Discovery of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs
Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nakao, Akira [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Feeding European sea bass ( - Torrecillas, S. ELSEVIER, 2018, a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:24 ; year:2014 ; number:17 ; day:1 ; month:09 ; pages:4336-4340 ; extent:5 |
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| DOI / URN: |
10.1016/j.bmcl.2014.06.008 |
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ELV012504939 |
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| 520 | |a Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value of 1.5nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels. | ||
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10.1016/j.bmcl.2014.06.008 doi GBVA2014016000002.pica (DE-627)ELV012504939 (ELSEVIER)S0960-894X(14)00636-2 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Nakao, Akira verfasserin aut Discovery of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs 2014 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value of 1.5nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels. Competitive Elsevier S-Adenosyl-l-homocysteine hydrolase inhibitors Elsevier Homocysteine Elsevier Suzuki, Hiroko oth Ueno, Hiroaki oth Iwasaki, Hiroshi oth Setsuta, Tomofumi oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:24 year:2014 number:17 day:1 month:09 pages:4336-4340 extent:5 https://doi.org/10.1016/j.bmcl.2014.06.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 24 2014 17 1 0901 4336-4340 5 045F 540 |
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10.1016/j.bmcl.2014.06.008 doi GBVA2014016000002.pica (DE-627)ELV012504939 (ELSEVIER)S0960-894X(14)00636-2 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 630 VZ 22 ssgn 46.00 bkl Nakao, Akira verfasserin aut Discovery of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs 2014 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value of 1.5nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels. Competitive Elsevier S-Adenosyl-l-homocysteine hydrolase inhibitors Elsevier Homocysteine Elsevier Suzuki, Hiroko oth Ueno, Hiroaki oth Iwasaki, Hiroshi oth Setsuta, Tomofumi oth Enthalten in Elsevier Science Torrecillas, S. ELSEVIER Feeding European sea bass ( 2018 a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV000272361 volume:24 year:2014 number:17 day:1 month:09 pages:4336-4340 extent:5 https://doi.org/10.1016/j.bmcl.2014.06.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 24 2014 17 1 0901 4336-4340 5 045F 540 |
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Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value of 1.5nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels. |
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Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value of 1.5nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels. |
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Abstract High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a K i value of 1.5nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels. |
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