Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer
We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for f...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Win, Aung Ko [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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10908 |
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| Übergeordnetes Werk: |
Enthalten in: Ubiquitin protease Ubp8 is necessary for - Leo, Manuela ELSEVIER, 2018, official publication of the American Gastroenterological Association, Stanford, Calif |
|---|---|
| Übergeordnetes Werk: |
volume:146 ; year:2014 ; number:5 ; pages:1208-12115 ; extent:10908 |
| Links: |
|---|
| DOI / URN: |
10.1053/j.gastro.2014.01.022 |
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| 520 | |a We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. | ||
| 520 | |a We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. | ||
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10.1053/j.gastro.2014.01.022 doi GBVA2014021000027.pica (DE-627)ELV012637092 (ELSEVIER)S0016-5085(14)00080-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Win, Aung Ko verfasserin aut Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer 2014transfer abstract 10908 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. DNA Damage Response Elsevier Base Excision Repair Gene Elsevier Colon Cancer Elsevier Genetics Elsevier Dowty, James G. oth Cleary, Sean P. oth Kim, Hyeja oth Buchanan, Daniel D. oth Young, Joanne P. oth Clendenning, Mark oth Rosty, Christophe oth MacInnis, Robert J. oth Giles, Graham G. oth Boussioutas, Alex oth Macrae, Finlay A. oth Parry, Susan oth Goldblatt, Jack oth Baron, John A. oth Burnett, Terrilea oth Le Marchand, Loïc oth Newcomb, Polly A. oth Haile, Robert W. oth Hopper, John L. oth Cotterchio, Michelle oth Gallinger, Steven oth Lindor, Noralane M. oth Tucker, Katherine M. oth Winship, Ingrid M. oth Jenkins, Mark A. oth Enthalten in HighWire Press Leo, Manuela ELSEVIER Ubiquitin protease Ubp8 is necessary for 2018 official publication of the American Gastroenterological Association Stanford, Calif (DE-627)ELV000307017 volume:146 year:2014 number:5 pages:1208-12115 extent:10908 https://doi.org/10.1053/j.gastro.2014.01.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 146 2014 5 1208-12115 10908 045F 610 |
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10.1053/j.gastro.2014.01.022 doi GBVA2014021000027.pica (DE-627)ELV012637092 (ELSEVIER)S0016-5085(14)00080-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Win, Aung Ko verfasserin aut Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer 2014transfer abstract 10908 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. DNA Damage Response Elsevier Base Excision Repair Gene Elsevier Colon Cancer Elsevier Genetics Elsevier Dowty, James G. oth Cleary, Sean P. oth Kim, Hyeja oth Buchanan, Daniel D. oth Young, Joanne P. oth Clendenning, Mark oth Rosty, Christophe oth MacInnis, Robert J. oth Giles, Graham G. oth Boussioutas, Alex oth Macrae, Finlay A. oth Parry, Susan oth Goldblatt, Jack oth Baron, John A. oth Burnett, Terrilea oth Le Marchand, Loïc oth Newcomb, Polly A. oth Haile, Robert W. oth Hopper, John L. oth Cotterchio, Michelle oth Gallinger, Steven oth Lindor, Noralane M. oth Tucker, Katherine M. oth Winship, Ingrid M. oth Jenkins, Mark A. oth Enthalten in HighWire Press Leo, Manuela ELSEVIER Ubiquitin protease Ubp8 is necessary for 2018 official publication of the American Gastroenterological Association Stanford, Calif (DE-627)ELV000307017 volume:146 year:2014 number:5 pages:1208-12115 extent:10908 https://doi.org/10.1053/j.gastro.2014.01.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 146 2014 5 1208-12115 10908 045F 610 |
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10.1053/j.gastro.2014.01.022 doi GBVA2014021000027.pica (DE-627)ELV012637092 (ELSEVIER)S0016-5085(14)00080-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Win, Aung Ko verfasserin aut Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer 2014transfer abstract 10908 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. DNA Damage Response Elsevier Base Excision Repair Gene Elsevier Colon Cancer Elsevier Genetics Elsevier Dowty, James G. oth Cleary, Sean P. oth Kim, Hyeja oth Buchanan, Daniel D. oth Young, Joanne P. oth Clendenning, Mark oth Rosty, Christophe oth MacInnis, Robert J. oth Giles, Graham G. oth Boussioutas, Alex oth Macrae, Finlay A. oth Parry, Susan oth Goldblatt, Jack oth Baron, John A. oth Burnett, Terrilea oth Le Marchand, Loïc oth Newcomb, Polly A. oth Haile, Robert W. oth Hopper, John L. oth Cotterchio, Michelle oth Gallinger, Steven oth Lindor, Noralane M. oth Tucker, Katherine M. oth Winship, Ingrid M. oth Jenkins, Mark A. oth Enthalten in HighWire Press Leo, Manuela ELSEVIER Ubiquitin protease Ubp8 is necessary for 2018 official publication of the American Gastroenterological Association Stanford, Calif (DE-627)ELV000307017 volume:146 year:2014 number:5 pages:1208-12115 extent:10908 https://doi.org/10.1053/j.gastro.2014.01.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 146 2014 5 1208-12115 10908 045F 610 |
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10.1053/j.gastro.2014.01.022 doi GBVA2014021000027.pica (DE-627)ELV012637092 (ELSEVIER)S0016-5085(14)00080-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Win, Aung Ko verfasserin aut Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer 2014transfer abstract 10908 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. DNA Damage Response Elsevier Base Excision Repair Gene Elsevier Colon Cancer Elsevier Genetics Elsevier Dowty, James G. oth Cleary, Sean P. oth Kim, Hyeja oth Buchanan, Daniel D. oth Young, Joanne P. oth Clendenning, Mark oth Rosty, Christophe oth MacInnis, Robert J. oth Giles, Graham G. oth Boussioutas, Alex oth Macrae, Finlay A. oth Parry, Susan oth Goldblatt, Jack oth Baron, John A. oth Burnett, Terrilea oth Le Marchand, Loïc oth Newcomb, Polly A. oth Haile, Robert W. oth Hopper, John L. oth Cotterchio, Michelle oth Gallinger, Steven oth Lindor, Noralane M. oth Tucker, Katherine M. oth Winship, Ingrid M. oth Jenkins, Mark A. oth Enthalten in HighWire Press Leo, Manuela ELSEVIER Ubiquitin protease Ubp8 is necessary for 2018 official publication of the American Gastroenterological Association Stanford, Calif (DE-627)ELV000307017 volume:146 year:2014 number:5 pages:1208-12115 extent:10908 https://doi.org/10.1053/j.gastro.2014.01.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 146 2014 5 1208-12115 10908 045F 610 |
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10.1053/j.gastro.2014.01.022 doi GBVA2014021000027.pica (DE-627)ELV012637092 (ELSEVIER)S0016-5085(14)00080-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Win, Aung Ko verfasserin aut Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer 2014transfer abstract 10908 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. DNA Damage Response Elsevier Base Excision Repair Gene Elsevier Colon Cancer Elsevier Genetics Elsevier Dowty, James G. oth Cleary, Sean P. oth Kim, Hyeja oth Buchanan, Daniel D. oth Young, Joanne P. oth Clendenning, Mark oth Rosty, Christophe oth MacInnis, Robert J. oth Giles, Graham G. oth Boussioutas, Alex oth Macrae, Finlay A. oth Parry, Susan oth Goldblatt, Jack oth Baron, John A. oth Burnett, Terrilea oth Le Marchand, Loïc oth Newcomb, Polly A. oth Haile, Robert W. oth Hopper, John L. oth Cotterchio, Michelle oth Gallinger, Steven oth Lindor, Noralane M. oth Tucker, Katherine M. oth Winship, Ingrid M. oth Jenkins, Mark A. oth Enthalten in HighWire Press Leo, Manuela ELSEVIER Ubiquitin protease Ubp8 is necessary for 2018 official publication of the American Gastroenterological Association Stanford, Calif (DE-627)ELV000307017 volume:146 year:2014 number:5 pages:1208-12115 extent:10908 https://doi.org/10.1053/j.gastro.2014.01.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 146 2014 5 1208-12115 10908 045F 610 |
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risk of colorectal cancer for carriers of mutations in mutyh, with and without a family history of cancer |
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Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer |
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We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. |
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We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. |
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We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. |
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We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). 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