Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease
Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wilson, Caroline L. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
8 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Identification of the antigenic region of - Abdelbaky, Hanan H. ELSEVIER, 2018, official journal of the European Association for the Study of the Liver, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:63 ; year:2015 ; number:6 ; pages:1421-1428 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jhep.2015.07.034 |
|---|
| Katalog-ID: |
ELV012871710 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV012871710 | ||
| 003 | DE-627 | ||
| 005 | 20230623102227.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180602s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jhep.2015.07.034 |2 doi | |
| 028 | 5 | 2 | |a GBVA2015006000007.pica |
| 035 | |a (DE-627)ELV012871710 | ||
| 035 | |a (ELSEVIER)S0168-8278(15)00537-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 44.44 |2 bkl | ||
| 100 | 1 | |a Wilson, Caroline L. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| 264 | 1 | |c 2015 | |
| 300 | |a 8 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. | ||
| 650 | 7 | |a CCl4 |2 Elsevier | |
| 650 | 7 | |a BDL |2 Elsevier | |
| 650 | 7 | |a CDK |2 Elsevier | |
| 650 | 7 | |a Ub |2 Elsevier | |
| 650 | 7 | |a DUB |2 Elsevier | |
| 650 | 7 | |a PDGFBB |2 Elsevier | |
| 650 | 7 | |a Rb |2 Elsevier | |
| 650 | 7 | |a UCHL1 |2 Elsevier | |
| 650 | 7 | |a USP |2 Elsevier | |
| 650 | 7 | |a qHSC |2 Elsevier | |
| 650 | 7 | |a αSMA |2 Elsevier | |
| 650 | 7 | |a HSC |2 Elsevier | |
| 650 | 7 | |a ALD |2 Elsevier | |
| 650 | 7 | |a aHSC |2 Elsevier | |
| 650 | 7 | |a IPF |2 Elsevier | |
| 700 | 1 | |a Murphy, Lindsay B. |4 oth | |
| 700 | 1 | |a Leslie, Jack |4 oth | |
| 700 | 1 | |a Kendrick, Stuart |4 oth | |
| 700 | 1 | |a French, Jeremy |4 oth | |
| 700 | 1 | |a Fox, Christopher R. |4 oth | |
| 700 | 1 | |a Sheerin, Neil S. |4 oth | |
| 700 | 1 | |a Fisher, Andrew |4 oth | |
| 700 | 1 | |a Robinson, John H. |4 oth | |
| 700 | 1 | |a Tiniakos, Dina G. |4 oth | |
| 700 | 1 | |a Gray, Douglas A. |4 oth | |
| 700 | 1 | |a Oakley, Fiona |4 oth | |
| 700 | 1 | |a Mann, Derek A. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Abdelbaky, Hanan H. ELSEVIER |t Identification of the antigenic region of |d 2018 |d official journal of the European Association for the Study of the Liver |g Amsterdam [u.a.] |w (DE-627)ELV000433829 |
| 773 | 1 | 8 | |g volume:63 |g year:2015 |g number:6 |g pages:1421-1428 |g extent:8 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jhep.2015.07.034 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 44.44 |j Parasitologie |x Medizin |q VZ |
| 951 | |a AR | ||
| 952 | |d 63 |j 2015 |e 6 |h 1421-1428 |g 8 | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
c l w cl clw |
|---|---|
| matchkey_str |
wilsoncarolinelmurphylindsayblesliejackk:2015----:bqiicemnlyrls1nvlucinlakrolvryfbolssnahrpu |
| hierarchy_sort_str |
2015 |
| bklnumber |
44.44 |
| publishDate |
2015 |
| allfields |
10.1016/j.jhep.2015.07.034 doi GBVA2015006000007.pica (DE-627)ELV012871710 (ELSEVIER)S0168-8278(15)00537-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.44 bkl Wilson, Caroline L. verfasserin aut Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease 2015 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Elsevier Murphy, Lindsay B. oth Leslie, Jack oth Kendrick, Stuart oth French, Jeremy oth Fox, Christopher R. oth Sheerin, Neil S. oth Fisher, Andrew oth Robinson, John H. oth Tiniakos, Dina G. oth Gray, Douglas A. oth Oakley, Fiona oth Mann, Derek A. oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:63 year:2015 number:6 pages:1421-1428 extent:8 https://doi.org/10.1016/j.jhep.2015.07.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 63 2015 6 1421-1428 8 045F 610 |
| spelling |
10.1016/j.jhep.2015.07.034 doi GBVA2015006000007.pica (DE-627)ELV012871710 (ELSEVIER)S0168-8278(15)00537-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.44 bkl Wilson, Caroline L. verfasserin aut Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease 2015 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Elsevier Murphy, Lindsay B. oth Leslie, Jack oth Kendrick, Stuart oth French, Jeremy oth Fox, Christopher R. oth Sheerin, Neil S. oth Fisher, Andrew oth Robinson, John H. oth Tiniakos, Dina G. oth Gray, Douglas A. oth Oakley, Fiona oth Mann, Derek A. oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:63 year:2015 number:6 pages:1421-1428 extent:8 https://doi.org/10.1016/j.jhep.2015.07.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 63 2015 6 1421-1428 8 045F 610 |
| allfields_unstemmed |
10.1016/j.jhep.2015.07.034 doi GBVA2015006000007.pica (DE-627)ELV012871710 (ELSEVIER)S0168-8278(15)00537-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.44 bkl Wilson, Caroline L. verfasserin aut Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease 2015 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Elsevier Murphy, Lindsay B. oth Leslie, Jack oth Kendrick, Stuart oth French, Jeremy oth Fox, Christopher R. oth Sheerin, Neil S. oth Fisher, Andrew oth Robinson, John H. oth Tiniakos, Dina G. oth Gray, Douglas A. oth Oakley, Fiona oth Mann, Derek A. oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:63 year:2015 number:6 pages:1421-1428 extent:8 https://doi.org/10.1016/j.jhep.2015.07.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 63 2015 6 1421-1428 8 045F 610 |
| allfieldsGer |
10.1016/j.jhep.2015.07.034 doi GBVA2015006000007.pica (DE-627)ELV012871710 (ELSEVIER)S0168-8278(15)00537-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.44 bkl Wilson, Caroline L. verfasserin aut Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease 2015 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Elsevier Murphy, Lindsay B. oth Leslie, Jack oth Kendrick, Stuart oth French, Jeremy oth Fox, Christopher R. oth Sheerin, Neil S. oth Fisher, Andrew oth Robinson, John H. oth Tiniakos, Dina G. oth Gray, Douglas A. oth Oakley, Fiona oth Mann, Derek A. oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:63 year:2015 number:6 pages:1421-1428 extent:8 https://doi.org/10.1016/j.jhep.2015.07.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 63 2015 6 1421-1428 8 045F 610 |
| allfieldsSound |
10.1016/j.jhep.2015.07.034 doi GBVA2015006000007.pica (DE-627)ELV012871710 (ELSEVIER)S0168-8278(15)00537-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.44 bkl Wilson, Caroline L. verfasserin aut Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease 2015 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Elsevier Murphy, Lindsay B. oth Leslie, Jack oth Kendrick, Stuart oth French, Jeremy oth Fox, Christopher R. oth Sheerin, Neil S. oth Fisher, Andrew oth Robinson, John H. oth Tiniakos, Dina G. oth Gray, Douglas A. oth Oakley, Fiona oth Mann, Derek A. oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:63 year:2015 number:6 pages:1421-1428 extent:8 https://doi.org/10.1016/j.jhep.2015.07.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 63 2015 6 1421-1428 8 045F 610 |
| language |
English |
| source |
Enthalten in Identification of the antigenic region of Amsterdam [u.a.] volume:63 year:2015 number:6 pages:1421-1428 extent:8 |
| sourceStr |
Enthalten in Identification of the antigenic region of Amsterdam [u.a.] volume:63 year:2015 number:6 pages:1421-1428 extent:8 |
| format_phy_str_mv |
Article |
| bklname |
Parasitologie |
| institution |
findex.gbv.de |
| topic_facet |
CCl4 BDL CDK Ub DUB PDGFBB Rb UCHL1 USP qHSC αSMA HSC ALD aHSC IPF |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Identification of the antigenic region of |
| authorswithroles_txt_mv |
Wilson, Caroline L. @@aut@@ Murphy, Lindsay B. @@oth@@ Leslie, Jack @@oth@@ Kendrick, Stuart @@oth@@ French, Jeremy @@oth@@ Fox, Christopher R. @@oth@@ Sheerin, Neil S. @@oth@@ Fisher, Andrew @@oth@@ Robinson, John H. @@oth@@ Tiniakos, Dina G. @@oth@@ Gray, Douglas A. @@oth@@ Oakley, Fiona @@oth@@ Mann, Derek A. @@oth@@ |
| publishDateDaySort_date |
2015-01-01T00:00:00Z |
| hierarchy_top_id |
ELV000433829 |
| dewey-sort |
3610 |
| id |
ELV012871710 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV012871710</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230623102227.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180602s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jhep.2015.07.034</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2015006000007.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV012871710</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0168-8278(15)00537-1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.44</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wilson, Caroline L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">CCl4</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">BDL</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">CDK</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Ub</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">DUB</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">PDGFBB</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Rb</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">UCHL1</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">USP</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">qHSC</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">αSMA</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">HSC</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">ALD</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">aHSC</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">IPF</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Murphy, Lindsay B.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Leslie, Jack</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kendrick, Stuart</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">French, Jeremy</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fox, Christopher R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sheerin, Neil S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fisher, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Robinson, John H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tiniakos, Dina G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gray, Douglas A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oakley, Fiona</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mann, Derek A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Abdelbaky, Hanan H. ELSEVIER</subfield><subfield code="t">Identification of the antigenic region of</subfield><subfield code="d">2018</subfield><subfield code="d">official journal of the European Association for the Study of the Liver</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV000433829</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:1421-1428</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.jhep.2015.07.034</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.44</subfield><subfield code="j">Parasitologie</subfield><subfield code="x">Medizin</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">2015</subfield><subfield code="e">6</subfield><subfield code="h">1421-1428</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
Wilson, Caroline L. |
| spellingShingle |
Wilson, Caroline L. ddc 610 bkl 44.44 Elsevier CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| authorStr |
Wilson, Caroline L. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV000433829 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 610 VZ 44.44 bkl Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF Elsevier |
| topic |
ddc 610 bkl 44.44 Elsevier CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF |
| topic_unstemmed |
ddc 610 bkl 44.44 Elsevier CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF |
| topic_browse |
ddc 610 bkl 44.44 Elsevier CCl4 Elsevier BDL Elsevier CDK Elsevier Ub Elsevier DUB Elsevier PDGFBB Elsevier Rb Elsevier UCHL1 Elsevier USP Elsevier qHSC Elsevier αSMA Elsevier HSC Elsevier ALD Elsevier aHSC Elsevier IPF |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
l b m lb lbm j l jl s k sk j f jf c r f cr crf n s s ns nss a f af j h r jh jhr d g t dg dgt d a g da dag f o fo d a m da dam |
| hierarchy_parent_title |
Identification of the antigenic region of |
| hierarchy_parent_id |
ELV000433829 |
| dewey-tens |
610 - Medicine & health |
| hierarchy_top_title |
Identification of the antigenic region of |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV000433829 |
| title |
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| ctrlnum |
(DE-627)ELV012871710 (ELSEVIER)S0168-8278(15)00537-1 |
| title_full |
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| author_sort |
Wilson, Caroline L. |
| journal |
Identification of the antigenic region of |
| journalStr |
Identification of the antigenic region of |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology |
| recordtype |
marc |
| publishDateSort |
2015 |
| contenttype_str_mv |
zzz |
| container_start_page |
1421 |
| author_browse |
Wilson, Caroline L. |
| container_volume |
63 |
| physical |
8 |
| class |
610 610 DE-600 610 VZ 44.44 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Wilson, Caroline L. |
| doi_str_mv |
10.1016/j.jhep.2015.07.034 |
| dewey-full |
610 |
| title_sort |
ubiquitin c-terminal hydrolase 1: a novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| title_auth |
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| abstract |
Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. |
| abstractGer |
Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. |
| abstract_unstemmed |
Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| container_issue |
6 |
| title_short |
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease |
| url |
https://doi.org/10.1016/j.jhep.2015.07.034 |
| remote_bool |
true |
| author2 |
Murphy, Lindsay B. Leslie, Jack Kendrick, Stuart French, Jeremy Fox, Christopher R. Sheerin, Neil S. Fisher, Andrew Robinson, John H. Tiniakos, Dina G. Gray, Douglas A. Oakley, Fiona Mann, Derek A. |
| author2Str |
Murphy, Lindsay B. Leslie, Jack Kendrick, Stuart French, Jeremy Fox, Christopher R. Sheerin, Neil S. Fisher, Andrew Robinson, John H. Tiniakos, Dina G. Gray, Douglas A. Oakley, Fiona Mann, Derek A. |
| ppnlink |
ELV000433829 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth oth oth oth |
| doi_str |
10.1016/j.jhep.2015.07.034 |
| up_date |
2024-07-06T17:23:13.198Z |
| _version_ |
1803851234752331776 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV012871710</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230623102227.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180602s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jhep.2015.07.034</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2015006000007.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV012871710</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0168-8278(15)00537-1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.44</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wilson, Caroline L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Ubiquitination is a reversible protein modification involved in the major cellular processes that define cell phenotype and behaviour. Ubiquitin modifications are removed by a large family of proteases named deubiquitinases. The role of deubiquitinases in hepatic stellate cell (HSC) activation and their contribution to fibrogenesis are poorly defined. We have identified that the deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) is highly induced following HSC activation, determined its function in activated HSC and its potential as a therapeutic target for fibrosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">CCl4</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">BDL</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">CDK</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Ub</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">DUB</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">PDGFBB</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Rb</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">UCHL1</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">USP</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">qHSC</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">αSMA</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">HSC</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">ALD</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">aHSC</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">IPF</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Murphy, Lindsay B.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Leslie, Jack</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kendrick, Stuart</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">French, Jeremy</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fox, Christopher R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sheerin, Neil S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fisher, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Robinson, John H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tiniakos, Dina G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gray, Douglas A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oakley, Fiona</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mann, Derek A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Abdelbaky, Hanan H. ELSEVIER</subfield><subfield code="t">Identification of the antigenic region of</subfield><subfield code="d">2018</subfield><subfield code="d">official journal of the European Association for the Study of the Liver</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV000433829</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:1421-1428</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.jhep.2015.07.034</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.44</subfield><subfield code="j">Parasitologie</subfield><subfield code="x">Medizin</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">2015</subfield><subfield code="e">6</subfield><subfield code="h">1421-1428</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.398587 |