PBDE levels in breast milk are decreasing in California
To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Guo, Weihong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata - Shterenlikht, Anton ELSEVIER, 2019, chemistry, biology and toxicology as related to environmental problems, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:150 ; year:2016 ; pages:505-513 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.chemosphere.2015.11.032 |
|---|
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ELV013594591 |
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| 520 | |a To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. | ||
| 520 | |a To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. | ||
| 650 | 7 | |a Maternal blood |2 Elsevier | |
| 650 | 7 | |a PCBs |2 Elsevier | |
| 650 | 7 | |a Cord blood |2 Elsevier | |
| 650 | 7 | |a PBDEs |2 Elsevier | |
| 650 | 7 | |a Breast milk |2 Elsevier | |
| 700 | 1 | |a Holden, Arthur |4 oth | |
| 700 | 1 | |a Smith, Sabrina Crispo |4 oth | |
| 700 | 1 | |a Gephart, Rosanne |4 oth | |
| 700 | 1 | |a Petreas, Myrto |4 oth | |
| 700 | 1 | |a Park, June-Soo |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Shterenlikht, Anton ELSEVIER |t MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |d 2019 |d chemistry, biology and toxicology as related to environmental problems |g Amsterdam [u.a.] |w (DE-627)ELV002112701 |
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10.1016/j.chemosphere.2015.11.032 doi GBV00000000000198A.pica (DE-627)ELV013594591 (ELSEVIER)S0045-6535(15)30365-9 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Guo, Weihong verfasserin aut PBDE levels in breast milk are decreasing in California 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. Maternal blood Elsevier PCBs Elsevier Cord blood Elsevier PBDEs Elsevier Breast milk Elsevier Holden, Arthur oth Smith, Sabrina Crispo oth Gephart, Rosanne oth Petreas, Myrto oth Park, June-Soo oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:150 year:2016 pages:505-513 extent:9 https://doi.org/10.1016/j.chemosphere.2015.11.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 150 2016 505-513 9 045F 333.7 |
| spelling |
10.1016/j.chemosphere.2015.11.032 doi GBV00000000000198A.pica (DE-627)ELV013594591 (ELSEVIER)S0045-6535(15)30365-9 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Guo, Weihong verfasserin aut PBDE levels in breast milk are decreasing in California 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. Maternal blood Elsevier PCBs Elsevier Cord blood Elsevier PBDEs Elsevier Breast milk Elsevier Holden, Arthur oth Smith, Sabrina Crispo oth Gephart, Rosanne oth Petreas, Myrto oth Park, June-Soo oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:150 year:2016 pages:505-513 extent:9 https://doi.org/10.1016/j.chemosphere.2015.11.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 150 2016 505-513 9 045F 333.7 |
| allfields_unstemmed |
10.1016/j.chemosphere.2015.11.032 doi GBV00000000000198A.pica (DE-627)ELV013594591 (ELSEVIER)S0045-6535(15)30365-9 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Guo, Weihong verfasserin aut PBDE levels in breast milk are decreasing in California 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. Maternal blood Elsevier PCBs Elsevier Cord blood Elsevier PBDEs Elsevier Breast milk Elsevier Holden, Arthur oth Smith, Sabrina Crispo oth Gephart, Rosanne oth Petreas, Myrto oth Park, June-Soo oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:150 year:2016 pages:505-513 extent:9 https://doi.org/10.1016/j.chemosphere.2015.11.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 150 2016 505-513 9 045F 333.7 |
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10.1016/j.chemosphere.2015.11.032 doi GBV00000000000198A.pica (DE-627)ELV013594591 (ELSEVIER)S0045-6535(15)30365-9 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Guo, Weihong verfasserin aut PBDE levels in breast milk are decreasing in California 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. Maternal blood Elsevier PCBs Elsevier Cord blood Elsevier PBDEs Elsevier Breast milk Elsevier Holden, Arthur oth Smith, Sabrina Crispo oth Gephart, Rosanne oth Petreas, Myrto oth Park, June-Soo oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:150 year:2016 pages:505-513 extent:9 https://doi.org/10.1016/j.chemosphere.2015.11.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 150 2016 505-513 9 045F 333.7 |
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10.1016/j.chemosphere.2015.11.032 doi GBV00000000000198A.pica (DE-627)ELV013594591 (ELSEVIER)S0045-6535(15)30365-9 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Guo, Weihong verfasserin aut PBDE levels in breast milk are decreasing in California 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. Maternal blood Elsevier PCBs Elsevier Cord blood Elsevier PBDEs Elsevier Breast milk Elsevier Holden, Arthur oth Smith, Sabrina Crispo oth Gephart, Rosanne oth Petreas, Myrto oth Park, June-Soo oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:150 year:2016 pages:505-513 extent:9 https://doi.org/10.1016/j.chemosphere.2015.11.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 150 2016 505-513 9 045F 333.7 |
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PBDE levels in breast milk are decreasing in California |
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To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. |
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To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. |
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To assess the efficacy of the bans in reducing PBDE levels, we recruited 67 California first time mothers (sampled during 2009–2012) and collected cord blood at birth (n = 31), breast milk (n = 66) and maternal blood (n = 65) at 3–8 weeks postpartum. Using the same sample extraction procedures and analytical instrumentation method (GC-HRMS), we compared PBDE as well as PCB levels in these breast milk samples to those from our previous study (n = 82, sampled during 2003–2005) and found that the sum of PBDEs over the ∼7 year course declined by 39% (GeoMean = 67.8 ng/g lipid in 2003–2005; 41.5 ng/g lipid in 2009–2012) and that the sum of PCBs declined by 36% (GeoMean = 71.6 ng/g lipid in 2003–2005; 45.7 ng/g lipid in 2009–2012). This supports our earlier finding of a PBDE decline (39%) in blood. We also found that the PBDE concentrations and congener profiles were similar in breast milk and their matched maternal/cord blood: BDE-47 was the dominant congener, followed by BDE-153, -99, and -100. Similar levels and congener profiles of PBDEs in these matrices suggest that they are at equilibrium. Therefore, we propose that maternal serum levels may be used to predict an infant's daily dose of PBDE exposure from breastfeeding when breast milk levels are not available. In addition, our study confirmed that breastfeeding babies are still exposed to high levels of PBDEs, even though PBDE levels are decreasing. |
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