Genetics of cardiovascular disease: Importance of sex and ethnicity
Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent diffi...
Ausführliche Beschreibung
Autor*in: |
Winham, Stacey J. [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015transfer abstract |
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Umfang: |
10 |
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Übergeordnetes Werk: |
Enthalten in: No title available - 241(2015), 1, Seite 219-228 |
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Übergeordnetes Werk: |
volume:241 ; year:2015 ; number:1 ; pages:219-228 ; extent:10 |
Links: |
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DOI / URN: |
10.1016/j.atherosclerosis.2015.03.021 |
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ELV013529323 |
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10.1016/j.atherosclerosis.2015.03.021 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015022000002.pica (DE-627)ELV013529323 (ELSEVIER)S0021-9150(15)00181-1 DE-627 ger DE-627 rakwb eng Winham, Stacey J. verfasserin aut Genetics of cardiovascular disease: Importance of sex and ethnicity 2015transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. Women Elsevier Coronary arterial calcification Elsevier Sex chromosomes Elsevier Atherosclerosis Elsevier Men Elsevier Carotid intima-medial thickness Elsevier de Andrade, Mariza oth Miller, Virginia M. oth Enthalten in No title available 241(2015), 1, Seite 219-228 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:241 year:2015 number:1 pages:219-228 extent:10 https://doi.org/10.1016/j.atherosclerosis.2015.03.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 241 2015 1 219-228 10 |
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10.1016/j.atherosclerosis.2015.03.021 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015022000002.pica (DE-627)ELV013529323 (ELSEVIER)S0021-9150(15)00181-1 DE-627 ger DE-627 rakwb eng Winham, Stacey J. verfasserin aut Genetics of cardiovascular disease: Importance of sex and ethnicity 2015transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. Women Elsevier Coronary arterial calcification Elsevier Sex chromosomes Elsevier Atherosclerosis Elsevier Men Elsevier Carotid intima-medial thickness Elsevier de Andrade, Mariza oth Miller, Virginia M. oth Enthalten in No title available 241(2015), 1, Seite 219-228 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:241 year:2015 number:1 pages:219-228 extent:10 https://doi.org/10.1016/j.atherosclerosis.2015.03.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 241 2015 1 219-228 10 |
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10.1016/j.atherosclerosis.2015.03.021 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015022000002.pica (DE-627)ELV013529323 (ELSEVIER)S0021-9150(15)00181-1 DE-627 ger DE-627 rakwb eng Winham, Stacey J. verfasserin aut Genetics of cardiovascular disease: Importance of sex and ethnicity 2015transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. Women Elsevier Coronary arterial calcification Elsevier Sex chromosomes Elsevier Atherosclerosis Elsevier Men Elsevier Carotid intima-medial thickness Elsevier de Andrade, Mariza oth Miller, Virginia M. oth Enthalten in No title available 241(2015), 1, Seite 219-228 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:241 year:2015 number:1 pages:219-228 extent:10 https://doi.org/10.1016/j.atherosclerosis.2015.03.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 241 2015 1 219-228 10 |
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Genetics of cardiovascular disease: Importance of sex and ethnicity |
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title_full |
Genetics of cardiovascular disease: Importance of sex and ethnicity |
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Winham, Stacey J. |
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Winham, Stacey J. |
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Winham, Stacey J. |
doi_str_mv |
10.1016/j.atherosclerosis.2015.03.021 |
title_sort |
genetics of cardiovascular disease: importance of sex and ethnicity |
title_auth |
Genetics of cardiovascular disease: Importance of sex and ethnicity |
abstract |
Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. |
abstractGer |
Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. |
abstract_unstemmed |
Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying the contribution of the sex chromosomes in women due to X chromosome inactivation. This paper will provide general background on the X and Y chromosomes (including gene content, the pseudoautosomal regions, and X chromosome inactivation), discuss how sex chromosomes have been ignored in Genome-wide Association Studies (GWAS) of cardiovascular diseases, and discuss genetics influencing development of cardiovascular risk factors and atherosclerosis with particular attention to carotid intima-medial thickness, and coronary arterial calcification based on sex-specific studies. In addition, a brief discussion of how ethnicity and hormonal status act as confounding variables in sex-based analysis will be considered along with methods for statistical analysis to account for sex in cardiovascular disease. |
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title_short |
Genetics of cardiovascular disease: Importance of sex and ethnicity |
url |
https://doi.org/10.1016/j.atherosclerosis.2015.03.021 |
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author2 |
de Andrade, Mariza Miller, Virginia M. |
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de Andrade, Mariza Miller, Virginia M. |
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up_date |
2024-07-06T19:07:09.816Z |
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