Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis
Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic revie...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ueno, Fumihiko [verfasserIn] Iwata, Yusuke [verfasserIn] Nakajima, Shinichiro [verfasserIn] Caravaggio, Fernando [verfasserIn] Rubio, Jose M. [verfasserIn] Horga, Guillermo [verfasserIn] Cassidy, Clifford M. [verfasserIn] Torres-Carmona, Edgardo [verfasserIn] de Luca, Vincenzo [verfasserIn] Tsugawa, Sakiko [verfasserIn] Honda, Shiori [verfasserIn] Moriguchi, Sho [verfasserIn] Noda, Yoshihiro [verfasserIn] Gerretsen, Philip [verfasserIn] Graff-Guerrero, Ariel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Neuroscience & biobehavioral reviews - Amsterdam [u.a.] : Elsevier Science, 1978, 132, Seite 1205-1213 |
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| Übergeordnetes Werk: |
volume:132 ; pages:1205-1213 |
| DOI / URN: |
10.1016/j.neubiorev.2021.10.028 |
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| Katalog-ID: |
ELV009997598 |
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| 520 | |a Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. | ||
| 650 | 4 | |a Dopamine | |
| 650 | 4 | |a Neuromelanin | |
| 650 | 4 | |a NM-MRI | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Substantia nigra | |
| 700 | 1 | |a Iwata, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajima, Shinichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Caravaggio, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Rubio, Jose M. |e verfasserin |4 aut | |
| 700 | 1 | |a Horga, Guillermo |e verfasserin |4 aut | |
| 700 | 1 | |a Cassidy, Clifford M. |e verfasserin |4 aut | |
| 700 | 1 | |a Torres-Carmona, Edgardo |e verfasserin |4 aut | |
| 700 | 1 | |a de Luca, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugawa, Sakiko |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Shiori |e verfasserin |4 aut | |
| 700 | 1 | |a Moriguchi, Sho |e verfasserin |4 aut | |
| 700 | 1 | |a Noda, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Gerretsen, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Graff-Guerrero, Ariel |e verfasserin |0 (orcid)0000-0001-9301-2171 |4 aut | |
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10.1016/j.neubiorev.2021.10.028 doi (DE-627)ELV009997598 (ELSEVIER)S0149-7634(21)00468-1 DE-627 ger DE-627 rda eng 150 610 VZ BIODIV DE-30 fid 77.50 bkl 44.90 bkl Ueno, Fumihiko verfasserin (orcid)0000-0003-3463-5672 aut Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. Dopamine Neuromelanin NM-MRI Review Schizophrenia Substantia nigra Iwata, Yusuke verfasserin aut Nakajima, Shinichiro verfasserin aut Caravaggio, Fernando verfasserin aut Rubio, Jose M. verfasserin aut Horga, Guillermo verfasserin aut Cassidy, Clifford M. verfasserin aut Torres-Carmona, Edgardo verfasserin aut de Luca, Vincenzo verfasserin aut Tsugawa, Sakiko verfasserin aut Honda, Shiori verfasserin aut Moriguchi, Sho verfasserin aut Noda, Yoshihiro verfasserin aut Gerretsen, Philip verfasserin aut Graff-Guerrero, Ariel verfasserin (orcid)0000-0001-9301-2171 aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 132, Seite 1205-1213 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:132 pages:1205-1213 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie VZ 44.90 Neurologie VZ AR 132 1205-1213 |
| spelling |
10.1016/j.neubiorev.2021.10.028 doi (DE-627)ELV009997598 (ELSEVIER)S0149-7634(21)00468-1 DE-627 ger DE-627 rda eng 150 610 VZ BIODIV DE-30 fid 77.50 bkl 44.90 bkl Ueno, Fumihiko verfasserin (orcid)0000-0003-3463-5672 aut Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. Dopamine Neuromelanin NM-MRI Review Schizophrenia Substantia nigra Iwata, Yusuke verfasserin aut Nakajima, Shinichiro verfasserin aut Caravaggio, Fernando verfasserin aut Rubio, Jose M. verfasserin aut Horga, Guillermo verfasserin aut Cassidy, Clifford M. verfasserin aut Torres-Carmona, Edgardo verfasserin aut de Luca, Vincenzo verfasserin aut Tsugawa, Sakiko verfasserin aut Honda, Shiori verfasserin aut Moriguchi, Sho verfasserin aut Noda, Yoshihiro verfasserin aut Gerretsen, Philip verfasserin aut Graff-Guerrero, Ariel verfasserin (orcid)0000-0001-9301-2171 aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 132, Seite 1205-1213 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:132 pages:1205-1213 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie VZ 44.90 Neurologie VZ AR 132 1205-1213 |
| allfields_unstemmed |
10.1016/j.neubiorev.2021.10.028 doi (DE-627)ELV009997598 (ELSEVIER)S0149-7634(21)00468-1 DE-627 ger DE-627 rda eng 150 610 VZ BIODIV DE-30 fid 77.50 bkl 44.90 bkl Ueno, Fumihiko verfasserin (orcid)0000-0003-3463-5672 aut Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. Dopamine Neuromelanin NM-MRI Review Schizophrenia Substantia nigra Iwata, Yusuke verfasserin aut Nakajima, Shinichiro verfasserin aut Caravaggio, Fernando verfasserin aut Rubio, Jose M. verfasserin aut Horga, Guillermo verfasserin aut Cassidy, Clifford M. verfasserin aut Torres-Carmona, Edgardo verfasserin aut de Luca, Vincenzo verfasserin aut Tsugawa, Sakiko verfasserin aut Honda, Shiori verfasserin aut Moriguchi, Sho verfasserin aut Noda, Yoshihiro verfasserin aut Gerretsen, Philip verfasserin aut Graff-Guerrero, Ariel verfasserin (orcid)0000-0001-9301-2171 aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 132, Seite 1205-1213 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:132 pages:1205-1213 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie VZ 44.90 Neurologie VZ AR 132 1205-1213 |
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10.1016/j.neubiorev.2021.10.028 doi (DE-627)ELV009997598 (ELSEVIER)S0149-7634(21)00468-1 DE-627 ger DE-627 rda eng 150 610 VZ BIODIV DE-30 fid 77.50 bkl 44.90 bkl Ueno, Fumihiko verfasserin (orcid)0000-0003-3463-5672 aut Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. Dopamine Neuromelanin NM-MRI Review Schizophrenia Substantia nigra Iwata, Yusuke verfasserin aut Nakajima, Shinichiro verfasserin aut Caravaggio, Fernando verfasserin aut Rubio, Jose M. verfasserin aut Horga, Guillermo verfasserin aut Cassidy, Clifford M. verfasserin aut Torres-Carmona, Edgardo verfasserin aut de Luca, Vincenzo verfasserin aut Tsugawa, Sakiko verfasserin aut Honda, Shiori verfasserin aut Moriguchi, Sho verfasserin aut Noda, Yoshihiro verfasserin aut Gerretsen, Philip verfasserin aut Graff-Guerrero, Ariel verfasserin (orcid)0000-0001-9301-2171 aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 132, Seite 1205-1213 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:132 pages:1205-1213 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie VZ 44.90 Neurologie VZ AR 132 1205-1213 |
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10.1016/j.neubiorev.2021.10.028 doi (DE-627)ELV009997598 (ELSEVIER)S0149-7634(21)00468-1 DE-627 ger DE-627 rda eng 150 610 VZ BIODIV DE-30 fid 77.50 bkl 44.90 bkl Ueno, Fumihiko verfasserin (orcid)0000-0003-3463-5672 aut Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. Dopamine Neuromelanin NM-MRI Review Schizophrenia Substantia nigra Iwata, Yusuke verfasserin aut Nakajima, Shinichiro verfasserin aut Caravaggio, Fernando verfasserin aut Rubio, Jose M. verfasserin aut Horga, Guillermo verfasserin aut Cassidy, Clifford M. verfasserin aut Torres-Carmona, Edgardo verfasserin aut de Luca, Vincenzo verfasserin aut Tsugawa, Sakiko verfasserin aut Honda, Shiori verfasserin aut Moriguchi, Sho verfasserin aut Noda, Yoshihiro verfasserin aut Gerretsen, Philip verfasserin aut Graff-Guerrero, Ariel verfasserin (orcid)0000-0001-9301-2171 aut Enthalten in Neuroscience & biobehavioral reviews Amsterdam [u.a.] : Elsevier Science, 1978 132, Seite 1205-1213 Online-Ressource (DE-627)306588706 (DE-600)1498433-7 (DE-576)105430552 1873-7528 nnns volume:132 pages:1205-1213 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie VZ 44.90 Neurologie VZ AR 132 1205-1213 |
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Enthalten in Neuroscience & biobehavioral reviews 132, Seite 1205-1213 volume:132 pages:1205-1213 |
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Ueno, Fumihiko Iwata, Yusuke Nakajima, Shinichiro Caravaggio, Fernando Rubio, Jose M. Horga, Guillermo Cassidy, Clifford M. Torres-Carmona, Edgardo de Luca, Vincenzo Tsugawa, Sakiko Honda, Shiori Moriguchi, Sho Noda, Yoshihiro Gerretsen, Philip Graff-Guerrero, Ariel |
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neuromelanin accumulation in patients with schizophrenia: a systematic review and meta-analysis |
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Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis |
| abstract |
Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. |
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Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. |
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Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder. |
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