Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies le...
Ausführliche Beschreibung
Autor*in: |
Stammers, Timothy A. [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2013 |
---|
Schlagwörter: |
---|
Umfang: |
5 |
---|
Übergeordnetes Werk: |
Enthalten in: Feeding European sea bass ( - Torrecillas, S. ELSEVIER, 2018, a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Amsterdam [u.a.] |
---|---|
Übergeordnetes Werk: |
volume:23 ; year:2013 ; number:9 ; day:1 ; month:05 ; pages:2585-2589 ; extent:5 |
Links: |
---|
DOI / URN: |
10.1016/j.bmcl.2013.02.110 |
---|
Katalog-ID: |
ELV011760540 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | ELV011760540 | ||
003 | DE-627 | ||
005 | 20230623092802.0 | ||
007 | cr uuu---uuuuu | ||
008 | 180602s2013 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.bmcl.2013.02.110 |2 doi | |
028 | 5 | 2 | |a GBVA2013016000014.pica |
035 | |a (DE-627)ELV011760540 | ||
035 | |a (ELSEVIER)S0960-894X(13)00297-7 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | |a 540 |a 610 | |
082 | 0 | 4 | |a 540 |q DE-600 |
082 | 0 | 4 | |a 610 |q DE-600 |
082 | 0 | 4 | |a 630 |q VZ |
084 | |a 22 |2 ssgn | ||
084 | |a 46.00 |2 bkl | ||
100 | 1 | |a Stammers, Timothy A. |e verfasserin |4 aut | |
245 | 1 | 0 | |a Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors |
264 | 1 | |c 2013 | |
300 | |a 5 | ||
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a nicht spezifiziert |b z |2 rdamedia | ||
338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
520 | |a Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. | ||
650 | 7 | |a Non-nucleoside inhibitor |2 Elsevier | |
650 | 7 | |a Parallel synthesis |2 Elsevier | |
650 | 7 | |a Antiviral |2 Elsevier | |
650 | 7 | |a NS5B polymerase |2 Elsevier | |
650 | 7 | |a Hepatitis C virus |2 Elsevier | |
650 | 7 | |a Structure based drug design |2 Elsevier | |
700 | 1 | |a Coulombe, René |4 oth | |
700 | 1 | |a Rancourt, Jean |4 oth | |
700 | 1 | |a Thavonekham, Bounkham |4 oth | |
700 | 1 | |a Fazal, Gulrez |4 oth | |
700 | 1 | |a Goulet, Sylvie |4 oth | |
700 | 1 | |a Jakalian, Araz |4 oth | |
700 | 1 | |a Wernic, Dominic |4 oth | |
700 | 1 | |a Tsantrizos, Youla |4 oth | |
700 | 1 | |a Poupart, Marc-André |4 oth | |
700 | 1 | |a Bös, Michael |4 oth | |
700 | 1 | |a McKercher, Ginette |4 oth | |
700 | 1 | |a Thauvette, Louise |4 oth | |
700 | 1 | |a Kukolj, George |4 oth | |
700 | 1 | |a Beaulieu, Pierre L. |4 oth | |
773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Torrecillas, S. ELSEVIER |t Feeding European sea bass ( |d 2018 |d a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines |g Amsterdam [u.a.] |w (DE-627)ELV000272361 |
773 | 1 | 8 | |g volume:23 |g year:2013 |g number:9 |g day:1 |g month:05 |g pages:2585-2589 |g extent:5 |
856 | 4 | 0 | |u https://doi.org/10.1016/j.bmcl.2013.02.110 |3 Volltext |
912 | |a GBV_USEFLAG_U | ||
912 | |a GBV_ELV | ||
912 | |a SYSFLAG_U | ||
936 | b | k | |a 46.00 |j Tiermedizin: Allgemeines |q VZ |
951 | |a AR | ||
952 | |d 23 |j 2013 |e 9 |b 1 |c 0501 |h 2585-2589 |g 5 | ||
953 | |2 045F |a 540 |
author_variant |
t a s ta tas |
---|---|
matchkey_str |
stammerstimothyacoulomberenrancourtjeant:2013----:icvroaoesreonnuloiehmpce2cn5 |
hierarchy_sort_str |
2013 |
bklnumber |
46.00 |
publishDate |
2013 |
allfields |
10.1016/j.bmcl.2013.02.110 doi GBVA2013016000014.pica (DE-627)ELV011760540 (ELSEVIER)S0960-894X(13)00297-7 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Stammers, Timothy A. verfasserin aut Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Elsevier Coulombe, René oth Rancourt, Jean oth Thavonekham, Bounkham oth Fazal, Gulrez oth Goulet, Sylvie oth Jakalian, Araz oth Wernic, Dominic oth Tsantrizos, Youla oth Poupart, Marc-André oth Bös, Michael oth McKercher, Ginette oth Thauvette, Louise oth Kukolj, George oth Beaulieu, Pierre L. oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 https://doi.org/10.1016/j.bmcl.2013.02.110 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 23 2013 9 1 0501 2585-2589 5 045F 540 |
spelling |
10.1016/j.bmcl.2013.02.110 doi GBVA2013016000014.pica (DE-627)ELV011760540 (ELSEVIER)S0960-894X(13)00297-7 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Stammers, Timothy A. verfasserin aut Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Elsevier Coulombe, René oth Rancourt, Jean oth Thavonekham, Bounkham oth Fazal, Gulrez oth Goulet, Sylvie oth Jakalian, Araz oth Wernic, Dominic oth Tsantrizos, Youla oth Poupart, Marc-André oth Bös, Michael oth McKercher, Ginette oth Thauvette, Louise oth Kukolj, George oth Beaulieu, Pierre L. oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 https://doi.org/10.1016/j.bmcl.2013.02.110 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 23 2013 9 1 0501 2585-2589 5 045F 540 |
allfields_unstemmed |
10.1016/j.bmcl.2013.02.110 doi GBVA2013016000014.pica (DE-627)ELV011760540 (ELSEVIER)S0960-894X(13)00297-7 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Stammers, Timothy A. verfasserin aut Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Elsevier Coulombe, René oth Rancourt, Jean oth Thavonekham, Bounkham oth Fazal, Gulrez oth Goulet, Sylvie oth Jakalian, Araz oth Wernic, Dominic oth Tsantrizos, Youla oth Poupart, Marc-André oth Bös, Michael oth McKercher, Ginette oth Thauvette, Louise oth Kukolj, George oth Beaulieu, Pierre L. oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 https://doi.org/10.1016/j.bmcl.2013.02.110 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 23 2013 9 1 0501 2585-2589 5 045F 540 |
allfieldsGer |
10.1016/j.bmcl.2013.02.110 doi GBVA2013016000014.pica (DE-627)ELV011760540 (ELSEVIER)S0960-894X(13)00297-7 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Stammers, Timothy A. verfasserin aut Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Elsevier Coulombe, René oth Rancourt, Jean oth Thavonekham, Bounkham oth Fazal, Gulrez oth Goulet, Sylvie oth Jakalian, Araz oth Wernic, Dominic oth Tsantrizos, Youla oth Poupart, Marc-André oth Bös, Michael oth McKercher, Ginette oth Thauvette, Louise oth Kukolj, George oth Beaulieu, Pierre L. oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 https://doi.org/10.1016/j.bmcl.2013.02.110 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 23 2013 9 1 0501 2585-2589 5 045F 540 |
allfieldsSound |
10.1016/j.bmcl.2013.02.110 doi GBVA2013016000014.pica (DE-627)ELV011760540 (ELSEVIER)S0960-894X(13)00297-7 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Stammers, Timothy A. verfasserin aut Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Elsevier Coulombe, René oth Rancourt, Jean oth Thavonekham, Bounkham oth Fazal, Gulrez oth Goulet, Sylvie oth Jakalian, Araz oth Wernic, Dominic oth Tsantrizos, Youla oth Poupart, Marc-André oth Bös, Michael oth McKercher, Ginette oth Thauvette, Louise oth Kukolj, George oth Beaulieu, Pierre L. oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 https://doi.org/10.1016/j.bmcl.2013.02.110 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 23 2013 9 1 0501 2585-2589 5 045F 540 |
language |
English |
source |
Enthalten in Feeding European sea bass ( Amsterdam [u.a.] volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 |
sourceStr |
Enthalten in Feeding European sea bass ( Amsterdam [u.a.] volume:23 year:2013 number:9 day:1 month:05 pages:2585-2589 extent:5 |
format_phy_str_mv |
Article |
bklname |
Tiermedizin: Allgemeines |
institution |
findex.gbv.de |
topic_facet |
Non-nucleoside inhibitor Parallel synthesis Antiviral NS5B polymerase Hepatitis C virus Structure based drug design |
dewey-raw |
540 |
isfreeaccess_bool |
false |
container_title |
Feeding European sea bass ( |
authorswithroles_txt_mv |
Stammers, Timothy A. @@aut@@ Coulombe, René @@oth@@ Rancourt, Jean @@oth@@ Thavonekham, Bounkham @@oth@@ Fazal, Gulrez @@oth@@ Goulet, Sylvie @@oth@@ Jakalian, Araz @@oth@@ Wernic, Dominic @@oth@@ Tsantrizos, Youla @@oth@@ Poupart, Marc-André @@oth@@ Bös, Michael @@oth@@ McKercher, Ginette @@oth@@ Thauvette, Louise @@oth@@ Kukolj, George @@oth@@ Beaulieu, Pierre L. @@oth@@ |
publishDateDaySort_date |
2013-01-01T00:00:00Z |
hierarchy_top_id |
ELV000272361 |
dewey-sort |
3540 |
id |
ELV011760540 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV011760540</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230623092802.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180602s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.bmcl.2013.02.110</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2013016000014.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV011760540</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0960-894X(13)00297-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">540</subfield><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">22</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">46.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Stammers, Timothy A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Non-nucleoside inhibitor</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parallel synthesis</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Antiviral</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">NS5B polymerase</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Hepatitis C virus</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Structure based drug design</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coulombe, René</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rancourt, Jean</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thavonekham, Bounkham</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fazal, Gulrez</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goulet, Sylvie</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jakalian, Araz</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wernic, Dominic</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tsantrizos, Youla</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Poupart, Marc-André</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bös, Michael</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McKercher, Ginette</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thauvette, Louise</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kukolj, George</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Beaulieu, Pierre L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Torrecillas, S. ELSEVIER</subfield><subfield code="t">Feeding European sea bass (</subfield><subfield code="d">2018</subfield><subfield code="d">a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV000272361</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:9</subfield><subfield code="g">day:1</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:2585-2589</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.bmcl.2013.02.110</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">46.00</subfield><subfield code="j">Tiermedizin: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2013</subfield><subfield code="e">9</subfield><subfield code="b">1</subfield><subfield code="c">0501</subfield><subfield code="h">2585-2589</subfield><subfield code="g">5</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
|
author |
Stammers, Timothy A. |
spellingShingle |
Stammers, Timothy A. ddc 540 ddc 610 ddc 630 ssgn 22 bkl 46.00 Elsevier Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors |
authorStr |
Stammers, Timothy A. |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV000272361 |
format |
electronic Article |
dewey-ones |
540 - Chemistry & allied sciences 610 - Medicine & health 630 - Agriculture & related technologies |
delete_txt_mv |
keep |
author_role |
aut |
collection |
elsevier |
remote_str |
true |
illustrated |
Not Illustrated |
topic_title |
540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design Elsevier |
topic |
ddc 540 ddc 610 ddc 630 ssgn 22 bkl 46.00 Elsevier Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design |
topic_unstemmed |
ddc 540 ddc 610 ddc 630 ssgn 22 bkl 46.00 Elsevier Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design |
topic_browse |
ddc 540 ddc 610 ddc 630 ssgn 22 bkl 46.00 Elsevier Non-nucleoside inhibitor Elsevier Parallel synthesis Elsevier Antiviral Elsevier NS5B polymerase Elsevier Hepatitis C virus Elsevier Structure based drug design |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
zu |
author2_variant |
r c rc j r jr b t bt g f gf s g sg a j aj d w dw y t yt m a p map m b mb g m gm l t lt g k gk p l b pl plb |
hierarchy_parent_title |
Feeding European sea bass ( |
hierarchy_parent_id |
ELV000272361 |
dewey-tens |
540 - Chemistry 610 - Medicine & health 630 - Agriculture |
hierarchy_top_title |
Feeding European sea bass ( |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)ELV000272361 |
title |
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors |
ctrlnum |
(DE-627)ELV011760540 (ELSEVIER)S0960-894X(13)00297-7 |
title_full |
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors |
author_sort |
Stammers, Timothy A. |
journal |
Feeding European sea bass ( |
journalStr |
Feeding European sea bass ( |
lang_code |
eng |
isOA_bool |
false |
dewey-hundreds |
500 - Science 600 - Technology |
recordtype |
marc |
publishDateSort |
2013 |
contenttype_str_mv |
zzz |
container_start_page |
2585 |
author_browse |
Stammers, Timothy A. |
container_volume |
23 |
physical |
5 |
class |
540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl |
format_se |
Elektronische Aufsätze |
author-letter |
Stammers, Timothy A. |
doi_str_mv |
10.1016/j.bmcl.2013.02.110 |
dewey-full |
540 610 630 |
title_sort |
discovery of a novel series of non-nucleoside thumb pocket 2 hcv ns5b polymerase inhibitors |
title_auth |
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors |
abstract |
Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. |
abstractGer |
Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. |
abstract_unstemmed |
Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point. |
collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U |
container_issue |
9 |
title_short |
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors |
url |
https://doi.org/10.1016/j.bmcl.2013.02.110 |
remote_bool |
true |
author2 |
Coulombe, René Rancourt, Jean Thavonekham, Bounkham Fazal, Gulrez Goulet, Sylvie Jakalian, Araz Wernic, Dominic Tsantrizos, Youla Poupart, Marc-André Bös, Michael McKercher, Ginette Thauvette, Louise Kukolj, George Beaulieu, Pierre L. |
author2Str |
Coulombe, René Rancourt, Jean Thavonekham, Bounkham Fazal, Gulrez Goulet, Sylvie Jakalian, Araz Wernic, Dominic Tsantrizos, Youla Poupart, Marc-André Bös, Michael McKercher, Ginette Thauvette, Louise Kukolj, George Beaulieu, Pierre L. |
ppnlink |
ELV000272361 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth oth oth oth oth oth oth oth oth oth oth oth oth |
doi_str |
10.1016/j.bmcl.2013.02.110 |
up_date |
2024-07-06T20:45:37.765Z |
_version_ |
1803863969251721216 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV011760540</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230623092802.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180602s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.bmcl.2013.02.110</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2013016000014.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV011760540</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0960-894X(13)00297-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">540</subfield><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">22</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">46.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Stammers, Timothy A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a–c and 12a–c from a weak-binding fragment-like structure 1 as a starting point.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Non-nucleoside inhibitor</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parallel synthesis</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Antiviral</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">NS5B polymerase</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Hepatitis C virus</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Structure based drug design</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coulombe, René</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rancourt, Jean</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thavonekham, Bounkham</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fazal, Gulrez</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goulet, Sylvie</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jakalian, Araz</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wernic, Dominic</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tsantrizos, Youla</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Poupart, Marc-André</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bös, Michael</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McKercher, Ginette</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thauvette, Louise</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kukolj, George</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Beaulieu, Pierre L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Torrecillas, S. ELSEVIER</subfield><subfield code="t">Feeding European sea bass (</subfield><subfield code="d">2018</subfield><subfield code="d">a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV000272361</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:9</subfield><subfield code="g">day:1</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:2585-2589</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.bmcl.2013.02.110</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">46.00</subfield><subfield code="j">Tiermedizin: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2013</subfield><subfield code="e">9</subfield><subfield code="b">1</subfield><subfield code="c">0501</subfield><subfield code="h">2585-2589</subfield><subfield code="g">5</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
|
score |
7.3996124 |