Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients
Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and charact...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jahreiß, Marie-Christina [verfasserIn] Hoogeman, Mischa [verfasserIn] Aben, Katja KH [verfasserIn] Dirkx, Maarten [verfasserIn] Snieders, Renier [verfasserIn] Pos, Floris J [verfasserIn] Janssen, Tomas [verfasserIn] Dekker, Andre [verfasserIn] Vanneste, Ben [verfasserIn] Minken, Andre [verfasserIn] Hoekstra, Carel [verfasserIn] Smeenk, Robert J [verfasserIn] Incrocci, Luca [verfasserIn] Heemsbergen, Wilma D [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Radiotherapy and oncology - Amsterdam [u.a.] : Elsevier Science, 1983, 183 |
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| Übergeordnetes Werk: |
volume:183 |
| DOI / URN: |
10.1016/j.radonc.2023.109659 |
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| Katalog-ID: |
ELV010110976 |
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| 100 | 1 | |a Jahreiß, Marie-Christina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients |
| 264 | 1 | |c 2023 | |
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| 520 | |a Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. | ||
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a Second primary cancer | |
| 650 | 4 | |a Survivorship | |
| 650 | 4 | |a Intensity-modulated radiotherapy | |
| 650 | 4 | |a Three-dimensional conformal radiotherapy | |
| 700 | 1 | |a Hoogeman, Mischa |e verfasserin |4 aut | |
| 700 | 1 | |a Aben, Katja KH |e verfasserin |4 aut | |
| 700 | 1 | |a Dirkx, Maarten |e verfasserin |4 aut | |
| 700 | 1 | |a Snieders, Renier |e verfasserin |4 aut | |
| 700 | 1 | |a Pos, Floris J |e verfasserin |4 aut | |
| 700 | 1 | |a Janssen, Tomas |e verfasserin |4 aut | |
| 700 | 1 | |a Dekker, Andre |e verfasserin |4 aut | |
| 700 | 1 | |a Vanneste, Ben |e verfasserin |4 aut | |
| 700 | 1 | |a Minken, Andre |e verfasserin |4 aut | |
| 700 | 1 | |a Hoekstra, Carel |e verfasserin |4 aut | |
| 700 | 1 | |a Smeenk, Robert J |e verfasserin |4 aut | |
| 700 | 1 | |a Incrocci, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Heemsbergen, Wilma D |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiotherapy and oncology |d Amsterdam [u.a.] : Elsevier Science, 1983 |g 183 |h Online-Ressource |w (DE-627)306710110 |w (DE-600)1500707-8 |w (DE-576)082435731 |x 1879-0887 |7 nnns |
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10.1016/j.radonc.2023.109659 doi (DE-627)ELV010110976 (ELSEVIER)S0167-8140(23)00197-4 DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl 44.64 bkl Jahreiß, Marie-Christina verfasserin aut Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy Hoogeman, Mischa verfasserin aut Aben, Katja KH verfasserin aut Dirkx, Maarten verfasserin aut Snieders, Renier verfasserin aut Pos, Floris J verfasserin aut Janssen, Tomas verfasserin aut Dekker, Andre verfasserin aut Vanneste, Ben verfasserin aut Minken, Andre verfasserin aut Hoekstra, Carel verfasserin aut Smeenk, Robert J verfasserin aut Incrocci, Luca verfasserin aut Heemsbergen, Wilma D verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 183 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:183 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ 44.64 Radiologie VZ AR 183 |
| spelling |
10.1016/j.radonc.2023.109659 doi (DE-627)ELV010110976 (ELSEVIER)S0167-8140(23)00197-4 DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl 44.64 bkl Jahreiß, Marie-Christina verfasserin aut Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy Hoogeman, Mischa verfasserin aut Aben, Katja KH verfasserin aut Dirkx, Maarten verfasserin aut Snieders, Renier verfasserin aut Pos, Floris J verfasserin aut Janssen, Tomas verfasserin aut Dekker, Andre verfasserin aut Vanneste, Ben verfasserin aut Minken, Andre verfasserin aut Hoekstra, Carel verfasserin aut Smeenk, Robert J verfasserin aut Incrocci, Luca verfasserin aut Heemsbergen, Wilma D verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 183 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:183 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ 44.64 Radiologie VZ AR 183 |
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10.1016/j.radonc.2023.109659 doi (DE-627)ELV010110976 (ELSEVIER)S0167-8140(23)00197-4 DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl 44.64 bkl Jahreiß, Marie-Christina verfasserin aut Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy Hoogeman, Mischa verfasserin aut Aben, Katja KH verfasserin aut Dirkx, Maarten verfasserin aut Snieders, Renier verfasserin aut Pos, Floris J verfasserin aut Janssen, Tomas verfasserin aut Dekker, Andre verfasserin aut Vanneste, Ben verfasserin aut Minken, Andre verfasserin aut Hoekstra, Carel verfasserin aut Smeenk, Robert J verfasserin aut Incrocci, Luca verfasserin aut Heemsbergen, Wilma D verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 183 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:183 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ 44.64 Radiologie VZ AR 183 |
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10.1016/j.radonc.2023.109659 doi (DE-627)ELV010110976 (ELSEVIER)S0167-8140(23)00197-4 DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl 44.64 bkl Jahreiß, Marie-Christina verfasserin aut Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy Hoogeman, Mischa verfasserin aut Aben, Katja KH verfasserin aut Dirkx, Maarten verfasserin aut Snieders, Renier verfasserin aut Pos, Floris J verfasserin aut Janssen, Tomas verfasserin aut Dekker, Andre verfasserin aut Vanneste, Ben verfasserin aut Minken, Andre verfasserin aut Hoekstra, Carel verfasserin aut Smeenk, Robert J verfasserin aut Incrocci, Luca verfasserin aut Heemsbergen, Wilma D verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 183 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:183 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ 44.64 Radiologie VZ AR 183 |
| allfieldsSound |
10.1016/j.radonc.2023.109659 doi (DE-627)ELV010110976 (ELSEVIER)S0167-8140(23)00197-4 DE-627 ger DE-627 rda eng 610 VZ 44.81 bkl 44.64 bkl Jahreiß, Marie-Christina verfasserin aut Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy Hoogeman, Mischa verfasserin aut Aben, Katja KH verfasserin aut Dirkx, Maarten verfasserin aut Snieders, Renier verfasserin aut Pos, Floris J verfasserin aut Janssen, Tomas verfasserin aut Dekker, Andre verfasserin aut Vanneste, Ben verfasserin aut Minken, Andre verfasserin aut Hoekstra, Carel verfasserin aut Smeenk, Robert J verfasserin aut Incrocci, Luca verfasserin aut Heemsbergen, Wilma D verfasserin aut Enthalten in Radiotherapy and oncology Amsterdam [u.a.] : Elsevier Science, 1983 183 Online-Ressource (DE-627)306710110 (DE-600)1500707-8 (DE-576)082435731 1879-0887 nnns volume:183 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie VZ 44.64 Radiologie VZ AR 183 |
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Enthalten in Radiotherapy and oncology 183 volume:183 |
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Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy |
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Jahreiß, Marie-Christina @@aut@@ Hoogeman, Mischa @@aut@@ Aben, Katja KH @@aut@@ Dirkx, Maarten @@aut@@ Snieders, Renier @@aut@@ Pos, Floris J @@aut@@ Janssen, Tomas @@aut@@ Dekker, Andre @@aut@@ Vanneste, Ben @@aut@@ Minken, Andre @@aut@@ Hoekstra, Carel @@aut@@ Smeenk, Robert J @@aut@@ Incrocci, Luca @@aut@@ Heemsbergen, Wilma D @@aut@@ |
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2023-01-01T00:00:00Z |
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In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. 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Jahreiß, Marie-Christina |
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Jahreiß, Marie-Christina ddc 610 bkl 44.81 bkl 44.64 misc Prostate cancer misc Second primary cancer misc Survivorship misc Intensity-modulated radiotherapy misc Three-dimensional conformal radiotherapy Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients |
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610 VZ 44.81 bkl 44.64 bkl Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients Prostate cancer Second primary cancer Survivorship Intensity-modulated radiotherapy Three-dimensional conformal radiotherapy |
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ddc 610 bkl 44.81 bkl 44.64 misc Prostate cancer misc Second primary cancer misc Survivorship misc Intensity-modulated radiotherapy misc Three-dimensional conformal radiotherapy |
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ddc 610 bkl 44.81 bkl 44.64 misc Prostate cancer misc Second primary cancer misc Survivorship misc Intensity-modulated radiotherapy misc Three-dimensional conformal radiotherapy |
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Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients |
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Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients |
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Jahreiß, Marie-Christina |
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Jahreiß, Marie-Christina Hoogeman, Mischa Aben, Katja KH Dirkx, Maarten Snieders, Renier Pos, Floris J Janssen, Tomas Dekker, Andre Vanneste, Ben Minken, Andre Hoekstra, Carel Smeenk, Robert J Incrocci, Luca Heemsbergen, Wilma D |
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Jahreiß, Marie-Christina |
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10.1016/j.radonc.2023.109659 |
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verfasserin |
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advances in radiotherapy and its impact on second primary cancer risk: a multi-center cohort study in prostate cancer patients |
| title_auth |
Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients |
| abstract |
Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. |
| abstractGer |
Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. |
| abstract_unstemmed |
Background: Modelling studies suggest that advanced intensity-modulated radiotherapy may increase second primary cancer (SPC) risks, due to increased radiation exposure of tissues located outside the treatment fields. In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. With constantly evolving EBRT protocols, evaluation of associated SPC risks remains important. |
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Hoogeman, Mischa Aben, Katja KH Dirkx, Maarten Snieders, Renier Pos, Floris J Janssen, Tomas Dekker, Andre Vanneste, Ben Minken, Andre Hoekstra, Carel Smeenk, Robert J Incrocci, Luca Heemsbergen, Wilma D |
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10.1016/j.radonc.2023.109659 |
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In the current study we investigated the association between SPC risks and characteristics of applied external beam radiotherapy (EBRT) protocols for localized prostate cancer (PCa).Methods: We collected EBRT protocol characteristics (2000–2016) from five Dutch RT institutes for the 3D-CRT and advanced EBRT era (N = 7908). From the Netherlands Cancer Registry we obtained patient/tumour characteristics, SPC data, and survival information. Standardized incidence ratios (SIR) were calculated for pelvis and non-pelvis SPC. Nationwide SIRs were calculated as a reference, using calendar period as a proxy to label 3D-CRT/advanced EBRT.Results: From 2000-2006, 3D-CRT with 68–78 Gy in 2 Gy fractions, delivered with 10–23 MV and weekly portal imaging was the most dominant protocol. By the year 2010 all institutes routinely used advanced EBRT (IMRT, VMAT, tomotherapy), mainly delivering 78 Gy in 2 Gy fractions, using various kV/MV imaging protocols. Sixteen percent (N = 1268) developed ≥ 1 SPC. SIRs for pelvis and non-pelvis SPC (all institutes, advanced EBRT vs 3D-CRT) were 1.17 (1.00–1.36) vs 1.39 (1.21–1.59), and 1.01 (0.89–1.07) vs 1.03 (0.94–1.13), respectively. Nationwide non-pelvis SIR was 1.07 (1.01–1.13) vs 1.02 (0.98–1.07). Other RT protocol characteristics did not correlate with SPC endpoints.Conclusion: None of the studied RT characteristics of advanced EBRT was associated with increased out-of-field SPC risks. 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