Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: New potential treatment of abdominal pain associated with inflammatory bowel diseases
• Recent reports indicate the role of the endogenous opioid system and opioid receptors in the course of inflammatory bowel disease (IBD). • Biphalin is a linear octapeptide with a dimeric structure based on two identical portions derived from enkephalins. • Biphalin injected i.p. and i.c. (5mg/kg)...
Ausführliche Beschreibung
Gespeichert in:
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Sobczak, Marta [verfasserIn] |
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Englisch |
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2014 |
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| Schlagwörter: |
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5 |
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| Übergeordnetes Werk: |
Enthalten in: Lag projective synchronization of fractional-order delayed chaotic systems - Zhang, Weiwei ELSEVIER, 2018, an international journal, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:60 ; year:2014 ; pages:102-106 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.peptides.2014.08.005 |
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| 520 | |a • Recent reports indicate the role of the endogenous opioid system and opioid receptors in the course of inflammatory bowel disease (IBD). • Biphalin is a linear octapeptide with a dimeric structure based on two identical portions derived from enkephalins. • Biphalin injected i.p. and i.c. (5mg/kg) displayed a potent antinociceptive action in mouse models of colitis. • Biphalin may become a novel opioid-based antinociceptive agent in the therapy of gastrointestinal inflammatory diseases. | ||
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anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseases |
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Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: New potential treatment of abdominal pain associated with inflammatory bowel diseases |
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• Recent reports indicate the role of the endogenous opioid system and opioid receptors in the course of inflammatory bowel disease (IBD). • Biphalin is a linear octapeptide with a dimeric structure based on two identical portions derived from enkephalins. • Biphalin injected i.p. and i.c. (5mg/kg) displayed a potent antinociceptive action in mouse models of colitis. • Biphalin may become a novel opioid-based antinociceptive agent in the therapy of gastrointestinal inflammatory diseases. |
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• Recent reports indicate the role of the endogenous opioid system and opioid receptors in the course of inflammatory bowel disease (IBD). • Biphalin is a linear octapeptide with a dimeric structure based on two identical portions derived from enkephalins. • Biphalin injected i.p. and i.c. (5mg/kg) displayed a potent antinociceptive action in mouse models of colitis. • Biphalin may become a novel opioid-based antinociceptive agent in the therapy of gastrointestinal inflammatory diseases. |
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• Recent reports indicate the role of the endogenous opioid system and opioid receptors in the course of inflammatory bowel disease (IBD). • Biphalin is a linear octapeptide with a dimeric structure based on two identical portions derived from enkephalins. • Biphalin injected i.p. and i.c. (5mg/kg) displayed a potent antinociceptive action in mouse models of colitis. • Biphalin may become a novel opioid-based antinociceptive agent in the therapy of gastrointestinal inflammatory diseases. |
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Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: New potential treatment of abdominal pain associated with inflammatory bowel diseases |
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https://doi.org/10.1016/j.peptides.2014.08.005 |
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Pilarczyk, Andrzej Jonakowski, Mateusz Jarmuż, Agata Sałaga, Maciej Lipkowski, Andrzej W. Fichna, Jakub |
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Pilarczyk, Andrzej Jonakowski, Mateusz Jarmuż, Agata Sałaga, Maciej Lipkowski, Andrzej W. Fichna, Jakub |
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