Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer
The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy...
Ausführliche Beschreibung
Autor*in: |
Lao, Juanfeng [verfasserIn] Xu, Huiting [verfasserIn] Liang, Zibin [verfasserIn] Luo, Changliang [verfasserIn] Shu, Liuyang [verfasserIn] Xie, Yuping [verfasserIn] Wu, Yongjian [verfasserIn] Hao, Yanrong [verfasserIn] Yuan, Yulin [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Immunobiology - München : Elsevier, 1979, 228 |
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Übergeordnetes Werk: |
volume:228 |
DOI / URN: |
10.1016/j.imbio.2023.152391 |
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Katalog-ID: |
ELV010321969 |
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520 | |a The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. | ||
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10.1016/j.imbio.2023.152391 doi (DE-627)ELV010321969 (ELSEVIER)S0171-2985(23)00059-1 DE-627 ger DE-627 rda eng 570 610 VZ 42.00 bkl 44.45 bkl Lao, Juanfeng verfasserin aut Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. NSCLC Anti-PD-1 immunotherapy Co-stimulatory molecules Co-inhibitory molecules Cytokines Xu, Huiting verfasserin aut Liang, Zibin verfasserin aut Luo, Changliang verfasserin aut Shu, Liuyang verfasserin aut Xie, Yuping verfasserin aut Wu, Yongjian verfasserin aut Hao, Yanrong verfasserin aut Yuan, Yulin verfasserin (orcid)0000-0003-0393-7475 aut Enthalten in Immunobiology München : Elsevier, 1979 228 Online-Ressource (DE-627)335415989 (DE-600)2060227-3 (DE-576)096290919 1878-3279 nnns volume:228 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_168 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4251 GBV_ILN_4323 42.00 Biologie: Allgemeines VZ 44.45 Immunologie VZ AR 228 |
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10.1016/j.imbio.2023.152391 doi (DE-627)ELV010321969 (ELSEVIER)S0171-2985(23)00059-1 DE-627 ger DE-627 rda eng 570 610 VZ 42.00 bkl 44.45 bkl Lao, Juanfeng verfasserin aut Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. NSCLC Anti-PD-1 immunotherapy Co-stimulatory molecules Co-inhibitory molecules Cytokines Xu, Huiting verfasserin aut Liang, Zibin verfasserin aut Luo, Changliang verfasserin aut Shu, Liuyang verfasserin aut Xie, Yuping verfasserin aut Wu, Yongjian verfasserin aut Hao, Yanrong verfasserin aut Yuan, Yulin verfasserin (orcid)0000-0003-0393-7475 aut Enthalten in Immunobiology München : Elsevier, 1979 228 Online-Ressource (DE-627)335415989 (DE-600)2060227-3 (DE-576)096290919 1878-3279 nnns volume:228 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_168 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4251 GBV_ILN_4323 42.00 Biologie: Allgemeines VZ 44.45 Immunologie VZ AR 228 |
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10.1016/j.imbio.2023.152391 doi (DE-627)ELV010321969 (ELSEVIER)S0171-2985(23)00059-1 DE-627 ger DE-627 rda eng 570 610 VZ 42.00 bkl 44.45 bkl Lao, Juanfeng verfasserin aut Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. NSCLC Anti-PD-1 immunotherapy Co-stimulatory molecules Co-inhibitory molecules Cytokines Xu, Huiting verfasserin aut Liang, Zibin verfasserin aut Luo, Changliang verfasserin aut Shu, Liuyang verfasserin aut Xie, Yuping verfasserin aut Wu, Yongjian verfasserin aut Hao, Yanrong verfasserin aut Yuan, Yulin verfasserin (orcid)0000-0003-0393-7475 aut Enthalten in Immunobiology München : Elsevier, 1979 228 Online-Ressource (DE-627)335415989 (DE-600)2060227-3 (DE-576)096290919 1878-3279 nnns volume:228 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_168 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4251 GBV_ILN_4323 42.00 Biologie: Allgemeines VZ 44.45 Immunologie VZ AR 228 |
allfieldsGer |
10.1016/j.imbio.2023.152391 doi (DE-627)ELV010321969 (ELSEVIER)S0171-2985(23)00059-1 DE-627 ger DE-627 rda eng 570 610 VZ 42.00 bkl 44.45 bkl Lao, Juanfeng verfasserin aut Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. NSCLC Anti-PD-1 immunotherapy Co-stimulatory molecules Co-inhibitory molecules Cytokines Xu, Huiting verfasserin aut Liang, Zibin verfasserin aut Luo, Changliang verfasserin aut Shu, Liuyang verfasserin aut Xie, Yuping verfasserin aut Wu, Yongjian verfasserin aut Hao, Yanrong verfasserin aut Yuan, Yulin verfasserin (orcid)0000-0003-0393-7475 aut Enthalten in Immunobiology München : Elsevier, 1979 228 Online-Ressource (DE-627)335415989 (DE-600)2060227-3 (DE-576)096290919 1878-3279 nnns volume:228 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_168 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4251 GBV_ILN_4323 42.00 Biologie: Allgemeines VZ 44.45 Immunologie VZ AR 228 |
allfieldsSound |
10.1016/j.imbio.2023.152391 doi (DE-627)ELV010321969 (ELSEVIER)S0171-2985(23)00059-1 DE-627 ger DE-627 rda eng 570 610 VZ 42.00 bkl 44.45 bkl Lao, Juanfeng verfasserin aut Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. NSCLC Anti-PD-1 immunotherapy Co-stimulatory molecules Co-inhibitory molecules Cytokines Xu, Huiting verfasserin aut Liang, Zibin verfasserin aut Luo, Changliang verfasserin aut Shu, Liuyang verfasserin aut Xie, Yuping verfasserin aut Wu, Yongjian verfasserin aut Hao, Yanrong verfasserin aut Yuan, Yulin verfasserin (orcid)0000-0003-0393-7475 aut Enthalten in Immunobiology München : Elsevier, 1979 228 Online-Ressource (DE-627)335415989 (DE-600)2060227-3 (DE-576)096290919 1878-3279 nnns volume:228 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_168 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4251 GBV_ILN_4323 42.00 Biologie: Allgemeines VZ 44.45 Immunologie VZ AR 228 |
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Lao, Juanfeng @@aut@@ Xu, Huiting @@aut@@ Liang, Zibin @@aut@@ Luo, Changliang @@aut@@ Shu, Liuyang @@aut@@ Xie, Yuping @@aut@@ Wu, Yongjian @@aut@@ Hao, Yanrong @@aut@@ Yuan, Yulin @@aut@@ |
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Lao, Juanfeng |
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Lao, Juanfeng ddc 570 bkl 42.00 bkl 44.45 misc NSCLC misc Anti-PD-1 immunotherapy misc Co-stimulatory molecules misc Co-inhibitory molecules misc Cytokines Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer |
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peripheral changes in t cells predict efficacy of anti-pd-1 immunotherapy in non-small cell lung cancer |
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Peripheral changes in T cells predict efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer |
abstract |
The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. |
abstractGer |
The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. |
abstract_unstemmed |
The application of programmed cell death protein 1 (PD-1) antibodies has brought great benefits to non-small cell lung cancer (NSCLC) patients. Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. This study indicates that monitoring the alterations of immune markers in circulating cells from NSCLC patients may be helpful to discriminate responders and non-responders, which provides a potential novel way to assess efficacy of anti-PD-1 immunotherapy. |
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Nevertheless, not all patients respond to anti-PD-1 immunotherapy. This study aimed to find response markers to predict efficacy of anti-PD-1 immunotherapy in NSCLC patients. 80 patients with NSCLC who would accept anti-PD-1 immunotherapy were recruited, and peripheral blood was obtained before and after treatment. Flow cytometry was used to detect proportions of circulating cell subsets and expression of co-stimulatory molecules, co-inhibitory molecules and cytokines in T cells from pre- and post-treatment patients. Results showed that proportions of CD4+ and CD8+ T cells, NK, γδT and mucosal-associated invariant T (MAIT) cells were higher and regulatory T cells (Tregs) were lower in responders (n = 50) after treatment but no obvious difference was found in non-responders (n = 30). After treatment, responders showed an increase in the frequency of co-stimulatory and co-inhibitory molecules, as well as the production of cytokines in T cells. 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score |
7.399867 |