Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in s...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Licata, Luca [verfasserIn] Mariani, Marco [verfasserIn] Rossari, Federico [verfasserIn] Viale, Giulia [verfasserIn] Notini, Giulia [verfasserIn] Naldini, Matteo Maria [verfasserIn] Bosi, Carlo [verfasserIn] Piras, Marta [verfasserIn] Dugo, Matteo [verfasserIn] Bianchini, Giampaolo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Immune checkpoint inhibitors Predictive biomarkers Breast cancer

Übergeordnetes Werk:	Enthalten in: The breast - Amsterdam [u.a.] : Elsevier, 1992, 69, Seite 330-341
Übergeordnetes Werk:	volume:69 ; pages:330-341

DOI / URN:	10.1016/j.breast.2023.03.014

Katalog-ID:	ELV010416528

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allfields	10.1016/j.breast.2023.03.014 doi (DE-627)ELV010416528 (ELSEVIER)S0960-9776(23)00431-9 DE-627 ger DE-627 rda eng 610 VZ 44.92 bkl Licata, Luca verfasserin (orcid)0000-0002-0331-3585 aut Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer. Immune checkpoint inhibitors Predictive biomarkers Breast cancer Mariani, Marco verfasserin aut Rossari, Federico verfasserin aut Viale, Giulia verfasserin aut Notini, Giulia verfasserin aut Naldini, Matteo Maria verfasserin aut Bosi, Carlo verfasserin aut Piras, Marta verfasserin aut Dugo, Matteo verfasserin aut Bianchini, Giampaolo verfasserin (orcid)0000-0002-6790-6267 aut Enthalten in The breast Amsterdam [u.a.] : Elsevier, 1992 69, Seite 330-341 Online-Ressource (DE-627)320475042 (DE-600)2009043-2 (DE-576)103868151 1532-3080 nnns volume:69 pages:330-341 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.92 Gynäkologie VZ AR 69 330-341
spelling	10.1016/j.breast.2023.03.014 doi (DE-627)ELV010416528 (ELSEVIER)S0960-9776(23)00431-9 DE-627 ger DE-627 rda eng 610 VZ 44.92 bkl Licata, Luca verfasserin (orcid)0000-0002-0331-3585 aut Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer. Immune checkpoint inhibitors Predictive biomarkers Breast cancer Mariani, Marco verfasserin aut Rossari, Federico verfasserin aut Viale, Giulia verfasserin aut Notini, Giulia verfasserin aut Naldini, Matteo Maria verfasserin aut Bosi, Carlo verfasserin aut Piras, Marta verfasserin aut Dugo, Matteo verfasserin aut Bianchini, Giampaolo verfasserin (orcid)0000-0002-6790-6267 aut Enthalten in The breast Amsterdam [u.a.] : Elsevier, 1992 69, Seite 330-341 Online-Ressource (DE-627)320475042 (DE-600)2009043-2 (DE-576)103868151 1532-3080 nnns volume:69 pages:330-341 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.92 Gynäkologie VZ AR 69 330-341
allfields_unstemmed	10.1016/j.breast.2023.03.014 doi (DE-627)ELV010416528 (ELSEVIER)S0960-9776(23)00431-9 DE-627 ger DE-627 rda eng 610 VZ 44.92 bkl Licata, Luca verfasserin (orcid)0000-0002-0331-3585 aut Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer. Immune checkpoint inhibitors Predictive biomarkers Breast cancer Mariani, Marco verfasserin aut Rossari, Federico verfasserin aut Viale, Giulia verfasserin aut Notini, Giulia verfasserin aut Naldini, Matteo Maria verfasserin aut Bosi, Carlo verfasserin aut Piras, Marta verfasserin aut Dugo, Matteo verfasserin aut Bianchini, Giampaolo verfasserin (orcid)0000-0002-6790-6267 aut Enthalten in The breast Amsterdam [u.a.] : Elsevier, 1992 69, Seite 330-341 Online-Ressource (DE-627)320475042 (DE-600)2009043-2 (DE-576)103868151 1532-3080 nnns volume:69 pages:330-341 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.92 Gynäkologie VZ AR 69 330-341
allfieldsGer	10.1016/j.breast.2023.03.014 doi (DE-627)ELV010416528 (ELSEVIER)S0960-9776(23)00431-9 DE-627 ger DE-627 rda eng 610 VZ 44.92 bkl Licata, Luca verfasserin (orcid)0000-0002-0331-3585 aut Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer. Immune checkpoint inhibitors Predictive biomarkers Breast cancer Mariani, Marco verfasserin aut Rossari, Federico verfasserin aut Viale, Giulia verfasserin aut Notini, Giulia verfasserin aut Naldini, Matteo Maria verfasserin aut Bosi, Carlo verfasserin aut Piras, Marta verfasserin aut Dugo, Matteo verfasserin aut Bianchini, Giampaolo verfasserin (orcid)0000-0002-6790-6267 aut Enthalten in The breast Amsterdam [u.a.] : Elsevier, 1992 69, Seite 330-341 Online-Ressource (DE-627)320475042 (DE-600)2009043-2 (DE-576)103868151 1532-3080 nnns volume:69 pages:330-341 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.92 Gynäkologie VZ AR 69 330-341
allfieldsSound	10.1016/j.breast.2023.03.014 doi (DE-627)ELV010416528 (ELSEVIER)S0960-9776(23)00431-9 DE-627 ger DE-627 rda eng 610 VZ 44.92 bkl Licata, Luca verfasserin (orcid)0000-0002-0331-3585 aut Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer. Immune checkpoint inhibitors Predictive biomarkers Breast cancer Mariani, Marco verfasserin aut Rossari, Federico verfasserin aut Viale, Giulia verfasserin aut Notini, Giulia verfasserin aut Naldini, Matteo Maria verfasserin aut Bosi, Carlo verfasserin aut Piras, Marta verfasserin aut Dugo, Matteo verfasserin aut Bianchini, Giampaolo verfasserin (orcid)0000-0002-6790-6267 aut Enthalten in The breast Amsterdam [u.a.] : Elsevier, 1992 69, Seite 330-341 Online-Ressource (DE-627)320475042 (DE-600)2009043-2 (DE-576)103868151 1532-3080 nnns volume:69 pages:330-341 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.92 Gynäkologie VZ AR 69 330-341
language	English
source	Enthalten in The breast 69, Seite 330-341 volume:69 pages:330-341
sourceStr	Enthalten in The breast 69, Seite 330-341 volume:69 pages:330-341
format_phy_str_mv	Article
bklname	Gynäkologie
institution	findex.gbv.de
topic_facet	Immune checkpoint inhibitors Predictive biomarkers Breast cancer
dewey-raw	610
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container_title	The breast
authorswithroles_txt_mv	Licata, Luca @@aut@@ Mariani, Marco @@aut@@ Rossari, Federico @@aut@@ Viale, Giulia @@aut@@ Notini, Giulia @@aut@@ Naldini, Matteo Maria @@aut@@ Bosi, Carlo @@aut@@ Piras, Marta @@aut@@ Dugo, Matteo @@aut@@ Bianchini, Giampaolo @@aut@@
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author	Licata, Luca
spellingShingle	Licata, Luca ddc 610 bkl 44.92 misc Immune checkpoint inhibitors misc Predictive biomarkers misc Breast cancer Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer
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topic_title	610 VZ 44.92 bkl Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer Immune checkpoint inhibitors Predictive biomarkers Breast cancer
topic	ddc 610 bkl 44.92 misc Immune checkpoint inhibitors misc Predictive biomarkers misc Breast cancer
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title	Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer
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title_full	Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer
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title_sort	tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer
title_auth	Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer
abstract	Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer.
abstractGer	Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer.
abstract_unstemmed	Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and now represent the mainstay of treatment for many tumor types, including triple-negative breast cancer and two agnostic registrations. However, despite impressive durable responses suggestive of an even curative potential in some cases, most patients receiving ICIs do not derive a substantial benefit, highlighting the need for more precise patient selection and stratification. The identification of predictive biomarkers of response to ICIs may play a pivotal role in optimizing the therapeutic use of such compounds. In this Review, we describe the current landscape of tissue and blood biomarkers that could serve as predictive factors for ICI treatment in breast cancer.
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title_short	Tissue- and liquid biopsy-based biomarkers for immunotherapy in breast cancer
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author2	Mariani, Marco Rossari, Federico Viale, Giulia Notini, Giulia Naldini, Matteo Maria Bosi, Carlo Piras, Marta Dugo, Matteo Bianchini, Giampaolo
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doi_str	10.1016/j.breast.2023.03.014
up_date	2024-07-06T17:54:56.370Z
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