, Jiliang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Song, Bo verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 99 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 99 |
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10.1016/j.jff.2022.105347 doi (DE-627)ELV009959173 (ELSEVIER)S1756-4646(22)00417-0 DE-627 ger DE-627 rda eng 630 640 610 VZ Liu, Shanshan verfasserin aut Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. Soybean genotypes Hypercholesterolemia Rat Hypocholesterolemic effect Fenofibrate Luo, Tingting verfasserin aut Song, Yanru verfasserin aut Ren, Hongbo verfasserin aut Qiu, Zhendong verfasserin aut Ma, Chongxuan verfasserin aut Tian, Yusu verfasserin aut Wu, Qi verfasserin aut Wang, Fu verfasserin aut Krishnan, Hari B. verfasserin aut Yu, Wenhua verfasserin aut Yang, Jiliang verfasserin aut Xu, Pengfei verfasserin aut Zhang, Shuzhen verfasserin aut Song, Bo verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 99 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 99 |
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Liu, Shanshan Luo, Tingting Song, Yanru Ren, Hongbo Qiu, Zhendong Ma, Chongxuan Tian, Yusu Wu, Qi Wang, Fu Krishnan, Hari B. Yu, Wenhua Yang, Jiliang Xu, Pengfei Zhang, Shuzhen Song, Bo |
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Liu, Shanshan |
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| title_sort |
hypocholesterolemic effects of soy protein isolates from soybeans differing in 7s and 11s globulin subunits vary in rats fed a high cholesterol diet |
| title_auth |
Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet |
| abstract |
The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. |
| abstractGer |
The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. |
| abstract_unstemmed |
The objective of this study was to determine if genotypes with differing globulin subunit compositions affect the hypocholesterolemic effect (HCE) of soy protein isolates (SPIs). Six SPIs (300 mg/kg/day), which differed in the 11S/7S globulin subunit composition, and fenofibrate (FF) (30 mg/kg/day), a hypocholesterolemic drug, were administered by gavage for 28 days to hypercholesterolemic model rats (HMRs). Blood samples were collected to measure serum lipid parameters. Hepatic histopathologic and lipid biochemical data were collected, and the expression of cholesterol metabolism-related key genes was analyzed. Our results demonstrated that soybeans differing in genotype generate SPIs with marked different HCEs, and the mechanism underlying the various HCEs of SPIs is associated with differential expression of hepatic cholesterol metabolism-related key genes in HMRs. 7S(α′+α)-Null genotype provided a greater effect on increasing HDL-C level, and daily ingestion of SPI-2 (null α′, α) might significantly contribute to increase HDL-C level in HMRs. |
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| title_short |
Hypocholesterolemic effects of soy protein isolates from soybeans differing in 7S and 11S globulin subunits vary in rats fed a high cholesterol diet |
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Luo, Tingting Song, Yanru Ren, Hongbo Qiu, Zhendong Ma, Chongxuan Tian, Yusu Wu, Qi Wang, Fu Krishnan, Hari B. Yu, Wenhua Yang, Jiliang Xu, Pengfei Zhang, Shuzhen Song, Bo |
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Luo, Tingting Song, Yanru Ren, Hongbo Qiu, Zhendong Ma, Chongxuan Tian, Yusu Wu, Qi Wang, Fu Krishnan, Hari B. Yu, Wenhua Yang, Jiliang Xu, Pengfei Zhang, Shuzhen Song, Bo |
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| doi_str |
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