Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bansal, Samiksha [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation - Arteaga, Alberto A. ELSEVIER, 2018, JSR : clinical and laboratory investigation : official publication of the Association for Academic Surgery : official publication of the Association of Veterans Administration Surgeons, Orlando, Fla |
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| Übergeordnetes Werk: |
volume:186 ; year:2014 ; number:1 ; pages:29-38 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.jss.2013.07.001 |
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ELV012587117 |
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| 520 | |a Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. | ||
| 520 | |a Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. | ||
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10.1016/j.jss.2013.07.001 doi GBVA2014021000004.pica (DE-627)ELV012587117 (ELSEVIER)S0022-4804(13)00687-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.94 bkl Bansal, Samiksha verfasserin aut Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma 2014transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Chemotherapy Elsevier Stearoyl-CoA desaturase Elsevier Lipid metabolism Elsevier Carcinogenesis Elsevier Apoptosis Elsevier Berk, Michael oth Alkhouri, Naim oth Partrick, David A. oth Fung, John J. oth Feldstein, Ariel oth Enthalten in Academic Press Arteaga, Alberto A. ELSEVIER Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation 2018 JSR : clinical and laboratory investigation : official publication of the Association for Academic Surgery : official publication of the Association of Veterans Administration Surgeons Orlando, Fla (DE-627)ELV00028954X volume:186 year:2014 number:1 pages:29-38 extent:10 https://doi.org/10.1016/j.jss.2013.07.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 186 2014 1 29-38 10 045F 610 |
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10.1016/j.jss.2013.07.001 doi GBVA2014021000004.pica (DE-627)ELV012587117 (ELSEVIER)S0022-4804(13)00687-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.94 bkl Bansal, Samiksha verfasserin aut Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma 2014transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Chemotherapy Elsevier Stearoyl-CoA desaturase Elsevier Lipid metabolism Elsevier Carcinogenesis Elsevier Apoptosis Elsevier Berk, Michael oth Alkhouri, Naim oth Partrick, David A. oth Fung, John J. oth Feldstein, Ariel oth Enthalten in Academic Press Arteaga, Alberto A. ELSEVIER Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation 2018 JSR : clinical and laboratory investigation : official publication of the Association for Academic Surgery : official publication of the Association of Veterans Administration Surgeons Orlando, Fla (DE-627)ELV00028954X volume:186 year:2014 number:1 pages:29-38 extent:10 https://doi.org/10.1016/j.jss.2013.07.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 186 2014 1 29-38 10 045F 610 |
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10.1016/j.jss.2013.07.001 doi GBVA2014021000004.pica (DE-627)ELV012587117 (ELSEVIER)S0022-4804(13)00687-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.94 bkl Bansal, Samiksha verfasserin aut Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma 2014transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Chemotherapy Elsevier Stearoyl-CoA desaturase Elsevier Lipid metabolism Elsevier Carcinogenesis Elsevier Apoptosis Elsevier Berk, Michael oth Alkhouri, Naim oth Partrick, David A. oth Fung, John J. oth Feldstein, Ariel oth Enthalten in Academic Press Arteaga, Alberto A. ELSEVIER Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation 2018 JSR : clinical and laboratory investigation : official publication of the Association for Academic Surgery : official publication of the Association of Veterans Administration Surgeons Orlando, Fla (DE-627)ELV00028954X volume:186 year:2014 number:1 pages:29-38 extent:10 https://doi.org/10.1016/j.jss.2013.07.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 186 2014 1 29-38 10 045F 610 |
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10.1016/j.jss.2013.07.001 doi GBVA2014021000004.pica (DE-627)ELV012587117 (ELSEVIER)S0022-4804(13)00687-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.94 bkl Bansal, Samiksha verfasserin aut Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma 2014transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. Chemotherapy Elsevier Stearoyl-CoA desaturase Elsevier Lipid metabolism Elsevier Carcinogenesis Elsevier Apoptosis Elsevier Berk, Michael oth Alkhouri, Naim oth Partrick, David A. oth Fung, John J. oth Feldstein, Ariel oth Enthalten in Academic Press Arteaga, Alberto A. ELSEVIER Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation 2018 JSR : clinical and laboratory investigation : official publication of the Association for Academic Surgery : official publication of the Association of Veterans Administration Surgeons Orlando, Fla (DE-627)ELV00028954X volume:186 year:2014 number:1 pages:29-38 extent:10 https://doi.org/10.1016/j.jss.2013.07.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 186 2014 1 29-38 10 045F 610 |
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Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation |
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Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation |
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Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma |
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Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma |
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Bansal, Samiksha |
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Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation |
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stearoyl-coa desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma |
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Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma |
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Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. |
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Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. |
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Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, when it is not amenable for aggressive therapies such as surgical resection or liver transplantation. Current therapeutic options achieve clinical responses in only a small percentage of cases. As a consequence, effective approaches for prevention and treatment are greatly needed. Altered lipid metabolism has been recently linked to HCC pathogenesis. The aims of this study were to define the cellular and molecular mechanisms linking stearoyl-CoA desaturase (SCD), the rate-limiting enzyme and an essential regulator of lipid homeostasis in liver cells, to carcinogenesis in HCC. |
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Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma |
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