Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)

Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepa...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Skiba-Cassy, Sandrine [verfasserIn] Geurden, Inge Panserat, Stéphane Seiliez, Iban

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016transfer abstract

Umfang:	10

Übergeordnetes Werk:	Enthalten in: MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS - Tong, Liqi ELSEVIER, 2019, an international journal devoted to research on the exploration, improvement and management of all aquatic food resources, both floristic and faunistic, from freshwater, brackish and marine environment, Amsterdam [u.a.]
Übergeordnetes Werk:	volume:454 ; year:2016 ; day:1 ; month:03 ; pages:56-65 ; extent:10

Links:	Volltext

DOI / URN:	10.1016/j.aquaculture.2015.12.015

Katalog-ID:	ELV013583174

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520			\|a Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess.
520			\|a Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess.
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author_variant	s s c ssc
matchkey_str	skibacassysandrinegeurdeningepanseratstp:2016----:itrmtinniblneleshtasrpinleuainfeeivleiguoeiiadmnaimtblsit
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allfields	10.1016/j.aquaculture.2015.12.015 doi GBVA2016001000008.pica (DE-627)ELV013583174 (ELSEVIER)S0044-8486(15)30285-4 DE-627 ger DE-627 rakwb eng 570 550 570 DE-600 550 DE-600 610 VZ 44.68 bkl Skiba-Cassy, Sandrine verfasserin aut Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss) 2016transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Geurden, Inge oth Panserat, Stéphane oth Seiliez, Iban oth Enthalten in Elsevier Science Tong, Liqi ELSEVIER MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS 2019 an international journal devoted to research on the exploration, improvement and management of all aquatic food resources, both floristic and faunistic, from freshwater, brackish and marine environment Amsterdam [u.a.] (DE-627)ELV003008401 volume:454 year:2016 day:1 month:03 pages:56-65 extent:10 https://doi.org/10.1016/j.aquaculture.2015.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.68 Gerontologie Geriatrie VZ AR 454 2016 1 0301 56-65 10 045F 570
spelling	10.1016/j.aquaculture.2015.12.015 doi GBVA2016001000008.pica (DE-627)ELV013583174 (ELSEVIER)S0044-8486(15)30285-4 DE-627 ger DE-627 rakwb eng 570 550 570 DE-600 550 DE-600 610 VZ 44.68 bkl Skiba-Cassy, Sandrine verfasserin aut Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss) 2016transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Geurden, Inge oth Panserat, Stéphane oth Seiliez, Iban oth Enthalten in Elsevier Science Tong, Liqi ELSEVIER MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS 2019 an international journal devoted to research on the exploration, improvement and management of all aquatic food resources, both floristic and faunistic, from freshwater, brackish and marine environment Amsterdam [u.a.] (DE-627)ELV003008401 volume:454 year:2016 day:1 month:03 pages:56-65 extent:10 https://doi.org/10.1016/j.aquaculture.2015.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.68 Gerontologie Geriatrie VZ AR 454 2016 1 0301 56-65 10 045F 570
allfields_unstemmed	10.1016/j.aquaculture.2015.12.015 doi GBVA2016001000008.pica (DE-627)ELV013583174 (ELSEVIER)S0044-8486(15)30285-4 DE-627 ger DE-627 rakwb eng 570 550 570 DE-600 550 DE-600 610 VZ 44.68 bkl Skiba-Cassy, Sandrine verfasserin aut Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss) 2016transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Geurden, Inge oth Panserat, Stéphane oth Seiliez, Iban oth Enthalten in Elsevier Science Tong, Liqi ELSEVIER MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS 2019 an international journal devoted to research on the exploration, improvement and management of all aquatic food resources, both floristic and faunistic, from freshwater, brackish and marine environment Amsterdam [u.a.] (DE-627)ELV003008401 volume:454 year:2016 day:1 month:03 pages:56-65 extent:10 https://doi.org/10.1016/j.aquaculture.2015.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.68 Gerontologie Geriatrie VZ AR 454 2016 1 0301 56-65 10 045F 570
allfieldsGer	10.1016/j.aquaculture.2015.12.015 doi GBVA2016001000008.pica (DE-627)ELV013583174 (ELSEVIER)S0044-8486(15)30285-4 DE-627 ger DE-627 rakwb eng 570 550 570 DE-600 550 DE-600 610 VZ 44.68 bkl Skiba-Cassy, Sandrine verfasserin aut Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss) 2016transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Geurden, Inge oth Panserat, Stéphane oth Seiliez, Iban oth Enthalten in Elsevier Science Tong, Liqi ELSEVIER MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS 2019 an international journal devoted to research on the exploration, improvement and management of all aquatic food resources, both floristic and faunistic, from freshwater, brackish and marine environment Amsterdam [u.a.] (DE-627)ELV003008401 volume:454 year:2016 day:1 month:03 pages:56-65 extent:10 https://doi.org/10.1016/j.aquaculture.2015.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.68 Gerontologie Geriatrie VZ AR 454 2016 1 0301 56-65 10 045F 570
allfieldsSound	10.1016/j.aquaculture.2015.12.015 doi GBVA2016001000008.pica (DE-627)ELV013583174 (ELSEVIER)S0044-8486(15)30285-4 DE-627 ger DE-627 rakwb eng 570 550 570 DE-600 550 DE-600 610 VZ 44.68 bkl Skiba-Cassy, Sandrine verfasserin aut Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss) 2016transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess. Geurden, Inge oth Panserat, Stéphane oth Seiliez, Iban oth Enthalten in Elsevier Science Tong, Liqi ELSEVIER MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS 2019 an international journal devoted to research on the exploration, improvement and management of all aquatic food resources, both floristic and faunistic, from freshwater, brackish and marine environment Amsterdam [u.a.] (DE-627)ELV003008401 volume:454 year:2016 day:1 month:03 pages:56-65 extent:10 https://doi.org/10.1016/j.aquaculture.2015.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.68 Gerontologie Geriatrie VZ AR 454 2016 1 0301 56-65 10 045F 570
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source	Enthalten in MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS Amsterdam [u.a.] volume:454 year:2016 day:1 month:03 pages:56-65 extent:10
sourceStr	Enthalten in MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS Amsterdam [u.a.] volume:454 year:2016 day:1 month:03 pages:56-65 extent:10
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author	Skiba-Cassy, Sandrine
spellingShingle	Skiba-Cassy, Sandrine ddc 570 ddc 550 ddc 610 bkl 44.68 Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
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topic_title	570 550 570 DE-600 550 DE-600 610 VZ 44.68 bkl Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
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title	Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
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title_full	Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
author_sort	Skiba-Cassy, Sandrine
journal	MODULATION OF HISTONE H3 LYSINE 9 TRIMETHYLATION REGULATES SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS
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title_sort	dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (oncorhynchus mykiss)
title_auth	Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
abstract	Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess.
abstractGer	Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess.
abstract_unstemmed	Supplementation of fish diets with crystalline methionine is needed to overcome the low methionine content of plant based diet and to ensure good growth performances of the farmed fish. The study aimed to investigate the consequences of methionine imbalance on the expression of genes related to hepatic intermediary metabolism in rainbow trout. For this purpose, juvenile trout were fed during 6weeks diets containing either deficient, adequate or excess levels of methionine. The results indicate that the methionine deficiency increased the expression of the activating transcription factor 4 (ATF4) target genes asparagine synthetase (ASNS), system A amino acid transporter 2 (SNAT2) and cationic amino acid transporter 1 (CAT1) as a result of the activation of the GCN2/eIF2α pathway. In contrast, dietary methionine supplied in excess produced broader changes on hepatic gene expression by increasing the levels of transcripts related to fatty acid synthesis (fatty acid synthesis, FAS) and oxidation (hydroxyacyl-CoA dehydrogenase, HOAD), gluconeogenesis (glucose-6-phosphatase 2, G6Pase2 and phosphoénolpyruvate carboxykinase, PEPCK) and amino acid catabolism (glutamate dehydrogenase 1 and 2, GDH 1 and 2). Methionine excess also led to a post-prandial down-regulation of G6Pase2 and PEPCK gene expression not occurring in fish fed the methionine deficient or adequate diet. This study shows that a dietary methionine imbalance in juvenile trout strongly affects hepatic gene expression and that the response highly depends on the nature of the imbalance: deficiency or excess.
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title_short	Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)
url	https://doi.org/10.1016/j.aquaculture.2015.12.015
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up_date	2024-07-06T19:16:23.653Z
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Dietary methionine imbalance alters the transcriptional regulation of genes involved in glucose, lipid and amino acid metabolism in the liver of rainbow trout (Oncorhynchus mykiss)

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